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SI1781802T1 - Proizvodnja tnfr-ig fuzijskega proteina - Google Patents

Proizvodnja tnfr-ig fuzijskega proteina

Info

Publication number
SI1781802T1
SI1781802T1 SI200530874T SI200530874T SI1781802T1 SI 1781802 T1 SI1781802 T1 SI 1781802T1 SI 200530874 T SI200530874 T SI 200530874T SI 200530874 T SI200530874 T SI 200530874T SI 1781802 T1 SI1781802 T1 SI 1781802T1
Authority
SI
Slovenia
Prior art keywords
tnfr
production
fusion protein
fusion
protein
Prior art date
Application number
SI200530874T
Other languages
English (en)
Inventor
Denis Drapeau
Yen-Tung Luan
James R Mercer
Wenge Wang
Daniel R Lasko
Original Assignee
Wyeth Res Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35500648&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1781802(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Res Ireland Ltd filed Critical Wyeth Res Ireland Ltd
Publication of SI1781802T1 publication Critical patent/SI1781802T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/32Amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components
    • C12N2500/95Protein-free medium and culture conditions

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SI200530874T 2004-08-27 2005-08-26 Proizvodnja tnfr-ig fuzijskega proteina SI1781802T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60537904P 2004-08-27 2004-08-27
EP05791482A EP1781802B1 (en) 2004-08-27 2005-08-26 Production of a tnfr-ig fusion protein

Publications (1)

Publication Number Publication Date
SI1781802T1 true SI1781802T1 (sl) 2010-01-29

Family

ID=35500648

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200530874T SI1781802T1 (sl) 2004-08-27 2005-08-26 Proizvodnja tnfr-ig fuzijskega proteina
SI200530984T SI1992697T1 (sl) 2004-08-27 2005-08-26 Proizvodnja TNFR-Fc

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200530984T SI1992697T1 (sl) 2004-08-27 2005-08-26 Proizvodnja TNFR-Fc

Country Status (38)

Country Link
US (1) US7300773B2 (sl)
EP (2) EP1781802B1 (sl)
JP (3) JP2008511330A (sl)
KR (1) KR100988451B1 (sl)
CN (2) CN101061231B (sl)
AR (2) AR050537A1 (sl)
AT (2) ATE461285T1 (sl)
AU (1) AU2005280036B2 (sl)
BR (1) BRPI0514694B8 (sl)
CA (1) CA2578138C (sl)
CL (1) CL2017000577A1 (sl)
CR (2) CR8998A (sl)
CY (2) CY1109721T1 (sl)
DE (2) DE602005017285D1 (sl)
DK (2) DK1992697T3 (sl)
EC (1) ECSP077354A (sl)
EG (1) EG26922A (sl)
ES (2) ES2335518T3 (sl)
GT (2) GT200500233A (sl)
HK (2) HK1121497A1 (sl)
HN (1) HN2005000485A (sl)
HR (2) HRP20100011T1 (sl)
IL (1) IL181588A (sl)
MX (1) MX2007002381A (sl)
MY (1) MY137803A (sl)
NO (1) NO344785B1 (sl)
NZ (1) NZ579208A (sl)
PE (2) PE20060815A1 (sl)
PL (2) PL1992697T3 (sl)
PT (2) PT1781802E (sl)
RS (2) RS51255B (sl)
RU (1) RU2458988C2 (sl)
SI (2) SI1781802T1 (sl)
SV (1) SV2006002211A (sl)
TW (1) TWI364458B (sl)
UA (1) UA89383C2 (sl)
WO (1) WO2006026447A2 (sl)
ZA (1) ZA200701672B (sl)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7335491B2 (en) 2004-08-27 2008-02-26 Wyeth Research Ireland Limited Production of anti-abeta
US7294484B2 (en) * 2004-08-27 2007-11-13 Wyeth Research Ireland Limited Production of polypeptides
WO2006138181A2 (en) 2005-06-14 2006-12-28 Amgen Inc. Self-buffering protein formulations
PE20070796A1 (es) * 2005-10-24 2007-08-15 Wyeth Corp Metodo de produccion proteica utilizando compuestos anti-senescencia
US20070231895A1 (en) * 2005-11-02 2007-10-04 Lee Gene W Methods for adapting mammalian cells
EP2495307B9 (en) * 2006-07-13 2018-05-02 Wyeth LLC Production of coagulation factor IX with improved glycosylation pattern
WO2008055260A2 (en) * 2006-11-03 2008-05-08 Wyeth Glycolysis-inhibiting substances in cell culture
MX2009004974A (es) * 2006-11-08 2009-05-20 Wyeth Corp Medios diseñado racionalmente para cultivo celular.
EP2115126B1 (en) * 2007-03-02 2015-04-08 Wyeth LLC Use of copper and glutamate in cell culture for production of polypeptides
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
ES2624185T3 (es) 2007-04-26 2017-07-13 Chugai Seiyaku Kabushiki Kaisha Método de cultivo celular que utiliza un medio enriquecido con aminoácidos
CN107090481A (zh) * 2008-04-17 2017-08-25 惠氏有限责任公司 提高骨形成蛋白产量的方法
CN102007207B (zh) * 2008-04-18 2012-05-30 上海抗体药物国家工程研究中心有限公司 一种浓缩培养液及其使用方法
US8318416B2 (en) * 2008-08-08 2012-11-27 Biogen Idec Ma Inc. Nutrient monitoring and feedback control for increased bioproduct production
BR112012002974B1 (pt) 2009-08-11 2022-06-07 Genentech, Inc Processo para produzir um anticorpo em uma célula hospedeira de célula ovário de hamster chinês (cho) expressando o referido polipeptídeo
EP2507267B1 (en) * 2009-12-02 2016-09-14 Acceleron Pharma, Inc. Compositions and methods for increasing serum half-life of fc fusion proteins
PT2563906T (pt) 2010-04-26 2018-02-16 Novartis Ag Processo para cultivo de células cho
BR112012027434B1 (pt) 2010-04-26 2020-09-29 Novartis Ag Processo para produção de um polipeptídeo recombinante compreendendo uma fase de produção
US20130150554A1 (en) 2010-08-20 2013-06-13 Wyeth Llc Cell culture of growth factor-free adapted cells
US20130331554A1 (en) * 2010-11-15 2013-12-12 Biogen Idec Inc. Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography
KR101591671B1 (ko) 2011-04-29 2016-02-04 바이오콘 리서치 리미티드 항체의 이질성을 감소시키는 방법 및 그 항체의 제조방법
US8883982B2 (en) 2011-06-08 2014-11-11 Acceleron Pharma, Inc. Compositions and methods for increasing serum half-life
US10493151B2 (en) 2011-10-18 2019-12-03 Coherus Biosciences, Inc. Etanercept formulations stabilized with sodium chloride
US10293049B2 (en) 2011-10-18 2019-05-21 Coherus Biosciences, Inc. Etanercept formulations stabilized with amino acids
SG11201401220SA (en) 2011-10-21 2014-07-30 Pfizer Addition of iron to improve cell culture
KR20140135766A (ko) * 2012-02-22 2014-11-26 엔브이아이피 피티와이 리미티드 종양괴사인자 수용체 융합 단백질 및 이를 이용하는 방법
EP2869817A4 (en) 2012-07-09 2016-04-06 Coherus Biosciences Inc STABLE AQUEOUS FORMULATIONS OF ETANERCEPT
KR102250937B1 (ko) 2012-09-11 2021-05-12 코히러스 바이오사이언시즈, 인코포레이티드 고순도 및 탁월한 수율의 정확하게 폴딩된 에타너셉트
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
KR20150133833A (ko) 2013-03-26 2015-11-30 코히러스 바이오사이언시즈, 인코포레이티드 단백질 생산 방법
KR101439195B1 (ko) 2013-04-18 2014-09-12 동아대학교 산학협력단 에셰리키아 콜리 a-53 균주를 이용하여 섬유소 분해효소의 생산성을 향상시키는 공정
EA033783B1 (ru) * 2013-10-11 2019-11-25 Regeneron Pharma Метаболически оптимизированная клеточная культура
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
EP3099324B1 (en) 2014-01-30 2020-04-01 Coherus Biosciences, Inc. Perfusion media
US20160347787A1 (en) 2014-02-04 2016-12-01 Biogen Ma Inc. Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications
PT3227454T (pt) * 2014-12-01 2020-04-06 Amgen Inc Processo para a manipulação do nível do teor de glicano de uma glicoproteína
KR102007930B1 (ko) 2014-12-31 2019-08-06 주식회사 엘지화학 재조합 당단백질의 글리코실화 조절 방법
CN105777897A (zh) * 2015-03-20 2016-07-20 广东东阳光药业有限公司 一种cho细胞收获液的前处理方法
CN114807010A (zh) * 2015-04-01 2022-07-29 勃林格殷格翰国际公司 细胞培养基
KR101936049B1 (ko) * 2015-10-15 2019-01-08 (주)알테오젠 IgG Fc 도메인을 가지는 융합 단백질의 생산방법
EA201990998A1 (ru) 2016-10-21 2019-11-29 Фармацевтические составы и способы их получения
CN110484487A (zh) * 2019-08-21 2019-11-22 安徽欣乐生物技术有限公司 一种适用于cho细胞培养用无蛋白培养基及其培养方法
US20240083972A1 (en) 2020-12-22 2024-03-14 Amgen Inc. Cell culture method
CN115073607A (zh) * 2021-03-12 2022-09-20 上海康岱生物医药技术股份有限公司 Tnfr2与baff受体的融合蛋白
CN114480492B (zh) * 2022-01-28 2023-04-21 景泽生物医药(合肥)股份有限公司 一种重组人抗体融合蛋白的制备方法

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US5672502A (en) 1985-06-28 1997-09-30 Celltech Therapeutics Limited Animal cell culture
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US6048728A (en) 1988-09-23 2000-04-11 Chiron Corporation Cell culture medium for enhanced cell growth, culture longevity, and product expression
WO1990003430A1 (en) * 1988-09-23 1990-04-05 Cetus Corporation Cell culture medium for enhanced cell growth, culture longevity and product expression
US6291159B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US5605690A (en) 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
US5395760A (en) 1989-09-05 1995-03-07 Immunex Corporation DNA encoding tumor necrosis factor-α and -β receptors
NZ235148A (en) 1989-09-05 1991-12-23 Immunex Corp Tumour necrosis factor receptor protein and dna sequences
JPH0396383A (ja) 1989-09-08 1991-04-22 Riso Kagaku Corp 画像形成装置
DK0417563T3 (da) 1989-09-12 2000-11-06 Hoffmann La Roche TNF-bindende proteiner
AU638762B2 (en) 1989-10-05 1993-07-08 Optein Inc Cell-free synthesis and isolation of novel genes and polypeptides
US6657103B1 (en) 1990-01-12 2003-12-02 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5538983A (en) 1990-05-16 1996-07-23 The Rockefeller University Method of treating amyloidosis by modulation of calcium
US5156964A (en) 1990-08-16 1992-10-20 Cetus Corporation Methods for adapting cells for increased product production through exposure to ammonia
US5122469A (en) * 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
GB9021679D0 (en) 1990-10-05 1990-11-21 Gorman Scott David Antibody preparation
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
GB2251249B (en) 1990-12-28 1995-06-21 Mogam Biotech Res Inst High-density medium for animal cell culture
GB9118664D0 (en) 1991-08-30 1991-10-16 Celltech Ltd Cell culture
US5447851B1 (en) 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
JP3504963B2 (ja) 1993-10-22 2004-03-08 智靖 羅 抗ヒト高親和性IgE受容体モノクローナル抗体に係るアミノ酸配列をコードするDNA断片
US6310185B1 (en) 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies
US5856179A (en) 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US5589154A (en) 1994-11-22 1996-12-31 Rutgers, The State University Of New Jersey Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
IL117175A (en) * 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
US5705364A (en) 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
US5721121A (en) 1995-06-06 1998-02-24 Genentech, Inc. Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
US6656466B1 (en) * 1995-06-06 2003-12-02 Genetech, Inc. Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
JP4306813B2 (ja) * 1995-09-19 2009-08-05 アスビオファーマ株式会社 動物細胞の新規培養方法
US20020012991A1 (en) 1997-04-07 2002-01-31 Florence Chua Nee Ho Kit Fong Cell culture media for enhanced protein production
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
WO2000023082A1 (en) 1998-10-19 2000-04-27 Yeda Research And Development Co. Ltd. Treatment of systemic lupus erythematosus by down-regulating the autoimmune response to autoantigens
PE20020574A1 (es) 2000-12-06 2002-07-02 Wyeth Corp Anticuerpos humanizados que reconocen el peptido amiloideo beta
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
AU2002257162A1 (en) 2001-04-30 2002-11-11 Eli Lilly And Company Humanized antibodies
AU2002258808A1 (en) 2001-04-30 2002-11-11 Eli Lilly And Company Humanized antibodies
US20030087372A1 (en) 2001-06-13 2003-05-08 Genentech, Inc. Methods of culturing animal cells and polypeptide production in animal cells
US7320789B2 (en) 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
US7192717B2 (en) 2002-02-21 2007-03-20 Wyeth GASP1: a follistatin domain containing protein
WO2003072714A2 (en) 2002-02-21 2003-09-04 Wyeth Follistatin domain containing proteins
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
SI2371392T1 (sl) 2002-05-02 2015-10-30 Wyeth Holdings Llc Konjugati derivat-nosilec kaliheamicina
AR047392A1 (es) 2002-10-22 2006-01-18 Wyeth Corp Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines
US20040223966A1 (en) 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor
US7335491B2 (en) 2004-08-27 2008-02-26 Wyeth Research Ireland Limited Production of anti-abeta
US7294484B2 (en) 2004-08-27 2007-11-13 Wyeth Research Ireland Limited Production of polypeptides

Also Published As

Publication number Publication date
AR050537A1 (es) 2006-11-01
HN2005000485A (es) 2009-06-09
ATE446376T1 (de) 2009-11-15
ATE461285T1 (de) 2010-04-15
GT200500234A (es) 2006-10-10
DK1992697T3 (da) 2010-05-17
CA2578138C (en) 2010-10-05
NO344785B1 (no) 2020-04-27
JP2016056214A (ja) 2016-04-21
WO2006026447A9 (en) 2006-06-01
DE602005020076D1 (de) 2010-04-29
RS51255B (sr) 2010-12-31
MY137803A (en) 2009-03-31
MX2007002381A (es) 2007-06-15
US7300773B2 (en) 2007-11-27
EP1992697A1 (en) 2008-11-19
PE20060815A1 (es) 2006-09-14
WO2006026447A2 (en) 2006-03-09
SI1992697T1 (sl) 2010-07-30
PT1992697E (pt) 2010-04-21
AU2005280036A1 (en) 2006-03-09
TW200619388A (en) 2006-06-16
BRPI0514694B8 (pt) 2021-05-25
UA89383C2 (ru) 2010-01-25
KR20070069140A (ko) 2007-07-02
GT200500233A (es) 2006-03-09
AU2005280036B2 (en) 2011-11-03
PL1992697T3 (pl) 2010-08-31
DE602005017285D1 (sl) 2009-12-03
CN101061231A (zh) 2007-10-24
EP1992697B1 (en) 2010-03-17
IL181588A (en) 2010-12-30
BRPI0514694A (pt) 2008-06-17
HK1099941A1 (en) 2007-08-31
CA2578138A1 (en) 2006-03-09
RS51072B (sr) 2010-10-31
NZ579208A (en) 2012-01-12
KR100988451B1 (ko) 2010-10-18
CL2017000577A1 (es) 2017-12-01
US20060121569A1 (en) 2006-06-08
JP2008511330A (ja) 2008-04-17
HRP20100011T1 (hr) 2010-02-28
AR088824A2 (es) 2014-07-10
ZA200701672B (en) 2012-04-24
BRPI0514694B1 (pt) 2019-04-24
WO2006026447A3 (en) 2006-04-20
RU2458988C2 (ru) 2012-08-20
JP5921910B2 (ja) 2016-05-24
SV2006002211A (es) 2006-10-04
HK1121497A1 (en) 2009-04-24
JP2012095672A (ja) 2012-05-24
EP1781802B1 (en) 2009-10-21
NO20071570L (no) 2007-05-23
PT1781802E (pt) 2010-01-04
CY1110092T1 (el) 2015-01-14
PL1781802T3 (pl) 2010-03-31
PE20100448A1 (es) 2010-06-22
CR20120560A (es) 2012-12-04
EG26922A (en) 2014-12-25
DK1781802T3 (da) 2010-01-25
HRP20100271T1 (hr) 2010-06-30
IL181588A0 (en) 2007-07-04
CR8998A (es) 2007-11-23
ES2335518T3 (es) 2010-03-29
TWI364458B (en) 2012-05-21
ES2341390T3 (es) 2010-06-18
CN101061231B (zh) 2012-09-26
CY1109721T1 (el) 2014-08-13
EP1781802A2 (en) 2007-05-09
RU2007108717A (ru) 2008-10-10
CN102876761A (zh) 2013-01-16
ECSP077354A (es) 2007-05-30

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