SG10201913957PA - Nanoparticle compositions for sustained therapy - Google Patents
Nanoparticle compositions for sustained therapyInfo
- Publication number
- SG10201913957PA SG10201913957PA SG10201913957PA SG10201913957PA SG10201913957PA SG 10201913957P A SG10201913957P A SG 10201913957PA SG 10201913957P A SG10201913957P A SG 10201913957PA SG 10201913957P A SG10201913957P A SG 10201913957PA SG 10201913957P A SG10201913957P A SG 10201913957PA
- Authority
- SG
- Singapore
- Prior art keywords
- nanoparticle compositions
- sustained therapy
- sustained
- therapy
- nanoparticle
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 239000002105 nanoparticle Substances 0.000 title 1
- 230000002459 sustained effect Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562157933P | 2015-05-06 | 2015-05-06 | |
US201562273953P | 2015-12-31 | 2015-12-31 | |
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Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
CN104781279A (zh) * | 2012-11-30 | 2015-07-15 | 罗切格利卡特公司 | 利用包含癌细胞靶向性mhc i类的多功能蛋白通过循环中的病毒特异性细胞毒性t细胞清除癌细胞 |
PL2935328T3 (pl) | 2012-12-21 | 2019-02-28 | Hoffmann La Roche | Połączone wiązaniem dwusiarczkowym wielowartościowe białka wielofunkcyjne zawierające MHC klasy I |
US10124045B2 (en) | 2013-11-04 | 2018-11-13 | Uti Limited Partnership | Methods and compositions for sustained immunotherapy |
WO2015188839A2 (en) | 2014-06-13 | 2015-12-17 | Immudex Aps | General detection and isolation of specific cells by binding of labeled molecules |
KR20180011135A (ko) | 2015-05-06 | 2018-01-31 | 유티아이 리미티드 파트너쉽 | 지속 치료를 위한 나노입자 조성물 |
CN110291111A (zh) * | 2016-11-09 | 2019-09-27 | 优迪有限合伙公司 | 重组pMHC II类分子 |
CN117024560A (zh) | 2016-12-22 | 2023-11-10 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
EP4431109A2 (en) | 2017-03-15 | 2024-09-18 | Cue Biopharma, Inc. | Combination of multimeric fusion polypeptides and immune checkpoint inhibitor for treating hpv-associated cancer |
SG11201909290TA (en) * | 2017-04-07 | 2019-11-28 | Uti Lp | Assay to measure the potency of receptor-ligand interactions in nanomedicines |
JP7270946B2 (ja) * | 2017-08-08 | 2023-05-11 | 国立大学法人浜松医科大学 | 自己免疫疾患の治療又は予防剤 |
AU2018374569B2 (en) * | 2017-11-29 | 2024-10-17 | Uti Limited Partnership | Methods of treating autoimmune disease |
WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
US10709792B1 (en) * | 2018-04-06 | 2020-07-14 | Verily Life Sciences Llc | Passivated magnetic nanoparticles for cell targeting and methods of preparation and use |
CN109126648B (zh) * | 2018-06-05 | 2021-09-03 | 青岛明月生物医用材料有限公司 | 一种壳聚糖和藻酸丙二醇酯共混微胶囊的制备及其应用 |
TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
JP2022522404A (ja) * | 2019-03-06 | 2022-04-19 | キュー バイオファーマ, インコーポレイテッド | T細胞調節抗原提示ポリペプチド及びその使用方法 |
EP3958892A4 (en) * | 2019-05-23 | 2023-06-14 | UTI Limited Partnership | METHOD OF TREATMENT OF LIVER DISEASE |
EP4078178B1 (en) * | 2019-12-20 | 2024-10-23 | Miltenyi Biotec B.V. & Co. KG | Reversible cell detection via mhc with conjugates having an enzymatically cleavable detection moiety |
GB201919222D0 (en) * | 2019-12-23 | 2020-02-05 | Apitope Int Nv | Composition |
WO2021134512A1 (zh) * | 2019-12-31 | 2021-07-08 | 厦门大学 | 一种拟穴青蟹抗菌肽Scyreprocin新功能及其应用 |
TW202144389A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在多發性骨髓瘤中表現之新抗原及其用途 |
TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
CN111514306B (zh) * | 2020-04-23 | 2022-05-13 | 中国科学院化学研究所 | 一种增强抗肿瘤免疫治疗的富勒烯纳米颗粒 |
IL296209A (en) | 2020-05-12 | 2022-11-01 | Cue Biopharma Inc | Multimeric t-cell modulatory polypeptides and methods of using them |
WO2022056014A1 (en) | 2020-09-09 | 2022-03-17 | Cue Biopharma, Inc. | Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof |
KR20240099285A (ko) * | 2021-10-21 | 2024-06-28 | 코어 파마슈티칼스 디벨롭먼트 컴퍼니 인크. | 관용성 나노입자를 사용한 원발 담즙성 담관염 (pbc)의 치료 |
WO2023102132A1 (en) * | 2021-12-01 | 2023-06-08 | Emory University | Multi-cytokine surface loaded particles and uses in stimulating immune cells for therapeutic applications |
CN118829420A (zh) * | 2022-01-14 | 2024-10-22 | 卡尔马Abc有限责任公司 | 用于诱导体内系统性免疫耐受的多囊泡脂质纳米颗粒耐受性疫苗 |
CN114601920A (zh) * | 2022-03-23 | 2022-06-10 | 宁波御坊堂生物科技有限公司 | 一种用于改善骨关节健康的口服脂质体组合物及其制备方法 |
CN116082483B (zh) * | 2022-09-09 | 2024-05-28 | 大连工业大学 | 一种具有改善骨质疏松、增强骨密度的多肽制备方法及应用 |
FR3139820A1 (fr) * | 2022-09-15 | 2024-03-22 | Universite Toulouse III – Paul Sabatier | Molécule hybride comprenant un fragment Fc d’anticorps et au moins un peptide se liant à un lymphocyte auto-réactif impliqué dans une vascularite auto-immune, et ses utilisations |
CN115594776B (zh) * | 2022-09-19 | 2024-03-15 | 山东大学 | 一种ROS响应性聚合物Mal-PHB-Dextran及细胞背包载药系统 |
WO2024097859A1 (en) * | 2022-11-03 | 2024-05-10 | Board Of Regents, The University Of Texas System | An adjuvant and cd47-blockade combination cancer treatment and methods of using the same |
Family Cites Families (148)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US112292A (en) * | 1871-02-28 | Improvement in numbering and paging machines | ||
US4367110A (en) | 1979-07-02 | 1983-01-04 | Toppan Printing Co. | Decorative laminate and a manufacturing method therefor |
US4452901A (en) | 1980-03-20 | 1984-06-05 | Ciba-Geigy Corporation | Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays |
US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
FR2504010B1 (fr) | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
GB2097032B (en) | 1981-04-22 | 1984-09-19 | Teron International Urban Dev | A combined ceiling air and services distribution system mechanical chasse and structural roof member |
US4478946A (en) | 1981-07-02 | 1984-10-23 | South African Inventions Development Corporation | Carrier bound immunosorbent |
US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US4589071A (en) | 1982-04-19 | 1986-05-13 | Nissan Motor Co., Ltd. | Method and apparatus for controlling reduction ratio of continuously variable transmission with acceleration compensation |
US4818542A (en) | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
US4659839A (en) | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
EP0188256B1 (en) | 1985-01-14 | 1991-08-21 | NeoRx | Metal radionuclide labeled proteins for diagnosis and therapy |
US5171582A (en) | 1985-07-31 | 1992-12-15 | Ghent William R | Treatment of iodine deficiency diseases |
US4680338A (en) | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
US4699784A (en) | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
US5258499A (en) | 1988-05-16 | 1993-11-02 | Vestar, Inc. | Liposome targeting using receptor specific ligands |
US5260422A (en) | 1988-06-23 | 1993-11-09 | Anergen, Inc. | MHC conjugates useful in ameliorating autoimmunity |
US6106840A (en) | 1988-06-23 | 2000-08-22 | Anergen, Inc. | MHC conjugates useful in ameliorating autoimmunity |
US4859839A (en) | 1988-07-08 | 1989-08-22 | Counter Computer Corporation | Point-of-sale terminal for laundry or dry cleaning establishments |
US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
EP0630255B1 (en) | 1991-04-23 | 2002-12-18 | Anergen, Inc. | Mhc conjugates useful in ameliorating autoimmunity |
US5200189A (en) | 1991-07-23 | 1993-04-06 | Ecolab Inc. | Peroxyacid antimicrobial composition |
CA2130997A1 (en) | 1992-02-27 | 1993-09-02 | C. Garrison Fathman | Early antigen for autoimmune diabetes |
JP2631436B2 (ja) | 1992-07-24 | 1997-07-16 | 徳厚 小島 | 排水立て管継手 |
US5972336A (en) | 1992-11-03 | 1999-10-26 | Oravax Merieux Co. | Urease-based vaccine against helicobacter infection |
AU2076895A (en) | 1994-03-28 | 1995-10-17 | Daiichi Pharmaceutical Co., Ltd. | Liposomes |
US6103379A (en) | 1994-10-06 | 2000-08-15 | Bar-Ilan University | Process for the preparation of microspheres and microspheres made thereby |
WO1996018105A1 (en) | 1994-12-06 | 1996-06-13 | The President And Fellows Of Harvard College | Single chain t-cell receptor |
DE19508058A1 (de) | 1995-02-21 | 1996-08-22 | Schering Ag | Verfahren zur Herstellung von DTPA-Tetraestern der terminalen Carbonsäuren und deren Verwendung zur Herstellung pharmazeutischer Mittel |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
US6033864A (en) | 1996-04-12 | 2000-03-07 | The Regents Of The University Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens |
NZ333915A (en) | 1996-08-16 | 2000-11-24 | Harvard College | Soluble monovalent and multivalent MHC class II fusion proteins |
US20050003431A1 (en) | 1996-08-16 | 2005-01-06 | Wucherpfennig Kai W. | Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor |
AU741130B2 (en) | 1997-09-16 | 2001-11-22 | Oregon Health Sciences University | Recombinant MHC molecules useful for manipulation of antigen-specific T-cells |
BR9908082A (pt) | 1998-02-19 | 2000-10-31 | Harvard College | Proteìna de fusão do complexo de histocompatibilidade principal classe ii, conjugado dos domìnios de ligação do complexo de histocompatibilidade principal multimérico, processos para detectar células t tendo uma especificidade do complexo definido de mhc / peptìdeo, para conferir a um indivìduo imunidade adotiva a um complexo definido de mhc / peptìdeo, para estimular ou ativar as células t reativas a um complexo definido de mhc / peptìdeo, para seletivamente matar células t reativas a um complexo definido de mhc / peptìdeo, para tolerizar um indivìduo humano a um complexo definido de mhc / peptìdeo, e, ácido nucleico isolado |
EP1094828A4 (en) | 1998-05-07 | 2005-01-26 | Univ California | USE OF TARGETED, NEGLIGATED TISSUE ANTIGENS TO MODULATE IMMUNE REACTIONS |
DE19825371A1 (de) | 1998-06-06 | 1999-12-09 | Bayer Ag | Elektrochrome Anzeigevorrichtung mit isolierten Zuleitungen |
IL125608A0 (en) | 1998-07-30 | 1999-03-12 | Yeda Res & Dev | Tumor associated antigen peptides and use of same as anti-tumor vaccines |
US7807377B2 (en) | 1998-10-20 | 2010-10-05 | Salvatore Albani | Method of isolating antigen-specific T cells employing artificial antigen presenting cells |
US6150022A (en) | 1998-12-07 | 2000-11-21 | Flex Products, Inc. | Bright metal flake based pigments |
JP2000213425A (ja) | 1999-01-20 | 2000-08-02 | Hino Motors Ltd | Egrク―ラ |
US7090973B1 (en) | 1999-04-09 | 2006-08-15 | Oscient Pharmaceuticals Corporation | Nucleic acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics |
AU4825700A (en) | 1999-05-06 | 2000-11-21 | Genetics Institute Inc. | Use of soluble costimulatory molecules to enhance immune responses |
AU784551B2 (en) | 1999-10-06 | 2006-05-04 | Trustees Of The University Of Pennsylvania, The | Cell targeting compositions and methods of using the same |
US6585947B1 (en) | 1999-10-22 | 2003-07-01 | The Board Of Trustess Of The University Of Illinois | Method for producing silicon nanoparticles |
US6651655B1 (en) | 2000-01-18 | 2003-11-25 | Quadrant Technologies Limited | Inhaled vaccines |
US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
KR100379250B1 (ko) | 2000-12-04 | 2003-04-08 | 한국과학기술연구원 | 나노 단위 크기의 금속 입자가 함유된 고분자 복합 소재및 그 제조 방법 |
US7094555B2 (en) | 2001-04-05 | 2006-08-22 | Benaroya Research Institute At Virginia Mason | Methods of MHC class II epitope mapping, detection of autoimmune T cells and antigens, and autoimmune treatment |
DE10117858A1 (de) | 2001-04-10 | 2002-10-24 | Gsf Forschungszentrum Umwelt | MHC-Tetramere |
CA2449990A1 (en) | 2001-06-22 | 2003-01-03 | The University Of British Columbia | Type 1 diabetes diagnostics and therapeutics |
US20070129307A1 (en) | 2001-06-22 | 2007-06-07 | The University Of British Columbia | Insulin epitopes for the treatment of type 1 diabetes |
US20030124149A1 (en) | 2001-07-06 | 2003-07-03 | Shalaby Shalaby W. | Bioactive absorbable microparticles as therapeutic vaccines |
WO2003051278A2 (en) | 2001-07-10 | 2003-06-26 | North Carolina State University | Nanoparticle delivery vehicle |
DE10144252A1 (de) | 2001-08-31 | 2003-03-27 | Fraunhofer Ges Forschung | Nanopartikel mit daran immobilisiertem biologisch aktivem TNF |
CA2476755C (en) | 2001-12-17 | 2014-08-26 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of inflammatory bowel disease |
US6688494B2 (en) | 2001-12-20 | 2004-02-10 | Cima Nanotech, Inc. | Process for the manufacture of metal nanoparticle |
US7285289B2 (en) | 2002-04-12 | 2007-10-23 | Nagy Jon O | Nanoparticle vaccines |
DE60334474D1 (de) | 2002-07-12 | 2010-11-18 | Univ Johns Hopkins | Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptoren |
DE10310261A1 (de) | 2003-03-05 | 2004-09-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Identifizierung von Antigen-Epitopen |
US20040197304A1 (en) | 2003-04-01 | 2004-10-07 | The Procter & Gamble Company And Alimentary Health, Ltd. | Methods of determining efficacy of treatments of inflammatory diseases of the bowel |
US6929675B1 (en) | 2003-04-24 | 2005-08-16 | Sandia Corporation | Synthesis metal nanoparticle |
US20050118102A1 (en) | 2003-04-28 | 2005-06-02 | Intematix Corporation | Spin resonance heating and/or imaging in medical applications |
DE60334250D1 (de) | 2003-05-08 | 2010-10-28 | Life Technologies Corp | Erzeugung und isolierung antigenspezifischer t-zellen |
AU2004278652A1 (en) | 2003-05-20 | 2005-04-14 | Albert Einstein College Of Medicine Of Yeshiva University | Antigens targeted by prevalent pathogenic T cells in type 1 diabetes and uses thereof |
US7060121B2 (en) | 2003-06-25 | 2006-06-13 | Hsing Kuang Lin | Method of producing gold nanoparticle |
WO2005007673A2 (en) | 2003-07-03 | 2005-01-27 | Rush University Medical Center | Immunogenic peptides |
WO2005020933A2 (en) | 2003-09-02 | 2005-03-10 | University Of South Florida | Nanoparticles for drug-delivery |
GB0321937D0 (en) | 2003-09-19 | 2003-10-22 | Univ Liverpool | Nanoparticle conjugates and method of production thereof |
CA2540633C (en) | 2003-10-09 | 2012-12-04 | Emerson Electric Co. | Valve assembly |
DE102004023187A1 (de) | 2004-05-11 | 2005-12-01 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
JP2008512350A (ja) | 2004-07-01 | 2008-04-24 | イェール ユニバーシティ | 標的化され、そして高密度で薬物が負荷されるポリマー性物質 |
EP1793863B1 (en) | 2004-10-01 | 2017-04-12 | Midatech Ltd. | Nanoparticles comprising antigens and adjuvants capable of stimulating t helper cells |
WO2006054806A1 (ja) | 2004-11-22 | 2006-05-26 | Locomogene, Inc. | クローン病関連自己抗原 |
US7462446B2 (en) | 2005-03-18 | 2008-12-09 | University Of Washington | Magnetic nanoparticle compositions and methods |
US20070059775A1 (en) | 2005-03-29 | 2007-03-15 | The Trustees Of Columbia University In The City Of New York | Synthesis and conjugation of iron oxide nanoparticles to antibodies for targeting specific cells using fluorescence and MR imaging techniques |
US7562421B2 (en) | 2005-04-03 | 2009-07-21 | Magen Eco Energy A.C.S. Ltd. | Connecting clasp |
US7326399B2 (en) | 2005-04-15 | 2008-02-05 | Headwaters Technology Innovation, Llc | Titanium dioxide nanoparticles and nanoparticle suspensions and methods of making the same |
EP1932538A4 (en) | 2005-08-25 | 2009-10-21 | Taiho Pharmaceutical Co Ltd | BIODEGRADABLE NANOTEHICLES WITH IMMOBILIZED OR CAPACITATED T-CELL-RECOGNIZABLE EPITOPEPEPID |
WO2008051245A2 (en) | 2005-12-02 | 2008-05-02 | Novartis Ag | Nanoparticles for use in immunogenic compositions |
US20100061984A1 (en) | 2006-01-20 | 2010-03-11 | The Trustees Of The University Of Pennsylvania | Compositions and methods for modulation of suppressor t cell activation |
US9249202B2 (en) | 2006-08-11 | 2016-02-02 | Life Sciences Research Partners Vzw | Immunogenic peptides and their use in immune disorders |
US7816814B1 (en) | 2006-08-18 | 2010-10-19 | Hennessy Michael J | Bi-directional power converters |
WO2008046014A1 (en) | 2006-10-12 | 2008-04-17 | Remedy Pharmaceuticals, Inc. | Treatment of alzheimer's disease using compounds that reduce the activity of non-selective ca++- activated atp-sensitive cation channels regulated by sur1 receptors |
US10004703B2 (en) | 2006-10-12 | 2018-06-26 | Biogen Chesapeake Llc | Treatment of alzheimer's disease using compounds that reduce the activity of non-selective CA++ activated ATP-sensitive cation channels regulated by SUR1 channels |
CA2674632A1 (en) | 2006-12-29 | 2008-07-10 | University Of Washington | Dual-functional nonfouling surfaces and materials |
US8889117B2 (en) | 2007-02-15 | 2014-11-18 | Yale University | Modular nanoparticles for adaptable vaccines |
JP5650406B2 (ja) | 2007-03-07 | 2015-01-07 | ユーティーアイ リミテッド パートナーシップ | 自己免疫状態の予防および治療のための組成物および方法 |
US20150250871A1 (en) | 2007-03-07 | 2015-09-10 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
US20140105980A1 (en) | 2012-10-11 | 2014-04-17 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
US20100151031A1 (en) | 2007-03-23 | 2010-06-17 | Desimone Joseph M | Discrete size and shape specific organic nanoparticles designed to elicit an immune response |
EP3023436A1 (en) | 2007-07-03 | 2016-05-25 | Dako Denmark A/S | Improved methods for generation, labeling and use of mhc multimers |
US8666532B2 (en) | 2007-07-22 | 2014-03-04 | Camtek Ltd. | Method and system for controlling a manufacturing process |
JP5085240B2 (ja) | 2007-09-03 | 2012-11-28 | 日本電波工業株式会社 | 水晶デバイス及び水晶デバイスの製造方法 |
WO2009040811A2 (en) | 2007-09-24 | 2009-04-02 | Bar-Ilan University | Polymer nanoparticles coated by magnetic metal oxide and uses thereof |
WO2009064273A1 (en) | 2007-11-16 | 2009-05-22 | Paul Appelbaum | Apparatus and method for packaging articles in clear plastic packages |
WO2009078799A1 (en) | 2007-12-17 | 2009-06-25 | Marfl Ab | New vaccine for the treatment of mycobacterium related disorders |
WO2009094273A2 (en) | 2008-01-15 | 2009-07-30 | Yale University | Compositions and methods for adoptive and active immunotherapy |
WO2009098510A2 (en) | 2008-02-04 | 2009-08-13 | Ulive Enterprises Limited | Nanoparticle conjugates |
CN102014874A (zh) | 2008-03-04 | 2011-04-13 | 流体科技公司 | 免疫调节剂颗粒和治疗方法 |
WO2009126835A2 (en) | 2008-04-09 | 2009-10-15 | University Of Washington Techtransfer Invention Licensing | Magnetic nanoparticle and method for imaging t cells |
US20090258355A1 (en) | 2008-04-11 | 2009-10-15 | Brookhaven Science Associates, Llc | Nanoscale Clusters and Methods of Making Same |
EA201170375A1 (ru) | 2008-08-25 | 2012-03-30 | Эмплиммьюн, Инк. | Антагонисты pd-1 и способы их применения |
US8323696B2 (en) | 2008-08-29 | 2012-12-04 | Ecole Polytechnique Federale De Lausanne | Nanoparticles for immunotherapy |
WO2010037397A1 (en) | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cmv immune monitoring |
EP2337795A2 (en) * | 2008-10-01 | 2011-06-29 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
CA2642141A1 (en) | 2008-10-20 | 2010-04-20 | Innovative Microelectronics Inc. | Flange alignment pin |
JP2012508865A (ja) | 2008-11-12 | 2012-04-12 | イエダ リサーチ アンド ディベロプメント カンパニー リミテッド | 多発性硬化症の診断 |
WO2010080032A2 (en) | 2009-01-09 | 2010-07-15 | Stichting Het Nederlands Kanker Instituut | Bead-assisted viral transduction |
SG173041A1 (en) | 2009-01-20 | 2011-08-29 | Univ Northwestern | Compositions and methods for induction of antigen-specific tolerance |
US8383085B2 (en) | 2009-05-29 | 2013-02-26 | University Of Manitoba | Methods of making iron-containing nanoparticles |
CA2777053A1 (en) | 2009-10-06 | 2011-04-14 | The Board Of Trustees Of The University Of Illinois | Human single-chain t cell receptors |
GB0922066D0 (en) | 2009-12-17 | 2010-02-03 | Univ Belfast | Modulator |
GB201003088D0 (en) | 2010-02-24 | 2010-04-14 | Univ Exeter | Method for the preparation of a novel nanoparticle conjugate |
SG187201A1 (en) | 2010-07-26 | 2013-02-28 | Qu Biolog Inc | Immunogenic anti-inflammatory compositions |
PL2640711T3 (pl) | 2010-08-25 | 2016-06-30 | Davuluri Ramamohan Rao | Ulepszony sposób otrzymywania rufinamidu |
US20130171179A1 (en) | 2010-09-03 | 2013-07-04 | Oregon Health & Science University | Recombinant t-cell receptor ligands with covalently bound peptides |
KR101972291B1 (ko) | 2010-09-29 | 2019-08-16 | 유티아이 리미티드 파트너쉽 | 생체적합성, 생흡수성 나노구를 사용하는 자가면역 질병의 치료방법 |
US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
WO2012121528A2 (en) | 2011-03-04 | 2012-09-13 | Samsung Life Public Welfare Foundation | Magnetic nanocomposite specific for thyroid cancer and use thereof |
US9598479B2 (en) | 2011-09-07 | 2017-03-21 | Midatech Ltd. | Nanoparticle-peptide compositions |
US20140251917A1 (en) | 2011-09-22 | 2014-09-11 | Marv Enterprises,LLC | Method for the treatment of multiple sclerosis |
EP2591801A1 (en) | 2011-11-14 | 2013-05-15 | Universitätsklinikum Hamburg-Eppendorf | Nanoparticle compositions for generation of regulatory T cells and treatment of autoimmune diseases and other chronic inflammatory conditions |
US20130128138A1 (en) | 2011-11-18 | 2013-05-23 | Shenzhen China Star Optoelectronics Technolog Co., LTD. | Flat Panel Display Device, Stereoscopic Display Device, Plasma Display Device |
JP2015500296A (ja) | 2011-12-09 | 2015-01-05 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 定義された動的形状を有する人工抗原提示細胞 |
US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
WO2013184976A2 (en) | 2012-06-06 | 2013-12-12 | Northwestern University | Compositions and methods for antigen-specific tolerance |
US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
PL2935328T3 (pl) | 2012-12-21 | 2019-02-28 | Hoffmann La Roche | Połączone wiązaniem dwusiarczkowym wielowartościowe białka wielofunkcyjne zawierające MHC klasy I |
KR102266819B1 (ko) | 2013-04-29 | 2021-06-18 | 에프. 호프만-라 로슈 아게 | Fc-수용체 결합 개질된 비대칭 항체 및 이의 사용 방법 |
MY175347A (en) | 2013-08-31 | 2020-06-22 | Halliburton Energy Services Inc | Deflector assembly for a lateral wellbore |
US9335768B2 (en) | 2013-09-12 | 2016-05-10 | Lam Research Corporation | Cluster mass flow devices and multi-line mass flow devices incorporating the same |
JP2015063616A (ja) | 2013-09-25 | 2015-04-09 | Dic株式会社 | 活性エネルギー線硬化性組成物、その硬化塗膜、及び該硬化塗膜を有する物品 |
US10124045B2 (en) | 2013-11-04 | 2018-11-13 | Uti Limited Partnership | Methods and compositions for sustained immunotherapy |
AU2015279738A1 (en) | 2014-06-25 | 2016-12-22 | Selecta Biosciences, Inc. | Methods and compositions for treatment with synthetic nanocarriers and immune checkpoint inhibitors |
CA2969056C (en) | 2014-12-19 | 2023-09-05 | Eth Zurich | Chimeric antigen receptors and methods of use |
EP3067366A1 (en) | 2015-03-13 | 2016-09-14 | Max-Delbrück-Centrum Für Molekulare Medizin | Combined T cell receptor gene therapy of cancer against MHC I and MHC II-restricted epitopes of the tumor antigen NY-ESO-1 |
WO2016145605A1 (zh) | 2015-03-17 | 2016-09-22 | 王忠堂 | 一种便携式智能超声多普勒动态实时监测装置 |
WO2016160721A1 (en) | 2015-03-27 | 2016-10-06 | President And Fellows Of Harvard College | Modified t cells and methods of making and using the same |
KR20180011135A (ko) | 2015-05-06 | 2018-01-31 | 유티아이 리미티드 파트너쉽 | 지속 치료를 위한 나노입자 조성물 |
MA44907A (fr) | 2015-09-11 | 2018-07-18 | Agenus Inc | Cellules hôtes génétiquement modifiées et leurs procédés d'utilisation |
CN110291111A (zh) | 2016-11-09 | 2019-09-27 | 优迪有限合伙公司 | 重组pMHC II类分子 |
SG11201909290TA (en) | 2017-04-07 | 2019-11-28 | Uti Lp | Assay to measure the potency of receptor-ligand interactions in nanomedicines |
AU2018374569B2 (en) | 2017-11-29 | 2024-10-17 | Uti Limited Partnership | Methods of treating autoimmune disease |
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IL291932B1 (en) | 2023-03-01 |
AU2016275312A1 (en) | 2018-01-04 |
AU2016275312B2 (en) | 2021-12-23 |
MX2017014199A (es) | 2018-03-28 |
RU2017142636A (ru) | 2019-06-06 |
US20170095544A1 (en) | 2017-04-06 |
CO2017011437A2 (es) | 2018-01-31 |
HK1252348A1 (zh) | 2019-05-24 |
JP6920211B2 (ja) | 2021-08-18 |
EP3291832A4 (en) | 2018-09-12 |
AU2022202021A1 (en) | 2022-04-14 |
US10485882B2 (en) | 2019-11-26 |
RU2017142636A3 (ko) | 2019-10-11 |
WO2016198932A2 (en) | 2016-12-15 |
CN107847582A (zh) | 2018-03-27 |
IL255426A0 (en) | 2017-12-31 |
JP2018524267A (ja) | 2018-08-30 |
EP3291832A2 (en) | 2018-03-14 |
IL291932A (en) | 2022-06-01 |
US20190060484A1 (en) | 2019-02-28 |
IL291932B2 (en) | 2023-07-01 |
IL255426B (en) | 2022-05-01 |
KR20180011135A (ko) | 2018-01-31 |
BR112017023853A2 (pt) | 2018-07-17 |
WO2016198932A3 (en) | 2017-04-13 |
CA2984485A1 (en) | 2016-12-15 |
US20240299536A1 (en) | 2024-09-12 |
US12011480B2 (en) | 2024-06-18 |
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