PE20090730A1 - Derivados de piridina como moduladores de los canales de sodio - Google Patents
Derivados de piridina como moduladores de los canales de sodioInfo
- Publication number
- PE20090730A1 PE20090730A1 PE2008000775A PE2008000775A PE20090730A1 PE 20090730 A1 PE20090730 A1 PE 20090730A1 PE 2008000775 A PE2008000775 A PE 2008000775A PE 2008000775 A PE2008000775 A PE 2008000775A PE 20090730 A1 PE20090730 A1 PE 20090730A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- amino
- carboxamide
- pyridin
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE N-[6-AMINO-5-ARIL-PIRIDIN-2-IL]-CARBOXAMIDA DE FORMULA (I), DONDE R1 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALO, -CN, ALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS, UN GRUPO HETEROARILO DE 5 MIEMBROS CON: a) 1 A 4 ATOMOS DE NITROGENO O b) UN ATOMO DE O O S Y 1 O 2 ATOMOS DE N, DONDE HETEROARILO ESTA OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C4, HALOALCOXI C1-C4, ALQUILO C1-C4-AMINO, ENTRE OTROS; Ar ES UN GRUPO (a), (b) O (c), DONDE LA FLECHA INDICA EL PUNTO DE UNION AL ANILLO DE PIRIMIDINA; R2 ES HALO, -CN, ALQUILO C1-C4, HALOALQUILO C1-C4, ENTRE OTROS; n ES UN ENTERO DE 0 A 4; m ES UN ENTERO DE 0 A 7; p ES UN ENTERO DE 0 A 3; R3 ES H, ALQUILO C1-C4, OR4, ENTRE OTROS; R4 ES H, ALQUILO C1-C4, ALCOXI C1-C4, CICLOALQUILO C3-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[6-AMINO-5-(2-CLORO-5-METOXIFENIL)PIRIDIN-2-IL]-1-METIL-1H-PIRAZOL-5-CARBOXAMIDA, N-[6-AMINO-5-(2-CLORO-5-METOXIFENIL)PIRIDIN-2-IL]-3-METILISOXAZOL-4-CARBOXAMIDA, N-[6-AMINO-5-(7-CLORO-2,3-DIHIDRO-1,4-BENZODIOXIN-5-IL)PIRIDIN-2-IL]-3-METILISOXAZOL-4-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL CANAL DE SODIO, PARTICULARMENTE DE LOS CANALES Nav1,8 Y SON UTILES EN EL TRATAMIENTO DEL DOLOR AGUDO, DOLOR CRONICO, DOLOR NEUROPATICO, ENTRE OTROS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91574507P | 2007-05-03 | 2007-05-03 | |
| US95753607P | 2007-08-23 | 2007-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090730A1 true PE20090730A1 (es) | 2009-07-11 |
Family
ID=39855225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000775A PE20090730A1 (es) | 2007-05-03 | 2008-04-30 | Derivados de piridina como moduladores de los canales de sodio |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US8134007B2 (es) |
| EP (1) | EP2183241B1 (es) |
| JP (1) | JP4657384B2 (es) |
| KR (1) | KR20100007956A (es) |
| CN (1) | CN101675040A (es) |
| AP (1) | AP2516A (es) |
| AR (1) | AR070636A1 (es) |
| AU (1) | AU2008247102B2 (es) |
| BR (1) | BRPI0810202A2 (es) |
| CA (1) | CA2684105C (es) |
| CL (1) | CL2008001268A1 (es) |
| CO (1) | CO6251367A2 (es) |
| CR (1) | CR11061A (es) |
| CU (1) | CU23846B1 (es) |
| DO (1) | DOP2009000254A (es) |
| EA (1) | EA015952B1 (es) |
| EC (1) | ECSP099710A (es) |
| ES (1) | ES2398606T3 (es) |
| GE (1) | GEP20125379B (es) |
| GT (1) | GT200900280A (es) |
| IL (1) | IL201569A0 (es) |
| MA (1) | MA31419B1 (es) |
| MX (1) | MX2009011816A (es) |
| NI (1) | NI200900192A (es) |
| NZ (1) | NZ581614A (es) |
| PA (1) | PA8779201A1 (es) |
| PE (1) | PE20090730A1 (es) |
| SV (1) | SV2009003400A (es) |
| TN (1) | TN2009000450A1 (es) |
| TW (1) | TWI375675B (es) |
| UY (1) | UY31063A1 (es) |
| WO (1) | WO2008135826A2 (es) |
| ZA (1) | ZA200907609B (es) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3241832A1 (en) | 2008-08-06 | 2017-11-08 | Medivation Technologies, Inc. | Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) |
| PL2385938T3 (pl) | 2009-01-12 | 2015-07-31 | Pfizer Ltd | Pochodne sulfonamidu |
| CN101638352B (zh) * | 2009-08-14 | 2011-08-31 | 大连理工大学 | 一种芳基取代的氮杂环化合物的制备方法 |
| WO2011077313A1 (en) | 2009-12-22 | 2011-06-30 | Pfizer Inc. | Piperidinecarboxamides as mpges - 1 inhibitors |
| TW201139406A (en) * | 2010-01-14 | 2011-11-16 | Glaxo Group Ltd | Voltage-gated sodium channel blockers |
| CN101768036B (zh) * | 2010-01-23 | 2013-05-08 | 大连理工大学 | 一种在醇溶剂中制备芳基取代的氮杂芳环化合物的方法 |
| AU2011212928B2 (en) | 2010-02-03 | 2016-06-23 | Medivation Technologies Llc | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose) polymerase (PARP) for use in treatment of diseases associated with a PTEN deficiency |
| ES2606174T3 (es) | 2010-02-08 | 2017-03-23 | Medivation Technologies, Inc. | Procesos de síntesis de derivados de dihidropiridoftalazinona |
| CA2789606A1 (en) | 2010-02-25 | 2011-09-01 | Pfizer Limited | Peptide analogues as opioid receptor agonists |
| EP2590951B1 (en) | 2010-07-09 | 2015-01-07 | Pfizer Limited | Benzenesulfonamides useful as sodium channel inhibitors |
| EP2590957B1 (en) | 2010-07-09 | 2014-11-12 | Pfizer Limited | N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels |
| JP2013532185A (ja) | 2010-07-12 | 2013-08-15 | ファイザー・リミテッド | 化合物 |
| EP2593431B1 (en) | 2010-07-12 | 2014-11-19 | Pfizer Limited | N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels |
| US8772343B2 (en) | 2010-07-12 | 2014-07-08 | Pfizer Limited | Chemical compounds |
| WO2012007861A1 (en) | 2010-07-12 | 2012-01-19 | Pfizer Limited | N-sulfonylbenzamide derivatives useful as voltage gated sodium channel inhibitors |
| JP2013536165A (ja) | 2010-07-12 | 2013-09-19 | ファイザー・リミテッド | 痛みの処置のためのｎａｖ１．７阻害薬としてのスルホンアミド誘導体 |
| EP2593434A1 (en) | 2010-07-16 | 2013-05-22 | Purdue Pharma LP | Pyridine compounds as sodium channel blockers |
| MX2013004307A (es) * | 2010-10-18 | 2013-07-17 | Raqualia Pharma Inc | Derivados de arilamida como bloqueadores de ttx-s. |
| PT2630146T (pt) | 2010-10-21 | 2020-07-20 | Medivation Tech Llc | Sal tosilato de (8s,9r)-5-fluoro-8-(4-fluorofenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-di-hidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona cristalino |
| WO2012095781A1 (en) | 2011-01-13 | 2012-07-19 | Pfizer Limited | Indazole derivatives as sodium channel inhibitors |
| WO2012120398A1 (en) | 2011-03-04 | 2012-09-13 | Pfizer Limited | Aryl substituted carboxamide derivatives as trpm8 modulators |
| KR20130133905A (ko) | 2011-04-05 | 2013-12-09 | 화이자 리미티드 | 트로포미오신-관련 키나제의 억제제인 피롤로[2,3-d]피리미딘 유도체 |
| ES2564366T3 (es) | 2011-07-13 | 2016-03-22 | Pfizer Limited | Análogos de encefalina |
| WO2013054185A1 (en) | 2011-10-13 | 2013-04-18 | Pfizer, Inc. | Pyrimidine and pyridine derivatives useful in therapy |
| BR112014009102A2 (pt) | 2011-10-26 | 2017-04-18 | Pfizer Ltd | compostos químicos |
| ES2648901T3 (es) | 2011-10-28 | 2018-01-08 | Inhibitaxin Limited | Derivados de piridazina útiles en terapia |
| JP6058023B2 (ja) | 2011-12-15 | 2017-01-11 | ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ | スルホンアミド誘導体 |
| WO2013093688A1 (en) | 2011-12-19 | 2013-06-27 | Pfizer Limited | Sulfonamide derivatives and use thereof as vgsc inhibitors |
| WO2013102826A1 (en) | 2012-01-04 | 2013-07-11 | Pfizer Limited | N-aminosulfonyl benzamides |
| EP2809655B1 (en) | 2012-02-03 | 2015-08-12 | Pfizer Inc | Benziimidazole and imidazopyridine derivatives as sodium channel modulators |
| AU2013203824A1 (en) | 2012-03-16 | 2013-10-03 | Purdue Pharma L.P. | Substituted pyridines and pryimidines as sodium channel blockers |
| ES2743402T3 (es) * | 2012-04-25 | 2020-02-19 | Raqualia Pharma Inc | Derivados de amidas como bloqueadores TTX-S |
| EP2912036A1 (en) | 2012-10-04 | 2015-09-02 | Pfizer Limited | Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors |
| US20150218172A1 (en) | 2012-10-04 | 2015-08-06 | Pfizer Limited | Pyrrolo[2,3-D]Pyrimidine Tropomyosin-Related Kinase Inhibitors |
| CA2885247A1 (en) | 2012-10-04 | 2014-04-10 | Pfizer Limited | Tropomyosin-related kinase inhibitors |
| US9944634B2 (en) * | 2012-10-31 | 2018-04-17 | Raqualia Pharma Inc. | Pyrazolopyridine derivatives as TTX-S blockers |
| US9714252B2 (en) | 2012-12-20 | 2017-07-25 | Purdue Pharma L.P. | Cyclic sulfonamides as sodium channel blockers |
| ES2620379T3 (es) | 2013-01-31 | 2017-06-28 | Vertex Pharmaceuticals Inc. | Quinolina y quinoxalina amidas como moduladores de canales de sodio |
| PT2953931T (pt) | 2013-01-31 | 2017-06-14 | Vertex Pharma | Piridona amidas como moduladores dos canais de sódio |
| KR20150124985A (ko) | 2013-03-08 | 2015-11-06 | 암젠 인크 | 베타-세크레타제 억제제로서 퍼플루오르화된 사이클로프로필 융합된 1,3-옥사진-2-아민 화합물 및 그의 사용 방법 |
| MX364155B (es) | 2013-07-19 | 2019-04-12 | Vertex Pharma | Sulfonamidas como moduladores de canales de sodio. |
| CA2926313A1 (en) | 2013-10-15 | 2015-04-23 | Kristi A. Leonard | Secondary alcohol quinolinyl modulators of roryt |
| TW201605814A (zh) | 2013-11-07 | 2016-02-16 | 拜奧馬林製藥公司 | 用於合成經保護之ｎ－烷基三唑甲醛的三唑中間體 |
| JP6463580B2 (ja) | 2013-12-13 | 2019-02-06 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | ナトリウムチャネルの調節剤として有用なピリドンアミドのプロドラッグ |
| US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| AU2015315167A1 (en) * | 2014-09-10 | 2017-03-16 | Epizyme, Inc. | Isoxazole carboxamide compounds |
| CN106674264A (zh) * | 2016-12-20 | 2017-05-17 | 苏州汉德创宏生化科技有限公司 | (2,2,2‑三氟乙氧基)苯硼酸类化合物的合成方法 |
| US11358977B2 (en) | 2017-05-16 | 2022-06-14 | Vertex Pharmaceuticals Incorporated | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels |
| SG11202000230VA (en) | 2017-07-11 | 2020-02-27 | Vertex Pharma | Carboxamides as modulators of sodium channels |
| WO2019036657A1 (en) * | 2017-08-17 | 2019-02-21 | Kyn Therapeutics | AHR INHIBITORS AND USES THEREOF |
| KR20200118005A (ko) * | 2018-02-05 | 2020-10-14 | 위니베르시떼 드 스트라스부르 | 통증 치료용 화합물 및 조성물 |
| US20190343817A1 (en) | 2018-02-12 | 2019-11-14 | Vertex Pharmaceuticals Incorporated | Method of treating pain |
| CN109053434A (zh) * | 2018-07-18 | 2018-12-21 | 上海华堇生物技术有限责任公司 | 一种2,4-二甲氧基苯甲酰氯的新制备方法 |
| CN108794328A (zh) * | 2018-08-03 | 2018-11-13 | 上海华堇生物技术有限责任公司 | 3,4-二甲氧基苯甲酰氯的制备方法 |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| US20230062053A1 (en) | 2019-01-10 | 2023-03-02 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2020176763A1 (en) | 2019-02-27 | 2020-09-03 | Vertex Pharmaceuticals Incorporated | Dosage form comprising prodrug of na 1.8 sodium channel inhibitor |
| WO2020219867A1 (en) | 2019-04-25 | 2020-10-29 | Vertex Pharmaceuticals Incorporated | Pyridone amide co-crystal compositions for the treatment of pain |
| CN114269730A (zh) * | 2019-08-06 | 2022-04-01 | 多曼治疗学公司 | 作为神经肽ff受体拮抗剂的5-杂芳基-吡啶-2-胺化合物 |
| MX2022006865A (es) | 2019-12-06 | 2022-07-11 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio. |
| CN113248455A (zh) * | 2021-05-25 | 2021-08-13 | 湖北科技学院 | 一种3,5-二取代异噁唑类衍生物及其合成方法 |
| US20240285596A1 (en) | 2021-06-04 | 2024-08-29 | Vertex Pharmaceuticals Incorporated | Solid dosage forms and dosing regimens comprising (2r,3s,4s,5r)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide |
| EP4347032A1 (en) | 2021-06-04 | 2024-04-10 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels |
| JP2024520646A (ja) | 2021-06-04 | 2024-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | ナトリウムチャネルのモジュレーターとしてのｎ－（ヒドロキシアルキル（ヘテロ）アリール）テトラヒドロフランカルボキサミド類似体 |
| AU2022286511A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
| WO2022256676A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran analogs as modulators of sodium channels |
| CR20230586A (es) | 2021-06-04 | 2024-05-07 | Vertex Pharma | N-(hydroxyalquil (hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio |
| CN115703719B (zh) * | 2021-08-03 | 2024-04-30 | 联化科技股份有限公司 | 一种溴化肟类化合物的制备方法 |
| AU2023257313A1 (en) | 2022-04-22 | 2024-10-31 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| AU2023256603A1 (en) | 2022-04-22 | 2024-11-07 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| AU2023255558A1 (en) | 2022-04-22 | 2024-10-31 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| AU2023255771A1 (en) | 2022-04-22 | 2024-10-31 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2024123815A1 (en) | 2022-12-06 | 2024-06-13 | Vertex Pharmaceuticals Incorporated | Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2102367T3 (es) | 1990-05-18 | 1997-08-01 | Hoechst Ag | Amidas de acidos isoxazol-4-carboxilicos y amidas de acidos hidroxialquiliden-cianoaceticos, medicamentos que contienen estos compuestos y su utilizacion. |
| EP0674627A1 (en) | 1992-12-18 | 1995-10-04 | The Wellcome Foundation Limited | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
| WO1996018616A1 (en) | 1994-12-12 | 1996-06-20 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| AU4515896A (en) | 1994-12-12 | 1996-07-03 | Merck & Co., Inc. | Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase |
| US6011051A (en) | 1996-07-31 | 2000-01-04 | Hoechst Aktiengesellschaft | Use of isoxazole and crotonamide derivatives for the modulation of apoptosis |
| US6020357A (en) | 1996-12-23 | 2000-02-01 | Dupont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| US6060491A (en) | 1997-06-19 | 2000-05-09 | Dupont Pharmaceuticals | 6-membered aromatics as factor Xa inhibitors |
| DE19857009A1 (de) | 1998-12-10 | 2000-06-15 | Aventis Pharma Gmbh | Zubereitung mit verbesserter therapeutischer Breite, enthaltend Nukleotidsyntheseinhibitoren |
| US6458789B1 (en) | 1999-09-29 | 2002-10-01 | Lion Bioscience Ag | 2-aminopyridine derivatives and combinatorial libraries thereof |
| GB0002666D0 (en) * | 2000-02-04 | 2000-03-29 | Univ London | Blockade of voltage dependent sodium channels |
| AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| US6689779B2 (en) | 2000-06-05 | 2004-02-10 | Dong A Pharm. Co., Ltd. | Oxazolidinone derivatives and a process for the preparation thereof |
| US6849660B1 (en) | 2000-08-01 | 2005-02-01 | Isis Pharmaceuticals, Inc. | Antimicrobial biaryl compounds |
| DE10132308A1 (de) | 2001-07-06 | 2003-01-30 | Aventis Behring Gmbh | Kombinationspräparat zur Therapie von immunologischen Erkrankungen |
| AR037233A1 (es) | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| AR036873A1 (es) | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
| JP2003086564A (ja) * | 2001-09-14 | 2003-03-20 | Mitsubishi Electric Corp | 遠心乾燥装置および半導体装置の製造方法ならびに半導体製造装置 |
| AU2002363250A1 (en) * | 2001-11-01 | 2003-05-12 | Icagen, Inc. | Pyrazole-amides and-sulfonamides |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| DK1474395T3 (da) | 2002-02-12 | 2008-02-11 | Smithkline Beecham Corp | Nicotinamidderivater, der er nyttige som p38-inhibitorer |
| WO2004080999A1 (en) | 2003-03-14 | 2004-09-23 | Biolipox Ab | Pyrazole compounds useful in the treatment of inflammation |
| CA2524352A1 (en) | 2003-05-09 | 2004-11-18 | Pharmacia & Upjohn Company Llc | Substituted pyrimidine derivatives |
| AR044688A1 (es) | 2003-06-12 | 2005-09-21 | Euro Celtique Sa | Agentes terapeuticos utiles para el tratamiento del dolor |
| ES2317052T3 (es) | 2003-09-22 | 2009-04-16 | Euro-Celtique S.A. | Agentes terapeuticos utiles para el tratamiento del dolor. |
| AU2005218615A1 (en) | 2004-03-02 | 2005-09-15 | Neurogen Corporation | Heteroalkyl-substituted biphenyl-4-carboxylic acid arylamide analogues |
| BRPI0513717A (pt) * | 2004-07-23 | 2008-05-13 | Pfizer | derivados de piridina |
| CA2585490A1 (en) | 2004-11-12 | 2006-05-18 | Galapagos Nv | Nitrogen heteroaromatic compounds which bind to the active site of protein kinase enzymes |
| US20060106011A1 (en) | 2004-11-12 | 2006-05-18 | Bock Mark G | 2-(Bicyclo)alkylamino-derivatives as mediators of chronic pain and inflammation |
| WO2007026920A2 (en) | 2005-09-02 | 2007-03-08 | Astellas Pharma Inc. | Amide derivatives as rock inhibitors |
| TWI378101B (en) | 2005-09-09 | 2012-12-01 | Glaxosmithkline Llc | Pyridine derivatives and their use in the treatment of psychotic disorders |
| EP1764093A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
| EP1764095A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| TW200732320A (en) | 2005-10-31 | 2007-09-01 | Biolipox Ab | Pyrazoles useful in the treatment of inflammation |
| TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| CN101300236A (zh) | 2005-10-31 | 2008-11-05 | 比奥里波克斯公司 | 作为脂肪加氧酶抑制剂的三唑化合物 |
| NL2000284C2 (nl) | 2005-11-04 | 2007-09-28 | Pfizer Ltd | Pyrazine-derivaten. |
| EP2404919B1 (en) | 2005-11-08 | 2013-08-21 | Vertex Pharmaceuticals Incorporated | Heterocyclic compound useful as a modulator of ATP-binding cassette transporters. |
| WO2007058990A2 (en) | 2005-11-14 | 2007-05-24 | Kemia, Inc. | Therapy using cytokine inhibitors |
| JP5169220B2 (ja) | 2005-11-30 | 2013-03-27 | アステラス製薬株式会社 | ２−アミノベンズアミド誘導体 |
| WO2007083239A1 (en) | 2006-01-23 | 2007-07-26 | Pfizer Limited | Pyridine derivatives as sodium channel modulators |
| CA2639927A1 (en) | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Substituted biaryl compounds for inflammation and immune-related uses |
| EP1984338B8 (en) | 2006-01-31 | 2013-05-22 | Synta Pharmaceuticals Corp. | Pyridylphenyl compounds for inflammation and immune-related uses |
| WO2007093901A1 (en) | 2006-02-17 | 2007-08-23 | Pfizer Limited | 3 -deazapurine derivatives as tlr7 modulators |
| DK2004607T3 (da) | 2006-03-31 | 2012-01-30 | Novartis Ag | (4-(4-[6-(trifluormethyl-pyridin-3-ylamino)-N-holdige-heteroaryl]-phenyl)-cyclohexyl)-eddikesyrederivater og farmaceutiske anvendelser deraf |
| PE20080906A1 (es) | 2006-08-17 | 2008-07-05 | Kemia Inc | Derivados heteroarilo como inhibidores de citocina |
| US7795249B2 (en) | 2006-12-22 | 2010-09-14 | Millennium Pharmaceuticals, Inc. | Certain pyrazoline derivatives with kinase inhibitory activity |
| AU2008205252B2 (en) | 2007-01-09 | 2013-02-21 | Amgen Inc. | Bis-aryl amide derivatives useful for the treatment of cancer |
| US8822497B2 (en) | 2007-03-01 | 2014-09-02 | Novartis Ag | PIM kinase inhibitors and methods of their use |
| JP2010526051A (ja) | 2007-05-03 | 2010-07-29 | ファイザー・リミテッド | 疼痛を治療するためのｎａｖ１．８チャネルモジュレーターとしてのｎ−［６−アミノ−５−（フェニル）ピラジン−２−イル］−イソオキサゾール−４−カルボキサミド誘導体および関連化合物 |
-
2008
- 2008-04-21 EP EP08737559A patent/EP2183241B1/en active Active
- 2008-04-21 BR BRPI0810202-3A2A patent/BRPI0810202A2/pt not_active IP Right Cessation
- 2008-04-21 WO PCT/IB2008/001050 patent/WO2008135826A2/en active Application Filing
- 2008-04-21 NZ NZ581614A patent/NZ581614A/en not_active IP Right Cessation
- 2008-04-21 GE GEAP200811541A patent/GEP20125379B/en unknown
- 2008-04-21 KR KR1020097025183A patent/KR20100007956A/ko active IP Right Grant
- 2008-04-21 CA CA2684105A patent/CA2684105C/en not_active Expired - Fee Related
- 2008-04-21 AP AP2009005009A patent/AP2516A/xx active
- 2008-04-21 MX MX2009011816A patent/MX2009011816A/es active IP Right Grant
- 2008-04-21 EA EA200970913A patent/EA015952B1/ru not_active IP Right Cessation
- 2008-04-21 ES ES08737559T patent/ES2398606T3/es active Active
- 2008-04-21 AU AU2008247102A patent/AU2008247102B2/en not_active Ceased
- 2008-04-21 CN CN200880014589A patent/CN101675040A/zh active Pending
- 2008-04-21 JP JP2010504893A patent/JP4657384B2/ja not_active Expired - Fee Related
- 2008-04-30 PE PE2008000775A patent/PE20090730A1/es not_active Application Discontinuation
- 2008-04-30 UY UY31063A patent/UY31063A1/es not_active Application Discontinuation
- 2008-05-02 PA PA20088779201A patent/PA8779201A1/es unknown
- 2008-05-02 US US12/114,258 patent/US8134007B2/en active Active
- 2008-05-02 TW TW097116408A patent/TWI375675B/zh not_active IP Right Cessation
- 2008-05-02 AR ARP080101868A patent/AR070636A1/es not_active Application Discontinuation
- 2008-05-02 CL CL2008001268A patent/CL2008001268A1/es unknown
-
2009
- 2009-10-13 CR CR11061A patent/CR11061A/es not_active Application Discontinuation
- 2009-10-15 IL IL201569A patent/IL201569A0/en unknown
- 2009-10-26 CU CU2009000180A patent/CU23846B1/es not_active IP Right Cessation
- 2009-10-28 NI NI200900192A patent/NI200900192A/es unknown
- 2009-10-29 TN TNP2009000450A patent/TN2009000450A1/fr unknown
- 2009-10-29 ZA ZA2009/07609A patent/ZA200907609B/en unknown
- 2009-10-29 GT GT200900280A patent/GT200900280A/es unknown
- 2009-10-30 SV SV2009003400A patent/SV2009003400A/es unknown
- 2009-10-30 EC EC2009009710A patent/ECSP099710A/es unknown
- 2009-10-30 DO DO2009000254A patent/DOP2009000254A/es unknown
- 2009-11-03 MA MA32327A patent/MA31419B1/fr unknown
- 2009-11-03 CO CO09123852A patent/CO6251367A2/es not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20090730A1 (es) | Derivados de piridina como moduladores de los canales de sodio | |
| PE20070715A1 (es) | Derivados de pirazina | |
| PE20080093A1 (es) | Inhibidores de la replicacion del virus de la inmunodeficiencia humana | |
| PE20221515A1 (es) | Oxinitruro de piridina, metodo para su preparacion y uso de este | |
| EA200701176A1 (ru) | Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их | |
| PE20201448A1 (es) | Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos | |
| DE60320012D1 (de) | Aminoheterocyclen als vr-1 antagonisten zur behandlung von schmerzen | |
| MX2009005881A (es) | Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida. | |
| CY1109072T1 (el) | Βητα κρυσταλλικη μορφη του υδροχλωρικου αλατος της ιβαμπραδινης, μεθοδος παρασκευης αυτου και φαρμακευτικης συνθεσεις που το περιεχουν | |
| CY1114491T1 (el) | Παραγωγα βενζαζεπινης χρησιμα ως ανταγωνιστες της βαζοπρεσινης | |
| EA200970156A1 (ru) | Пиридизиноновые производные | |
| EA200500203A1 (ru) | Новый способ синтеза и новая кристаллическая форма агомелатина и фармацевтические композиции, которые её содержат | |
| PE20140961A1 (es) | Inhibidores macrociclicos de serina proteasas de hepatitis c | |
| PE20071110A1 (es) | Agentes citotoxicos que comprenden derivados de tomaimicina | |
| TW200716528A (en) | Cyclopropanecarboxamide derivatives | |
| EA200700099A1 (ru) | Производные пиридина | |
| TW200640879A (en) | Amide derivatives | |
| PE20070592A1 (es) | Derivados de prolinamida como moduladores de canales de sodio | |
| ME00962B (me) | Benzimidazolski derivati | |
| UY30316A1 (es) | Derivados sustituidos de benzamidas, nicotinamidas, propanamidas, acetamidas y carboxamidas n-(2-(piperidin-1-ilmetil)ciclohexil)sustituidas, procesos de preparacion, composiciones conteniéndolos y aplicaciones | |
| EA200870196A1 (ru) | Индолсульфонамидные модуляторы рецепторов прогестерона | |
| TW200612936A (en) | Indole derivatives | |
| MX2010000658A (es) | Derivados de pirimidina 934. | |
| DE602007004740D1 (de) | Antibiotische spiroderivate | |
| UY29312A1 (es) | Piperazin-1-carboxamidas n,4,sustituidas y sus derivados, composiciones que los contienen, procedimientos de preparación y aplicaciones |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |