Nothing Special   »   [go: up one dir, main page]

PE20020537A1 - Compuestos heteroaromaticos biciclicos como agonistas de la hormona luteinizante (lh) - Google Patents

Compuestos heteroaromaticos biciclicos como agonistas de la hormona luteinizante (lh)

Info

Publication number
PE20020537A1
PE20020537A1 PE2001000954A PE2001000954A PE20020537A1 PE 20020537 A1 PE20020537 A1 PE 20020537A1 PE 2001000954 A PE2001000954 A PE 2001000954A PE 2001000954 A PE2001000954 A PE 2001000954A PE 20020537 A1 PE20020537 A1 PE 20020537A1
Authority
PE
Peru
Prior art keywords
agonists
alkyl
bicycle
luteinizing hormone
carboxamide
Prior art date
Application number
PE2001000954A
Other languages
English (en)
Inventor
Cornelis Marius Timmers
Willem Frederik Johan Karstens
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of PE20020537A1 publication Critical patent/PE20020537A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE COMPUESTOS AROMATICOS BICICLICOS DE FORMULA I DONDE R1 ES CICLOALQUILO C3-C8, HETEROCICLOALQUILO C2-C7, ARILO C6-C14, HETEROARILO C4-C13, ENTRE OTROS CON N(R4)R5; R2 ES ALQUILO C1-C4, ALQUENILO C2-C4, ALQUINILO C2-C4, ARILO C6-C14, ENTRE OTROS; R3 ES ALQUILO C1-C8, CICLOALQUILO C3-C8, HETEROCICLOALQUILO C2-C7, ENTRE OTROS; R4 ES IGUAL A R2; R5 ES ARILO C6-14, HETEROARILO C4-C13, ENTRE OTROS; Y ES CH, N; Z ES NH2; A ES S, N(H), N(R4); B ES N(H), O, ENLACE; X1-X2 ES C=C, C(O)-NH, NH-C(O) ENTRE OTROS. SON COMPUESTOS PREFERIDOS TER-BUTIL 5-AMINO-2-METILTIO-4-(3-(METOXICARBONILOXI)-FENIL)-TIENO[2,3-d]PIRIMIDINA-6-CARBOXAMIDA, TER-BUTIL 5-AMINO-2-METILTIO-4-(3-(ALILOXICARBONILOXI)-FENIL)-TIENO[2,3-d]PIRIMIDINA-6-CARBOXAMIDA, TER-BUTIL 5-AMINO-2-METILTIO-4-(3-(BENCILOXICARBONILOXI)-FENIL)-TIENO[2,3-d]PIRIMIDINA-6-CARBOXAMIDA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON AGONISTAS DE LA HORMONA LUTEINIZANTE (LH) Y SON UTILES PARA LA REGULACION DE LA FERTILIDAD
PE2001000954A 2000-09-22 2001-09-21 Compuestos heteroaromaticos biciclicos como agonistas de la hormona luteinizante (lh) PE20020537A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00203287 2000-09-22

Publications (1)

Publication Number Publication Date
PE20020537A1 true PE20020537A1 (es) 2002-06-20

Family

ID=8172046

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000954A PE20020537A1 (es) 2000-09-22 2001-09-21 Compuestos heteroaromaticos biciclicos como agonistas de la hormona luteinizante (lh)

Country Status (32)

Country Link
US (2) US7229990B2 (es)
EP (2) EP1322651B1 (es)
JP (1) JP4977940B2 (es)
KR (1) KR100860040B1 (es)
CN (1) CN1247594C (es)
AR (1) AR030784A1 (es)
AT (1) ATE384726T1 (es)
AU (2) AU1392902A (es)
BR (1) BR0113987A (es)
CA (1) CA2422054C (es)
CY (1) CY1107308T1 (es)
CZ (1) CZ297136B6 (es)
DE (1) DE60132607T2 (es)
DK (1) DK1322651T3 (es)
EC (1) ECSP034523A (es)
ES (1) ES2299524T3 (es)
HK (1) HK1054942A1 (es)
HR (1) HRP20030220B1 (es)
HU (1) HU229422B1 (es)
IL (2) IL154624A0 (es)
IS (1) IS2531B (es)
MX (1) MXPA03002478A (es)
NO (1) NO328683B1 (es)
NZ (1) NZ524444A (es)
PE (1) PE20020537A1 (es)
PL (1) PL207755B1 (es)
PT (1) PT1322651E (es)
RU (1) RU2271360C2 (es)
SK (1) SK287554B6 (es)
TW (1) TWI290143B (es)
WO (1) WO2002024703A1 (es)
ZA (1) ZA200301588B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4977940B2 (ja) * 2000-09-22 2012-07-18 エム・エス・ディー・オス・ベー・フェー 二環式ヘテロ芳香族化合物
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
US7737155B2 (en) * 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
CA2608405A1 (en) * 2005-05-17 2006-11-23 Schering Corporation Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia
WO2007136776A2 (en) * 2006-05-17 2007-11-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pyrimidine low molecular weight ligands for modulating hormone receptors
JP5302389B2 (ja) 2008-04-29 2013-10-02 エフ．ホフマン−ラ ロシュ アーゲー Ｊｎｋのピリミジニルピリドンインヒビター
AU2008363295B2 (en) * 2008-10-20 2015-05-07 Forschungsverbund Berlin E.V. Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists
US9206154B2 (en) 2010-04-08 2015-12-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inverse agonists and neutral antagonists for the TSH receptor
HUE065564T2 (hu) 2011-08-23 2024-06-28 Libertas Bio Inc Pirimido-piridazinon vegyületek és alkalmazásuk
CN113680386B (zh) * 2021-08-23 2023-08-11 深圳湾实验室坪山生物医药研发转化中心 氮杂环卡宾-方酰胺双功能催化剂及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL181895B1 (pl) * 1994-06-16 2001-10-31 Pfizer Nowe pirazolo-i pirolopirydyny _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ PL PL PL PL
EP0920319A4 (en) * 1996-05-20 2002-05-02 Merck & Co Inc GONADOLIBERIN ANTAGONISTS
TW564247B (en) * 1999-04-08 2003-12-01 Akzo Nobel Nv Bicyclic heteraromatic compound
JP4977940B2 (ja) * 2000-09-22 2012-07-18 エム・エス・ディー・オス・ベー・フェー 二環式ヘテロ芳香族化合物

Also Published As

Publication number Publication date
HU229422B1 (hu) 2013-12-30
PT1322651E (pt) 2008-02-28
AU1392902A (en) 2002-04-02
ES2299524T3 (es) 2008-06-01
CZ2003828A3 (cs) 2003-08-13
DE60132607T2 (de) 2009-01-29
SK3312003A3 (en) 2003-08-05
RU2271360C2 (ru) 2006-03-10
IL154624A (en) 2009-09-01
PL207755B1 (pl) 2011-01-31
CA2422054A1 (en) 2002-03-28
IS2531B (is) 2009-07-15
ZA200301588B (en) 2004-06-22
JP4977940B2 (ja) 2012-07-18
KR100860040B1 (ko) 2008-09-25
EP1322651A1 (en) 2003-07-02
KR20030040483A (ko) 2003-05-22
EP1886999A3 (en) 2008-03-12
HK1054942A1 (en) 2003-12-19
TWI290143B (en) 2007-11-21
CY1107308T1 (el) 2012-11-21
US7618963B2 (en) 2009-11-17
JP2004509896A (ja) 2004-04-02
WO2002024703A1 (en) 2002-03-28
HUP0302648A3 (en) 2004-11-29
DK1322651T3 (da) 2008-06-02
DE60132607D1 (de) 2008-03-13
ATE384726T1 (de) 2008-02-15
CN1247594C (zh) 2006-03-29
SK287554B6 (sk) 2011-01-04
HRP20030220A2 (en) 2003-06-30
NZ524444A (en) 2004-03-26
EP1886999A2 (en) 2008-02-13
IS6732A (is) 2003-02-28
HUP0302648A2 (hu) 2003-11-28
PL360675A1 (en) 2004-09-20
NO20031314L (no) 2003-03-21
US20070197527A1 (en) 2007-08-23
CZ297136B6 (cs) 2006-09-13
US20030225113A1 (en) 2003-12-04
MXPA03002478A (es) 2004-05-05
IL154624A0 (en) 2003-09-17
AU2002213929B2 (en) 2006-04-13
ECSP034523A (es) 2003-04-25
NO328683B1 (no) 2010-04-26
EP1322651B1 (en) 2008-01-23
BR0113987A (pt) 2003-08-12
HRP20030220B1 (en) 2011-10-31
NO20031314D0 (no) 2003-03-21
CA2422054C (en) 2011-01-11
AR030784A1 (es) 2003-09-03
US7229990B2 (en) 2007-06-12
CN1462273A (zh) 2003-12-17
EP1886999A8 (en) 2010-08-04

Similar Documents

Publication Publication Date Title
PE20020537A1 (es) Compuestos heteroaromaticos biciclicos como agonistas de la hormona luteinizante (lh)
GB0015876D0 (en) Organic compounds
DK1177176T3 (da) Triarylsyrederivater som PPAR-receptorligander
UA87622C2 (uk) Селективний гербіцидний засіб та проміжні сполуки для одержання 2,4-дигалоген-6-(c2-с3-алкіл)фенілзаміщених похідних тетрамової кислоти
TW200745077A (en) Thiophene compound having sulfonyl group and process for producing the same
GB1046506A (en) Guanidine compounds and process for their manufacture
WO2004110976A3 (en) Process for the preparation of aromatic amines
AR018607A1 (es) Preparacion farmaceutica que en calidad de ingrediente activo contiene levotiroxina sodica, y un procedimiento para su preparacion
WO2004054986A8 (en) Process for the preparation of pyrimidine compounds
AR045668A1 (es) Mezcla de agentes tensioactivos y solventes
IS7130A (is) Þénó[2,3-d]pýrimidín með sameinaðri LH og FSH gerandefnisvirkni
PE20020413A1 (es) Derivados de 1-aminobutano-3-ol como agonistas de la gabapentina
ES2196682T3 (es) Sosporte para clavija/enchufe electrico que permite el transporte con manos libres.
IL145449A0 (en) Processes for preparing pesticidal intermediates
DE60318716D1 (de) Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren
PE20030467A1 (es) TIENO[2,3-d] PIRIMIDINAS SUSTITUIDAS CON GLICINA CON ACTIVIDAD AGONISTA COMBINADA DE LH Y FSH
DK1399138T3 (da) Fremgangsmåde til fremstilling af faste formuleringer af natrium-3-hydroxy-3-methylbutyrat
GB9907055D0 (en) Antibacterial agents
AU5296199A (en) Antibacterial agents
EA200401234A1 (ru) Способ приготовления клопидогрела
WO1999023092A3 (en) 3-aminoalkylamino-2h-1,4-benzoxa(thia-)zines and pharmaceutical compositions containing them
AR044329A1 (es) Proceso de sintesis de modafinil
BR9810685B1 (pt) processo para a prepraração de um composto.
AU8459401A (en) Process for preparing a substituted imidazopyridine compound
PE20010996A1 (es) Uso de compuestos de 4-amino-1-fenilbutano-2-ol sustituidos como reguladores para el sistema nociceptina/orfanina fq ligando de receptor orl1 y para la preparacion de medicamentos

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed