DE69226669D1 - Neue makrocyclische Stickstoff-Liganden, Verfahren zu ihrer Herstellung, Metallkomplexe, diagnostische und therapeutische Zusammensetzungen - Google Patents
Neue makrocyclische Stickstoff-Liganden, Verfahren zu ihrer Herstellung, Metallkomplexe, diagnostische und therapeutische ZusammensetzungenInfo
- Publication number
- DE69226669D1 DE69226669D1 DE69226669T DE69226669T DE69226669D1 DE 69226669 D1 DE69226669 D1 DE 69226669D1 DE 69226669 T DE69226669 T DE 69226669T DE 69226669 T DE69226669 T DE 69226669T DE 69226669 D1 DE69226669 D1 DE 69226669D1
- Authority
- DE
- Germany
- Prior art keywords
- diagnostic
- processes
- preparation
- metal complexes
- therapeutic compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003446 ligand Substances 0.000 title abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 239000002184 metal Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 229910052769 Ytterbium Inorganic materials 0.000 abstract 1
- 229910052788 barium Inorganic materials 0.000 abstract 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052797 bismuth Inorganic materials 0.000 abstract 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 238000006073 displacement reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229910021644 lanthanide ion Inorganic materials 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 238000009206 nuclear medicine Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229910001428 transition metal ion Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9100811A FR2672051B1 (fr) | 1991-01-24 | 1991-01-24 | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes polymetalliques, composition de diagnostic et therapeutique. |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69226669D1 true DE69226669D1 (de) | 1998-09-24 |
DE69226669T2 DE69226669T2 (de) | 1999-04-15 |
Family
ID=9409017
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69226669T Expired - Fee Related DE69226669T2 (de) | 1991-01-24 | 1992-01-22 | Neue makrocyclische Stickstoff-Liganden, Verfahren zu ihrer Herstellung, Metallkomplexe, diagnostische und therapeutische Zusammensetzungen |
Country Status (18)
Country | Link |
---|---|
US (1) | US5374416A (de) |
EP (1) | EP0499501B1 (de) |
JP (1) | JPH0735381B2 (de) |
KR (1) | KR960014355B1 (de) |
AT (1) | ATE169916T1 (de) |
AU (1) | AU650325B2 (de) |
CA (1) | CA2078983A1 (de) |
CZ (1) | CZ281225B6 (de) |
DE (1) | DE69226669T2 (de) |
FR (1) | FR2672051B1 (de) |
HU (1) | HUT70023A (de) |
IE (1) | IE920204A1 (de) |
IL (1) | IL100717A (de) |
MX (1) | MX9200319A (de) |
NO (1) | NO923673L (de) |
NZ (1) | NZ241356A (de) |
WO (1) | WO1992012978A1 (de) |
ZA (1) | ZA92470B (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69024826T2 (de) * | 1989-02-10 | 1996-06-27 | Celltech Therapeutics Ltd | Aza-Macrozyklen und Verfahren zu deren Herstellung |
US5645818A (en) * | 1989-03-24 | 1997-07-08 | Guerbet S.A. | Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions |
GB9126677D0 (en) * | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
US5462725A (en) * | 1993-05-06 | 1995-10-31 | The Dow Chemical Company | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
DE4318369C1 (de) * | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
US6693190B1 (en) | 1994-05-11 | 2004-02-17 | Bracco International B.V. | Enhanced relaxivity monomeric and multimeric compounds |
US20050187126A1 (en) * | 2002-08-27 | 2005-08-25 | Busch Daryle H. | Catalysts and methods for catalytic oxidation |
US20030017941A1 (en) * | 1997-03-07 | 2003-01-23 | The Procter & Gamble Company | Catalysts and methods for catalytic oxidation |
MA24594A1 (fr) * | 1997-03-07 | 1999-04-01 | Procter & Gamble | Compositions de blanchiment |
ZA981883B (en) * | 1997-03-07 | 1998-09-01 | Univ Kansas | Catalysts and methods for catalytic oxidation |
US20080125344A1 (en) * | 2006-11-28 | 2008-05-29 | Daryle Hadley Busch | Bleach compositions |
US6565828B2 (en) | 2000-04-07 | 2003-05-20 | Bristol-Myers Squibb Company | Macrocyclic chelants for metallopharmaceuticals |
IL154400A0 (en) * | 2000-09-29 | 2003-09-17 | Anormed Inc | Process for preparation of n-1 protected n ring nitrogen containing cyclic polyamines and products thereof |
DE10117242C1 (de) * | 2001-04-06 | 2002-05-16 | Schering Ag | Unsymmetrische dimere Metallkomplexe, Liganden für diese Metallkomplexe, Verfahren zu deren Herstellung, Arzneimittel bzw. Diagnosemittel, die die Metallkomplexe enthalten, insbesondere Kontrastmittel |
SI2371361T1 (sl) * | 2001-07-31 | 2019-10-30 | Genzyme Corp | Metode za mobilizacijo predniških/matičnih celic |
US20040048763A1 (en) * | 2002-08-27 | 2004-03-11 | The Procter & Gamble Co. | Bleach compositions |
EP1637524A1 (de) * | 2004-09-20 | 2006-03-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | 10-substituierte 1-, 4, 7,-tris (carboxymethyl)-1,4,7,10-tetraazacyclo-dodecanederivate zur Verwendung als Kontrastmittel |
TWI429404B (zh) * | 2008-03-03 | 2014-03-11 | Senomyx Inc | 異山梨醇衍生物及彼等作為風味改良劑、促味劑及促味增強劑之用途 |
JP5735791B2 (ja) * | 2010-12-07 | 2015-06-17 | 住友化学株式会社 | 金属錯体を含む素子 |
FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
US10918742B2 (en) | 2016-03-25 | 2021-02-16 | Nanoprobes, Inc. | Iodine-based particles |
WO2017178301A1 (en) | 2016-04-13 | 2017-10-19 | Bracco Imaging Spa | Contrast agents |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53144592A (en) * | 1977-05-19 | 1978-12-15 | Tabuse Iwao | 122alkyll1*4*7*100tetrazacyclotridecane |
ES2086445T3 (es) * | 1987-07-16 | 1996-07-01 | Nycomed Imaging As | Acidos aminocarboxilicos y sus derivados. |
DE3728525A1 (de) * | 1987-08-24 | 1989-03-16 | Schering Ag | Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
JP2930709B2 (ja) * | 1988-12-22 | 1999-08-03 | ザ ダウ ケミカル カンパニー | モノ―n―アルキル化ポリアザ大員環の製造方法 |
-
1991
- 1991-01-24 FR FR9100811A patent/FR2672051B1/fr not_active Expired - Fee Related
-
1992
- 1992-01-21 IL IL10071792A patent/IL100717A/en not_active IP Right Cessation
- 1992-01-22 JP JP4505010A patent/JPH0735381B2/ja not_active Expired - Lifetime
- 1992-01-22 NZ NZ241356A patent/NZ241356A/en unknown
- 1992-01-22 AT AT92400174T patent/ATE169916T1/de not_active IP Right Cessation
- 1992-01-22 CZ CS922909A patent/CZ281225B6/cs unknown
- 1992-01-22 EP EP92400174A patent/EP0499501B1/de not_active Expired - Lifetime
- 1992-01-22 DE DE69226669T patent/DE69226669T2/de not_active Expired - Fee Related
- 1992-01-22 HU HU9203029A patent/HUT70023A/hu unknown
- 1992-01-22 KR KR1019920702286A patent/KR960014355B1/ko active IP Right Grant
- 1992-01-22 WO PCT/FR1992/000057 patent/WO1992012978A1/fr active IP Right Grant
- 1992-01-22 US US07/924,016 patent/US5374416A/en not_active Expired - Fee Related
- 1992-01-22 CA CA002078983A patent/CA2078983A1/fr not_active Abandoned
- 1992-01-22 AU AU12562/92A patent/AU650325B2/en not_active Ceased
- 1992-01-23 IE IE020492A patent/IE920204A1/en unknown
- 1992-01-23 ZA ZA92470A patent/ZA92470B/xx unknown
- 1992-01-24 MX MX9200319A patent/MX9200319A/es unknown
- 1992-09-22 NO NO92923673A patent/NO923673L/no unknown
Also Published As
Publication number | Publication date |
---|---|
KR960014355B1 (ko) | 1996-10-15 |
US5374416A (en) | 1994-12-20 |
AU650325B2 (en) | 1994-06-16 |
EP0499501A3 (de) | 1992-08-26 |
EP0499501A2 (de) | 1992-08-19 |
FR2672051B1 (fr) | 1993-05-21 |
ZA92470B (en) | 1993-07-23 |
FR2672051A1 (fr) | 1992-07-31 |
DE69226669T2 (de) | 1999-04-15 |
CZ281225B6 (cs) | 1996-07-17 |
IL100717A (en) | 1996-06-18 |
HU9203029D0 (en) | 1992-12-28 |
NZ241356A (en) | 1995-02-24 |
IL100717A0 (en) | 1992-09-06 |
NO923673D0 (no) | 1992-09-22 |
JPH0735381B2 (ja) | 1995-04-19 |
AU1256292A (en) | 1992-08-27 |
HUT70023A (en) | 1995-09-28 |
NO923673L (no) | 1992-11-24 |
WO1992012978A1 (fr) | 1992-08-06 |
JPH05504361A (ja) | 1993-07-08 |
CA2078983A1 (fr) | 1992-07-25 |
MX9200319A (es) | 1992-07-01 |
ATE169916T1 (de) | 1998-09-15 |
EP0499501B1 (de) | 1998-08-19 |
CZ290992A3 (en) | 1993-02-17 |
IE920204A1 (en) | 1992-07-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69226669D1 (de) | Neue makrocyclische Stickstoff-Liganden, Verfahren zu ihrer Herstellung, Metallkomplexe, diagnostische und therapeutische Zusammensetzungen | |
DE69019584D1 (de) | Makrocyclische Stickstoffliganden Verfahren zu ihrer Herstellung, ihre Metallkomplexe, sie enthaltende Diagnostische und therapeutische Mittel. | |
IL86059A0 (en) | Nitrogen-containing cyclic ligands,metallic complexes thereof,diagnostic compositions containing these complexes and the preparation of the ligands | |
EP0448191B1 (de) | 1,4,7,10-Tetraazacyclododecan-butyltriole, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel | |
ATE135237T1 (de) | Molekularsieb enthaltende pharmazeutische ionen für diagnose | |
IL109852A0 (en) | Iodinated paramagnetic chelates | |
KR930007462A (ko) | 진단용 조영제 | |
EP0463644A3 (en) | Use of chelate complexes | |
KR930019648A (ko) | 테트라아자시클로도덴칸 유도체 및 그의 용도 | |
US5840273A (en) | Technetium-99m complexes for use as radiopharmaceuticals | |
EP0483704A1 (de) | Verfahren zur Herstellung einer radiopharmazeutischer Zubereitung | |
EP1355913A4 (de) | Komplexverbindungen aus paramagnetischem metall und phthalocyanin und kontrastmittel, bei dem diese verbindungen verwendet werden | |
ZA94512B (en) | Derivated DTPA complexes pharmaceutical agents containing these compounds their use and process for their production | |
WO1995014678A1 (de) | 1,4,7,10-tetraazacyclododecan-derivate, deren verwendung, diese enthaltende pharmazeutische mittel und verfahren zu deren herstellung | |
DE19641197C2 (de) | Ionenpaare und ihre Verwendung als Kontrastmittel | |
NO912755L (no) | Chelateringsmiddel-derivater. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |