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RU94046411A - Производные витамина д, способ их получения, фармацевтическая композиция на их основе и способ ее получения, способ лечения - Google Patents

Производные витамина д, способ их получения, фармацевтическая композиция на их основе и способ ее получения, способ лечения

Info

Publication number
RU94046411A
RU94046411A RU94046411/04A RU94046411A RU94046411A RU 94046411 A RU94046411 A RU 94046411A RU 94046411/04 A RU94046411/04 A RU 94046411/04A RU 94046411 A RU94046411 A RU 94046411A RU 94046411 A RU94046411 A RU 94046411A
Authority
RU
Russia
Prior art keywords
synthesis
derivatives
compounds
vitamin
preparing
Prior art date
Application number
RU94046411/04A
Other languages
English (en)
Other versions
RU2114825C1 (ru
Inventor
Оге Свенсгор Бреттинг Клаус
Dk]
Original Assignee
Лео Фармасьютикал Продактс А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) (DK)
Лео Фармасьютикал Продактс А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лео Фармасьютикал Продактс А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) (DK), Лео Фармасьютикал Продактс А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) filed Critical Лео Фармасьютикал Продактс А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) (DK)
Publication of RU94046411A publication Critical patent/RU94046411A/ru
Application granted granted Critical
Publication of RU2114825C1 publication Critical patent/RU2114825C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к соединениям, которые проявляют противовоспалительное и имунномодулирующее действие, также как сильную активность в индуцировании дифференциации и ингибировании пролиферации некоторых клеток.

Claims (1)

  1. Изобретение относится к соединениям, которые проявляют противовоспалительное и имунномодулирующее действие, также как сильную активность в индуцировании дифференциации и ингибировании пролиферации некоторых клеток.
RU94046411A 1992-07-03 1993-06-07 Производные витамина d RU2114825C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9214202.5 1992-07-03
GB929214202A GB9214202D0 (en) 1992-07-03 1992-07-03 Chemical compounds

Publications (2)

Publication Number Publication Date
RU94046411A true RU94046411A (ru) 1996-10-10
RU2114825C1 RU2114825C1 (ru) 1998-07-10

Family

ID=10718182

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94046411A RU2114825C1 (ru) 1992-07-03 1993-06-07 Производные витамина d

Country Status (17)

Country Link
US (1) US5545633A (ru)
EP (1) EP0648207B1 (ru)
JP (1) JPH08504746A (ru)
KR (1) KR100285146B1 (ru)
AT (1) ATE150013T1 (ru)
AU (1) AU667378B2 (ru)
CA (1) CA2131631A1 (ru)
DE (1) DE69308852T2 (ru)
DK (1) DK0648207T3 (ru)
ES (1) ES2101319T3 (ru)
FI (1) FI106120B (ru)
GB (1) GB9214202D0 (ru)
GR (1) GR3023407T3 (ru)
HU (1) HU222775B1 (ru)
NZ (1) NZ253026A (ru)
RU (1) RU2114825C1 (ru)
WO (1) WO1994001398A1 (ru)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226860D0 (en) * 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Novel treatment
DE4427690A1 (de) * 1994-08-04 1996-02-08 Bogdahn Ulrich Prof Deuterium enthaltende pharmazeutische Zusammensetzung als Zytostatikum oder Tumor-Therapeutikum
DE69508895T2 (de) * 1994-12-14 1999-10-21 Duphar International Research B.V., Weesp Vitamin-D-Derivate und Verfahren zur Herstellung dieser Verbindungen
TW422696B (en) * 1995-03-20 2001-02-21 Katsuhiko Mukai Ophthalmic composition containing active vitamin D
GB9526208D0 (en) * 1995-12-21 1996-02-21 Res Inst Medicine Chem Chemical compounds
GB9721156D0 (en) * 1997-10-06 1997-12-03 Leo Pharm Prod Ltd Novel vitamin d analogues
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
CA2461740C (en) * 2001-10-19 2013-02-12 Isotechnika Inc. Synthesis of cyclosporin analogs
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
US20080293647A1 (en) 2004-11-12 2008-11-27 Luciano Adorini Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer
ATE469127T1 (de) 2004-11-22 2010-06-15 Wisconsin Alumni Res Found 17,20(z)-dehydro-vitamin-d-analoge und deren verwendungen
US8193169B2 (en) * 2006-04-06 2012-06-05 Wisconsin Alumni Research Foundation (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs
US8193170B2 (en) * 2008-07-10 2012-06-05 Wisconsin Alumni Research Foundation 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs
US7888339B2 (en) 2008-07-10 2011-02-15 Wisconsin Alumni Research Foundation 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
US7648974B1 (en) * 2008-07-10 2010-01-19 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 3,2-dihydrofuran ring
US7879829B2 (en) * 2008-07-10 2011-02-01 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 1,2-dihydrofuran ring
US8399439B2 (en) * 2008-07-10 2013-03-19 Wisconsin Alumni Research Foundation 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs
US8222236B2 (en) * 2008-07-10 2012-07-17 Wisconsin Alumni Research Foundation 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs
US7893043B2 (en) 2008-07-10 2011-02-22 Wisconsin Alumni Research Foundation 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs
US7713953B2 (en) * 2008-07-10 2010-05-11 Wisconsin Alumni Research Foundation 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs
CA2730734C (en) * 2008-07-15 2017-04-25 Theracos, Inc. Deuterated 2,3,4-trihydroxy-tetrahydropyranyl-benzylbenzene compounds having sodium glucose cotransporter inhibitory activity
EA201691980A1 (ru) 2009-01-27 2017-07-31 БЕРГ ЭлЭлСи Способы уменьшения побочных эффектов, связанных с химиотерапией
JP5978130B2 (ja) 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンｄ３およびその類似体
WO2011041579A2 (en) 2009-10-02 2011-04-07 Wisconsin Alumni Research Foundation (20S,22E)-2-METHYLENE-19-NOR-22-ENE-1α,25-DIHYDROXYVITAMIN D3 ANALOGS
WO2011041596A2 (en) 2009-10-02 2011-04-07 Wisconsin Alumni Research Foundation 19-nor-vitamin d analogs with 1,2-or 3,2-cyclopentene ring
EP2714656B1 (en) 2011-06-03 2017-05-03 Wisconsin Alumni Research Foundation (22e)-2-methylene-26,27-cyclo-22-dehydro-1alpha-hydroxy-19-norvitamin d3 derivatives
WO2013003307A1 (en) 2011-06-28 2013-01-03 Wisconsin Alumni Research Foundation 2-methylene-(22e)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-vitamin d analogs
US20130178449A1 (en) 2011-07-18 2013-07-11 Wisconsin Alumni Research Foundation 2-Methylene-20(21)-Dehydro-19,24,25,26,27-Pentanor-Vitamin D Analogs
US9416102B2 (en) 2013-01-23 2016-08-16 Wisconsin Alumni Research Foundation (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs
JP6608810B2 (ja) 2013-05-29 2019-11-20 バーグ エルエルシー ビタミンｄを使用する化学療法誘発性脱毛症の予防又は軽減
WO2016083325A1 (en) 2014-11-25 2016-06-02 Jan Faergemann Treatment of skin atrophy with a combination of triiodothyroacetic acid (triac) and dehydroepiandrosterone (dhea)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i

Also Published As

Publication number Publication date
DE69308852T2 (de) 1997-11-27
DE69308852D1 (de) 1997-04-17
AU667378B2 (en) 1996-03-21
AU4311193A (en) 1994-01-31
CA2131631A1 (en) 1994-01-20
HU9402484D0 (en) 1994-11-28
EP0648207B1 (en) 1997-03-12
ES2101319T3 (es) 1997-07-01
HUT68025A (en) 1995-05-29
GR3023407T3 (en) 1997-08-29
KR950700876A (ko) 1995-02-20
DK0648207T3 (da) 1997-06-23
WO1994001398A1 (en) 1994-01-20
EP0648207A1 (en) 1995-04-19
GB9214202D0 (en) 1992-08-12
KR100285146B1 (ko) 2001-04-02
RU2114825C1 (ru) 1998-07-10
FI950023A0 (fi) 1995-01-02
ATE150013T1 (de) 1997-03-15
FI950023A (fi) 1995-01-02
NZ253026A (en) 1997-07-27
HU222775B1 (hu) 2003-10-28
US5545633A (en) 1996-08-13
JPH08504746A (ja) 1996-05-21
FI106120B (fi) 2000-11-30

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Legal Events

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20050608