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KR900011712A - 페닐 프로피온산 유도체의 제조방법 - Google Patents

페닐 프로피온산 유도체의 제조방법 Download PDF

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Publication number
KR900011712A
KR900011712A KR1019900000526A KR900000526A KR900011712A KR 900011712 A KR900011712 A KR 900011712A KR 1019900000526 A KR1019900000526 A KR 1019900000526A KR 900000526 A KR900000526 A KR 900000526A KR 900011712 A KR900011712 A KR 900011712A
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KR
South Korea
Prior art keywords
aminophenyl
propionic acid
transfer catalyst
phase transfer
general formula
Prior art date
Application number
KR1019900000526A
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English (en)
Other versions
KR0177151B1 (ko
Inventor
끌루드 뻬싱
Original Assignee
원본 미기재
부샤라 에스. 아
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Publication of KR900011712A publication Critical patent/KR900011712A/ko
Application granted granted Critical
Publication of KR0177151B1 publication Critical patent/KR0177151B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음

Description

페닐 프로피온산 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 불활성 수불혼화성 비극성 유기용매내에 미리용해된 채로 다음 일반식(Ⅱ)의 2| (4-아미노페닐) 프로피온산 유도체를 수성매질내에서 상간이동촉매 및 염기성 시약의 존재하에, 불균일상의 알킬화제와 반응시켜서 다음 일반식(Ⅰ)의 원하는 2-(4-R-아미노페닐)프로피온산을 생성하는 것을 특징으로 하는, 알킬 아미노그룹으로 치환된 일반식(Ⅰ)의 2-페닐프로피온산의 제조방법 :
    상기식에서, R은 히드록시 치환될 수 있는 저급알킬, 저급알케닐기, 저급알키닐기, 또는 아릴저급알킬기이고, R1은 C1-C6알킬 또는 수소이다.
  2. 제1항에 있어서, 라디칼 R이 메탈릴기인 것을 특징으로 하는 방법.
  3. 제1항에 있어서, 수불혼화성 유기용매가 액상 방향족 탄화수소인 것을 특징으로 하는 방법.
  4. 제1항에 있어서, 상간이동촉매는 소수성용매 및 물에 녹을 수 있는 사차화 암모늄염 및 사차화 포스포늄염으로 이루어진 그룹에서 선택된 사차화 유도체인 것을 특징으로 하는 방법.
  5. 제1항에 있어서, 상간이동촉매가 트리알킬페닐 포스포늄의 염인 것을 특징으로 하는 방법.
  6. 제1항에 있어서, 상간이동촉매가 메틸트리옥틸암모늄 브로마이드인 것을 특징으로 하는 방법.
  7. 제1내지 6항중 어느 한 항에 있어서, 반응혼합물에 첨가될 상간이동촉매의 양은 2-(4-아미노페닐)프로피온산 1몰당 10g정도인 것을 특징으로 하는 방법.
  8. 제1내지 7항중 어느 한 항에 있어서, 일반식(Ⅱ)의 2-(4-아미노페닐)프로피온산 유도체의 농도는 수불혼화성 유기용매 400mⅠ당 한 1몰인 것을 특징으로 하는 방법.
  9. 제1내지 8항중 어느 한 항에 있어서, 알킬화제의 농도는 2-(4-아미노페닐)프로피온산 1몰당 1몰 내지 1.4몰인 것을 특징으로 하는 방법.
  10. 제1내지 9항중 어느 한 항에 있어서, 메틸릴화제의 농도는 2-(4-아미노페닐) 1몰당 1.1몰 내지 1.4몰인 것을 특징으로 하는 방법.
  11. 제1내지 10항의 방법에 따라 제조되거나 얻어질 수 있는, 제1항에 따른 일반식(Ⅰ)의 2-(4-아미노페닐)프로피온산.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900000526A 1989-01-16 1990-01-16 페닐 프로피온산 유도체의 제조방법 KR0177151B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR89-00522 1989-01-16
FR8900522A FR2642752B1 (fr) 1989-01-16 1989-01-16 Nouveau procede d'obtention d'un acide phenyl propionique

Publications (2)

Publication Number Publication Date
KR900011712A true KR900011712A (ko) 1990-08-02
KR0177151B1 KR0177151B1 (ko) 1999-04-15

Family

ID=9377804

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900000526A KR0177151B1 (ko) 1989-01-16 1990-01-16 페닐 프로피온산 유도체의 제조방법

Country Status (12)

Country Link
EP (1) EP0379423B1 (ko)
JP (1) JP2852393B2 (ko)
KR (1) KR0177151B1 (ko)
CN (1) CN1042330C (ko)
AT (1) ATE90934T1 (ko)
DE (1) DE69002011T2 (ko)
DK (1) DK0379423T3 (ko)
ES (1) ES2058828T3 (ko)
FI (1) FI101960B (ko)
FR (1) FR2642752B1 (ko)
IE (1) IE65258B1 (ko)
PT (1) PT92873B (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102206150A (zh) * 2011-04-11 2011-10-05 启东东岳药业有限公司 2-苯基丙酸的纯化方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH538449A (de) * 1967-07-22 1973-06-30 Merck Patent Gmbh Verfahren zur Herstellung von Aminophenylessigsäure- Derivaten
DE1913742A1 (de) * 1968-03-27 1969-10-09 Ciba Geigy Tertiaere aliphatische Aminosaeuren
FR2137211B1 (ko) 1971-05-17 1974-08-02 Bouchara Emile
FR2193579A2 (en) * 1972-07-25 1974-02-22 Bouchara Emile Para amino phenyl acetic acids - analgesics and antiinflammatories, prepd. by alkylation of prim amino acid

Also Published As

Publication number Publication date
JP2852393B2 (ja) 1999-02-03
PT92873B (pt) 1995-12-29
FI900226A0 (fi) 1990-01-15
FR2642752A1 (fr) 1990-08-10
FI101960B1 (fi) 1998-09-30
KR0177151B1 (ko) 1999-04-15
CN1042330C (zh) 1999-03-03
EP0379423B1 (fr) 1993-06-23
PT92873A (pt) 1990-07-31
ATE90934T1 (de) 1993-07-15
DE69002011T2 (de) 1993-12-23
IE65258B1 (en) 1995-10-18
IE900164L (en) 1990-07-16
JPH02262547A (ja) 1990-10-25
DK0379423T3 (da) 1993-11-15
FI101960B (fi) 1998-09-30
FR2642752B1 (fr) 1991-04-12
DE69002011D1 (de) 1993-07-29
EP0379423A1 (fr) 1990-07-25
CN1058206A (zh) 1992-01-29
ES2058828T3 (es) 1994-11-01

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