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KR900003177A - 테트라시클릭계 우울증 치료제 - Google Patents

테트라시클릭계 우울증 치료제 Download PDF

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Publication number
KR900003177A
KR900003177A KR1019890012102A KR890012102A KR900003177A KR 900003177 A KR900003177 A KR 900003177A KR 1019890012102 A KR1019890012102 A KR 1019890012102A KR 890012102 A KR890012102 A KR 890012102A KR 900003177 A KR900003177 A KR 900003177A
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KR
South Korea
Prior art keywords
general formula
alkyl
functional derivatives
different substituents
substituents
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Application number
KR1019890012102A
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English (en)
Inventor
후베르투스 비린가 요하네스
Original Assignee
에이.쥐.제이.베르메렌.에프. 쥐. 엠. 헤르만스
악조 엔.브이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 에이.쥐.제이.베르메렌.에프. 쥐. 엠. 헤르만스, 악조 엔.브이. filed Critical 에이.쥐.제이.베르메렌.에프. 쥐. 엠. 헤르만스
Publication of KR900003177A publication Critical patent/KR900003177A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

내용 없음

Description

테트라시클릭계 우울증 치료제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 하기 일반식(Ⅰ)의 테트라시클릭 화합물 및 그의 작용성 유도체:
    상기 식에서, R1은 1개 또는 2개의 동일하거나 다른 치환기 H, OH, 할로겐, C1-C4알킬 또는 C1-C4알콕시이고; R2는 R1과 동일한 정의를 갖는, 1개 또는 2개의 동일하거나 다른 치환기이며; R3과 R4는 시스 배위를 갖는 2개의 치환기로서, 그들 중 1개는 H이고 나머지 다른 1개는 OH이고; R5는 H 또는 C1-C4알킬이며; X는 0 또는 S이고; n은 0 또는 1이다.
  2. 제1항에 있어서, 하기 일반식(Ⅱ)를 갖는 화합물 및 그의 작용성 유도체.
    (식중, R1,R2,R5및 n은 제1항에서 정의한 바와 같다)
  3. 제1항에 있어서, 하기 일반식(Ⅲ)을 갖는 화합물 및 그의 작용성 유도체:
  4. 제1항에 있어서, 하기 일반식(Ⅳ)를 갖는 화합물 및 그의 작용성 유도체:
  5. 관련 화합물들의 제조방법과 유사한 방법으로 제조공정을 실시하는 것을 특징으로 하는 제1항에서 정의한 화합물의 합성방법.
  6. 활성성분이 제1항에서 정의한 물질들중 1종 이상으로 구성되는 것을 특징으로 하는 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890012102A 1988-08-26 1989-08-25 테트라시클릭계 우울증 치료제 KR900003177A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL88.02109 1988-08-26
NL8802109 1988-08-26

Publications (1)

Publication Number Publication Date
KR900003177A true KR900003177A (ko) 1990-03-23

Family

ID=19852805

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890012102A KR900003177A (ko) 1988-08-26 1989-08-25 테트라시클릭계 우울증 치료제

Country Status (16)

Country Link
US (1) US4977158A (ko)
EP (1) EP0357126B1 (ko)
JP (1) JP2521157B2 (ko)
KR (1) KR900003177A (ko)
AT (1) ATE104981T1 (ko)
AU (1) AU618392B2 (ko)
CA (1) CA1325807C (ko)
DE (1) DE68914917T2 (ko)
DK (1) DK415789A (ko)
ES (1) ES2056194T3 (ko)
FI (1) FI91638C (ko)
IE (1) IE62754B1 (ko)
MX (1) MX9203809A (ko)
NZ (1) NZ230128A (ko)
PT (1) PT91555B (ko)
ZA (1) ZA895623B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW420672B (en) * 1995-02-08 2001-02-01 Novartis Ag Anti-neurodegeneratively active 10-aminoaliphatyl-dibenz[b,f]oxepines
AU2418499A (en) * 1997-12-19 1999-07-12 Akzo Nobel N.V. Org-5222 in the treatment of depression
HRP20020305A8 (en) 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020440B1 (en) 2002-05-21 2008-02-29 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
HRP20020452A2 (en) 2002-05-23 2004-02-29 Pliva D D 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
JP5245428B2 (ja) * 2007-07-06 2013-07-24 住友化学株式会社 トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体
US20090233957A1 (en) * 2008-02-19 2009-09-17 Adolor Corporation (-)-beloxepin and methods for its synthesis and use
BRPI0908098A2 (pt) 2008-02-19 2015-08-18 Adolor Corp Beloxepina, composição, métodos para tratar dor em um mamífero, para inibir a recaptação de ne, para antagonizar um receptor de 5ht2 e para tratar um distúrbio em um paciente que é responsivo ao tratamento com um composto nri e com um composto antagonista de 5ht2
US20090233959A1 (en) * 2008-02-19 2009-09-17 Adolor Corporation Beloxepin and analogs for the treatment of pain
US20090233958A1 (en) * 2008-02-19 2009-09-17 Adolor Corporation (+)-beloxepin and methods for its synthesis and use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
US4271179A (en) * 1976-05-24 1981-06-02 Akzona Incorporated 1,2,3,3a,8,12b-Hexahydro-dibenzo[1,2;5,6]cyclohepta[3,4-C]pyrroles and pharmaceutical use thereof
US4271177A (en) * 1976-05-24 1981-06-02 Akzona Incorporated 2,3,3a,12b-Tetrahydro-1H-dibenzo[2,3;6,7]thiepino[4,5-c]pyrroles and pharmaceutical use thereof
US4158059A (en) * 1976-05-24 1979-06-12 Akzona Incorporated Tension reducing 2,3,4,4a,9,136-hexahydro-dibenz[1,2;5,6]cyclohepta[3,4-c]py
WO1988000049A1 (en) * 1986-06-26 1988-01-14 Kyowa Hakko Kogyo Co., Ltd. Antiarrhythmic agent

Also Published As

Publication number Publication date
ZA895623B (en) 1990-05-30
FI91638B (fi) 1994-04-15
FI893901A (fi) 1990-02-27
IE892363L (en) 1990-02-26
DE68914917D1 (de) 1994-06-01
EP0357126B1 (en) 1994-04-27
AU4002289A (en) 1990-03-01
DK415789D0 (da) 1989-08-23
ATE104981T1 (de) 1994-05-15
PT91555A (pt) 1990-03-08
EP0357126A1 (en) 1990-03-07
MX9203809A (es) 1992-07-01
NZ230128A (en) 1990-10-26
CA1325807C (en) 1994-01-04
DE68914917T2 (de) 1994-08-11
ES2056194T3 (es) 1994-10-01
PT91555B (pt) 1995-05-04
FI893901A0 (fi) 1989-08-18
AU618392B2 (en) 1991-12-19
FI91638C (fi) 1994-07-25
JP2521157B2 (ja) 1996-07-31
JPH02111776A (ja) 1990-04-24
US4977158A (en) 1990-12-11
IE62754B1 (en) 1995-02-22
DK415789A (da) 1990-02-27

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