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PL1776358T3 - Pochodne podstawionej propenylopiperazyny jako nowe inhibitory deacetylazy histonowej - Google Patents

Pochodne podstawionej propenylopiperazyny jako nowe inhibitory deacetylazy histonowej

Info

Publication number
PL1776358T3
PL1776358T3 PL05777776T PL05777776T PL1776358T3 PL 1776358 T3 PL1776358 T3 PL 1776358T3 PL 05777776 T PL05777776 T PL 05777776T PL 05777776 T PL05777776 T PL 05777776T PL 1776358 T3 PL1776358 T3 PL 1776358T3
Authority
PL
Poland
Prior art keywords
histone deacetylase
piperazine derivatives
novel inhibitors
substituted propenyl
propenyl piperazine
Prior art date
Application number
PL05777776T
Other languages
English (en)
Inventor
Brandt Sven F A Van
Emelen Kristof Van
Patrick R Angibaud
Laurence F B Marconnet-Decrane
Janine Arts
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39294123&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1776358(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PL1776358T3 publication Critical patent/PL1776358T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
PL05777776T 2004-07-28 2005-07-25 Pochodne podstawionej propenylopiperazyny jako nowe inhibitory deacetylazy histonowej PL1776358T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP04077171 2004-07-28
US59235704P 2004-07-29 2004-07-29
EP05777776A EP1776358B1 (en) 2004-07-28 2005-07-25 Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase
PCT/EP2005/053611 WO2006010749A2 (en) 2004-07-28 2005-07-25 Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase

Publications (1)

Publication Number Publication Date
PL1776358T3 true PL1776358T3 (pl) 2009-10-30

Family

ID=39294123

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05777776T PL1776358T3 (pl) 2004-07-28 2005-07-25 Pochodne podstawionej propenylopiperazyny jako nowe inhibitory deacetylazy histonowej

Country Status (26)

Country Link
EP (1) EP1776358B1 (pl)
JP (1) JP5279268B2 (pl)
KR (1) KR101282833B1 (pl)
CN (1) CN1993356B (pl)
AR (1) AR050189A1 (pl)
AT (1) ATE432274T1 (pl)
AU (1) AU2005266311B2 (pl)
BR (1) BRPI0513891B8 (pl)
CA (1) CA2572971C (pl)
CY (1) CY1110358T1 (pl)
DE (1) DE602005014646D1 (pl)
DK (1) DK1776358T3 (pl)
EA (1) EA011932B1 (pl)
ES (1) ES2327253T3 (pl)
HK (1) HK1106236A1 (pl)
HR (1) HRP20090439T1 (pl)
IL (1) IL180961A0 (pl)
MX (1) MX2007001119A (pl)
MY (1) MY142831A (pl)
NO (1) NO20071117L (pl)
NZ (1) NZ552758A (pl)
PL (1) PL1776358T3 (pl)
PT (1) PT1776358E (pl)
SI (1) SI1776358T1 (pl)
TW (1) TWI394752B (pl)
WO (1) WO2006010749A2 (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE424395T1 (de) 2002-03-13 2009-03-15 Janssen Pharmaceutica Nv Aminoderivate als histone-deacetylase-inhibitoren
JP4674045B2 (ja) 2002-03-13 2011-04-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのピペラジニル−、ピペリジニル−およびモルホリニル−誘導体
JP4725945B2 (ja) 2002-03-13 2011-07-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのスルホニルアミノ誘導体
MX2007001120A (es) 2004-07-28 2007-03-15 Janssen Pharmaceutica Nv Derivados de indolil alquil sustituidos como nuevos inhibidores de la histona desacetilasa.
AU2006248938B2 (en) 2005-05-18 2011-09-29 Janssen Pharmaceutica N.V. Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
WO2007049262A1 (en) * 2005-10-27 2007-05-03 Berand Limited Methods and compositions for the promotion of neuronal growth and the treatment of asociality and affective disorders
SI1981874T1 (sl) 2006-01-19 2009-10-31 Janssen Pharmaceutica Nv Aminofenilni derivati kot novi inhibitorji histon deacetilaze
WO2007082874A1 (en) * 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
US8101616B2 (en) 2006-01-19 2012-01-24 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
AU2007206950B2 (en) 2006-01-19 2012-02-02 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
EP1839656A1 (en) * 2006-03-31 2007-10-03 TopoTarget Germany AG Use of valproic acid for the topical treatment of mild to moderate acne vulgaris
RU2501787C2 (ru) * 2007-11-02 2013-12-20 Метилджен Инк. Ингибиторы гистондеацетилазы
CN101723896B (zh) * 2009-11-03 2012-10-31 山东大学 酪氨酸衍生物类组蛋白去乙酰化酶抑制剂及其应用
WO2012117421A1 (en) 2011-03-02 2012-09-07 Orchid Research Laboratories Ltd Histone deacetylase inhibitors
KR101419836B1 (ko) * 2012-05-10 2014-07-16 서울대학교산학협력단 Δ5-2-옥소피페라진 유도체를 포함하는 중간엽 줄기세포의 연골세포로의 분화 유도용 조성물
KR101586045B1 (ko) 2013-07-30 2016-01-15 충북대학교 산학협력단 신규 페닐티아졸 기반 히드록삼산 및 이를 유효성분으로 포함하는 항암용 조성물
KR102132078B1 (ko) 2018-09-20 2020-07-08 원광대학교산학협력단 방향족 화합물, 아민 및 친핵체를 이용한 3가지 성분 반응으로 1-에틸-4-페닐피페라진 유도체를 제조하는 방법
KR20230155310A (ko) 2022-05-03 2023-11-10 충북대학교 산학협력단 신규한 n-히드록시프로펜아미드 화합물 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
JP4674045B2 (ja) * 2002-03-13 2011-04-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのピペラジニル−、ピペリジニル−およびモルホリニル−誘導体
ATE424395T1 (de) * 2002-03-13 2009-03-15 Janssen Pharmaceutica Nv Aminoderivate als histone-deacetylase-inhibitoren
AU2003229883B2 (en) * 2002-04-03 2009-06-11 Topotarget Uk Limited Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors

Also Published As

Publication number Publication date
HRP20090439T1 (hr) 2009-09-30
NO20071117L (no) 2007-02-27
KR20070043978A (ko) 2007-04-26
BRPI0513891B1 (pt) 2020-09-29
WO2006010749A3 (en) 2006-06-08
EA200700143A1 (ru) 2007-06-29
ES2327253T3 (es) 2009-10-27
ATE432274T1 (de) 2009-06-15
HK1106236A1 (en) 2008-03-07
CN1993356A (zh) 2007-07-04
CN1993356B (zh) 2010-10-27
JP5279268B2 (ja) 2013-09-04
WO2006010749A2 (en) 2006-02-02
KR101282833B1 (ko) 2013-07-08
TWI394752B (zh) 2013-05-01
DE602005014646D1 (de) 2009-07-09
JP2008508234A (ja) 2008-03-21
MY142831A (en) 2011-01-14
DK1776358T3 (da) 2009-09-07
BRPI0513891A (pt) 2008-05-20
CA2572971A1 (en) 2006-02-02
PT1776358E (pt) 2009-08-13
EA011932B1 (ru) 2009-06-30
EP1776358B1 (en) 2009-05-27
IL180961A0 (en) 2007-07-04
AR050189A1 (es) 2006-10-04
AU2005266311B2 (en) 2011-08-11
TW200616998A (en) 2006-06-01
CY1110358T1 (el) 2015-04-29
EP1776358A2 (en) 2007-04-25
MX2007001119A (es) 2007-03-15
BRPI0513891B8 (pt) 2021-05-25
CA2572971C (en) 2013-01-15
SI1776358T1 (sl) 2009-10-31
NZ552758A (en) 2009-08-28
AU2005266311A1 (en) 2006-02-02

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