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KR930007462A - 진단용 조영제 - Google Patents

진단용 조영제 Download PDF

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Publication number
KR930007462A
KR930007462A KR1019920018074A KR920018074A KR930007462A KR 930007462 A KR930007462 A KR 930007462A KR 1019920018074 A KR1019920018074 A KR 1019920018074A KR 920018074 A KR920018074 A KR 920018074A KR 930007462 A KR930007462 A KR 930007462A
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KR
South Korea
Prior art keywords
contrast agent
diagnostic contrast
diagnostic
metal ion
ion
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KR1019920018074A
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English (en)
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KR100219004B1 (ko
Inventor
유지 하시구치
쿠미코 이와이
시게미 세리
스스무 콘도
마코토 아즈마
Original Assignee
도키 가츠유키
니혼 메디피직스 가부시키가이샤
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Application filed by 도키 가츠유키, 니혼 메디피직스 가부시키가이샤 filed Critical 도키 가츠유키
Publication of KR930007462A publication Critical patent/KR930007462A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)

Abstract

본 발명은 하기 구조식 Ⅰ또는 Ⅱ의 다핵형 화합물로 구성되는 화합물로 되는 진단용 조영제에 관한 것이다.
식중, X는 각각 수소 원자 또는 2관능성 리간드이고, 이들중 적어도 1개는 2관능성 리간드이며, m과 n은 각각 1내지 6의 정수이고, 적어도 1개의 금속 이온은 적어도 하나의 2관능성 리간드와 결합되어 있으며, 상기 금속이온은 21 내지 29, 31, 32, 37 내지 39, 42 내지 44, 49 및 56 내지 83의 원자번호를 갖는 금속 이온으로 되는 군중에서 선택된다.

Description

진단용 조영제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는(갈락토스아미노-펜타머)-〔1-(p-이소티오시아네이트벤질)-디에틸렌트리아민펜타아세트산〕-가돌리네이트(GPEN-DTES-Gd)용액의 투여 1시간 후 치사된 쥐의 심장을 포함하는 흉부의 횡단면도를 나타내는 MRI이고,
제2도는 DTPA-Gd(MAGNEVIST??)의 투여 1시간 후 치사된 쥐의 심장.

Claims (6)

  1. 다음 구조식의 다핵형 화합물로 구성되는 화합물로 되는 진단용 조영제.
    식중, X는 각각 수소 원자 또는 2관능성 리간드이며, 이들중 적어도 1개는 2관능성 리간드이며, m과 n은 각각 1내지 6의 정수이고, 적어도 1개의 금속 이온은 적어도 하나의 2관능성 리간드와 결합되어 있으며, 상기 금속이온은 21 내지 29, 31, 32, 37 내지 39, 42 내지 44, 49 및 56 내지 83의 원자번호를 갖는 금속 이온으로 되는 군중에서 선택된다.
  2. 제1항에 있어서, 2관능성 리간드가 디에틸렌트리아민펜타아세트산 1,4,7,10-테트라아자시클로데칸-1,4,7,10-테트라아세트산으로부터 유도되는 것을 특징으로 하는 진단용 조영제.
  3. 제1항에 있어서, 핵자기공명 진단용 조영제로서 유용하며, 상기 금속 이온이 Gd, Dy, Tb, Ho, Er 또는 Fe이온인 것을 특징으로 하는 진단용 조영제.
  4. 제1항에 있어서, X-레이 진단용 조영제로서 유용하며, 상기 금속 이온이 Bi, Pb 또는 Os 이온인 것을 특징으로 하는 진단용 조영제.
  5. 제1항에 있어서, 방사능 진단용 조영제로서 유용하며, 상기 금속 이온이 Co, Cu, Ga, Sr, Y, Tc, In, Sm, Gd, Yb, Re 또는 Ir이온인 것을 특징으로 하는 진단용 조영제.
  6. 제1항에 있어서, 혈증 체류시간이 0.5 내지 5시간의 반감기를 갖는 것을 특징으로 하는 진단용 조영제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920018074A 1991-10-04 1992-10-02 진단용 조영제 KR100219004B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3258017A JP2894879B2 (ja) 1991-10-04 1991-10-04 診断用造影剤
JP258017/1991 1991-10-04

Publications (2)

Publication Number Publication Date
KR930007462A true KR930007462A (ko) 1993-05-20
KR100219004B1 KR100219004B1 (ko) 1999-09-01

Family

ID=17314374

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920018074A KR100219004B1 (ko) 1991-10-04 1992-10-02 진단용 조영제

Country Status (9)

Country Link
US (3) US5271924A (ko)
EP (1) EP0535668B1 (ko)
JP (1) JP2894879B2 (ko)
KR (1) KR100219004B1 (ko)
AT (1) ATE141058T1 (ko)
CA (1) CA2079493C (ko)
DE (1) DE69212630T2 (ko)
DK (1) DK0535668T3 (ko)
ES (1) ES2093163T3 (ko)

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DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
AU698176B2 (en) * 1993-07-28 1998-10-29 Cis Bio International Radiolabelled glucans
EP0709100A1 (en) * 1994-09-30 1996-05-01 Nihon Medi-Physics Co., Ltd. Contrast agent, containing several detection groups per molecule
IL115670A (en) * 1994-10-21 1999-11-30 Nihon Mediphysics Co Ltd Diagnostic imaging agent
TW319763B (ko) * 1995-02-01 1997-11-11 Epix Medical Inc
US5762903A (en) * 1995-03-10 1998-06-09 Korea Atomic Energy Research Institute Radioactive chitosan complex for radiation therapy
US5702682A (en) * 1995-12-01 1997-12-30 Hercules Incorporated Methods for preparing radiopaque medical devices
DE19728954C1 (de) * 1997-06-30 1999-04-22 Schering Ag Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
WO2001008712A2 (en) * 1999-07-29 2001-02-08 Epix Medical, Inc. Targeting multimeric imaging agents through multilocus binding
IL145723A0 (en) * 2000-10-11 2002-07-25 Nihon Mediphysics Co Ltd Process for producing an amide compound
US20030050452A1 (en) * 2000-12-26 2003-03-13 Yuji Hashiguchi Process for producing metal complex of aminooligosaccharide derivative
US20030100830A1 (en) 2001-11-27 2003-05-29 Sheng-Ping Zhong Implantable or insertable medical devices visible under magnetic resonance imaging
US20040143180A1 (en) * 2001-11-27 2004-07-22 Sheng-Ping Zhong Medical devices visible under magnetic resonance imaging
EP1466629A1 (en) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
US8620406B2 (en) * 2004-01-23 2013-12-31 Boston Scientific Scimed, Inc. Medical devices visible by magnetic resonance imaging
US7483732B2 (en) * 2004-04-15 2009-01-27 Boston Scientific Scimed, Inc. Magnetic resonance imaging of a medical device and proximate body tissue
CA2593256A1 (en) * 2005-01-05 2006-07-13 Board Of Regents, The University Of Texas System Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
CN100382847C (zh) * 2005-02-05 2008-04-23 四川大学 用于影像诊断的配合体化合物及制备方法和影像诊断用化合物及其制备中间体
US7778684B2 (en) * 2005-08-08 2010-08-17 Boston Scientific Scimed, Inc. MRI resonator system with stent implant
US20070239256A1 (en) * 2006-03-22 2007-10-11 Jan Weber Medical devices having electrical circuits with multilayer regions
JP2008266194A (ja) * 2007-04-19 2008-11-06 Hiroshi Tanaka 分子プローブの原料として有用な新規有機化合物
JP2011063572A (ja) * 2009-09-18 2011-03-31 Kyushu Univ 診断用造影剤
EP2663338B1 (en) * 2011-01-14 2024-03-06 Emory University Glucose-based oligosaccharides comprising a positron-emitting radionuclide and their use for imaging
DE102019004953B4 (de) * 2019-07-17 2021-10-28 Günther Zimmer Brems- und/oder Klemmvorrichtung mit einteiligem Spaltgehäuse und Sensormodul
US11344638B2 (en) 2020-03-20 2022-05-31 Robert Norman Taub Composition for radiation treatment of intracavitary or metastatic deposits of malignancy and method for treatment therewith
CN114965543B (zh) * 2022-06-13 2023-10-20 青岛科技大学 壳寡糖nmr波谱的归属及脱乙酰度相关指标的测定方法

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Also Published As

Publication number Publication date
EP0535668A1 (en) 1993-04-07
CA2079493C (en) 2002-05-28
DE69212630T2 (de) 1997-01-23
US5422095A (en) 1995-06-06
DE69212630D1 (de) 1996-09-12
JPH0597712A (ja) 1993-04-20
ES2093163T3 (es) 1996-12-16
CA2079493A1 (en) 1993-04-05
JP2894879B2 (ja) 1999-05-24
EP0535668B1 (en) 1996-08-07
US5352431A (en) 1994-10-04
AU2619192A (en) 1993-04-08
KR100219004B1 (ko) 1999-09-01
AU650791B2 (en) 1994-06-30
DK0535668T3 (da) 1996-09-02
US5271924A (en) 1993-12-21
ATE141058T1 (de) 1996-08-15

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