RU2016121404A3 - - Google Patents

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Publication number: RU2016121404A3
Authority: RU; Russia

Application number

RU2016121404A

Other languages

Russian (ru)

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RU2016121404A (en

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-11-01

Filing date

2014-06-17

Publication date

2018-03-29

2013-12-30 Priority claimed from US13/998,974 external-priority patent/US10377989B2/en

2014-06-17 Application filed filed Critical

2017-12-04 Publication of RU2016121404A publication Critical patent/RU2016121404A/en

2018-03-29 Publication of RU2016121404A3 publication Critical patent/RU2016121404A3/ru

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
- C12N5/0075—General culture methods using substrates using microcarriers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/19—Growth and differentiation factors [GDF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2531/00—Microcarriers

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Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Developmental Biology & Embryology (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

RU2016121404A 2013-11-01 2014-06-17 SUSPENDING AND CLUSTERING OF HUMAN PLURIPOTENT STEM CELLS WITH THE PURPOSE OF THEIR DIFFERENTIATION IN PANCREATIC ENDOCRINE CELLS RU2016121404A (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201361962158P	2013-11-01	2013-11-01
US61/962,158		2013-11-01
US13/998,974		2013-12-30
US13/998,974 US10377989B2 (en)	2012-12-31	2013-12-30	Methods for suspension cultures of human pluripotent stem cells
PCT/US2014/042796 WO2015065537A1 (en)	2013-11-01	2014-06-17	Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells

Publications (2)

Publication Number	Publication Date
RU2016121404A RU2016121404A (en)	2017-12-04
RU2016121404A3 true RU2016121404A3 (en)	2018-03-29

Family

ID=53004904

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
RU2016121409A RU2689710C2 (en)	2013-11-01	2014-05-21	Suspending and clustering human pluripotent stem cells for their differentiation into pancreatic endocrine cells
RU2016121404A RU2016121404A (en)	2013-11-01	2014-06-17	SUSPENDING AND CLUSTERING OF HUMAN PLURIPOTENT STEM CELLS WITH THE PURPOSE OF THEIR DIFFERENTIATION IN PANCREATIC ENDOCRINE CELLS

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
RU2016121409A RU2689710C2 (en)	2013-11-01	2014-05-21	Suspending and clustering human pluripotent stem cells for their differentiation into pancreatic endocrine cells

Country Status (12)

Country	Link
EP (2)	EP3063268A4 (en)
JP (2)	JP2016534731A (en)
KR (4)	KR20180128529A (en)
CN (2)	CN105793413A (en)
AU (4)	AU2014342995C1 (en)
BR (1)	BR112016009393A8 (en)
CA (2)	CA2928639A1 (en)
MX (2)	MX2016005657A (en)
PH (2)	PH12016500783A1 (en)
RU (2)	RU2689710C2 (en)
SG (2)	SG11201603045VA (en)
WO (2)	WO2015065524A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN105793413A (en) *	2013-11-01	2016-07-20	詹森生物科技公司	Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells
KR20190029587A (en) *	2016-06-23	2019-03-20	티톤 바이오테크, 인크.	Cells expressing the parathyroid hormone 1 receptor and uses thereof
WO2018090084A1 (en) *	2016-11-16	2018-05-24	Cynata Therapeutics Limited	Pluripotent stem cell assay
US10391156B2 (en)	2017-07-12	2019-08-27	Viacyte, Inc.	University donor cells and related methods
EP3654996A4 (en) *	2017-07-21	2021-03-24	Semma Therapeutics, Inc.	Re-aggregation of stem cell-derived pancreatic beta cells
JP7000896B2 (en) *	2017-08-23	2022-01-19	王子ホールディングス株式会社	Cell sheet forming member, method for manufacturing cell sheet forming member, and method for manufacturing cell sheet
EP3735457A4 (en) *	2018-01-05	2021-08-25	Platelet Biogenesis, Inc.	Compositions and methods for producing megakaryocytes
SG11202006731VA (en) *	2018-01-18	2020-08-28	Agency Science Tech & Res	Method for differentiation of human pluripotent stem cell lines in suspension culture
KR102115360B1 (en) *	2018-05-30	2020-05-26	주식회사 바이블리오테카	Adult stem cell culture fluid and a producing method thereof
US20200080107A1 (en)	2018-09-07	2020-03-12	Crispr Therapeutics Ag	Universal donor cells
US20220370184A1 (en)	2019-05-31	2022-11-24	W. L. Gore & Associates, Inc.	A biocompatible membrane composite
CA3139585C (en)	2019-05-31	2024-01-23	W. L. Gore & Associates, Inc.	A biocompatible membrane composite
US20220233299A1 (en)	2019-05-31	2022-07-28	W. L. Gore & Associates, Inc.	Cell encapsulation devices with controlled oxygen diffusion distances
WO2020243663A1 (en)	2019-05-31	2020-12-03	W. L. Gore & Associates, Inc.	A biocompatible membrane composite
WO2021044379A1 (en)	2019-09-05	2021-03-11	Crispr Therapeutics Ag	Universal donor cells
US11116798B2 (en)	2019-09-05	2021-09-14	Crispr Therapeutics Ag	Universal donor cells
CN114729323B (en) *	2019-11-22	2024-09-17	诺和诺德股份有限公司	Rotationally aggregated neural microsphere and application thereof
JP2024503290A (en)	2020-12-31	2024-01-25	クリスパーセラピューティクスアクチェンゲゼルシャフト	universal donor cells
US20240191185A1 (en) *	2021-03-25	2024-06-13	Kaneka Corporation	Method for producing pluripotent stem cell population
CN116218766A (en) *	2023-04-21	2023-06-06	北京意胜生物科技有限公司	Method for preparing pancreatic precursor cells, culture medium and application of pancreatic precursor cells

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20050044393A (en) *	2001-11-09	2005-05-12	아르테셀 사이언스, 인크.	Endocrine pancreas differentiation of adipose tissue-derived stromal cells and uses thereof
ES2704401T3 (en) *	2006-08-02	2019-03-18	Technion Res & Dev Foundation	Methods of embryonic stem cell expansion in a suspension culture
JP5067949B2 (en) *	2006-11-09	2012-11-07	独立行政法人国立国際医療研究センター	Method for culturing and subculture of primate embryonic stem cells and method for inducing differentiation thereof
WO2008148105A1 (en) *	2007-05-25	2008-12-04	Medistem Laboratories, Inc.	Endometrial stem cells and methods of making and using same
EP2173862B1 (en) *	2007-07-01	2017-04-19	Lifescan, Inc.	Single pluripotent stem cell culture
GB0800524D0 (en) *	2008-01-14	2008-02-20	Univ Brighton	Cell culture system
JP2011514169A (en) *	2008-03-17	2011-05-06	エージェンシーフォーサイエンス，テクノロジーアンドリサーチ	Microcarrier for stem cell culture
MX2011000125A (en) *	2008-06-30	2011-02-25	Centocor Ortho Biotech Inc	Differentiation of pluripotent stem cells.
US8895300B2 (en) *	2008-11-04	2014-11-25	Viacyte, Inc.	Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
US8008075B2 (en) *	2008-11-04	2011-08-30	Viacyte, Inc.	Stem cell aggregate suspension compositions and methods of differentiation thereof
CA2770753C (en) *	2009-08-12	2019-01-15	Kyoto University	Method for inducing differentiation of pluripotent stem cells into neural precursor cells
US8932857B2 (en) *	2010-06-15	2015-01-13	Kyoto University	Method for selecting reduced differentiation resistance human induced pluripotent stem cells
US9085757B2 (en) *	2010-06-17	2015-07-21	Regents Of The University Of Minnesota	Production of insulin producing cells
AU2011296382B2 (en) *	2010-08-31	2016-04-14	Janssen Biotech, Inc.	Differentiation of human embryonic stem cells
WO2012117333A1 (en) *	2011-02-28	2012-09-07	Stempeutics Research Malaysia Sdn Bhd	Isolation and expansion of adult stem cells, their therapeutic composition and uses thereof
US8951798B2 (en) *	2011-10-13	2015-02-10	Wisconsin Alumni Research Foundation	Generation of cardiomyocytes from human pluripotent stem cells
CN105143446B (en) *	2011-12-22	2020-11-03	詹森生物科技公司	Differentiation of human embryonic stem cells into single hormone insulin positive cells
US10519422B2 (en) *	2012-02-29	2019-12-31	Riken	Method of producing human retinal pigment epithelial cells
EP2938722B1 (en) *	2012-12-31	2021-12-08	Janssen Biotech, Inc.	Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
CN105793413A (en) *	2013-11-01	2016-07-20	詹森生物科技公司	Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells

2014
- 2014-05-21 CN CN201480059910.5A patent/CN105793413A/en active Pending
- 2014-05-21 JP JP2016527338A patent/JP2016534731A/en active Pending
- 2014-05-21 RU RU2016121409A patent/RU2689710C2/en active
- 2014-05-21 MX MX2016005657A patent/MX2016005657A/en unknown
- 2014-05-21 SG SG11201603045VA patent/SG11201603045VA/en unknown
- 2014-05-21 AU AU2014342995A patent/AU2014342995C1/en not_active Ceased
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2016
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CA2928639A1 (en)	2015-05-07
PH12016500782A1 (en)	2016-06-13
RU2016121409A3 (en)	2018-03-29
SG11201603047PA (en)	2016-05-30
KR20180130001A (en)	2018-12-05
JP2017500013A (en)	2017-01-05
PH12016500783A1 (en)	2016-06-13
CA2928741A1 (en)	2015-05-07
AU2014342995C1 (en)	2018-08-09
EP3063268A2 (en)	2016-09-07
KR20160079071A (en)	2016-07-05
WO2015065524A2 (en)	2015-05-07
KR20160079072A (en)	2016-07-05
AU2014342995B2 (en)	2018-04-26
AU2014343007A1 (en)	2016-05-05
WO2015065524A3 (en)	2015-08-13
KR20180128529A (en)	2018-12-03
MX2016005658A (en)	2017-01-05
CN105793413A (en)	2016-07-20
MX2016005657A (en)	2017-01-05
AU2014343007C1 (en)	2018-08-09
AU2014342995A1 (en)	2016-05-05
EP3063269A1 (en)	2016-09-07
JP2016534731A (en)	2016-11-10
SG11201603045VA (en)	2016-05-30
RU2016121404A (en)	2017-12-04
CN105683362A (en)	2016-06-15
AU2018208707A1 (en)	2018-08-16
AU2014343007B2 (en)	2018-04-26
EP3063269A4 (en)	2017-07-12
BR112016009393A8 (en)	2020-03-24
RU2689710C2 (en)	2019-05-29
WO2015065537A1 (en)	2015-05-07
EP3063268A4 (en)	2017-11-29
RU2016121409A (en)	2017-12-04
AU2018208717A1 (en)	2018-08-16

Publication	Publication Date	Title
BR112015007533A2 (en)	2017-08-22
BR112014017733A2 (en)	2017-06-20
BR112014017739A2 (en)	2017-06-20
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RU2016121404A3 (en)	2018-03-29
BR112014018468A2 (en)	2017-06-20
BR112014017901A2 (en)	2017-06-20
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BR112014018578A2 (en)	2017-06-20
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BR112016004617A2 (en)	2017-08-01
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BR112015015312A2 (en)	2017-08-15
BR112014018353A2 (en)	2017-06-20
BR112016003323A2 (en)	2017-09-05

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