RU2018111462A - Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток - Google Patents
Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток Download PDFInfo
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- 239000000427 antigen Substances 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 210000004027 cell Anatomy 0.000 claims 26
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 13
- 208000034578 Multiple myelomas Diseases 0.000 claims 10
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims 8
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 6
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 230000006378 damage Effects 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 239000013598 vector Substances 0.000 claims 5
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 4
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 4
- 230000003834 intracellular effect Effects 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 230000001177 retroviral effect Effects 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000004068 intracellular signaling Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/70517—CD8
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0634—Cells from the blood or the immune system
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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Claims (30)
1. Химерный рецептор антигена (CAR), включающий:
(a) одноцепочечный вариабельный фрагмент (scFv), направленный против антигена созревания В-клеток (ВСМА), содержащий (i) определяющую комплементарность область (CDR) тяжелой цепи - CDR1, (ii) CDR2 тяжелой цепи, (iii) CDR3 тяжелой цепи, (iv) CDR1 легкой цепи, (v) CDR2 легкой цепи и (vi) CDR3 легкой цепи, имеющие аминокислотные последовательности, выбранные из группы, состоящей из: SEQ ID №4, SEQ ID №5, SEQ ID №6, SEQ ID №8, SEQ ID №9, SEQ ID №10, SEQ ID №11 и SEQ ID №12;
(b) трансмембранный домен CD28 или CD8α; и
(c) один или более внутриклеточных доменов сигналинга Т-клеток, выделенных из белка, выбранного из группы, состоящей из: CD28, CD3ζ, FcRγ, CD27, ОХ40 и белка 4-1ВВ.
2. CAR по п. 1, включающий трансмембранный домен CD28.
3. CAR по п. 1, включающий трансмембранный домен CD8α.
4. CAR по любому из пп. 1-3, включающий внутриклеточные домены сигналинга Т-клеток CD28 и CD3ζ.
5. CAR по любому из пп. 1-3, включающий внутриклеточные домены сигналинга Т-клеток ОХ40 и CD3ζ.
6. CAR по любому из пп. 1-3, включающий внутриклеточные домены сигналинга Т-клеток 4-1 ВВ и CD3ζ.
7. CAR по п. 1, включающий трансмембранный домен CD8α и внутриклеточные домены сигналинга Т-клеток 4-1ВВ и CD3ζ
8. Выделенная молекула нуклеиновой кислоты, кодирующая CAR по любому из пп. 1-7.
9. Экспрессионный вектор, содержащий выделенную молекулу нуклеиновой кислоты по п. 8.
10. Экспрессионный вектор по п. 9, где указанный вектор представляет собой ретровирусный вектор.
11. Экспрессионный вектор по п. 10, где указанный ретровирусный вектор представляет собой лентивирусный вектор.
12. Выделенная клетка, которая экспрессирует CAR по любому из пп. 1-7.
13. Выделенная клетка, содержащая выделенную молекулу нуклеиновой кислоты по п. 8.
14. Выделенная клетка, содержащая вектор по любому из пп. 9-11.
15. Выделенная клетка по любому из пп. 12-14, которая представляет собой Т-клетку.
16. Выделенная клетка по любому из пп. 12-14, которая является натуральным киллером (NK-клеткой).
17. Выделенная клетка по п. 12, где указанная клетка представляет собой CD8+ Т-клетку.
18. Композиция, содержащая выделенную клетку по любому из пп. 12-17 и фармацевтически приемлемый носитель или разбавитель.
19. Способ разрушения клеток множественной миеломы, который включает контактирование клеток множественной миеломы, экспрессирующих ВСМА, с одной или более чем одной из выделенных Т-клеток по п. 15, где CAR экспрессируется и связывается с ВСМА на клетках множественной миеломы, и клетки множественной миеломы разрушаются.
20. Способ разрушения клеток множественной миеломы, который включает контактирование клеток множественной миеломы, экспрессирующих ВСМА, с одной или более чем одной из выделенных NK-клеток по п. 16, где CAR экспрессируется и связывается с ВСМА на клетках множественной миеломы, и клетки множественной миеломы разрушаются
21. Способ по п. 19 или 20, где клетки множественной миеломы являются человеческими.
22. Применение CAR по любому из пп. 1-7 при производстве лекарственного средства для разрушения раковых клеток.
23. Применение выделенной нуклеиновой кислоты по п. 8 при производстве лекарственного средства для разрушения раковых клеток.
24. Применение экспрессионного вектора по любому из пп. 9-11 при производстве лекарственного средства для разрушения раковых клеток.
25. Применение выделенной клетки по любому из пп. 12-17 при производстве лекарственного средства для разрушения раковых клеток.
26. Применение композиции по п. 18 при производстве лекарственного средства для разрушения раковых клеток.
27. Применение по любому из пп. 21-25, где раковые клетки представляют собой клетки множественной миеломы или клетки лимфомы Ходжкина.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261622600P | 2012-04-11 | 2012-04-11 | |
| US61/622,600 | 2012-04-11 |
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| RU2014144143A Division RU2650805C2 (ru) | 2012-04-11 | 2013-03-15 | Химерные антигенные рецепторы, нацеленные на антиген созревания в-клеток |
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| RU2022102579A Division RU2022102579A (ru) | 2012-04-11 | 2022-02-03 | Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток |
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| Publication Number | Publication Date |
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| RU2018111462A true RU2018111462A (ru) | 2019-02-27 |
| RU2018111462A3 RU2018111462A3 (ru) | 2021-07-27 |
| RU2766608C2 RU2766608C2 (ru) | 2022-03-15 |
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| RU2014144143A RU2650805C2 (ru) | 2012-04-11 | 2013-03-15 | Химерные антигенные рецепторы, нацеленные на антиген созревания в-клеток |
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| US (19) | US9765342B2 (ru) |
| EP (2) | EP2836239A1 (ru) |
| JP (5) | JP6359520B2 (ru) |
| KR (5) | KR102086874B1 (ru) |
| CN (3) | CN110331154A (ru) |
| AU (5) | AU2013246443B2 (ru) |
| BR (1) | BR112014024893B8 (ru) |
| CA (1) | CA2869562C (ru) |
| EA (2) | EA201990959A1 (ru) |
| HK (1) | HK1203393A1 (ru) |
| IL (4) | IL234870B (ru) |
| IS (1) | IS9056A (ru) |
| MX (3) | MX2018008352A (ru) |
| NZ (1) | NZ700362A (ru) |
| RU (2) | RU2766608C2 (ru) |
| SG (1) | SG11201406414WA (ru) |
| WO (1) | WO2013154760A1 (ru) |
Families Citing this family (249)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201406414WA (en) | 2012-04-11 | 2014-11-27 | Us Health | Chimeric antigen receptors targeting b-cell maturation antigen |
| PL2953972T3 (pl) | 2013-02-05 | 2021-03-08 | Engmab Sàrl | Metoda wyboru przeciwciał przeciwko bcma |
| WO2014151960A2 (en) | 2013-03-14 | 2014-09-25 | Bellicum Pharmaceuticals, Inc. | Methods for controlling t cell proliferation |
| DK2997134T3 (da) | 2013-05-14 | 2020-09-28 | Univ Texas | Human anvendelse af genmanipulerede kimære antigenreceptor-(car)-t-celler |
| GB201317929D0 (en) | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
| AU2014348657A1 (en) | 2013-11-13 | 2016-05-19 | Novartis Ag | mTOR inhibitors for enhancing the immune response |
| WO2015120363A1 (en) | 2014-02-10 | 2015-08-13 | Emory University | Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer |
| WO2015123527A1 (en) * | 2014-02-14 | 2015-08-20 | Bellicum Pharmaceuticals, Inc. | Methods for activating t cells using an inducible chimeric polypeptide |
| EP3656864A1 (en) | 2014-02-14 | 2020-05-27 | Board of Regents, The University of Texas System | Chimeric antigen receptors and methods of making |
| JP6556156B2 (ja) | 2014-02-27 | 2019-08-07 | ユーシーエル ビジネス ピーエルシー | Ａｐｒｉｌバリアント |
| JP6689202B2 (ja) | 2014-03-19 | 2020-04-28 | セレクティスＣｅｌｌｅｃｔｉｓ | 癌免疫治療のためのｃｄ１２３特異的キメラ抗原受容体 |
| SG10201808825XA (en) * | 2014-04-10 | 2018-11-29 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Defined composition gene modified t-cell products |
| JP6698546B2 (ja) * | 2014-04-14 | 2020-05-27 | セレクティスＣｅｌｌｅｃｔｉｓ | 癌免疫療法のためのｂｃｍａ（ｃｄ２６９）特異的キメラ抗原受容体 |
| LT3134095T (lt) * | 2014-04-25 | 2020-06-10 | Bluebird Bio, Inc. | Patobulinti adaptyviųjų ląstelių gydymo priemonės gamybos būdai |
| RS62733B1 (sr) * | 2014-04-25 | 2022-01-31 | 2Seventy Bio Inc | Mnd promoter himernih antigenskih receptora |
| EP3166968B1 (en) | 2014-05-02 | 2021-09-22 | The Trustees of the University of Pennsylvania | Compositions and methods of chimeric autoantibody receptor t cells |
| AU2015270912B9 (en) | 2014-06-02 | 2021-01-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors targeting CD-19 |
| KR102485855B1 (ko) * | 2014-06-06 | 2023-01-09 | 2세븐티 바이오, 인코포레이티드 | 개선된 t 세포 조성물 |
| ES2813437T3 (es) * | 2014-07-11 | 2021-03-23 | Celgene Corp | Métodos para mejorar la eficiencia de la transducción vectorial en linfocitos T |
| EP3169773B1 (en) | 2014-07-15 | 2023-07-12 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
| EP3171882A1 (en) | 2014-07-21 | 2017-05-31 | Novartis AG | Treatment of cancer using a cll-1 chimeric antigen receptor |
| KR102612313B1 (ko) | 2014-07-21 | 2023-12-12 | 노파르티스 아게 | 인간화 항-bcma 키메라 항원 수용체를 사용한 암의 치료 |
| MX2017001079A (es) * | 2014-07-24 | 2017-09-12 | Bluebird Bio Inc | Receptores de antígeno quiméricos de antígeno de maduración de células b (bcma). |
| KR102048855B1 (ko) * | 2014-07-29 | 2019-11-26 | 셀렉티스 | 암 면역요법을 위한 ror1(ntrkr1) 특이적 키메라 항원 수용체 |
| EP2982692A1 (en) | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| EP3189148A4 (en) | 2014-09-02 | 2018-05-02 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides |
| EP3023437A1 (en) | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| EP3029068A1 (en) | 2014-12-03 | 2016-06-08 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases |
| CN113429485A (zh) | 2014-12-05 | 2021-09-24 | 纪念斯隆-凯特琳癌症中心 | 靶向b-细胞成熟抗原的抗体及其用途 |
| ES2966099T3 (es) * | 2014-12-05 | 2024-04-18 | Memorial Sloan Kettering Cancer Center | Receptores de antígeno quiméricos dirigidos al antígeno de maduración de células B y usos de los mismos |
| ES2750725T3 (es) | 2014-12-12 | 2020-03-26 | Bluebird Bio Inc | Receptores de antígeno quiméricos BCMA |
| JP2018504894A (ja) * | 2014-12-19 | 2018-02-22 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | キメラ抗原受容体およびその使用方法 |
| CN107548401A (zh) | 2014-12-24 | 2018-01-05 | 阿迪根有限公司 | 用于细胞内递送分子的肽和纳米颗粒 |
| JP2018504143A (ja) | 2015-01-26 | 2018-02-15 | セレクティスＣｅｌｌｅｃｔｉｓ | がん免疫治療のための抗ｈｓｐ７０特異的キメラ抗原受容体（ｃａｒ） |
| WO2016154055A1 (en) * | 2015-03-20 | 2016-09-29 | Bluebird Bio, Inc. | Vector formulations |
| WO2016160618A2 (en) | 2015-03-27 | 2016-10-06 | University Of Southern California | Car t-cell therapy directed to lhr for the treatment of solid tumors |
| CN114149511A (zh) * | 2015-04-13 | 2022-03-08 | 辉瑞公司 | 靶向b细胞成熟抗原的嵌合抗原受体 |
| BR112017019785B1 (pt) | 2015-04-13 | 2022-11-16 | Pfizer Inc | Anticorpo biespecífico, seu uso e composição farmacêutica |
| CN108136021A (zh) | 2015-04-25 | 2018-06-08 | 综合医院公司 | 用于治疗癌症的抗驱走性试剂和抗癌剂联合疗法和组合物 |
| GB201507119D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic Acid Construct |
| FI3298033T4 (fi) * | 2015-05-18 | 2023-09-22 | Tcr2 Therapeutics Inc | Koostumuksia ja lääkinnällisiä käyttöjä fuusioproteiineja käyttävälle tcr:n uudelleenohjelmoinnille |
| US10576076B2 (en) | 2015-05-20 | 2020-03-03 | Novartis Ag | Pharmaceutical combination of everolimus with dactolisib |
| CN107847601A (zh) * | 2015-06-04 | 2018-03-27 | 南加利福尼亚大学 | Lym‑1和lym‑2靶向的car细胞免疫疗法 |
| CA2983456A1 (en) * | 2015-06-12 | 2016-12-15 | Immunomedics, Inc. | Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs |
| CN115927474A (zh) | 2015-06-19 | 2023-04-07 | 塞巴斯蒂安·科博尔德 | Pd-1-cd28融合蛋白及其在医学中的用途 |
| MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
| DK3331910T3 (da) | 2015-08-03 | 2020-03-16 | Engmab Sarl | Monoklonale antistoffer mod humant b-cellemodningsantigen (bcma) |
| EP3331920A4 (en) | 2015-08-07 | 2019-04-03 | Seattle Children's Hospital, dba Seattle Children's Research Institute | T CARRIER CARRIER CELLS FOR BISPECIFICATION OF SOLID TUMOR TARGETING |
| CN105384825B (zh) * | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| US11478555B2 (en) | 2015-08-17 | 2022-10-25 | Seoul National University R&Db Foundation | Chimeric antigen receptor to which anti-cotinine antibody is linked, and use thereof |
| US11890348B2 (en) | 2015-09-18 | 2024-02-06 | The General Hospital Corporation | Localized delivery of anti-fugetactic agent for treatment of cancer |
| JP7018387B2 (ja) | 2015-10-16 | 2022-02-10 | ルードヴィッヒ－マクシミリアン－ユニヴェルシタート ミュンヘン | 腫瘍標的療法のためのｃｘｃｒ６形質導入ｔ細胞 |
| WO2017070042A1 (en) | 2015-10-20 | 2017-04-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing t cell populations using akt inhibitors |
| JP6901493B2 (ja) | 2015-11-13 | 2021-07-14 | アメリカ合衆国 | 抗ｂｃｍａポリペプチド及びタンパク質 |
| EP3381946A4 (en) * | 2015-11-26 | 2019-08-07 | Guangzhou Cas Lamvac Biotech Co., Ltd. | CHIMERIC ANTI-GENIC ANTI-SULFATE RECEPTOR OF PLACENTARY CHONDROITIN AND APPLICATION THEREOF |
| US11400145B2 (en) | 2015-11-27 | 2022-08-02 | Cartherics Pty. Ltd. | Genetically modified cells and uses thereof |
| US11479755B2 (en) | 2015-12-07 | 2022-10-25 | 2Seventy Bio, Inc. | T cell compositions |
| EP3184548A1 (en) * | 2015-12-23 | 2017-06-28 | Miltenyi Biotec GmbH | Chimeric antigen receptor with cytokine receptor activating or blocking domain |
| EP3399861A4 (en) | 2016-01-07 | 2019-08-07 | Mayo Foundation for Medical Education and Research | INTERFERON CANCER TREATMENT METHODS |
| US11090334B2 (en) | 2016-01-29 | 2021-08-17 | Med Manor Organics (P) Ltd. | Chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof |
| WO2017139199A1 (en) | 2016-02-10 | 2017-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inducible arginase |
| SI3436030T1 (sl) | 2016-04-01 | 2023-01-31 | Kite Pharma, Inc. | Himerni receptorji in načini njihove uporabe |
| EP3436079B1 (en) | 2016-04-01 | 2021-08-25 | Kite Pharma, Inc. | Chimeric antigen and t cell receptors and methods of use |
| BR112018070159A2 (pt) | 2016-04-01 | 2019-04-30 | Kite Pharma, Inc. | moléculas de ligação de bcma e métodos de uso das mesmas |
| AU2017271606B2 (en) | 2016-05-27 | 2024-08-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | FLT3-specific chimeric antigen receptors and methods using same |
| CN109641012A (zh) * | 2016-06-07 | 2019-04-16 | 马克思-德布鲁克-分子医学中心亥姆霍兹联合会 | 与bcma结合的嵌合抗原受体和car-t细胞 |
| JP7175769B2 (ja) | 2016-06-30 | 2022-11-21 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 改善された養子ｔ細胞療法 |
| WO2018026953A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| BR112019004711A2 (pt) * | 2016-09-14 | 2019-05-28 | Janssen Biotech Inc | receptores de antígeno quiméricos compreendendo domínios de fibronectina tipo iii específicos para bcma e usos dos mesmos |
| AU2017341048A1 (en) | 2016-10-07 | 2019-05-23 | TCR2 Therapeutics Inc. | Compositions and methods for T-cell receptors reprogramming using fusion proteins |
| BR112019008426A2 (pt) | 2016-11-02 | 2019-09-03 | Engmab Sarl | anticorpo biespecífico contra bcma e cd3 e um fármaco imunológico para uso combinado no tratamento de mieloma múltiplo |
| CN108004259B (zh) * | 2016-11-02 | 2020-06-30 | 上海恒润达生生物科技有限公司 | 靶向b细胞成熟抗原的嵌合抗原受体及其用途 |
| MA46723A (fr) | 2016-11-04 | 2019-09-11 | Bluebird Bio Inc | Compositions de lymphocytes t car anti-bcma |
| EP3544996A2 (en) | 2016-11-22 | 2019-10-02 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| CN110114070A (zh) | 2016-11-23 | 2019-08-09 | 诺华公司 | 使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法 |
| WO2018102752A1 (en) * | 2016-12-02 | 2018-06-07 | Cartesian Therapeutics, Inc. | Cancer immuno therapy with highly enriched cd8+ chimeric antigen receptor t cells |
| CN110291200B (zh) | 2016-12-12 | 2024-05-14 | 西雅图儿童医院（Dba西雅图儿童研究所） | 对哺乳动物细胞中转基因表达的药剂配体诱导具有增大的灵敏度的嵌合转录因子变异体 |
| JP7033601B2 (ja) | 2017-01-05 | 2022-03-10 | コリア リサーチ インスティチュート オブ バイオサイエンス アンド バイオテクノロジー | 抗コチニンキメラ抗原受容体を発現するナチュラルキラー細胞 |
| WO2018144535A1 (en) | 2017-01-31 | 2018-08-09 | Novartis Ag | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
| WO2018148224A1 (en) | 2017-02-07 | 2018-08-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Phospholipid ether (ple) car t cell tumor targeting (ctct) agents |
| KR20190116420A (ko) | 2017-02-17 | 2019-10-14 | 프레드 헛친슨 켄서 리서치 센터 | Bcma 관련 암 및 자가면역 장애의 치료를 위한 조합 요법 |
| JP7178355B2 (ja) | 2017-02-28 | 2022-11-25 | エンドサイト・インコーポレイテッド | Ｃａｒ ｔ細胞療法のための組成物および方法 |
| US11547694B2 (en) | 2017-03-23 | 2023-01-10 | The General Hospital Corporation | CXCR4/CXCR7 blockade and treatment of human papilloma virus-associated disease |
| JP2020511987A (ja) * | 2017-03-28 | 2020-04-23 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 移植された組織を拒絶反応から保護するための方法 |
| CA3057372A1 (en) | 2017-03-31 | 2018-10-04 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling |
| AU2018256436A1 (en) | 2017-04-19 | 2019-11-07 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
| EP3615068A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| US20200055948A1 (en) | 2017-04-28 | 2020-02-20 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| JP7299841B2 (ja) | 2017-05-01 | 2023-06-28 | ジュノー セラピューティクス インコーポレイテッド | 細胞療法と免疫調節化合物の併用 |
| AU2018367896B2 (en) | 2017-05-12 | 2023-06-01 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| EP3638218A4 (en) | 2017-06-14 | 2021-06-09 | The Broad Institute, Inc. | COMPOSITIONS AND METHOD OF TARGETING COMPLEMENTING COMPONENT 3 FOR INHIBITION OF TUMOR GROWTH |
| WO2018237037A2 (en) | 2017-06-20 | 2018-12-27 | Teneobio, Inc. | HEAVY CHAIN ANTIBODY ONLY ANTI-BCMA |
| WO2019000223A1 (en) * | 2017-06-27 | 2019-01-03 | Nanjing Legend Biotech Co., Ltd. | ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF |
| WO2019006072A1 (en) * | 2017-06-30 | 2019-01-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | CHIMERIC ANTIGENIC RECEPTORS TO ANTIGEN OF MATURATION OF LYMPHOCYTES B WITH HUMAN DOMAINS |
| WO2019014581A1 (en) | 2017-07-14 | 2019-01-17 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF A CYTOTOXIC LYMPHOCYTE |
| MA51447A (fr) | 2017-08-01 | 2020-06-10 | Medimmune Llc | Conjugué anticorps monoclonal-médicament dirigé contre bcma |
| WO2019053612A1 (en) | 2017-09-14 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | POLY THERAPY FOR THE TREATMENT OF CANCER |
| BR112020005028A2 (pt) | 2017-09-14 | 2020-09-15 | Glaxosmithkline Intellectual Property Development Limited | tratamento em combinação para câncer |
| BR112020005079A2 (pt) | 2017-09-14 | 2020-09-15 | Glaxosmithkline Intellectual Property Development Limited | tratamento de combinação para câncer |
| AU2018336791A1 (en) | 2017-09-19 | 2020-03-12 | Massachusetts Institute Of Technology | Compositions for chimeric antigen receptor T cell therapy and uses thereof |
| WO2019075055A1 (en) | 2017-10-11 | 2019-04-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | METHODS FOR PRODUCING T-CELL POPULATIONS USING P38 MAPK INHIBITORS |
| BR112020007576A2 (pt) | 2017-10-18 | 2020-09-24 | Novartis Ag | composições e métodos para degradação de proteína seletiva |
| TW201932482A (zh) | 2017-11-01 | 2019-08-16 | 美商奇諾治療有限公司 | 對b細胞成熟抗原具特異性之嵌合抗原受體及編碼聚核苷酸 |
| MA49911A (fr) | 2017-11-01 | 2020-06-24 | Juno Therapeutics Inc | Anticorps et récepteurs antigéniques chimériques spécifiques de l'antigene de maturation des lymphocytes b |
| WO2019089982A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
| CN109748968B (zh) * | 2017-11-03 | 2020-12-01 | 西安宇繁生物科技有限责任公司 | Bcma特异性嵌合抗原受体t细胞及其应用 |
| MX2020004568A (es) | 2017-11-06 | 2020-10-05 | Juno Therapeutics Inc | Combinación de una terapia celular y un inhibidor de gamma secretasa. |
| WO2019094983A1 (en) | 2017-11-13 | 2019-05-16 | The Broad Institute, Inc. | Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway |
| CN111787938A (zh) | 2017-11-15 | 2020-10-16 | 诺华股份有限公司 | 靶向bcma的嵌合抗原受体、靶向cd19的嵌合抗原受体及组合疗法 |
| JP2021503885A (ja) | 2017-11-22 | 2021-02-15 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 末梢血からの末梢血リンパ球（ｐｂｌ）の拡大培養 |
| TW201925782A (zh) | 2017-11-30 | 2019-07-01 | 瑞士商諾華公司 | 靶向bcma之嵌合抗原受體及其用途 |
| MX2020006689A (es) * | 2017-12-20 | 2020-11-06 | Poseida Therapeutics Inc | Composiciones de vcar y metodos de uso. |
| CN109971715A (zh) * | 2017-12-28 | 2019-07-05 | 深圳华大生命科学研究院 | 一种扩增特异性car-t细胞的培养方法 |
| CN109971716B (zh) * | 2017-12-28 | 2023-08-01 | 上海细胞治疗研究院 | 自分泌cd47抗体的egfr特异性car-t细胞及其用途 |
| TW201930591A (zh) | 2018-01-08 | 2019-08-01 | 瑞士商諾華公司 | 用於與嵌合抗原受體療法併用之免疫增強rna |
| EP3740217A4 (en) | 2018-01-22 | 2021-11-10 | Endocyte, Inc. | METHOD OF USE FOR CAR-T CELLS |
| WO2019152660A1 (en) | 2018-01-31 | 2019-08-08 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
| CN110709425B (zh) * | 2018-02-01 | 2022-09-16 | 南京驯鹿医疗技术有限公司 | 一种结合bcma的嵌合抗原受体（car）及其应用 |
| CN110662771B (zh) * | 2018-02-01 | 2023-07-28 | 南京驯鹿生物技术股份有限公司 | 一种结合bcma的嵌合抗原受体(car)及其应用 |
| CA3090512A1 (en) | 2018-02-09 | 2019-08-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tethered interleukin-15 and interleukin-21 |
| WO2019157516A1 (en) | 2018-02-12 | 2019-08-15 | resTORbio, Inc. | Combination therapies |
| CN110157675B (zh) * | 2018-02-12 | 2022-05-27 | 深圳宾德生物技术有限公司 | 一种靶向性t淋巴细胞及其制备方法和应用 |
| US20200399383A1 (en) | 2018-02-13 | 2020-12-24 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| CN116514995A (zh) * | 2018-04-12 | 2023-08-01 | 上海赛比曼生物科技有限公司 | 靶向bcma的嵌合抗原受体及其制法和应用 |
| CA3097858A1 (en) | 2018-04-24 | 2019-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing t cell populations using hydroxycitric acid and/or a salt thereof |
| US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
| KR20210008502A (ko) | 2018-05-11 | 2021-01-22 | 크리스퍼 테라퓨틱스 아게 | 암을 치료하기 위한 방법 및 조성물 |
| CR20200571A (es) | 2018-06-01 | 2021-01-18 | Novartis Ag | Moléculas de únion contra bcma y usos de las mismas |
| WO2019232542A2 (en) | 2018-06-01 | 2019-12-05 | Massachusetts Institute Of Technology | Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients |
| EP3806871A4 (en) | 2018-06-12 | 2022-02-23 | The Regents of the University of California | SINGLE-CHAIN BISPECIFIC CHEMICAL ANTIGEN RECEPTORS FOR THE TREATMENT OF CANCER |
| KR20210020932A (ko) | 2018-06-13 | 2021-02-24 | 노파르티스 아게 | Bcma 키메라 항원 수용체 및 이의 용도 |
| US12036240B2 (en) | 2018-06-14 | 2024-07-16 | The Broad Institute, Inc. | Compositions and methods targeting complement component 3 for inhibiting tumor growth |
| CN112714769A (zh) * | 2018-07-10 | 2021-04-27 | 普瑞赛格恩公司 | Ror-1特异性嵌合抗原受体及其用途 |
| US20210221903A1 (en) * | 2018-08-14 | 2021-07-22 | Hrain Biotechnology Co., Ltd. | Bcma-targeting chimeric antigen receptor and uses thereof |
| EP3844265A2 (en) | 2018-08-31 | 2021-07-07 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| CA3109959A1 (en) | 2018-08-31 | 2020-03-05 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| MX2021003636A (es) | 2018-09-27 | 2021-07-21 | Autolus Ltd | Receptor antigenico quimerico. |
| AU2019346335B2 (en) | 2018-09-28 | 2024-07-25 | Massachusetts Institute Of Technology | Collagen-localized immunomodulatory molecules and methods thereof |
| WO2020072700A1 (en) | 2018-10-02 | 2020-04-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
| US20210379057A1 (en) | 2018-10-16 | 2021-12-09 | Massachusetts Institute Of Technology | Nutlin-3a for use in treating a mycobacterium tuberculosis infection |
| US20200190163A1 (en) * | 2018-10-26 | 2020-06-18 | Lijun Wu | Humanized bcma-car-t cells |
| WO2020092455A2 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Car t cell transcriptional atlas |
| WO2020089794A1 (en) | 2018-10-31 | 2020-05-07 | Glaxosmithkline Intellectual Property Development Limited | Methods of treating cancer |
| BR112021007626A2 (pt) | 2018-11-01 | 2021-10-13 | Juno Therapeutics, Inc. | Receptores antigênicos quiméricos específicos pa-ra receptor acoplado à proteína g receptor de classe c, grupo 5, membro d (gprc5d) |
| EP3876958A1 (en) | 2018-11-08 | 2021-09-15 | Juno Therapeutics, Inc. | Methods and combinations for treatment and t cell modulation |
| US11793834B2 (en) | 2018-12-12 | 2023-10-24 | Kite Pharma, Inc. | Chimeric antigen and T cell receptors and methods of use |
| WO2020131586A2 (en) | 2018-12-17 | 2020-06-25 | The Broad Institute, Inc. | Methods for identifying neoantigens |
| JP7455127B2 (ja) * | 2018-12-20 | 2024-03-25 | オスロ ユニヴェルジテットサイケフス ホーエフ | キメラ抗原受容体（ｃａｒ）および医薬におけるその使用 |
| US11739156B2 (en) | 2019-01-06 | 2023-08-29 | The Broad Institute, Inc. Massachusetts Institute of Technology | Methods and compositions for overcoming immunosuppression |
| CN112074279B (zh) | 2019-01-16 | 2024-01-26 | 卡里布生物科学公司 | 人源化bcma抗体和bcma-car-t细胞 |
| JP2022520106A (ja) | 2019-02-15 | 2022-03-28 | ユニバーシティ オブ サザン カリフォルニア | Ｌｙｍ－１およびｌｙｍ－２抗体組成物ならびに改善されたｃａｒ構築物 |
| JP2022523204A (ja) | 2019-02-25 | 2022-04-21 | ノバルティス アーゲー | ウイルス送達のためのメソポーラスシリカ粒子組成物 |
| SG11202109331QA (en) | 2019-03-01 | 2021-09-29 | Iovance Biotherapeutics Inc | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
| WO2020182681A1 (en) | 2019-03-08 | 2020-09-17 | Klinikum Der Universität München | Ccr8 expressing lymphocytes for targeted tumor therapy |
| WO2020186101A1 (en) | 2019-03-12 | 2020-09-17 | The Broad Institute, Inc. | Detection means, compositions and methods for modulating synovial sarcoma cells |
| CN113631575A (zh) * | 2019-03-15 | 2021-11-09 | 笛卡尔疗法股份有限公司 | 抗bcma嵌合抗原受体 |
| EP3942023A1 (en) | 2019-03-18 | 2022-01-26 | The Broad Institute, Inc. | Compositions and methods for modulating metabolic regulators of t cell pathogenicity |
| WO2020191316A1 (en) | 2019-03-21 | 2020-09-24 | Novartis Ag | Car-t cell therapies with enhanced efficacy |
| CN113646426B (zh) | 2019-04-04 | 2024-09-13 | 上海医药集团股份有限公司 | 一种包含肿瘤抗原识别受体的免疫细胞及其应用 |
| EP3953455A1 (en) | 2019-04-12 | 2022-02-16 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| EP3959320A1 (en) | 2019-04-24 | 2022-03-02 | Novartis AG | Compositions and methods for selective protein degradation |
| MA55797A (fr) | 2019-04-30 | 2022-03-09 | Crispr Therapeutics Ag | Thérapie cellulaire allogénique de malignités de lymphocytes b à l'aide de lymphocytes t génétiquement modifiés ciblant cd19 |
| EP3733707A1 (en) | 2019-04-30 | 2020-11-04 | Celyad S.A. | Car t-cells targeting bcma and uses thereof |
| KR20220017914A (ko) | 2019-05-07 | 2022-02-14 | 그라셀 바이오테크놀로지스 (상하이) 컴퍼니, 리미티드 | Bcma를 표적으로 하는 조작된 면역 세포 및 그의 용도 |
| WO2020236967A1 (en) | 2019-05-20 | 2020-11-26 | The Broad Institute, Inc. | Random crispr-cas deletion mutant |
| JP2022538974A (ja) | 2019-06-26 | 2022-09-07 | マサチューセッツ インスチテュート オブ テクノロジー | 免疫調節融合タンパク質－金属水酸化物錯体およびその方法 |
| KR20220068984A (ko) | 2019-07-30 | 2022-05-26 | 상하이 한서 바이오메디컬 컴퍼니 리미티드 | 항-bcma 항체, 이의 항원-결합 단편 및 이의 의학적 용도 |
| BR112022002236A2 (pt) | 2019-08-06 | 2022-05-03 | Glaxosmithkline Ip Dev Ltd | Composições, composições farmacêuticas e uso das mesmas para tratar câncer, bem como formulações que compreendem as mesmas |
| WO2021030627A1 (en) | 2019-08-13 | 2021-02-18 | The General Hospital Corporation | Methods for predicting outcomes of checkpoint inhibition and treatment thereof |
| JP2022544592A (ja) | 2019-08-16 | 2022-10-19 | ヤンセン バイオテツク，インコーポレーテツド | 改善された機能を有する治療用免疫細胞及びその作製方法 |
| CN112409482B (zh) * | 2019-08-20 | 2022-08-26 | 杭州尚健生物技术有限公司 | Bcma抗体 |
| US20220298501A1 (en) | 2019-08-30 | 2022-09-22 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
| US20220370500A1 (en) * | 2019-09-18 | 2022-11-24 | Board Of Regents, The University Of Texas System | A method of engineering natural killer-cells to target bcma-positive tumors |
| WO2021061648A1 (en) | 2019-09-23 | 2021-04-01 | Massachusetts Institute Of Technology | Methods and compositions for stimulation of endogenous t cell responses |
| US11981922B2 (en) | 2019-10-03 | 2024-05-14 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment |
| US11793787B2 (en) | 2019-10-07 | 2023-10-24 | The Broad Institute, Inc. | Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis |
| CN110642953B (zh) * | 2019-10-12 | 2021-09-17 | 华夏源（上海）细胞基因工程股份有限公司 | 一种靶向bcma的t细胞受体融合蛋白和应用 |
| US11844800B2 (en) | 2019-10-30 | 2023-12-19 | Massachusetts Institute Of Technology | Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia |
| TW202134264A (zh) | 2019-11-26 | 2021-09-16 | 瑞士商諾華公司 | 嵌合抗原受體及其用途 |
| WO2021132746A1 (en) * | 2019-12-24 | 2021-07-01 | Abl Bio, Inc. | Anti-bcma/anti-4-1bb bispecific antibodies and uses thereof |
| EP4090337A4 (en) * | 2020-01-13 | 2024-04-24 | Nkarta, Inc. | BCMA-TARGETED CELLULAR IMMUNOTHERAPEUTIC COMPOSITIONS AND METHODS |
| EP4110377A2 (en) | 2020-02-27 | 2023-01-04 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| CN115175695A (zh) | 2020-02-27 | 2022-10-11 | 诺华股份有限公司 | 制备表达嵌合抗原受体的细胞的方法 |
| CA3173527A1 (en) | 2020-03-10 | 2021-09-16 | Massachusetts Institute Of Technology | Methods for generating engineered memory-like nk cells and compositions thereof |
| KR20220167276A (ko) | 2020-03-10 | 2022-12-20 | 매사추세츠 인스티튜트 오브 테크놀로지 | NPM1c-양성 암의 면역치료를 위한 조성물 및 방법 |
| KR102371151B1 (ko) * | 2020-03-13 | 2022-03-07 | 주식회사 큐로셀 | 항-bcma 결합 영역, 이를 포함하는 융합단백질, 및 이를 포함하는 조성물 |
| MX2022013530A (es) | 2020-04-28 | 2023-02-01 | Juno Therapeutics Inc | Combinación de terapia de células t dirigida a bcma y un compuesto inmunomodulador. |
| US20210338833A1 (en) | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Chimeric antigen receptor-targeting ligands and uses thereof |
| WO2021221783A1 (en) | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof |
| KR102400977B1 (ko) | 2020-05-29 | 2022-05-25 | 성균관대학교산학협력단 | 프로세서를 통한 페이지 폴트 처리 방법 |
| US20230332104A1 (en) | 2020-06-11 | 2023-10-19 | Novartis Ag | Zbtb32 inhibitors and uses thereof |
| WO2022035793A1 (en) * | 2020-08-10 | 2022-02-17 | Precision Biosciences, Inc. | Antibodies and fragments specific for b-cell maturation antigen and uses thereof |
| WO2022040586A2 (en) | 2020-08-21 | 2022-02-24 | Novartis Ag | Compositions and methods for in vivo generation of car expressing cells |
| CN116583537A (zh) | 2020-09-08 | 2023-08-11 | 美国卫生和人力服务部 | 与对过继细胞疗法的应答相关的t细胞表型 |
| WO2022078344A1 (zh) | 2020-10-12 | 2022-04-21 | 南京驯鹿医疗技术有限公司 | 一种结合cd70的抗体、嵌合抗原受体(car)及其应用 |
| CN116568709A (zh) | 2020-11-01 | 2023-08-08 | 南京驯鹿生物技术股份有限公司 | 靶向cd5的全人源抗体、全人源嵌合抗原受体（car）及其应用 |
| WO2022104035A2 (en) | 2020-11-13 | 2022-05-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Enhanced antigen reactivity of immune cells expressing a mutant non-signaling cd3 zeta chain |
| WO2022116952A1 (zh) | 2020-12-01 | 2022-06-09 | 苏州克睿基因生物科技有限公司 | 靶向cd70的抗原结合蛋白及其应用 |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| TW202241479A (zh) | 2020-12-30 | 2022-11-01 | 美商安迅生物製藥公司 | 遞送外來抗原之溶瘤病毒及表現靶向外來抗原之嵌合受體之經工程化免疫細胞之組合療法 |
| CN112321713B (zh) * | 2020-12-31 | 2021-05-25 | 北京艺妙神州医药科技有限公司 | 一种抗bcma的抗体及其应用 |
| WO2022152186A1 (zh) | 2021-01-12 | 2022-07-21 | 南京驯鹿医疗技术有限公司 | 靶向cd5的全人源单域串联嵌合抗原受体(car)及其应用 |
| KR20230165771A (ko) | 2021-03-03 | 2023-12-05 | 주노 쎄러퓨티크스 인코퍼레이티드 | T 세포 요법 및 dgk 억제제의 조합 |
| JP2024517413A (ja) | 2021-04-16 | 2024-04-22 | セルジーン コーポレーション | 以前に幹細胞移植を受けた患者におけるｔ細胞療法 |
| AU2022258832A1 (en) | 2021-04-16 | 2023-10-19 | Celgene Corporation | Combination therapies with bcma-directed t cell therapy |
| CN118056008A (zh) | 2021-04-27 | 2024-05-17 | 诺华股份有限公司 | 病毒载体生产系统 |
| KR20240018454A (ko) | 2021-05-06 | 2024-02-13 | 주노 테라퓨틱스 게엠베하 | T 세포의 자극 및 형질도입 방법 |
| WO2022248870A1 (en) | 2021-05-28 | 2022-12-01 | Glaxosmithkline Intellectual Property Development Limited | Combination therapies for treating cancer |
| TW202323822A (zh) | 2021-08-03 | 2023-06-16 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | 生藥組合物及穩定同位素標記肽之圖譜定位方法 |
| MX2024001208A (es) | 2021-08-11 | 2024-04-22 | Sana Biotechnology Inc | Celulas primarias geneticamente modificadas para terapia celular alogenica. |
| WO2023019227A1 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
| EP4384193A2 (en) | 2021-08-11 | 2024-06-19 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions |
| US20240358761A1 (en) | 2021-08-11 | 2024-10-31 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
| EP4387991A1 (en) | 2021-08-18 | 2024-06-26 | Julius-Maximilians-Universität Würzburg | Hybrid tumor/cancer therapy based on targeting the resolution of or inducing transcription-replication conflicts (trcs) |
| EP4388000A1 (en) | 2021-08-20 | 2024-06-26 | Novartis AG | Methods of making chimeric antigen receptor?expressing cells |
| JP2024531475A (ja) | 2021-08-24 | 2024-08-29 | 賽斯尓▲チン▼生物技術（上海）有限公司 | Ｔ細胞製品およびその使用 |
| WO2023025208A1 (zh) | 2021-08-24 | 2023-03-02 | 赛斯尔擎生物技术（上海）有限公司 | 一种修饰细胞的方法 |
| WO2023057893A1 (en) | 2021-10-05 | 2023-04-13 | Glaxosmithkline Intellectual Property Development Limited | Combination therapies for treating cancer |
| CN114015674B (zh) | 2021-11-02 | 2024-08-30 | 辉大(上海)生物科技有限公司 | 一种CRISPR-Cas12i系统 |
| EP4426339A1 (en) | 2021-11-03 | 2024-09-11 | Celgene Corporation | Chimeric antigen receptors specific for b-cell maturation antigen for use in treating myeloma |
| WO2023079494A1 (en) | 2021-11-03 | 2023-05-11 | Janssen Biotech, Inc. | Corticosteriod reduction in treatment with anti-cd38 antibodies |
| WO2023081715A1 (en) | 2021-11-03 | 2023-05-11 | Viracta Therapeutics, Inc. | Combination of car t-cell therapy with btk inhibitors and methods of use thereof |
| AU2022423984A1 (en) | 2021-12-30 | 2024-08-15 | Tr1X, Inc. | Cd4+ t cells expressing il-10 and chimeric antigen receptors and uses thereof |
| CA3241588A1 (en) | 2021-12-31 | 2023-07-06 | Sri Krishna | T cell therapy with vaccination as a combination immunotherapy against cancer |
| CN118591560A (zh) | 2022-01-25 | 2024-09-03 | 葛兰素史密斯克莱知识产权发展有限公司 | 癌症的组合疗法 |
| KR20240137075A (ko) | 2022-01-28 | 2024-09-19 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 조성물의 제조 방법 |
| KR20240155390A (ko) | 2022-02-17 | 2024-10-28 | 사나 바이오테크놀로지, 인크. | 조작된 cd47 단백질 및 이의 용도 |
| WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| WO2023220641A2 (en) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
| WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
| WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
| WO2023230512A1 (en) | 2022-05-26 | 2023-11-30 | 2Seventy Bio, Inc. | Compositions for maintaining lentiviral vector and uses thereof |
| US20240041929A1 (en) | 2022-08-05 | 2024-02-08 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for gprc5d and bcma |
| WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| WO2024054944A1 (en) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing |
| WO2024077256A1 (en) | 2022-10-07 | 2024-04-11 | The General Hospital Corporation | Methods and compositions for high-throughput discovery ofpeptide-mhc targeting binding proteins |
| WO2024089639A1 (en) | 2022-10-26 | 2024-05-02 | Novartis Ag | Lentiviral formulations |
| WO2024097905A1 (en) | 2022-11-02 | 2024-05-10 | Celgene Corporation | Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy |
| WO2024097315A2 (en) | 2022-11-02 | 2024-05-10 | Sana Biotechnology, Inc. | Cell therapy products and methods for producing same |
| WO2024098024A1 (en) | 2022-11-04 | 2024-05-10 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
| WO2024100604A1 (en) | 2022-11-09 | 2024-05-16 | Juno Therapeutics Gmbh | Methods for manufacturing engineered immune cells |
| WO2024121711A1 (en) | 2022-12-05 | 2024-06-13 | Glaxosmithkline Intellectual Property Development Limited | Methods of treatment using b-cell maturation antigen antagonists |
| WO2024124044A1 (en) | 2022-12-07 | 2024-06-13 | The Brigham And Women’S Hospital, Inc. | Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression |
| WO2024124132A1 (en) | 2022-12-09 | 2024-06-13 | Juno Therapeutics, Inc. | Machine learning methods for predicting cell phenotype using holographic imaging |
| WO2024161021A1 (en) | 2023-02-03 | 2024-08-08 | Juno Therapeutics Gmbh | Methods for non-viral manufacturing of engineered immune cells |
| WO2024168192A1 (en) | 2023-02-10 | 2024-08-15 | Celgene Corporation | Assessment of bcma in biological samples |
| CN116535521A (zh) * | 2023-03-08 | 2023-08-04 | 深圳细胞谷生物医药有限公司 | 靶向bcma嵌合抗原受体及其应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| IN165717B (ru) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| CA2096222C (en) | 1990-11-13 | 1998-12-29 | Stephen D. Lupton | Bifunctional selectable fusion genes |
| WO1994028143A1 (en) | 1993-05-21 | 1994-12-08 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| US5464758A (en) | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| US5814618A (en) | 1993-06-14 | 1998-09-29 | Basf Aktiengesellschaft | Methods for regulating gene expression |
| US5885827A (en) | 1996-01-23 | 1999-03-23 | The Regents Of The Universtiy Of California | Eukaryotic high rate mutagenesis system |
| US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| AU2005200008B2 (en) * | 1999-01-07 | 2008-03-06 | Zymogenetics, Inc. | Soluble receptor BR43x2 and methods of using |
| GB0013345D0 (en) * | 2000-06-01 | 2000-07-26 | Glaxo Group Ltd | Modified receptor and assay |
| FR2814642B1 (fr) | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
| AU2002238052A1 (en) | 2001-02-20 | 2002-09-04 | Zymogenetics, Inc. | Antibodies that bind both bcma and taci |
| EP1644492B1 (en) | 2003-06-18 | 2009-01-07 | Genelux Corporation | Modified recombinant vaccinia viruses, uses thereof |
| KR101422286B1 (ko) | 2004-07-22 | 2014-07-23 | 에라스무스 유니버시티 메디컬 센터 로테르담 | 결합 분자 |
| US20070009518A1 (en) | 2005-05-18 | 2007-01-11 | Biogen Idec Inc. | Methods for treating fibrotic conditions |
| WO2008103474A1 (en) | 2007-02-20 | 2008-08-28 | Anaptysbio, Inc. | Methods of generating libraries and uses thereof |
| WO2009091826A2 (en) | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
| DK2842575T3 (da) | 2008-03-18 | 2017-11-27 | Seattle Genetics Inc | Auristatin-lægemiddel-linker-konjugater |
| HRP20211788T1 (hr) | 2008-08-26 | 2022-02-18 | City Of Hope | Postupak i pripravci za poboljšanje anti-tumorskog efektorskog funkcioniranja t stanica |
| CN104877026B (zh) * | 2009-03-10 | 2019-10-25 | 比奥根Ma公司 | 抗-bcma抗体 |
| EP2483301A1 (en) * | 2009-10-01 | 2012-08-08 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| RU2444570C1 (ru) * | 2010-06-23 | 2012-03-10 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт эпидемиологии и микробиологии имени почетного академика Н.Ф.Гамалеи" Министерства здравоохранения и социального развития Российской Федерации | Способ получения рекомбинантной вакцины |
| PT3012268T (pt) * | 2010-09-08 | 2018-01-31 | Chemotherapeutisches Forschungsinstitut Georg Speyer Haus | Recetores de antigénio quimérico com uma região de charneira otimizada |
| WO2012136231A1 (en) | 2010-09-08 | 2012-10-11 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| KR20220101745A (ko) | 2010-12-09 | 2022-07-19 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 암을 치료하기 위한 키메릭 항원 수용체 변형 t 세포의 용도 |
| EP4338754A3 (en) | 2011-05-27 | 2024-07-10 | Glaxo Group Limited | Antigen binding proteins |
| AU2013221672B2 (en) | 2012-02-13 | 2017-11-09 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| CN104159917A (zh) * | 2012-02-22 | 2014-11-19 | 宾夕法尼亚大学董事会 | 使用icos基cars增强抗肿瘤活性和car持久性 |
| SG11201406414WA (en) * | 2012-04-11 | 2014-11-27 | Us Health | Chimeric antigen receptors targeting b-cell maturation antigen |
| JP6901493B2 (ja) * | 2015-11-13 | 2021-07-14 | アメリカ合衆国 | 抗ｂｃｍａポリペプチド及びタンパク質 |
| ES2936803T3 (es) * | 2017-01-09 | 2023-03-22 | Lentigen Tech Inc | Composiciones y métodos para tratar el cáncer con inmunoterapia antimesotelina |
| WO2019006072A1 (en) * | 2017-06-30 | 2019-01-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | CHIMERIC ANTIGENIC RECEPTORS TO ANTIGEN OF MATURATION OF LYMPHOCYTES B WITH HUMAN DOMAINS |
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