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CU23846B1 - Derivados de piridina 6-amino-2-aminocarbonil-5-sustituidos - Google Patents

Derivados de piridina 6-amino-2-aminocarbonil-5-sustituidos

Info

Publication number
CU23846B1
CU23846B1 CU2009000180A CU20090180A CU23846B1 CU 23846 B1 CU23846 B1 CU 23846B1 CU 2009000180 A CU2009000180 A CU 2009000180A CU 20090180 A CU20090180 A CU 20090180A CU 23846 B1 CU23846 B1 CU 23846B1
Authority
CU
Cuba
Prior art keywords
aminocarbonil
substitutes
amino
compounds
piridine derivatives
Prior art date
Application number
CU2009000180A
Other languages
English (en)
Other versions
CU20090180A7 (es
Inventor
Sharanjeet Kaur Bagal
Karl Richard Gibson
Mark Ian Kemp
Cedric Poinsard
Blanda Luiza Stammen
Stephen Martin Denton
Melanie Susanne Glossop
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of CU20090180A7 publication Critical patent/CU20090180A7/es
Publication of CU23846B1 publication Critical patent/CU23846B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula (I) ESPACIO PARA LA FÓRMULA y sus sales acetato, benzoato, besilato, bisulfato/sulfato, camsilato, citrato, fumarato, clorhidrato, hidrobromuro, mesilato, fosfato/dihidrogenofosfato, tosilato, calcio, potasio y sales de sodio y composiciones que contienen tales compuestos.
CU2009000180A 2007-05-03 2009-10-26 Derivados de piridina 6-amino-2-aminocarbonil-5-sustituidos CU23846B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91574507P 2007-05-03 2007-05-03
US95753607P 2007-08-23 2007-08-23
PCT/IB2008/001050 WO2008135826A2 (en) 2007-05-03 2008-04-21 2 -pyridine carboxamide derivatives as sodium channel modulators

Publications (2)

Publication Number Publication Date
CU20090180A7 CU20090180A7 (es) 2011-05-27
CU23846B1 true CU23846B1 (es) 2012-10-15

Family

ID=39855225

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2009000180A CU23846B1 (es) 2007-05-03 2009-10-26 Derivados de piridina 6-amino-2-aminocarbonil-5-sustituidos

Country Status (33)

Country Link
US (1) US8134007B2 (es)
EP (1) EP2183241B1 (es)
JP (1) JP4657384B2 (es)
KR (1) KR20100007956A (es)
CN (1) CN101675040A (es)
AP (1) AP2516A (es)
AR (1) AR070636A1 (es)
AU (1) AU2008247102B2 (es)
BR (1) BRPI0810202A2 (es)
CA (1) CA2684105C (es)
CL (1) CL2008001268A1 (es)
CO (1) CO6251367A2 (es)
CR (1) CR11061A (es)
CU (1) CU23846B1 (es)
DO (1) DOP2009000254A (es)
EA (1) EA015952B1 (es)
EC (1) ECSP099710A (es)
ES (1) ES2398606T3 (es)
GE (1) GEP20125379B (es)
GT (1) GT200900280A (es)
IL (1) IL201569A0 (es)
MA (1) MA31419B1 (es)
MX (1) MX2009011816A (es)
NI (1) NI200900192A (es)
NZ (1) NZ581614A (es)
PA (1) PA8779201A1 (es)
PE (1) PE20090730A1 (es)
SV (1) SV2009003400A (es)
TN (1) TN2009000450A1 (es)
TW (1) TWI375675B (es)
UY (1) UY31063A1 (es)
WO (1) WO2008135826A2 (es)
ZA (1) ZA200907609B (es)

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