NL300175I1 - Methylsulfonylfenyl-2-(5H)-furanonen als remmers van COX-2. - Google Patents

Methylsulfonylfenyl-2-(5H)-furanonen als remmers van COX-2.

Info

Publication number: NL300175I1
Authority: NL; Netherlands
Prior art keywords: furanones; methylsulfonylphenyl; cox; inhibitors; cyclooxygenase
Prior art date: 1995-10-13

Application number

NL300175C

Other languages

English (en)

Other versions

NL300175I2 (nl

Original Assignee

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-13

Filing date

2005-02-14

Publication date

2005-04-01

1996-02-13 Priority claimed from GBGB9602939.2A external-priority patent/GB9602939D0/en

1996-03-18 Priority claimed from GBGB9605645.2A external-priority patent/GB9605645D0/en

2005-02-14 Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc

2005-04-01 Publication of NL300175I1 publication Critical patent/NL300175I1/nl

2005-05-02 Publication of NL300175I2 publication Critical patent/NL300175I2/nl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyridine Compounds (AREA)
Seasonings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Fats And Perfumes (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

NL300175C 1995-10-13 2005-02-14 Methylsulfonylfenyl-2-(5H)-furanonen als remmers van COX-2. NL300175I2 (nl)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US537195P	1995-10-13	1995-10-13
GBGB9602939.2A GB9602939D0 (en)	1996-02-13	1996-02-13	(Methylsulfony)phenyl-2-(5h)-furanones as cox-2 inhibitors
US1163796P	1996-02-14	1996-02-14
GBGB9605645.2A GB9605645D0 (en)	1996-03-18	1996-03-18	(Methylsulfonyl)phenyl-2-(5H)- furanones as cox-2 inhibitors
PCT/CA1996/000682 WO1997014691A1 (en)	1995-10-13	1996-10-09	(methylsulfonyl)phenyl-2-(5h)-furanones as cox-2 inhibitors

Publications (2)

Publication Number	Publication Date
NL300175I1 true NL300175I1 (nl)	2005-04-01
NL300175I2 NL300175I2 (nl)	2005-05-02

Family

ID=27451401

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL300175C NL300175I2 (nl)	1995-10-13	2005-02-14	Methylsulfonylfenyl-2-(5H)-furanonen als remmers van COX-2.

Country Status (39)

Country	Link
EP (1)	EP0863891B1 (nl)
JP (2)	JP3337476B2 (nl)
KR (1)	KR100354940B1 (nl)
CN (1)	CN1203066C (nl)
AT (1)	ATE229515T1 (nl)
AU (1)	AU703871B2 (nl)
BG (1)	BG63391B1 (nl)
BR (1)	BR9611015A (nl)
CA (1)	CA2233178C (nl)
CO (1)	CO4770965A1 (nl)
CZ (1)	CZ295764B6 (nl)
DE (2)	DE122005000010I2 (nl)
DK (1)	DK0863891T3 (nl)
DZ (1)	DZ2103A1 (nl)
EA (1)	EA000795B1 (nl)
EE (1)	EE03969B1 (nl)
ES (1)	ES2187675T3 (nl)
HK (1)	HK1016980A1 (nl)
HR (1)	HRP960458B1 (nl)
HU (1)	HU222785B1 (nl)
IL (1)	IL123699A (nl)
IS (1)	IS2148B (nl)
LU (1)	LU91145I2 (nl)
MX (1)	MX9802836A (nl)
MY (1)	MY141773A (nl)
NL (1)	NL300175I2 (nl)
NO (1)	NO321042B1 (nl)
NZ (1)	NZ319090A (nl)
PE (1)	PE17198A1 (nl)
PL (1)	PL188918B1 (nl)
PT (1)	PT863891E (nl)
RO (1)	RO119884B1 (nl)
RS (1)	RS49885B (nl)
SA (1)	SA96170405B1 (nl)
SK (1)	SK282639B6 (nl)
TR (1)	TR199800585T2 (nl)
TW (1)	TW426679B (nl)
UA (1)	UA57002C2 (nl)
WO (1)	WO1997014691A1 (nl)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6515014B2 (en)	1995-06-02	2003-02-04	G. D. Searle & Co.	Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
KR19990082463A (ko)	1996-02-13	1999-11-25	돈 리사 로얄	혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체
ATE211134T1 (de)	1996-03-05	2002-01-15		4-anilinochinazolin derivate
US5883267A (en) *	1996-05-31	1999-03-16	Merck & Co., Inc.	Process for making phenyl heterocycles useful as cox-2 inhibitors
ES2201466T3 (es) *	1997-03-14	2004-03-16	MERCK FROSST CANADA & CO.	`(metilsulfonil)fenil-2-(5h)-furanonas con enlace con oxigeno como inhibidores de cox-2`.
US6071954A (en) *	1997-03-14	2000-06-06	Merk Frosst Canada, Inc.	(methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors
US6525053B1 (en)	1997-08-22	2003-02-25	Abbott Laboratories	Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6307047B1 (en)	1997-08-22	2001-10-23	Abbott Laboratories	Prostaglandin endoperoxide H synthase biosynthesis inhibitors
JP3516658B2 (ja) *	1997-09-24	2004-04-05	メルクエンドカムパニーインコーポレーテッド	Ｃｏｘ−２のインヒビターとして有用な３−アリールオキシ，４−アリールフラン−２−オンの製造方法
FR2770131A1 (fr) *	1997-10-27	1999-04-30	Union Pharma Scient Appl	Nouvelle association pharmaceutique a activite analgesique
GB2330833A (en) *	1997-10-29	1999-05-05	Merck & Co Inc	PREPARATION OF 4-(4-Methylsulfonylphenyl)-2-furanones USEFUL AS COX-2 INHIBITORS
US6133292A (en) *	1997-10-30	2000-10-17	Merck Frosst Canada & Co.	Diaryl-5-alkyl-5-methyl-2-(5H)-furanones as selective cyclooxygenase-2-inhibitors
JP2001521932A (ja) *	1997-10-30	2001-11-13	メルクフロストカナダアンドカンパニー	選択的シクロオキシゲナーゼ−２−阻害剤としてのジアリール−５−アルキル−５−メチル−２（５ｈ）−フラノン
FR2771005B1 (fr) *	1997-11-18	2002-06-07	Union Pharma Scient Appl	Nouvelle association pharmaceutique a activite analgesique
US6136804A (en)	1998-03-13	2000-10-24	Merck & Co., Inc.	Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
CA2322824A1 (en) *	1998-03-13	1999-09-16	Merck & Co., Inc.	Combination therapy and composition for acute coronary ischemic syndrome and related conditions
ES2140354B1 (es) *	1998-08-03	2000-11-01	S A L V A T Lab Sa	Imidazo (1,2a) azinas sustituidas como inhibidores selectivos de la cox-2.
AU758349B2 (en) *	1998-10-27	2003-03-20	Merck & Co., Inc.	Synthesis of methylthiophenyl hydroxyketones
NZ514101A (en) *	1999-04-14	2001-09-28	Pacific Corp	4,5-diaryl-3( 2H )-furanone derivatives as cyclooxygenase-2 inhibitors
ES2326849T3 (es)	1999-10-08	2009-10-20	Merial	sin titulo.
FR2799462B1 (fr) *	1999-10-08	2004-05-28	Merial Sas	Procede de preparation d'inhibiteurs cox-2
EE05330B1 (et)	1999-11-05	2010-08-16	Astrazeneca Ab	Kinasoliini derivaadid kui VEGF-i inhibiitorid
YU35102A (sh)	1999-12-03	2005-03-15	Pfizer Products Inc.	Derivati heterociklo-alkilsulfonil pirazola kao anti- inflamatorni/analgetički agensi
DK1104760T3 (da)	1999-12-03	2003-06-30	Pfizer Prod Inc	Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler
ES2200787T3 (es)	1999-12-03	2004-03-16	Pfizer Products Inc.	Derivados de acetileno como agentes antiinflamatorios/analgesicos.
ATE252576T1 (de)	1999-12-03	2003-11-15	Pfizer Prod Inc	Heteroarylphenylpyrazolverbindungen zur verwendung als analgetisches/entzündungshemmendes mittel
WO2001054688A1 (en) *	2000-01-28	2001-08-02	Merck & Co., Inc.	Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug
ES2241964T3 (es)	2001-07-05	2005-11-01	Pfizer Products Inc.	Heterocicloalquilsulfufonilpirazoles como agentes antiinflamatorios/abnalgesicos.
AR038957A1 (es)	2001-08-15	2005-02-02	Pharmacia Corp	Terapia de combinacion para el tratamiento del cancer
GT200200183A (es)	2001-09-28	2003-05-23		Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol
WO2003037336A1 (en)	2001-11-02	2003-05-08	Pfizer Products Inc.	1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer
UY27939A1 (es)	2002-08-21	2004-03-31	Glaxo Group Ltd	Compuestos
CN1309717C (zh) *	2003-06-03	2007-04-11	李小虎	4－芳基－5h－噻吩－2－酮衍生物、其制法和用途
WO2006041855A2 (en)	2004-10-04	2006-04-20	Nitromed, Inc.	Compositions and methods using apocynin compounds and nitric oxide donors
JP2008525363A (ja)	2004-12-23	2008-07-17	グラクソグループリミテッド	プロスタグランジン媒介疾患治療のためのピリジン化合物
WO2007016677A2 (en)	2005-08-02	2007-02-08	Nitromed, Inc.	Nitric oxide enhancing antimicrobial compounds, compositions and methods of use
CN104744234A (zh) *	2005-08-19	2015-07-01	爱密斯菲尔科技公司	用于递送活性剂的环丙基化合物和组合物
CA2647859C (en)	2006-03-29	2016-01-05	Nitromed, Inc.	Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
EP1878717A1 (en)	2006-07-14	2008-01-16	Bayer Schering Pharma Aktiengesellschaft	Benzyl amines, a process for their production and their use as anti-inflammatory agents
GB0704407D0 (en)	2007-03-07	2007-04-18	Glaxo Group Ltd	Compounds
US7943658B2 (en)	2007-07-23	2011-05-17	Bristol-Myers Squibb Company	Indole indane amide compounds useful as CB2 agonists and method
EP2062880A1 (en)	2007-11-22	2009-05-27	Bayer Schering Pharma Aktiengesellschaft	5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents
GB0813142D0 (en)	2008-07-17	2008-08-27	Glaxo Group Ltd	Novel compounds
GB0813144D0 (en)	2008-07-17	2008-08-27	Glaxo Group Ltd	Novel compounds
EP2177215A1 (en)	2008-10-17	2010-04-21	Laboratorios Del. Dr. Esteve, S.A.	Co-crystals of tramadol and NSAIDs
WO2011012622A1 (en)	2009-07-30	2011-02-03	Glaxo Group Limited	Benzoxazinone derivatives for the treatment of glytl mediated disorders
WO2011023753A1 (en)	2009-08-27	2011-03-03	Glaxo Group Limited	Benzoxazine derivatives as glycine transport inhibitors
GB201000685D0 (en)	2010-01-15	2010-03-03	Glaxo Group Ltd	Novel compounds
GB201007791D0 (en)	2010-05-10	2010-06-23	Glaxo Group Ltd	Novel compounds
GB201007789D0 (en)	2010-05-10	2010-06-23	Glaxo Group Ltd	Novel Compound
ES2529233T3 (es)	2010-07-09	2015-02-18	Convergence Pharmaceuticals Limited	Compuestos tetrazol como bloqueadores de canales de calcio
ES2541416T3 (es)	2011-01-19	2015-07-20	Convergence Pharmaceuticals Limited	Derivados de piperazina como bloqueadores de los canales de calcio Cav2.2
GB201122113D0 (en)	2011-12-22	2012-02-01	Convergence Pharmaceuticals	Novel compounds
CA2885762C (en) *	2012-09-21	2022-05-03	Rhode Island Hospital	Inhibitors of beta-hydroxylase for treatment of cancer
GB201417499D0 (en)	2014-10-03	2014-11-19	Convergence Pharmaceuticals	Novel use
GB201417497D0 (en)	2014-10-03	2014-11-19	Convergence Pharmaceuticals	Novel use
GB201417500D0 (en)	2014-10-03	2014-11-19	Convergence Pharmaceuticals	Novel use
CN104803956A (zh) *	2015-03-06	2015-07-29	江苏天和制药有限公司	非罗考昔的一种合成方法
EP3292213A1 (en)	2015-05-04	2018-03-14	Academisch Medisch Centrum	Biomarkers for the detection of aspirin insensitivity
PL3609877T3 (pl)	2017-04-14	2021-06-28	Cosma S.P.A.	Sposób syntezy firokoksybu
CN108178724B (zh) *	2017-12-22	2020-09-11	四川大学	化合物的制备方法
CN110240537B (zh) *	2019-05-22	2022-06-21	成都阿奇生物医药科技有限公司	一种茚氧乙酸类化合物及其制备方法和用途
CN110452198B (zh) *	2019-09-03	2021-03-26	山东鲁抗舍里乐药业有限公司	一种非罗考昔的制备方法
CN110452199B (zh) *	2019-09-03	2021-03-30	山东鲁抗舍里乐药业有限公司	一种非罗考昔的制备方法
DE102019214427A1 (de)	2019-09-23	2021-03-25	Multivac Marking & Inspection Gmbh & Co. Kg	Etikettierer mit Montageeinrichtung für Andrückelement
CN110746390B (zh) *	2019-11-14	2022-12-30	中国科学技术大学	制备5-甲酰基-2-呋喃甲酸酯的方法
WO2022195579A1 (en)	2021-03-15	2022-09-22	Saul Yedgar	Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases
CN113248458B (zh) *	2021-05-27	2022-09-27	陕西省煤田地质集团有限公司	一种α-羰基酰胺化合物的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5474995A (en) *	1993-06-24	1995-12-12	Merck Frosst Canada, Inc.	Phenyl heterocycles as cox-2 inhibitors
DE69529690T2 (de) *	1994-12-21	2003-11-13	Merck Frosst Canada & Co., Halifax	Diaryl-2(5h)-fuaranone als cox-2-inhibitoren

1996
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Also Published As

Publication number	Publication date
DE69625374D1 (en)	2003-01-23
MY141773A (en)	2010-06-30
CN1200119A (zh)	1998-11-25
CA2233178A1 (en)	1997-04-24
HRP960458B1 (en)	2003-08-31
JPH11500146A (ja)	1999-01-06
PL326203A1 (en)	1998-08-31
DK0863891T3 (da)	2003-03-17
JP2001199954A (ja)	2001-07-24
BG63391B1 (bg)	2001-12-29
KR100354940B1 (ko)	2003-01-24
IS4695A (is)	1998-03-20
UA57002C2 (uk)	2003-06-16
WO1997014691A1 (en)	1997-04-24
NZ319090A (en)	2000-01-28
LU91145I9 (nl)	2018-12-28
HUP9802506A2 (hu)	1999-05-28
NO981628L (no)	1998-05-27
EP0863891B1 (en)	2002-12-11
HK1016980A1 (en)	1999-11-12
EP0863891A1 (en)	1998-09-16
AU7123696A (en)	1997-05-07
LU91145I2 (fr)	2005-05-09
EE9800080A (et)	1998-10-15
JP4068802B2 (ja)	2008-03-26
EA199800290A1 (ru)	1998-10-29
CZ295764B6 (cs)	2005-10-12
IS2148B (is)	2006-10-13
EE03969B1 (et)	2003-02-17
TR199800585T2 (xx)	1998-07-21
CA2233178C (en)	2003-12-23
TW426679B (en)	2001-03-21
AU703871B2 (en)	1999-04-01
DE69625374T2 (de)	2003-09-11
DE122005000010I2 (de)	2006-03-16
IL123699A (en)	2002-03-10
BG102425A (en)	1999-06-30
DE122005000010I1 (de)	2005-06-23
HRP960458A2 (en)	1998-04-30
EA000795B1 (ru)	2000-04-24
HU222785B1 (hu)	2003-10-28
CO4770965A1 (es)	1999-04-30
ES2187675T3 (es)	2003-06-16
JP3337476B2 (ja)	2002-10-21
MX9802836A (es)	1998-09-30
NO321042B1 (no)	2006-03-06
CN1203066C (zh)	2005-05-25
NO981628D0 (no)	1998-04-08
PE17198A1 (es)	1998-04-16
YU54896A (sh)	1999-07-28
KR19990064265A (ko)	1999-07-26
SK45098A3 (en)	1998-12-02
SA96170405B1 (ar)	2006-08-22
BR9611015A (pt)	1999-09-14
IL123699A0 (en)	1998-10-30
RS49885B (sr)	2008-08-07
ATE229515T1 (de)	2002-12-15
PT863891E (pt)	2003-03-31
CZ110198A3 (cs)	1998-09-16
HUP9802506A3 (en)	1999-06-28
PL188918B1 (pl)	2005-05-31
NL300175I2 (nl)	2005-05-02
DZ2103A1 (fr)	2002-07-22
RO119884B1 (ro)	2005-05-30
SK282639B6 (sk)	2002-10-08

Publication	Publication Date	Title
NL300175I2 (nl)	2005-05-02	Methylsulfonylfenyl-2-(5H)-furanonen als remmers van COX-2.
ATE165825T1 (de)	1998-05-15	Phenyl heterocyclen als cyclooxygenase-2 inhibitoren
ATE212343T1 (de)	2002-02-15	3,4-diaryl-2-hydroxy-2,5-dihydrofurane als wirkstoffvorstufen von cox-2 inhibitoren
ATE223376T1 (de)	2002-09-15	Bisarylcyclobutenderivate als cyclooxygenasehemmer
DE69703791D1 (de)	2001-02-01	Diphenylstibene als prodrugs zu cox-2-inhibitoren
MY119407A (en)	2005-05-31	3-phenyl-4-(4(methylsulfonyl)phenyl)-2-(5h)-furanone as a cox-2 inhibitor.