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UA115034C2 - Імунокон'югат для застосування в лікуванні раку або запального порушення - Google Patents

Імунокон'югат для застосування в лікуванні раку або запального порушення

Info

Publication number
UA115034C2
UA115034C2 UAA201313703A UAA201313703A UA115034C2 UA 115034 C2 UA115034 C2 UA 115034C2 UA A201313703 A UAA201313703 A UA A201313703A UA A201313703 A UAA201313703 A UA A201313703A UA 115034 C2 UA115034 C2 UA 115034C2
Authority
UA
Ukraine
Prior art keywords
immunoconjugate
cancer
treatment
inflammatory disorder
fragment
Prior art date
Application number
UAA201313703A
Other languages
English (en)
Inventor
Олівер Аст
Петер Брюнкер
Томас У. ХОФЕР
Ральф Хоссе
Крістіан Кляйн
Еккехард Мьосснер
Пабло Умана
Original Assignee
Рош Глікарт Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46022216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA115034(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Рош Глікарт Аг filed Critical Рош Глікарт Аг
Publication of UA115034C2 publication Critical patent/UA115034C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

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Abstract

Винахід стосується імунокон'югата, який містить перший антигензв'язуючий фрагмент, Fc-домен, націлені на CEA і одиничний ефекторний фрагмент, виділеного полінуклеотиду, експресійного вектора, клітини-хазяїна, фармацевтичної композиції, способу одержання такого імунокон'югата, та спосіб застосування зазначеного імунокон'югата для лікування раку або запального захворювання.
UAA201313703A 2011-04-29 2012-04-26 Імунокон'югат для застосування в лікуванні раку або запального порушення UA115034C2 (uk)

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