MA46723A - Compositions de lymphocytes t car anti-bcma - Google Patents
Compositions de lymphocytes t car anti-bcmaInfo
- Publication number
- MA46723A MA46723A MA046723A MA46723A MA46723A MA 46723 A MA46723 A MA 46723A MA 046723 A MA046723 A MA 046723A MA 46723 A MA46723 A MA 46723A MA 46723 A MA46723 A MA 46723A
- Authority
- MA
- Morocco
- Prior art keywords
- bcma
- car anti
- lymphocytes compositions
- lymphocytes
- compositions
- Prior art date
Links
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Animal Husbandry (AREA)
- Hospice & Palliative Care (AREA)
- Biodiversity & Conservation Biology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662417840P | 2016-11-04 | 2016-11-04 | |
US201762514401P | 2017-06-02 | 2017-06-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA46723A true MA46723A (fr) | 2019-09-11 |
Family
ID=62076928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA046723A MA46723A (fr) | 2016-11-04 | 2017-11-03 | Compositions de lymphocytes t car anti-bcma |
Country Status (15)
Country | Link |
---|---|
US (1) | US12109234B2 (fr) |
EP (1) | EP3534968A4 (fr) |
JP (2) | JP7093346B2 (fr) |
KR (2) | KR20240005168A (fr) |
CN (1) | CN110022906A (fr) |
AU (2) | AU2017355504C1 (fr) |
BR (1) | BR112019009099A2 (fr) |
CA (1) | CA3042424A1 (fr) |
CL (1) | CL2019001224A1 (fr) |
CO (1) | CO2019004630A2 (fr) |
EC (1) | ECSP19031545A (fr) |
IL (1) | IL266316A (fr) |
MA (1) | MA46723A (fr) |
MX (1) | MX2019005277A (fr) |
WO (1) | WO2018085690A1 (fr) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
AU2014240083C1 (en) | 2013-03-15 | 2019-10-24 | Celgene Corporation | Modified T lymphocytes |
CN106795217B (zh) | 2014-07-24 | 2021-08-06 | 蓝鸟生物公司 | Bcma嵌合抗原受体 |
US10383929B2 (en) | 2014-12-12 | 2019-08-20 | Bluebird Bio, Inc. | BCMA chimeric antigen receptors |
CA3042424A1 (fr) | 2016-11-04 | 2018-05-11 | Bluebird Bio, Inc. | Compositions de lymphocytes t car anti-bcma |
SG11201907580SA (en) | 2017-02-17 | 2019-09-27 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
BR112020008638A2 (pt) | 2017-11-01 | 2020-10-20 | Juno Therapeutics Inc | receptores de antígenos quiméricos específicos para antígenos de maturação de células b (bcma) |
BR112021000249A2 (pt) * | 2018-07-11 | 2021-04-06 | Celgene Corporation | Usos de receptores de antígeno quimérico anti-bcma |
CN109134665B (zh) * | 2018-08-24 | 2021-06-11 | 上海先博生物科技有限公司 | 一种基于单域抗体的bcma嵌合抗原受体及应用 |
MX2021003745A (es) * | 2018-10-01 | 2021-05-14 | Adicet Bio Inc | Composiciones y métodos relacionados con células t gamma delta modificadas y no modificadas para el tratamiento de tumores hematológicos. |
PE20211058A1 (es) | 2018-11-01 | 2021-06-07 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el miembro d del grupo 5 de la clase c del receptor acoplado a proteina g (gprc5d) |
BR112021008289A2 (pt) * | 2018-11-01 | 2021-10-26 | Juno Therapeutics, Inc. | Métodos para tratamento utilizando receptores de antígeno quimérico específico para antígeno de maturação de célula b |
JP2022508131A (ja) * | 2018-11-16 | 2022-01-19 | ラパ セラピューティクス,エルエルシー | 製造されたt細胞でがんを治療するための方法 |
WO2020146239A1 (fr) * | 2019-01-07 | 2020-07-16 | Celledit Llc | Cellules immunitaires modifiées co-exprimant un récepteur antigénique chimérique et un antagoniste de l'il-6 pour diminuer la toxicité, et utilisations de ces dernières en thérapie cellulaire adoptive |
EP3941589A1 (fr) | 2019-03-21 | 2022-01-26 | Regeneron Pharmaceuticals, Inc. | Combinaison d'inhibiteurs de la voie il-4/il-13 et d'ablation de plasmocytes pour traiter une allergie |
EP3733707A1 (fr) * | 2019-04-30 | 2020-11-04 | Celyad S.A. | Cellules car-t de ciblage de bcma et leurs utilisations |
CA3151344A1 (fr) | 2019-08-16 | 2021-02-25 | Janssen Biotech, Inc. | Cellules immunitaires therapeutiques ayant une fonction amelioree et leurs procedes de fabrication |
CN110679588A (zh) * | 2019-10-23 | 2020-01-14 | 厦门生命互联科技有限公司 | 一种嵌合抗原受体t细胞冻存介质及用途 |
KR20230009386A (ko) | 2020-04-10 | 2023-01-17 | 주노 쎄러퓨티크스 인코퍼레이티드 | B-세포 성숙 항원을 표적화하는 키메라 항원 수용체로 조작된 세포 요법 관련 방법 및 용도 |
US20230165872A1 (en) * | 2020-04-28 | 2023-06-01 | Juno Therapeutics, Inc. | Combination of bcma-directed t cell therapy and an immunomodulatory compound |
WO2022221737A1 (fr) | 2021-04-16 | 2022-10-20 | Juno Therapeutics, Inc. | Thérapie par lymphocytes t chez des patients ayant antérieurement subi une transplantation de cellules souches |
EP4426339A1 (fr) | 2021-11-03 | 2024-09-11 | Celgene Corporation | Récepteurs antigéniques chimériques spécifiques de l'antigène de maturation des cellules b destinés à être utilisés dans le traitement d'un myélome |
KR20240137075A (ko) | 2022-01-28 | 2024-09-19 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 조성물의 제조 방법 |
EP4253418A1 (fr) | 2022-03-29 | 2023-10-04 | Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron | Cellules immunitaires exprimant des récepteurs d'antigène chimérique et anticorps bispécifiques et leurs utilisations |
WO2023220655A1 (fr) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Méthodes pour surmonter la résistance aux médicaments par ré-sensibilisation de cellules cancéreuses à un traitement avec une thérapie antérieure par l'intermédiaire d'un traitement avec une thérapie par lymphocytes t |
WO2023220641A2 (fr) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Méthodes et utilisations associées à une thérapie par lymphocytes t et leur production |
WO2023230548A1 (fr) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Procédé de prédiction d'une réponse à une thérapie par lymphocyte t |
WO2023230581A1 (fr) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Procédés de fabrication de thérapies par lymphocytes t |
WO2024031091A2 (fr) | 2022-08-05 | 2024-02-08 | Juno Therapeutics, Inc. | Récepteurs antigéniques chimériques spécifiques de gprc5d et bcma |
WO2024097905A1 (fr) | 2022-11-02 | 2024-05-10 | Celgene Corporation | Méthodes de traitement au moyen d'une thérapie par lymphocytes t et d'une thérapie d'entretien par agent immunomodulateur |
WO2024123835A1 (fr) | 2022-12-06 | 2024-06-13 | Dynamic Cell Therapies, Inc. | Commutateurs modifiés pour activité de cellules immunitaires et leurs procédés d'utilisation |
WO2024123836A1 (fr) | 2022-12-06 | 2024-06-13 | Dynamic Cell Therapies, Inc. | Complexes d'activation immunitaire |
WO2024168192A1 (fr) | 2023-02-10 | 2024-08-15 | Celgene Corporation | Évaluation de bcma dans des échantillons biologiques |
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- 2017-11-03 BR BR112019009099A patent/BR112019009099A2/pt unknown
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- 2017-11-03 US US16/346,393 patent/US12109234B2/en active Active
- 2017-11-03 JP JP2019523634A patent/JP7093346B2/ja active Active
- 2017-11-03 KR KR1020237044375A patent/KR20240005168A/ko active Application Filing
- 2017-11-03 MX MX2019005277A patent/MX2019005277A/es unknown
- 2017-11-03 EP EP17867273.9A patent/EP3534968A4/fr active Pending
- 2017-11-03 KR KR1020197014739A patent/KR20190082241A/ko not_active IP Right Cessation
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KR20190082241A (ko) | 2019-07-09 |
JP2022113883A (ja) | 2022-08-04 |
AU2024203372A1 (en) | 2024-07-11 |
KR20240005168A (ko) | 2024-01-11 |
IL266316A (en) | 2019-06-30 |
CA3042424A1 (fr) | 2018-05-11 |
CO2019004630A2 (es) | 2019-05-21 |
CN110022906A (zh) | 2019-07-16 |
ECSP19031545A (es) | 2019-08-30 |
JP7385709B2 (ja) | 2023-11-22 |
JP7093346B2 (ja) | 2022-06-29 |
AU2017355504A1 (en) | 2019-05-23 |
EP3534968A4 (fr) | 2020-07-01 |
US12109234B2 (en) | 2024-10-08 |
AU2017355504C1 (en) | 2024-06-20 |
JP2020502048A (ja) | 2020-01-23 |
EP3534968A1 (fr) | 2019-09-11 |
MX2019005277A (es) | 2019-09-27 |
BR112019009099A2 (pt) | 2019-07-16 |
AU2017355504B2 (en) | 2024-02-22 |
WO2018085690A1 (fr) | 2018-05-11 |
US20200261501A1 (en) | 2020-08-20 |
CL2019001224A1 (es) | 2019-10-18 |
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