SI2794849T1 - A process for producing high-efficiency salmonella strains - Google Patents
A process for producing high-efficiency salmonella strains Download PDFInfo
- Publication number
- SI2794849T1 SI2794849T1 SI201231125T SI201231125T SI2794849T1 SI 2794849 T1 SI2794849 T1 SI 2794849T1 SI 201231125 T SI201231125 T SI 201231125T SI 201231125 T SI201231125 T SI 201231125T SI 2794849 T1 SI2794849 T1 SI 2794849T1
- Authority
- SI
- Slovenia
- Prior art keywords
- salmonella typhi
- medium
- measuring
- initial
- optical density
- Prior art date
Links
- 241000607142 Salmonella Species 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 230000002238 attenuated effect Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 claims abstract 15
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims abstract 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract 6
- 239000008103 glucose Substances 0.000 claims abstract 6
- 102000053602 DNA Human genes 0.000 claims abstract 4
- 108091008605 VEGF receptors Proteins 0.000 claims abstract 3
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims abstract 3
- 238000000855 fermentation Methods 0.000 claims abstract 3
- 230000004151 fermentation Effects 0.000 claims abstract 3
- 230000005526 G1 to G0 transition Effects 0.000 claims abstract 2
- 238000012258 culturing Methods 0.000 claims abstract 2
- 230000003287 optical effect Effects 0.000 claims 5
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 239000001888 Peptone Substances 0.000 claims 2
- 108010080698 Peptones Proteins 0.000 claims 2
- 235000019319 peptone Nutrition 0.000 claims 2
- 229920001817 Agar Polymers 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000003337 fertilizer Substances 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 101150002054 galE gene Proteins 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 229930027917 kanamycin Natural products 0.000 claims 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 claims 1
- 229960000318 kanamycin Drugs 0.000 claims 1
- 229930182823 kanamycin A Natural products 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000005070 sampling Methods 0.000 claims 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 108010010662 galactose epimerase Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001109—Vascular endothelial growth factor receptors [VEGFR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q3/00—Condition responsive control processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11400061 | 2011-12-22 | ||
| PCT/EP2012/005364 WO2013091898A1 (en) | 2011-12-22 | 2012-12-21 | Method for producing high yield attenuated salmonella strains |
| EP12808264.1A EP2794849B1 (en) | 2011-12-22 | 2012-12-21 | Method for producing high yield attenuated salmonella strains |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2794849T1 true SI2794849T1 (en) | 2018-01-31 |
Family
ID=47458857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231125T SI2794849T1 (en) | 2011-12-22 | 2012-12-21 | A process for producing high-efficiency salmonella strains |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9493738B2 (ko) |
| EP (1) | EP2794849B1 (ko) |
| JP (1) | JP6251179B2 (ko) |
| KR (1) | KR102015932B1 (ko) |
| CN (1) | CN104066834B (ko) |
| AU (1) | AU2012359166B2 (ko) |
| BR (1) | BR112014015706A2 (ko) |
| CA (1) | CA2853656C (ko) |
| DK (1) | DK2794849T3 (ko) |
| ES (1) | ES2650269T3 (ko) |
| HU (1) | HUE035438T2 (ko) |
| IL (1) | IL233167A (ko) |
| LT (1) | LT2794849T (ko) |
| MX (1) | MX355134B (ko) |
| PL (1) | PL2794849T3 (ko) |
| RU (1) | RU2631924C2 (ko) |
| SG (1) | SG11201403525PA (ko) |
| SI (1) | SI2794849T1 (ko) |
| WO (1) | WO2013091898A1 (ko) |
| ZA (1) | ZA201404501B (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE046138T2 (hu) | 2012-07-05 | 2020-02-28 | Vaximm Ag | DNS vakcina hasnyálmirigyrákos betegekben történõ alkalmazásra |
| CA2932388A1 (en) * | 2013-12-18 | 2015-06-25 | Vaximm Gmbh | Novel msln targeting dna vaccine for cancer immunotherapy |
| SI3310379T1 (sl) | 2015-06-18 | 2020-02-28 | Vaximm Ag | DNA cepivo, ki cilja VEGFR-2, za kombinacijsko terapijo |
| US20180153976A1 (en) | 2015-06-18 | 2018-06-07 | Vaximm Ag | Novel cmv pp65 targeting dna vaccine for cancer immunotherapy |
| KR20230079514A (ko) * | 2016-07-13 | 2023-06-07 | 엔이씨 온코이뮤니티 에이에스 | 암 면역요법용 dna 백신을 제조하기 위한 방법 |
| CA3050833A1 (en) | 2017-02-17 | 2018-08-23 | Vaximm Ag | Novel vegfr-2 targeting immunotherapy approach |
| WO2020205528A1 (en) * | 2019-04-01 | 2020-10-08 | North Carolina State University | Probiotic bacteria capable of adaptive response to pomegranate extract and methods of production and use thereof |
| JP2023519562A (ja) | 2020-03-31 | 2023-05-11 | エンエーセー オンコイミュニティ アクスイェ セルスカプ | サルモネラに基づく新規コロナウイルスワクチン |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH542928A (de) * | 1971-04-29 | 1973-10-15 | Schweiz Serum & Impfinst | Verfahren zur Herstellung einer neuen Typhus-Vakzine |
| KR930001382B1 (ko) * | 1990-09-05 | 1993-02-27 | 보령신약 주식회사 | 경구용 장티프스 생균백신 및 그의 제조방법 |
| WO2002053180A2 (en) * | 2001-01-03 | 2002-07-11 | Willmar Poultry Company, Inc. | Immunizing compositions and methods of use |
| US7094410B2 (en) | 2002-03-02 | 2006-08-22 | The Scripps Research Institute | DNA vaccine against proliferating endothelial cells and methods of use thereof |
| EP1670505B1 (en) * | 2003-09-18 | 2012-11-14 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Dna promoters and anthrax vaccines |
| WO2010045620A1 (en) * | 2008-10-17 | 2010-04-22 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae |
| CN101985610A (zh) * | 2010-10-26 | 2011-03-16 | 中国人民解放军军事医学科学院微生物流行病研究所 | 一种伤寒沙门氏菌菌蜕、制备方法及作为递送系统的应用 |
-
2012
- 2012-12-21 PL PL12808264T patent/PL2794849T3/pl unknown
- 2012-12-21 RU RU2014130045A patent/RU2631924C2/ru not_active IP Right Cessation
- 2012-12-21 BR BR112014015706-5A patent/BR112014015706A2/pt not_active Application Discontinuation
- 2012-12-21 KR KR1020147020387A patent/KR102015932B1/ko active IP Right Grant
- 2012-12-21 EP EP12808264.1A patent/EP2794849B1/en active Active
- 2012-12-21 MX MX2014007575A patent/MX355134B/es active IP Right Grant
- 2012-12-21 US US14/366,186 patent/US9493738B2/en active Active
- 2012-12-21 LT LTEP12808264.1T patent/LT2794849T/lt unknown
- 2012-12-21 WO PCT/EP2012/005364 patent/WO2013091898A1/en active Application Filing
- 2012-12-21 DK DK12808264.1T patent/DK2794849T3/da active
- 2012-12-21 SI SI201231125T patent/SI2794849T1/en unknown
- 2012-12-21 SG SG11201403525PA patent/SG11201403525PA/en unknown
- 2012-12-21 ES ES12808264.1T patent/ES2650269T3/es active Active
- 2012-12-21 CN CN201280064144.2A patent/CN104066834B/zh active Active
- 2012-12-21 CA CA2853656A patent/CA2853656C/en active Active
- 2012-12-21 JP JP2014547768A patent/JP6251179B2/ja active Active
- 2012-12-21 AU AU2012359166A patent/AU2012359166B2/en active Active
- 2012-12-21 HU HUE12808264A patent/HUE035438T2/en unknown
-
2014
- 2014-06-16 IL IL233167A patent/IL233167A/en active IP Right Grant
- 2014-06-19 ZA ZA2014/04501A patent/ZA201404501B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013091898A1 (en) | 2013-06-27 |
| BR112014015706A2 (pt) | 2020-10-27 |
| ES2650269T3 (es) | 2018-01-17 |
| IL233167A0 (en) | 2014-07-31 |
| CN104066834A (zh) | 2014-09-24 |
| EP2794849A1 (en) | 2014-10-29 |
| DK2794849T3 (da) | 2017-11-06 |
| JP6251179B2 (ja) | 2017-12-20 |
| CA2853656A1 (en) | 2013-06-27 |
| AU2012359166B2 (en) | 2017-08-10 |
| MX355134B (es) | 2018-04-06 |
| MX2014007575A (es) | 2015-02-05 |
| EP2794849B1 (en) | 2017-08-30 |
| US20140349274A1 (en) | 2014-11-27 |
| KR102015932B1 (ko) | 2019-08-29 |
| KR20140105028A (ko) | 2014-08-29 |
| WO2013091898A8 (en) | 2015-03-12 |
| ZA201404501B (en) | 2016-02-24 |
| AU2012359166A1 (en) | 2014-06-19 |
| IL233167A (en) | 2017-08-31 |
| HUE035438T2 (en) | 2018-05-02 |
| US9493738B2 (en) | 2016-11-15 |
| RU2631924C2 (ru) | 2017-09-28 |
| CN104066834B (zh) | 2017-04-19 |
| JP2015502162A (ja) | 2015-01-22 |
| RU2014130045A (ru) | 2016-02-10 |
| SG11201403525PA (en) | 2014-10-30 |
| LT2794849T (lt) | 2017-12-11 |
| CA2853656C (en) | 2020-12-29 |
| PL2794849T3 (pl) | 2018-02-28 |
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