PT863891E - (metilsulfonil)fenil-2-(5h)furanonas como inibidores de cox-2 - Google Patents

(metilsulfonil)fenil-2-(5h)furanonas como inibidores de cox-2

Info

Publication number: PT863891E
Authority: PT; Portugal
Prior art keywords: furanones; methylsulfonyl; cox; inhibitors; phenyl
Prior art date: 1995-10-13

Application number

PT96932417T

Other languages

English (en)

Inventor

Cameron Black

Erich Grimm

Petpiboon Prasit

Jacques Yves Gauthier

Yves Leblanc

Patrick Roy

Michel Therirn

Michel Belley

Chung-Sing Li

Cheuk-Kun Lau

Original Assignee

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-13

Filing date

1996-10-09

Publication date

2003-03-31

1996-02-13 Priority claimed from GBGB9602939.2A external-priority patent/GB9602939D0/en

1996-03-18 Priority claimed from GBGB9605645.2A external-priority patent/GB9605645D0/en

1996-10-09 Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc

2003-03-31 Publication of PT863891E publication Critical patent/PT863891E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyridine Compounds (AREA)
Seasonings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Fats And Perfumes (AREA)

PT96932417T 1995-10-13 1996-10-09 (metilsulfonil)fenil-2-(5h)furanonas como inibidores de cox-2 PT863891E (pt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US537195P	1995-10-13	1995-10-13
GBGB9602939.2A GB9602939D0 (en)	1996-02-13	1996-02-13	(Methylsulfony)phenyl-2-(5h)-furanones as cox-2 inhibitors
US1163796P	1996-02-14	1996-02-14
GBGB9605645.2A GB9605645D0 (en)	1996-03-18	1996-03-18	(Methylsulfonyl)phenyl-2-(5H)- furanones as cox-2 inhibitors

Publications (1)

Publication Number	Publication Date
PT863891E true PT863891E (pt)	2003-03-31

Family

ID=27451401

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96932417T PT863891E (pt)	1995-10-13	1996-10-09	(metilsulfonil)fenil-2-(5h)furanonas como inibidores de cox-2

Country Status (39)

Country	Link
EP (1)	EP0863891B1 (pt)
JP (2)	JP3337476B2 (pt)
KR (1)	KR100354940B1 (pt)
CN (1)	CN1203066C (pt)
AT (1)	ATE229515T1 (pt)
AU (1)	AU703871B2 (pt)
BG (1)	BG63391B1 (pt)
BR (1)	BR9611015A (pt)
CA (1)	CA2233178C (pt)
CO (1)	CO4770965A1 (pt)
CZ (1)	CZ295764B6 (pt)
DE (2)	DE69625374T2 (pt)
DK (1)	DK0863891T3 (pt)
DZ (1)	DZ2103A1 (pt)
EA (1)	EA000795B1 (pt)
EE (1)	EE03969B1 (pt)
ES (1)	ES2187675T3 (pt)
HK (1)	HK1016980A1 (pt)
HR (1)	HRP960458B1 (pt)
HU (1)	HU222785B1 (pt)
IL (1)	IL123699A (pt)
IS (1)	IS2148B (pt)
LU (1)	LU91145I2 (pt)
MX (1)	MX9802836A (pt)
MY (1)	MY141773A (pt)
NL (1)	NL300175I2 (pt)
NO (1)	NO321042B1 (pt)
NZ (1)	NZ319090A (pt)
PE (1)	PE17198A1 (pt)
PL (1)	PL188918B1 (pt)
PT (1)	PT863891E (pt)
RO (1)	RO119884B1 (pt)
RS (1)	RS49885B (pt)
SA (1)	SA96170405B1 (pt)
SK (1)	SK282639B6 (pt)
TR (1)	TR199800585T2 (pt)
TW (1)	TW426679B (pt)
UA (1)	UA57002C2 (pt)
WO (1)	WO1997014691A1 (pt)

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US6515014B2 (en)	1995-06-02	2003-02-04	G. D. Searle & Co.	Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
CA2242425C (en)	1996-02-13	2006-07-18	Zeneca Limited	Quinazoline derivatives as vegf inhibitors
DE69709319T2 (de)	1996-03-05	2002-08-14	Astrazeneca Ab, Soedertaelje	4-anilinochinazolin derivate
US5883267A (en) *	1996-05-31	1999-03-16	Merck & Co., Inc.	Process for making phenyl heterocycles useful as cox-2 inhibitors
US6071954A (en) *	1997-03-14	2000-06-06	Merk Frosst Canada, Inc.	(methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors
CA2283100A1 (en) *	1997-03-14	1998-09-24	Merck Frosst Canada & Co.	(methylsulfonyl)phenyl-2-(5h)-furanones with oxygen link as cox-2 inhibitors
US6307047B1 (en)	1997-08-22	2001-10-23	Abbott Laboratories	Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6525053B1 (en)	1997-08-22	2003-02-25	Abbott Laboratories	Prostaglandin endoperoxide H synthase biosynthesis inhibitors
CN1271352A (zh) *	1997-09-24	2000-10-25	麦克公司	用作环氧合酶－2抑制剂的3－芳氧基,4－芳基呋喃－2－酮的制备方法
FR2770131A1 (fr) *	1997-10-27	1999-04-30	Union Pharma Scient Appl	Nouvelle association pharmaceutique a activite analgesique
GB2330833A (en) *	1997-10-29	1999-05-05	Merck & Co Inc	PREPARATION OF 4-(4-Methylsulfonylphenyl)-2-furanones USEFUL AS COX-2 INHIBITORS
US6133292A (en) *	1997-10-30	2000-10-17	Merck Frosst Canada & Co.	Diaryl-5-alkyl-5-methyl-2-(5H)-furanones as selective cyclooxygenase-2-inhibitors
AU741790B2 (en) *	1997-10-30	2001-12-06	Merck Frosst Canada & Co.	Diaryl-5-alkyl-5-methyl-2(5H)-furanones as selective cyclooxygenase-2 inhibitors
FR2771005B1 (fr) *	1997-11-18	2002-06-07	Union Pharma Scient Appl	Nouvelle association pharmaceutique a activite analgesique
US6136804A (en)	1998-03-13	2000-10-24	Merck & Co., Inc.	Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
WO1999045913A1 (en) *	1998-03-13	1999-09-16	Merck & Co., Inc.	Combination therapy and composition for acute coronary ischemic syndrome and related conditions
ES2140354B1 (es) *	1998-08-03	2000-11-01	S A L V A T Lab Sa	Imidazo (1,2a) azinas sustituidas como inhibidores selectivos de la cox-2.
EP1124798A4 (en) *	1998-10-27	2002-08-28	Merck & Co Inc	SYNTHESIS OF METHYLTHIOPHENYL HYDROXYKETONES
ES2213007T3 (es) *	1999-04-14	2004-08-16	Pacific Corporation	Derivados de 4,5-diaril-3(2h)-furanona como inhibidores de la ciclooxigenasa-2.
PT1090915E (pt) *	1999-10-08	2009-08-03	Merial Sas	Forma polimórfica b de 3-(ciclopropilmetoxi)-4-[-4-(metilsulfonil)fenil]-5,5-dimetil-5h-furan-2-ona
FR2799462B1 (fr) *	1999-10-08	2004-05-28	Merial Sas	Procede de preparation d'inhibiteurs cox-2
JP3522727B2 (ja)	1999-11-05	2004-04-26	アストラゼネカアクチボラグ	Ｖｅｇｆ阻害剤としてのキナゾリン誘導体
TR200302047T4 (tr)	1999-12-03	2004-01-21	Pfizer Products Inc.	Anti-iltihabik / analjezik maddeler olarak heteroaril fenil pirazol bileşikleri.
PT1104760E (pt)	1999-12-03	2003-06-30	Pfizer Prod Inc	Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios
ATE245639T1 (de)	1999-12-03	2003-08-15	Pfizer Prod Inc	Acetylenderivate zur verwendung als schmerzstillendes oder entzündungshemmendes mittel
EP1233959B1 (en)	1999-12-03	2005-03-16	Pfizer Products Inc.	Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents
CA2396593A1 (en) *	2000-01-28	2001-08-02	Merck & Co., Inc.	Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug
EP1273582B1 (en)	2001-07-05	2005-06-29	Pfizer Products Inc.	Heterocyclo-alkylsulfonyl pyrazoles as anti-inflammatory/analgesic agents
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Also Published As

Publication number	Publication date
EE03969B1 (et)	2003-02-17
JPH11500146A (ja)	1999-01-06
KR100354940B1 (ko)	2003-01-24
EA000795B1 (ru)	2000-04-24
EA199800290A1 (ru)	1998-10-29
MX9802836A (es)	1998-09-30
RO119884B1 (ro)	2005-05-30
SK45098A3 (en)	1998-12-02
KR19990064265A (ko)	1999-07-26
CZ110198A3 (cs)	1998-09-16
NO981628L (no)	1998-05-27
MY141773A (en)	2010-06-30
YU54896A (sh)	1999-07-28
ES2187675T3 (es)	2003-06-16
NO321042B1 (no)	2006-03-06
HRP960458A2 (en)	1998-04-30
HU222785B1 (hu)	2003-10-28
DZ2103A1 (fr)	2002-07-22
DK0863891T3 (da)	2003-03-17
EP0863891A1 (en)	1998-09-16
SA96170405B1 (ar)	2006-08-22
PL188918B1 (pl)	2005-05-31
HUP9802506A2 (hu)	1999-05-28
IL123699A (en)	2002-03-10
CA2233178C (en)	2003-12-23
CA2233178A1 (en)	1997-04-24
NL300175I1 (nl)	2005-04-01
CN1200119A (zh)	1998-11-25
HUP9802506A3 (en)	1999-06-28
CO4770965A1 (es)	1999-04-30
UA57002C2 (uk)	2003-06-16
WO1997014691A1 (en)	1997-04-24
LU91145I9 (pt)	2018-12-28
PL326203A1 (en)	1998-08-31
IS4695A (is)	1998-03-20
IL123699A0 (en)	1998-10-30
NO981628D0 (no)	1998-04-08
JP3337476B2 (ja)	2002-10-21
AU7123696A (en)	1997-05-07
RS49885B (sr)	2008-08-07
HK1016980A1 (en)	1999-11-12
HRP960458B1 (en)	2003-08-31
EE9800080A (et)	1998-10-15
CZ295764B6 (cs)	2005-10-12
PE17198A1 (es)	1998-04-16
JP4068802B2 (ja)	2008-03-26
TR199800585T2 (xx)	1998-07-21
IS2148B (is)	2006-10-13
NZ319090A (en)	2000-01-28
BG63391B1 (bg)	2001-12-29
CN1203066C (zh)	2005-05-25
LU91145I2 (fr)	2005-05-09
TW426679B (en)	2001-03-21
DE122005000010I1 (de)	2005-06-23
EP0863891B1 (en)	2002-12-11
DE69625374T2 (de)	2003-09-11
NL300175I2 (nl)	2005-05-02
BG102425A (en)	1999-06-30
BR9611015A (pt)	1999-09-14
ATE229515T1 (de)	2002-12-15
DE122005000010I2 (de)	2006-03-16
JP2001199954A (ja)	2001-07-24
DE69625374D1 (en)	2003-01-23
AU703871B2 (en)	1999-04-01
SK282639B6 (sk)	2002-10-08

Publication	Publication Date	Title
PT863891E (pt)	2003-03-31	(metilsulfonil)fenil-2-(5h)furanonas como inibidores de cox-2
ES2171723T3 (es)	2002-09-16	3,4-diaril-2-hidroxi-2,5-dihidrofuranos como profarmacos de inhibidores de cox-2.
DK0828724T3 (da)	2002-03-04	5-oxygenerede diaryl-2-(5H)-furanoner som COX-2-inhibitorer
ZA944501B (en)	1995-03-13	Phenyl heterocycles as cox-2 inhibitors
DE69702182D1 (de)	2000-07-06	Alkylierte styrole als prodrugs zu cox-2-inhibitoren
DE69816047D1 (en)	2003-08-07	(methylsulfonyl)phenyl-2-(5h)-furanone mit sauerstoff-bindung als cox-2-hemmer
ATE223376T1 (de)	2002-09-15	Bisarylcyclobutenderivate als cyclooxygenasehemmer
NO983511D0 (no)	1998-07-30	Difenylstilbener som pro-legemidler for COX-2-inhibitorer
ECSP961893A (es)	1997-10-17	(metil sulfonil) fenil -2-(5h)- furanomas como inhibidores de cox - 2''