JP6862418B2 - センサ、カートリッジ、および薬物送達デバイス - Google Patents
センサ、カートリッジ、および薬物送達デバイス Download PDFInfo
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- JP6862418B2 JP6862418B2 JP2018504826A JP2018504826A JP6862418B2 JP 6862418 B2 JP6862418 B2 JP 6862418B2 JP 2018504826 A JP2018504826 A JP 2018504826A JP 2018504826 A JP2018504826 A JP 2018504826A JP 6862418 B2 JP6862418 B2 JP 6862418B2
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- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
- G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
- G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
- G01F11/029—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type provided with electric controlling means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
- G01F23/22—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
- G01F23/22—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
- G01F23/26—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields
- G01F23/263—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields by measuring variations in capacitance of capacitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
ここで、一実施形態において、薬学的に活性な化合物は、最大1500Daまでの分子量を有し、および/または、ペプチド、タンパク質、多糖類、ワクチン、DNA、RNA、酵素、抗体もしくはそのフラグメント、ホルモンもしくはオリゴヌクレオチド、または上述の薬学的に活性な化合物の混合物であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病、または糖尿病性網膜症などの糖尿病関連の合併症、深部静脈血栓塞栓症または肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、がん、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症および/または関節リウマチの処置および/または予防に有用であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病または糖尿病性網膜症などの糖尿病に関連する合併症の処置および/または予防のための少なくとも1つのペプチドを含み、
ここで、さらなる実施形態において、薬学的に活性な化合物は、少なくとも1つのヒトインスリンもしくはヒトインスリン類似体もしくは誘導体、グルカゴン様ペプチド(GLP−1)もしくはその類似体もしくは誘導体、またはエキセンジン−3もしくはエキセンジン−4もしくはエキセンジン−3もしくはエキセンジン−4の類似体もしくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36エキセンジン−4(1−39)、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);または
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
(ここで、基−Lys6−NH2が、エキセンジン−4誘導体のC−末端に結合していてもよい);
desPro36エキセンジン−4(1−39)−Lys6−NH2(AVE0010)、
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
または前述のいずれか1つのエキセンジン−4誘導体の薬学的に許容される塩もしくは溶媒和化合物
から選択される。
2 薬物送達デバイス
3 薬物送達デバイス
4 ハウジング
5 駆動機構
10 カートリッジ
11 バレル
12 側壁
13 封止
14 ピストン
15 首部
16 液体物質
20 本体
21 投薬ボタン
22 用量ダイヤル
30 カートリッジホルダ
31 窓
32 ソケット
33 貫通口
36 電気エネルギー供給部
37 コンパートメント
38 クロージャ
39 貫通口
40 カートリッジホルダ
41 窓
42 ソケット
43 貫通口
50 保護キャップ
51 凹部
60 保護キャップ
66 電気エネルギー供給部
67 コンパートメント
68 クロージャ
69 貫通口
70 付属デバイス
71 延長部
72 締結クリップ
76 電気エネルギー供給部
77 コンパートメント
78 クロージャ
79 下面
100 センサ
101 可撓性箔
101a 面
101b 面
102 測定電極
102a ヒータ
103 長手方向端部セクション
104 測定電極
104a サーミスタ
105 導体
106 接点電極
108 接点電極
110 プロセッサ
112 操作要素
120 トランシーバ
130 バッテリ
132 接点要素
134 接点要素
140 センサアセンブリ
200 電子デバイス
Claims (16)
- 液体物質で充填されたカートリッジ(10)またはシリンジの少なくとも1つの物理的または化学的パラメータを測定するためのセンサであって:
カートリッジ(10)またはシリンジのバレル(11)の外周に配置可能な平面の可撓性箔(101)と、
前記箔(101)の面に配置され、静電容量測定電極または温度測定電極として構成された少なくとも第1および第2の測定電極(102、104)と、
前記箔(101)の面に配置され、外部エネルギー供給部との電気接触を提供するように構成された少なくとも第1および第2の接点電極(106;108)とを含み、
ここで、第1の接点電極(106)は第1の測定電極(102)に接続され、第2の接点電極(108)は第2の測定電極(104)に接続される前記センサ。 - 第1および第2の接点電極(106、108)は、箔(101)の長手方向端部セクション(103)に配置される、請求項1に記載のセンサ。
- 第1および第2の接点電極(106、108)は、長手方向(z)に分離され、横方向または周方向(u)に略平行に延びる、請求項1または2に記載のセンサ。
- 第1および第2の接点電極(106、108)は、概ね箔(101)の横方向寸法全体にわたって延びる、請求項1〜3のいずれか1項に記載のセンサ。
- 箔は略透明であり、第1および第2の測定電極(102、104)のうちの少なくとも一方または第1および第2の接点電極(106、108)のうちの少なくとも一方は、箔(101)上またはその内に印刷または被覆された導電性構造を含む、請求項1〜4のいずれか1項に記載のセンサ。
- 第1および第2の測定電極(102、104)ならびに第1および第2の接点電極(106、108)は、箔(101)の共通の面(101b)または箔(101)の両面(101a、101b)に位置する、請求項1〜5のいずれか1項に記載のセンサ。
- 第1および第2の測定電極(102、104)は、互いに分離している、請求項1〜6のいずれか1項に記載のセンサ。
- カートリッジであって、
液体物質で充填された管状バレル(11)を含み、
該バレル(11)の側壁(12)の外周に巻き付けられた請求項1〜7のいずれか1項に記載のセンサ(100;300)を含む前記カートリッジ。 - センサ(100;300)は、カートリッジ(10)のバレル(11)に接着により取り付けられる、請求項8に記載のカートリッジ。
- センサ(100;300)の接点電極(106、108)は、箔(101)の外向き面に位置する、請求項8または9に記載のカートリッジ。
- 液体薬剤の用量を投与するための薬物送達デバイスであって:
請求項8〜10のいずれか1項に記載のカートリッジ(10)を収容するハウジング(4)であって、カートリッジ(10)は、液体薬剤で充填され、バレル(11)内に摺動可能に受け入れられたピストン(14)を含む、ハウジングと、
遠位を向いた駆動力をピストン(14)に及ぼして液体薬剤の用量を排出する駆動機構(5)と、
センサ(100;300)の第1および第2の接点電極(106;108)に電気的に接続可能な電気エネルギー供給部(36;66;76)と、
該電気エネルギー供給部(36;66;76)に接続されたプロセッサ(110)と、
該プロセッサ(110)に接続されたトランシーバ(120)とを含む前記薬物送達デバイス。 - ハウジング(4)は、カートリッジ(10)が組み付けられるカートリッジホルダ(30;40)を含む、請求項11に記載の薬物送達デバイス。
- トランシーバ(120)は、外部RF場から電気エネルギーを引き出して取得し、かつ電気エネルギーを少なくともプロセッサ(110)に供給するように動作可能であり、または構成される、請求項11または12に記載の薬物送達デバイス。
- エネルギー供給部(36;66;76)、プロセッサ(110)、およびトランシーバ(120)のうちの少なくとも1つに電気的に接続されてセンサによる測定を開始し、またはトランシーバ(120)を用いた外部電子デバイス(200)との通信を開始する少なくとも1つの動作要素(112)をさらに含む、請求項11〜13のいずれか1項に記載の薬物送達デバイス。
- 電気エネルギー供給部(36;66;76)は、バッテリ(130)と第1および第2の接点要素(132、134)とを収容するコンパートメント(37;67;77)を含み、第1および第2の接点要素は、バッテリ(130)に電気的に接続され、ハウジング(4)の貫通口(39;69)を通って延びて、センサ(100;300)の第1および第2の接点電極(106、108)にそれぞれ電気的に接続する、請求項11〜14のいずれか1項に記載の薬物送達デバイス。
- コンパートメント(37;67;77)は、カートリッジホルダ(30)、カートリッジホルダ(40)の少なくとも遠位端を取り外し可能に覆う保護キャップ(60)、またはハウジング(4)に取り外し可能に連結可能な付属デバイス(70)に組み込まれる、
請求項11〜15のいずれか1項に記載の薬物送達デバイス。
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EP15179216.5 | 2015-07-31 | ||
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PCT/EP2016/067815 WO2017021229A1 (en) | 2015-07-31 | 2016-07-26 | Sensor, cartridge and drug delivery device |
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JP2018521794A JP2018521794A (ja) | 2018-08-09 |
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EP (1) | EP3328468A1 (ja) |
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