PL2281815T3 - Związek pośredni, ester etylowy kwasu 4-(acetyloamino)-3-[(4-chlorofenylo}tio]-2-metylo-1H-indolooctowego - Google Patents

Związek pośredni, ester etylowy kwasu 4-(acetyloamino)-3-[(4-chlorofenylo}tio]-2-metylo-1H-indolooctowego

Info

Publication number: PL2281815T3
Authority: PL; Poland
Prior art keywords: acetylamino; indole; chlorophenyl; thio; methyl
Prior art date: 2003-05-27

Application number

PL10180348T

Other languages

English (en)

Inventor

Rukhsana Tasneem Mohammed

Roger Victor Bonnert

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-27

Filing date

2004-05-25

Publication date

2012-08-31

2004-05-25 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2012-08-31 Publication of PL2281815T3 publication Critical patent/PL2281815T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL10180348T 2003-05-27 2004-05-25 Związek pośredni, ester etylowy kwasu 4-(acetyloamino)-3-[(4-chlorofenylo}tio]-2-metylo-1H-indolooctowego PL2281815T3 (pl)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
SE0301569A SE0301569D0 (sv)	2003-05-27	2003-05-27	Novel compounds
SE0302305A SE0302305D0 (sv)	2003-05-27	2003-08-27	Novel Compounds
EP10180348A EP2281815B1 (en)	2003-05-27	2004-05-25	4-(Acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid ethyl ester intermediate compound
EP08165755A EP2025670B1 (en)	2003-05-27	2004-05-25	Use of 3-phenylthio-1H-indole-1-acetic acid derivatives as modulators of CRTh2 receptor activity
EP04734774A EP1656346B1 (en)	2003-05-27	2004-05-25	1,2,3,4-tetrasubstituted indole for the treatment of respiratory diseases

Publications (1)

Publication Number	Publication Date
PL2281815T3 true PL2281815T3 (pl)	2012-08-31

Family

ID=33492578

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PL08165755T PL2025670T3 (pl)	2003-05-27	2004-05-25	Zastosowanie pochodnych kwasu 3-fenylotio-1H-indolo-1-octowego jako modulatorów aktywności receptora CRTh2
PL04734774T PL1656346T3 (pl)	2003-05-27	2004-05-25	1,2,3,4-Tetrapodstawiony indol do leczenia chorób dróg oddechowych
PL10180348T PL2281815T3 (pl)	2003-05-27	2004-05-25	Związek pośredni, ester etylowy kwasu 4-(acetyloamino)-3-[(4-chlorofenylo}tio]-2-metylo-1H-indolooctowego

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
PL08165755T PL2025670T3 (pl)	2003-05-27	2004-05-25	Zastosowanie pochodnych kwasu 3-fenylotio-1H-indolo-1-octowego jako modulatorów aktywności receptora CRTh2
PL04734774T PL1656346T3 (pl)	2003-05-27	2004-05-25	1,2,3,4-Tetrapodstawiony indol do leczenia chorób dróg oddechowych

Country Status (31)

Country	Link
US (4)	US7687535B2 (pl)
EP (3)	EP2281815B1 (pl)
JP (2)	JP4541361B2 (pl)
KR (3)	KR20110050754A (pl)
CN (2)	CN1795174B (pl)
AR (1)	AR044552A1 (pl)
AT (3)	ATE552243T1 (pl)
AU (1)	AU2004242624B2 (pl)
BR (1)	BRPI0410711B8 (pl)
CA (1)	CA2526866C (pl)
CO (1)	CO5630030A2 (pl)
CY (3)	CY1109104T1 (pl)
DE (2)	DE602004020072D1 (pl)
DK (3)	DK2025670T3 (pl)
ES (3)	ES2382606T3 (pl)
HK (3)	HK1090635A1 (pl)
HR (3)	HRP20090281T1 (pl)
IL (4)	IL171928A (pl)
IS (2)	IS2722B (pl)
MX (1)	MXPA05012680A (pl)
MY (1)	MY144483A (pl)
NO (1)	NO20056130L (pl)
NZ (1)	NZ543722A (pl)
PL (3)	PL2025670T3 (pl)
PT (3)	PT2025670E (pl)
RU (1)	RU2361860C2 (pl)
SE (2)	SE0301569D0 (pl)
SI (3)	SI1656346T1 (pl)
TW (2)	TWI328004B (pl)
WO (1)	WO2004106302A1 (pl)
ZA (1)	ZA200509598B (pl)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0201635D0 (sv)	2002-05-30	2002-05-30	Astrazeneca Ab	Novel compounds
TW200307542A (en) *	2002-05-30	2003-12-16	Astrazeneca Ab	Novel compounds
SE0202241D0 (sv) *	2002-07-17	2002-07-17	Astrazeneca Ab	Novel Compounds
SE0301569D0 (sv)	2003-05-27	2003-05-27	Astrazeneca Ab	Novel compounds
SE0302232D0 (sv) *	2003-08-18	2003-08-18	Astrazeneca Ab	Novel Compounds
SE0303180D0 (sv) *	2003-11-26	2003-11-26	Astrazeneca Ab	Novel compounds
BRPI0508540B8 (pt)	2004-03-11	2021-05-25	Actelion Pharmaceuticals Ltd	composto, composição farmacêutica, e, uso de um composto
DK1833791T3 (da)	2004-12-27	2011-10-24	Actelion Pharmaceuticals Ltd	2,3,4,9-tetrahydor-1H-carbazolderivater som CRTH2 receptorantagonister
GB0500604D0 (en) *	2005-01-13	2005-02-16	Astrazeneca Ab	Novel process
DOP2006000016A (es) *	2005-01-26	2006-07-31	Aventis Pharma Inc	2-fenil-indoles como antagonistas del receptor de la prostaglandina d2.
AU2006237365B2 (en)	2005-04-21	2012-09-20	Merck Serono Sa	2,3 substituted pyrazine sulfonamides as inhibitors of CRTH2
EP1891075B1 (en)	2005-05-24	2011-10-19	Merck Serono SA	Tricyclic spiro derivatives as crth2 modulators
EP1911759A4 (en)	2005-07-22	2010-07-21	Shionogi & Co	AZAINDOL DERIVATIVE ANTAGONISTIC EFFECT ON PGD2 RECEPTOR
ES2372701T3 (es)	2005-07-22	2012-01-25	Shionogi & Co., Ltd.	Derivado de indol que tiene actividad antagonista del receptor de pgd2.
RU2405770C2 (ru)	2005-09-27	2010-12-10	Сионоги Энд Ко., Лтд.	Производное сульфонамида, обладающее антагонистической активностью в отношении рецептора pgd2
WO2007036743A2 (en) *	2005-09-30	2007-04-05	Argenta Discovery Limited	Quinolines and their therapeutic use
CN101454284A (zh) *	2006-05-26	2009-06-10	阿斯利康(瑞典)有限公司	联芳基或芳基-杂芳基取代的吲哚类化合物
WO2013142295A1 (en)	2012-03-21	2013-09-26	The Trustees Of The University Of Pennsylvania	Compositions and methods for regulating hair growth
EP3175856A1 (en)	2006-06-16	2017-06-07	The Trustees of the University of Pennsylvania	Methods and compositions for inhibiting or reducing hair loss
KR20090042808A (ko) *	2006-07-22	2009-04-30	옥사겐 리미티드	씨알티에이치2 길항제 활성을 갖는 화합물
DK2051962T3 (da)	2006-08-07	2012-01-02	Actelion Pharmaceuticals Ltd	(3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-eddikesyrederivater
GB0702456D0 (en)	2007-02-08	2007-03-21	Astrazeneca Ab	New combination
WO2008156780A1 (en) *	2007-06-21	2008-12-24	Actimis Pharmaceuticals, Inc.	Particulates of a crth2 antagonist
MY149005A (en) *	2007-06-21	2013-06-28	Actimis Pharmaceuticals Inc	Amine salts of a crth2 antagonist
PL2229358T3 (pl)	2007-12-14	2011-09-30	Pulmagen Therapeutics Asthma Ltd	Związki indolowe i ich zastosowanie terapeutyczne
US7750027B2 (en)	2008-01-18	2010-07-06	Oxagen Limited	Compounds having CRTH2 antagonist activity
WO2010039982A1 (en) *	2008-10-01	2010-04-08	Ironwood Pharmaceuticals, Inc.	Crth2 modulators
EP2396295A1 (en)	2009-02-12	2011-12-21	Merck Serono S.A.	Phenoxy acetic acid derivatives
CA2767132C (en) *	2009-07-06	2017-06-20	Astrazeneca Ab	Intermediates and processes for the preparation of 4-(acetylamino))-3-[(4-chloro-phenyl)thio]-2-methyl-1h-indole-1-acetic acid
GB0913345D0 (en)	2009-07-31	2009-09-16	Astrazeneca Ab	New combination 802
WO2011061527A1 (en)	2009-11-17	2011-05-26	Astrazeneca Ab	Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
US9032565B2 (en)	2009-12-16	2015-05-19	Kohler Co.	Touchless faucet assembly and method of operation
WO2011073662A1 (en)	2009-12-17	2011-06-23	Astrazeneca Ab	Combination of a benzoxazinone and a further agent for treating respiratory diseases
BR112012024114B1 (pt)	2010-03-22	2021-02-09	Idorsia Pharmaceuticals Ltd	Compostos derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9h-carbazol, uso dos mesmos, e, composição farmacêutica
GB201021979D0 (en)	2010-12-23	2011-02-02	Astrazeneca Ab	New compound
GB201021992D0 (en)	2010-12-23	2011-02-02	Astrazeneca Ab	Compound
PL2697223T3 (pl)	2011-04-14	2017-01-31	Actelion Pharmaceuticals Ltd.	Pochodne kwasu 7-(heteroaryloamino)-6,7,8,9-tetrahydropirydo[1,2-a]indolooctowego i ich zastosowanie jako modulatorów receptora prostaglandyny D2
AU2012351342A1 (en)	2011-12-16	2014-07-24	Atopix Therapeutics Limited	Combination of CRTH2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
EP2903615B1 (en) *	2012-10-05	2021-04-07	Merck Sharp & Dohme Corp.	5-pyridin-3-yl-2,3-dihydro-1h-indole derivatives as aldosterone synthase (cyp11b2) inhibitors for the treatment of hypertension
US20140303121A1 (en)	2013-03-15	2014-10-09	Plexxikon Inc.	Heterocyclic compounds and uses thereof
CN105073747B (zh) *	2013-03-15	2017-06-06	普莱希科公司	杂环化合物及其应用
EP3004083A4 (en) *	2013-05-24	2016-11-16	California Inst Biomedical Res	COMPOUNDS FOR THE TREATMENT OF DRUG RESISTANT AND PERSISTENT TUBERCULOSIS
BR112016021471B1 (pt)	2014-03-17	2022-10-11	Idorsia Pharmaceuticals Ltd	Compostos derivados de ácido acético azaindol, composição farmacêutica, e, uso de um composto
CA2938107A1 (en)	2014-03-18	2015-09-24	Actelion Pharmaceuticals Ltd	Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
GB201407820D0 (en)	2014-05-02	2014-06-18	Atopix Therapeutics Ltd	Polymorphic form
GB201407807D0 (en)	2014-05-02	2014-06-18	Atopix Therapeutics Ltd	Polymorphic form
EP3256121B1 (en)	2015-02-13	2024-08-07	INSERM - Institut National de la Santé et de la Recherche Médicale	Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus
ES2947824T3 (es)	2015-07-30	2023-08-21	Univ Pennsylvania	Alelos polimórficos de un solo nucleótido del gen DP-2 humano para la detección de la susceptibilidad a la inhibición del crecimiento del cabello por antagonistas de PGD2
KR20180053345A (ko)	2015-09-15	2018-05-21	이도르시아 파마슈티컬스 리미티드	결정질 형태
WO2019075243A1 (en)	2017-10-13	2019-04-18	Plexxikon Inc.	SOLID FORMS OF A COMPOUND FOR MODULATING KINASES

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE790679A (fr)	1971-11-03	1973-04-27	Ici Ltd	Derives de l'indole
JPH0615542B2 (ja)	1986-07-22	1994-03-02	吉富製薬株式会社	ピラゾロピリジン化合物
US5095031A (en) *	1990-08-20	1992-03-10	Abbott Laboratories	Indole derivatives which inhibit leukotriene biosynthesis
WO1993005020A1 (en)	1991-09-06	1993-03-18	Merck & Co., Inc.	Indoles as inhibitors of hiv reverse transcriptase
FR2692574B1 (fr)	1992-06-23	1995-06-23	Sanofi Elf	Derives hydroxy-4 benzenethio, leur preparation ainsi que leur utilisation pour la preparation de derives aminoalkoxybenzenesulfonyles.
CN1119856A (zh)	1993-02-24	1996-04-03	麦克公司	Hiv逆转录酶抑制剂
US5486525A (en)	1993-12-16	1996-01-23	Abbott Laboratories	Platelet activating factor antagonists: imidazopyridine indoles
US5567711A (en) *	1995-04-19	1996-10-22	Abbott Laboratories	Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
GB9624482D0 (en)	1995-12-18	1997-01-15	Zeneca Phaema S A	Chemical compounds
KR19990082463A (ko)	1996-02-13	1999-11-25	돈 리사 로얄	혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체
ATE211134T1 (de)	1996-03-05	2002-01-15		4-anilinochinazolin derivate
TW472045B (en)	1996-09-25	2002-01-11	Astra Ab	Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
GB9718972D0 (en)	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
GB9714249D0 (en)	1997-07-08	1997-09-10	Angiogene Pharm Ltd	Vascular damaging agents
WO1999009007A1 (en)	1997-08-21	1999-02-25	American Home Products Corporation	Solid phase synthesis of 2,3-disubstituted indole compounds
ATE239013T1 (de)	1997-12-19	2003-05-15	Lilly Co Eli	Hypoglykamische imidazoline derivate
US6916841B2 (en) *	1998-02-25	2005-07-12	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
GB9900334D0 (en)	1999-01-07	1999-02-24	Angiogene Pharm Ltd	Tricylic vascular damaging agents
GB9900752D0 (en)	1999-01-15	1999-03-03	Angiogene Pharm Ltd	Benzimidazole vascular damaging agents
AU5886500A (en)	1999-06-23	2001-01-09	Sepracor, Inc.	Indolyl-benzimidazole antibacterials, and methods of use thereof
WO2001032621A1 (fr) *	1999-10-29	2001-05-10	Wakunaga Pharmaceutical Co., Ltd.	Nouveaux derives d'indole, et medicaments contenant lesdits derives comme principe actif
MXPA02006338A (es)	1999-12-24	2002-12-13	Aventis Pharma Ltd	Azaindoles.
BR0111230A (pt)	2000-05-31	2003-06-10	Astrazeneca Ab	Composto, e, uso e processo para a preparação do mesmo
EE200300015A (et)	2000-07-07	2004-10-15	Angiogene Pharmaceuticals Limited	Kolhinooli derivaadid kui angiogeneesi inhibiitorid
US6878522B2 (en) *	2000-07-07	2005-04-12	Baiyong Li	Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
MXPA02012905A (es)	2000-07-07	2004-07-30	Angiogene Pharm Ltd	Derivados de colquinol como agentes de dano vascular..
JP4595182B2 (ja) *	2000-09-07	2010-12-08	ソニー株式会社	情報記録装置、情報再生装置、情報記録方法、情報再生方法、および情報記録媒体、並びにプログラム提供媒体
TWI317634B (en) *	2001-12-13	2009-12-01	Nat Health Research Institutes	Aroyl indoles compounds
KR100656037B1 (ko)	2002-02-01	2006-12-11	에프. 호프만-라 로슈 아게	알파-1 작용제인 치환된 인돌
SE0200411D0 (sv)	2002-02-05	2002-02-05	Astrazeneca Ab	Novel use
SE0200356D0 (sv)	2002-02-05	2002-02-05	Astrazeneca Ab	Novel use
EP2423190A1 (en)	2002-05-16	2012-02-29	Shionogi&Co., Ltd.	Compounds Exhibiting PGD 2 Receptor Antagonism
SE0201635D0 (sv) *	2002-05-30	2002-05-30	Astrazeneca Ab	Novel compounds
TW200307542A (en) *	2002-05-30	2003-12-16	Astrazeneca Ab	Novel compounds
SE0202241D0 (sv) *	2002-07-17	2002-07-17	Astrazeneca Ab	Novel Compounds
SE0202463D0 (sv)	2002-08-14	2002-08-14	Astrazeneca Ab	Novel compounds
SE0301569D0 (sv) *	2003-05-27	2003-05-27	Astrazeneca Ab	Novel compounds
SE0302232D0 (sv)	2003-08-18	2003-08-18	Astrazeneca Ab	Novel Compounds
RU2006109108A (ru) *	2003-10-14	2007-11-20	Оксаген Лимитед (GB)	Соединения, обладающие активностью антагонистов crth2 рецепторов
SE0303180D0 (sv)	2003-11-26	2003-11-26	Astrazeneca Ab	Novel compounds
GB0500604D0 (en) *	2005-01-13	2005-02-16	Astrazeneca Ab	Novel process
GB2422831A (en)	2005-02-04	2006-08-09	Oxagen Ltd	Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor
CN101454284A (zh)	2006-05-26	2009-06-10	阿斯利康(瑞典)有限公司	联芳基或芳基-杂芳基取代的吲哚类化合物
AU2007256564A1 (en)	2006-06-08	2007-12-13	Neurokey A/S	Use of cannabinoid receptor agonists as hypothermia inducing drugs for the treatment of ischemia
CA2656150A1 (en)	2006-06-28	2008-01-03	Sanofi-Aventis	New cxcr2 inhibitors

2003
- 2003-05-27 SE SE0301569A patent/SE0301569D0/xx unknown
- 2003-08-27 SE SE0302305A patent/SE0302305D0/xx unknown
2004
- 2004-05-19 TW TW093114113A patent/TWI328004B/zh not_active IP Right Cessation
- 2004-05-19 TW TW099109193A patent/TW201024261A/zh unknown
- 2004-05-24 AR ARP040101792A patent/AR044552A1/es unknown
- 2004-05-25 DE DE602004020072T patent/DE602004020072D1/de not_active Expired - Lifetime
- 2004-05-25 EP EP10180348A patent/EP2281815B1/en not_active Expired - Lifetime
- 2004-05-25 PT PT08165755T patent/PT2025670E/pt unknown
- 2004-05-25 NZ NZ543722A patent/NZ543722A/xx not_active IP Right Cessation
- 2004-05-25 EP EP04734774A patent/EP1656346B1/en not_active Expired - Lifetime
- 2004-05-25 JP JP2006532212A patent/JP4541361B2/ja not_active Expired - Fee Related
- 2004-05-25 ES ES10180348T patent/ES2382606T3/es not_active Expired - Lifetime
- 2004-05-25 AT AT10180348T patent/ATE552243T1/de active
- 2004-05-25 KR KR1020117009790A patent/KR20110050754A/ko not_active Application Discontinuation
- 2004-05-25 RU RU2005137403/04A patent/RU2361860C2/ru active
- 2004-05-25 PT PT04734774T patent/PT1656346E/pt unknown
- 2004-05-25 US US10/558,228 patent/US7687535B2/en active Active
- 2004-05-25 SI SI200431120T patent/SI1656346T1/sl unknown
- 2004-05-25 CN CN2004800146027A patent/CN1795174B/zh not_active Expired - Fee Related
- 2004-05-25 PL PL08165755T patent/PL2025670T3/pl unknown
- 2004-05-25 KR KR1020057022513A patent/KR101067586B1/ko active IP Right Grant
- 2004-05-25 WO PCT/SE2004/000808 patent/WO2004106302A1/en active Application Filing
- 2004-05-25 AU AU2004242624A patent/AU2004242624B2/en not_active Ceased
- 2004-05-25 PT PT10180348T patent/PT2281815E/pt unknown
- 2004-05-25 KR KR1020117009788A patent/KR101067535B1/ko not_active IP Right Cessation
- 2004-05-25 PL PL04734774T patent/PL1656346T3/pl unknown
- 2004-05-25 CA CA2526866A patent/CA2526866C/en not_active Expired - Fee Related
- 2004-05-25 DK DK08165755.3T patent/DK2025670T3/da active
- 2004-05-25 SI SI200431874T patent/SI2281815T1/sl unknown
- 2004-05-25 AT AT04734774T patent/ATE425965T1/de active
- 2004-05-25 ES ES08165755T patent/ES2361485T3/es not_active Expired - Lifetime
- 2004-05-25 MY MYPI20041992A patent/MY144483A/en unknown
- 2004-05-25 ES ES04734774T patent/ES2322650T3/es not_active Expired - Lifetime
- 2004-05-25 DK DK10180348.4T patent/DK2281815T3/da active
- 2004-05-25 DK DK04734774T patent/DK1656346T3/da active
- 2004-05-25 DE DE602004031894T patent/DE602004031894D1/de not_active Expired - Lifetime
- 2004-05-25 SI SI200431669T patent/SI2025670T1/sl unknown
- 2004-05-25 BR BRPI0410711A patent/BRPI0410711B8/pt not_active IP Right Cessation
- 2004-05-25 PL PL10180348T patent/PL2281815T3/pl unknown
- 2004-05-25 CN CN2011102633202A patent/CN102391171A/zh active Pending
- 2004-05-25 MX MXPA05012680A patent/MXPA05012680A/es active IP Right Grant
- 2004-05-25 AT AT08165755T patent/ATE502010T1/de active
- 2004-05-25 EP EP08165755A patent/EP2025670B1/en not_active Expired - Lifetime
2005
- 2005-11-14 IL IL171928A patent/IL171928A/en not_active IP Right Cessation
- 2005-11-23 CO CO05118882A patent/CO5630030A2/es active IP Right Grant
- 2005-11-28 ZA ZA200509598A patent/ZA200509598B/en unknown
- 2005-12-20 IS IS8189A patent/IS2722B/is unknown
- 2005-12-22 NO NO20056130A patent/NO20056130L/no not_active Application Discontinuation
2006
- 2006-10-11 HK HK06111158.9A patent/HK1090635A1/xx not_active IP Right Cessation
2008
- 2008-10-23 IL IL194872A patent/IL194872A0/en unknown
2009
- 2009-03-04 US US12/397,618 patent/US20090163518A1/en not_active Abandoned
- 2009-05-15 HR HR20090281T patent/HRP20090281T1/xx unknown
- 2009-05-28 CY CY20091100564T patent/CY1109104T1/el unknown
- 2009-06-30 HK HK09105852.7A patent/HK1126773A1/xx not_active IP Right Cessation
- 2009-06-30 HK HK11107570.0A patent/HK1149563A1/xx not_active IP Right Cessation
2010
- 2010-03-31 JP JP2010082748A patent/JP2010155862A/ja active Pending
- 2010-08-09 IS IS8920A patent/IS8920A/is unknown
2011
- 2011-03-14 US US13/047,280 patent/US20110263614A1/en not_active Abandoned
- 2011-04-11 IL IL212265A patent/IL212265A0/en unknown
- 2011-04-14 IL IL212371A patent/IL212371A0/en unknown
- 2011-05-16 HR HR20110359T patent/HRP20110359T1/hr unknown
- 2011-05-16 CY CY20111100464T patent/CY1111469T1/el unknown
2012
- 2012-01-05 US US13/344,051 patent/US20120178764A1/en not_active Abandoned
- 2012-05-10 HR HRP20120390TT patent/HRP20120390T1/hr unknown
- 2012-05-29 CY CY20121100486T patent/CY1112853T1/el unknown

Also Published As

Publication number	Publication date
SI1656346T1 (sl)	2009-08-31
MXPA05012680A (es)	2006-02-08
US20120178764A1 (en)	2012-07-12
PT1656346E (pt)	2009-05-20
HRP20090281T1 (en)	2009-06-30
IL212371A0 (en)	2011-06-30
PT2281815E (pt)	2012-05-24
CO5630030A2 (es)	2006-04-28
PL1656346T3 (pl)	2009-07-31
DE602004031894D1 (de)	2011-04-28
JP4541361B2 (ja)	2010-09-08
US20080249110A1 (en)	2008-10-09
AU2004242624A1 (en)	2004-12-09
KR20110050754A (ko)	2011-05-16
MY144483A (en)	2011-09-30
KR101067535B1 (ko)	2011-09-27
IL194872A0 (en)	2011-08-01
IS8920A (is)	2010-08-09
EP2281815B1 (en)	2012-04-04
EP2025670A1 (en)	2009-02-18
EP2281815A1 (en)	2011-02-09
US20110263614A1 (en)	2011-10-27
DE602004020072D1 (de)	2009-04-30
CA2526866C (en)	2012-10-16
CN102391171A (zh)	2012-03-28
JP2010155862A (ja)	2010-07-15
BRPI0410711A (pt)	2006-06-13
WO2004106302A1 (en)	2004-12-09
ES2382606T3 (es)	2012-06-11
HK1090635A1 (en)	2006-12-29
HRP20120390T1 (hr)	2012-06-30
ZA200509598B (en)	2006-12-27
US20090163518A1 (en)	2009-06-25
DK2281815T3 (da)	2012-06-18
KR20110051297A (ko)	2011-05-17
IL171928A0 (en)	2006-04-10
EP2025670B1 (en)	2011-03-16
US7687535B2 (en)	2010-03-30
TWI328004B (en)	2010-08-01
ATE502010T1 (de)	2011-04-15
RU2361860C2 (ru)	2009-07-20
ES2361485T3 (es)	2011-06-17
CN1795174B (zh)	2011-09-28
BRPI0410711B1 (pt)	2018-09-25
SE0302305D0 (sv)	2003-08-27
PT2025670E (pt)	2011-05-24
SE0301569D0 (sv)	2003-05-27
KR20060015303A (ko)	2006-02-16
CY1111469T1 (el)	2015-08-05
AU2004242624B2 (en)	2008-03-13
AR044552A1 (es)	2005-09-21
SI2281815T1 (sl)	2012-06-29
RU2005137403A (ru)	2006-05-27
SI2025670T1 (sl)	2011-06-30
CY1109104T1 (el)	2014-07-02
DK1656346T3 (da)	2009-06-15
IL212265A0 (en)	2011-06-30
ES2322650T3 (es)	2009-06-24
DK2025670T3 (da)	2011-06-06
ATE425965T1 (de)	2009-04-15
EP1656346B1 (en)	2009-03-18
HK1149563A1 (pl)	2011-10-07
KR101067586B1 (ko)	2011-09-27
CA2526866A1 (en)	2004-12-09
ATE552243T1 (de)	2012-04-15
IS8189A (is)	2005-12-20
IL171928A (en)	2011-06-30
EP1656346A1 (en)	2006-05-17
CY1112853T1 (el)	2016-02-10
HRP20110359T1 (hr)	2011-06-30
JP2007501269A (ja)	2007-01-25
HK1126773A1 (pl)	2009-09-11
PL2025670T3 (pl)	2011-07-29
IS2722B (is)	2011-03-15
TW201024261A (en)	2010-07-01
BRPI0410711B8 (pt)	2021-05-25
NO20056130L (no)	2006-02-27
NZ543722A (en)	2007-05-31
TW200510301A (en)	2005-03-16
CN1795174A (zh)	2006-06-28

Publication	Publication Date	Title
PL2281815T3 (pl)	2012-08-31	Związek pośredni, ester etylowy kwasu 4-(acetyloamino)-3-[(4-chlorofenylo}tio]-2-metylo-1H-indolooctowego
AU2003296419A1 (en)	2005-07-21	Pyrenyloxysulfonic acid fluorescent agents
IL176189A0 (en)	2006-10-05	3-(4-benzyloxyphenyl) propanoic acid derivatives
AU2003278458A1 (en)	2004-06-15	Usage data harvesting
AU2004266485A1 (en)	2005-03-03	Phenoxiacetic acid derivatives
IL174398A0 (en)	2006-08-01	4-((phenoxyalkyl) thio)-phenoxyacetic acids and analogs
AU2003245308A1 (en)	2003-12-12	Fatty acid desaturases from fungi
AU2003279366A1 (en)	2004-06-07	Novel compounds
AU2003202265A1 (en)	2003-07-30	Fungicide compositions
HK1105199A1 (en)	2008-02-06	4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4- yl-benzothiazol-2-yl)-amide
IL174399A0 (en)	2006-08-01	4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
DE50313212D1 (de)	2010-12-02	Blausäure aus formamid
AU2003302305A1 (en)	2004-07-22	Benzoquinolizine-2-carboxylic acid-containing compositions
ZA200505679B (en)	2009-07-29	Nutritional formula comprising L(+)-lactic acid
AU2003228487A1 (en)	2003-11-17	Fatty acid containing teat dip
AU2002350381A1 (en)	2003-11-11	Fungicidal composition containing pqds
PL378119A1 (pl)	2006-03-06	Kwasy karboksylowe
AU2003224032A1 (en)	2003-10-13	Herbicidal composition comprising phenylpropynyloxypyridine compounds
AU2003215635A1 (en)	2003-10-13	Thiazol-2-yl-imine compounds as pde-7 inhibitors
AU2003251350A1 (en)	2005-02-25	Photo-curable urethane-acrylate compounds
AUPS044102A0 (en)	2002-03-07	New compound
AU2002953066A0 (en)	2002-12-19	Reel
AU2002951868A0 (en)	2002-10-24	Compound i
AU2002236267A1 (en)	2003-09-22	Quinolonecarboxylic acid derivative
AU2003201997A1 (en)	2003-07-24	Pediculicidal compound