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GB201021979D0 - New compound - Google Patents

New compound

Info

Publication number
GB201021979D0
GB201021979D0 GB201021979A GB201021979A GB201021979D0 GB 201021979 D0 GB201021979 D0 GB 201021979D0 GB 201021979 A GB201021979 A GB 201021979A GB 201021979 A GB201021979 A GB 201021979A GB 201021979 D0 GB201021979 D0 GB 201021979D0
Authority
GB
United Kingdom
Prior art keywords
inhibitor
antagonist
agonist
receptor
ccr1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB201021979A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pulmagen Therapeutics Synergy Ltd
AstraZeneca AB
Original Assignee
Pulmagen Therapeutics Synergy Ltd
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pulmagen Therapeutics Synergy Ltd, AstraZeneca AB filed Critical Pulmagen Therapeutics Synergy Ltd
Priority to GB201021979A priority Critical patent/GB201021979D0/en
Publication of GB201021979D0 publication Critical patent/GB201021979D0/en
Priority to PCT/GB2011/052560 priority patent/WO2012085583A1/en
Ceased legal-status Critical Current

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is N-Butyl-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H- benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)-3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-5 oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanamide or a salt thereof, and a second active ingredient selected from: a non-steroidal Glucocorticoid Receptor (GR Receptor) Agonist; an antioxidant; a CCR1 antagonist; a chemokine antagonist (not CCR1); a corticosteroid; a CRTh2 antagonist; a DP1 antagonist; an Histone Deacetylase activator; an IKK2 kinase inhibitor; a COX inhibitor; a lipoxygenase inhibitor; a leukotriene receptor antagonist; an MPO inhibitor; a PDE4 inhibitor; a PPAR? agonist; a protease inhibitor; a p38 inhibitor, a selective glucocorticoid receptor agonist (SEGRA), a Statin; a thromboxane antagonist; a vasodilator; or, an ENAC blocker (Epithelial Sodium-channel blocker); and its use in the treatment of respiratory disease.
GB201021979A 2010-12-23 2010-12-23 New compound Ceased GB201021979D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB201021979A GB201021979D0 (en) 2010-12-23 2010-12-23 New compound
PCT/GB2011/052560 WO2012085583A1 (en) 2010-12-23 2011-12-22 New compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201021979A GB201021979D0 (en) 2010-12-23 2010-12-23 New compound

Publications (1)

Publication Number Publication Date
GB201021979D0 true GB201021979D0 (en) 2011-02-02

Family

ID=43599002

Family Applications (1)

Application Number Title Priority Date Filing Date
GB201021979A Ceased GB201021979D0 (en) 2010-12-23 2010-12-23 New compound

Country Status (2)

Country Link
GB (1) GB201021979D0 (en)
WO (1) WO2012085583A1 (en)

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EA201500651A1 (en) 2012-12-18 2015-11-30 Альмираль, С.А. NEW DERIVATIVES AND cyclohexyl- HINUKLIDINILKARBAMATA having agonistic activity towards β2 adrenergic receptor and antagonistic activity against muscarinic receptors M3
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TWI641373B (en) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH MUSCARINIC RECEPTOR ANTAGONIST AND β2 ADRENERGIC RECEPTOR AGONIST ACTIVITIES
TW201517906A (en) 2013-07-25 2015-05-16 Almirall Sa Combinations comprising MABA compounds and corticosteroids
TW201617343A (en) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 New bicyclic derivatives having [beta]2 adrenergic agonist and M3 muscarinic antagonist activities
WO2018059537A1 (en) * 2016-09-30 2018-04-05 四川海思科制药有限公司 Diazaspiro[5.5]undecane derivative and use thereof

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Also Published As

Publication number Publication date
WO2012085583A1 (en) 2012-06-28

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