JP4657653B2 - Body temperature raising agent - Google Patents

Description

  The present invention relates to a body temperature raising agent. Further, the present invention relates to an agent for improving body temperature lowering in the peripheral region of the body.

Conventionally, a method of adding organic acids to a beverage (Patent Document 1), a method of adding a metabolic intermediate downstream from succinyl CoA (Patent Document 2), a method of adding a spicy spice component to a beverage (Patent Document) There has been proposed a method for activating metabolism and increasing body temperature by the method 3).
On the other hand, various symptoms accompanied by a decrease in body temperature in a peripheral region called so-called coldness are known due to a reduction in autonomic nerve adjustment, hypotension, anemia, and the like. Particularly in recent years, with regard to the adjustment function by the autonomic nerve, there is concern about stress and the decrease of the adjustment function due to cooling in the summer, and the possibility of falling into the above-mentioned symptoms is increasing.
However, although the above-described method for increasing body temperature has the effect of increasing body temperature by activating energy metabolism, a sufficient effect is not always obtained for improving body temperature reduction at peripheral sites.
JP 2003-210137 A JP 2003-012512 A JP 2000-189121 A

  The present invention provides a body temperature increasing agent and a peripheral region body temperature decrease improving agent capable of warming the body in a low temperature environment, particularly improving a decrease in body temperature in a peripheral region, and a food and drink containing them as an active ingredient. With the goal.

  The present invention relates to decanoic acid, 5-decenoic acid, 6-decenoic acid and

（式中Ｒ１は水素原子、水酸基および／または炭素数１〜３のアルキル基が結合してもよいフェニル基またはメチルフェニル基またはエチルフェニル基、水酸基で置換されてもよい炭素数１〜１０の直鎖または分岐鎖もしくは環を形成してもよい飽和または不飽和の炭素鎖を示す）で表されるアンゲリカ酸およびそのエステルから選ばれる少なくとも１つの化合物を有効成分として含有する体温上昇剤であり、さらには前記化合物群から選ばれる少なくとも１つの化合物を有効成分として含有する末梢部位体温低下改善剤である。
また、本発明の他の態様としては、前記体温上昇剤または末梢部位体温低下改善剤を有効成分として含有する飲食品である。

(In the formula, R1 represents a hydrogen atom, a hydroxyl group and / or a phenyl group, a methylphenyl group, an ethylphenyl group or a hydroxyl group which may be substituted by a hydroxyl group and / or a hydroxyl group having 1 to 3 carbon atoms. A body temperature-elevating agent containing, as an active ingredient, at least one compound selected from angelic acid represented by a straight chain, a branched chain or a saturated or unsaturated carbon chain that may form a ring) Furthermore, it is a peripheral part body temperature decrease improving agent containing at least one compound selected from the above compound group as an active ingredient.
Moreover, as another aspect of this invention, it is the food / beverage products which contain the said body temperature increasing agent or a peripheral part body temperature fall improvement agent as an active ingredient.

  The body temperature elevating agent or peripheral region body temperature lowering improving agent of the present invention increases body temperature and can warm the body in a low temperature environment in winter. Moreover, since a body temperature increasing effect can be effectively obtained at peripheral sites such as the hands and feet, so-called cooling properties and cooling due to cooling can be improved.

The decanoic acid, 5-decenoic acid and 6-decenoic acid of the present invention are generally commercially available as perfumes and can be easily obtained. Moreover, all can be manufactured by a well-known method. For example, 5 (or 6) -decenoic acid can be produced by the method described in JP-A-59-116247 and JP-A-58-059908.
The following formula 2 of the present invention

（式中Ｒ１は水素原子、水酸基および／または炭素数１〜３のアルキル基が結合してもよいフェニル基またはメチルフェニル基またはエチルフェニル基、水酸基で置換されてもよい炭素数１〜１０の直鎖または分岐鎖もしくは環を形成してもよい飽和または不飽和の炭素鎖を示す）で表されるアンゲリカ酸およびそのエステル類として具体的には例えば、アンゲリカ酸、２−メチル−２−ブテニルアンゲレート、３−ヘキセニルアンゲレート、２−ヒドロキシ−２−メチル−３−ブテニルアンゲレート、２−メチル−２−プロぺニルアンゲレート、２−メチルブチルアンゲレート、３−ヒドロキシ−２−メチリデンブチルアンゲレート、３−メチルペンチルアンゲレート、ベンジルアンゲレート、ブチルアンゲレート、エチルアンゲレート、ゲラニルアンゲレート、ヘプチルアンゲレート、ヘキシルアンゲレート、イソブチルアンゲレート、イソペンチルアンゲレート、イソプロピルアンゲレート、ノニルアンゲレート、オクチルアンゲレート、ペンチルアンゲレート、フェネチルアンゲレート、プロピルアンゲレート、セカンダリブチルアンゲレート、ターシャリブチルアンゲレートが挙げられる。これらの化合物は、一般に市販されているものを使用することができる。また、特開昭５７−１１２３４８号公報に記載された方法で製造することができる。また、これらの化合物はローマンカモミール（Ａｎｔｈｅｍｉｓ ｎｏｂｉｌｉｓ Ｌ．）の精油に含まれていることが知られており、この精油を用いることもできる。

(In the formula, R1 represents a hydrogen atom, a hydroxyl group and / or a phenyl group, a methylphenyl group, an ethylphenyl group or a hydroxyl group which may be substituted by a hydroxyl group and / or a hydroxyl group having 1 to 3 carbon atoms. Specific examples of the angelic acid and esters thereof represented by a straight chain, a branched chain or a saturated or unsaturated carbon chain that may form a ring include angelic acid, 2-methyl-2-but Tenenyl angelate, 3-hexenyl angelate, 2-hydroxy-2-methyl-3-butenyl angelate, 2-methyl-2-propenyl angelate, 2-methylbutyl angelate, 3-hydroxy- 2-methylidenebutyl angelate, 3-methylpentyl angelate, benzyl angelate, butyl angelate, ethyl angelate, Ranyl angelate, heptyl angelate, hexyl angelate, isobutyl angelate, isopentyl angelate, isopropyl angelate, nonyl angelate, octyl angelate, pentyl angelate, phenethyl angelate , Propyl angelate, secondary butyl angelate, and tertiary butyl angelate. As these compounds, commercially available compounds can be used. Moreover, it can manufacture by the method described in Unexamined-Japanese-Patent No. 57-112348. Further, these compounds are known to be contained in the essential oil of Roman chamomile (Anthemis nobilis L.), and this essential oil can also be used.

  The body temperature raising agent or the peripheral region body temperature lowering improving agent of the present invention may be used alone or in combination.

  The body temperature elevating agent or peripheral region body temperature lowering improving agent of the present invention is a solvent such as ethanol, water, propylene glycol, glycerin, edible oil or fat, or a mixed solution thereof, salts applicable to pharmaceuticals and foods, sugar , Sugar alcohols, excipients, solubilizers, emulsifiers, dispersants, stabilizers, antioxidants, pigments, fragrances and the like can be appropriately blended.

  In the body temperature increasing agent or the peripheral region body temperature lowering improving agent of the present invention, the content of the compound group is not particularly limited, but is preferably 0.0001 to 100% by mass.

  The form of the body temperature increasing agent or the peripheral region body temperature lowering improving agent of the present invention is not particularly limited. For example, it may remain in a liquid state, and can be appropriately selected depending on the application, such as emulsification, dispersion, and powderization by a known method.

  The body temperature elevating agent or peripheral region body temperature lowering improving agent of the present invention can be used in combination with nutrition enhancing agents such as vitamins, minerals and amino acids, antioxidants, antibacterial agents and other agents. Moreover, you may use the body temperature increasing agent of this invention together with another body temperature increasing agent.

  When formulating the body temperature increasing agent or peripheral region body temperature lowering improving agent of the present invention as a pharmaceutical product or a quasi-drug, a stabilizer, a coloring agent, a flavoring agent, a fragrance, an excipient, a solvent, if necessary. , Surfactants, emulsifiers, preservatives, solubilizers, tonicity agents, buffers, binders, coating agents, lubricants, disintegrants, etc., liquids, powders, powders, granules, tablets, dragees Any dosage form such as capsules, suspensions, suppositories and the like can be selected.

  Since the body temperature elevating agent or the peripheral body temperature lowering improving agent of the present invention is a compound used as a fragrance, it can be added to food and drink. For example, beverages such as milk beverages, soft drinks, taste beverages, alcoholic beverages, chocolate, candy, tablet confectionery, gum, snack confectionery, cookies, cakes, other baked confectionery, instant noodles, retort food, frozen food, etc. By adding to cooked foods, seasonings, dietary supplements and other foods, the body can be effectively warmed. Moreover, the function of maintaining health can be added to food and drink, such as improving coldness by ingesting these foods.

  When the body temperature elevating agent or the peripheral region body temperature lowering improving agent of the present invention is added to a food or drink, the amount of addition is not particularly limited, but it is preferably 0.0001 to 5% by mass.

  The method for adding the body temperature elevating agent or the peripheral region body temperature lowering improving agent of the present invention to a food or drink is not particularly limited, but an emulsifier, a dispersant, a stabilizer and the like can be added as necessary.

  When adding the body temperature increasing agent or peripheral region body temperature lowering improving agent of the present invention to foods and drinks, nutritional enhancing agents such as vitamins, minerals, amino acids, antioxidants, antibacterial agents, dietary fiber, blood flow promoters, antithrombotic agents Other functional components such as an agent and an antiallergic agent can be used in combination as long as the function of the body temperature increasing agent of the present invention is not inhibited.

The contents of the present invention will be described as the following experimental examples and examples, but are not limited thereto.
(Test Example 1)
Each test substance was dissolved in 70% by volume of water-containing ethanol to prepare a 1% solution, which was added to distilled water to prepare a sample containing 0.001% by mass of the test substance. As a control, distilled water to which 0.1% of 70% by volume of water-containing ethanol was added was used.
Test substance 1 ... 5-decenoic acid, 6-decenoic acid mixture Test substance 2 ... Isobutyl angelate Test substance 3 ... 3-methylpentyl angelate Test substance 4 ... Roman Chamomile oil

  The test was performed by drinking 100 ml of the sample or control in an environment at room temperature of 25 ° C. As a measuring device, a thermotracer (TH5104) manufactured by NEC Sanei Co., Ltd. was used, and the left and right palms and fixed point temperatures of fingers shown in FIG. 1 were measured.

(Figure 1)

  The temperature at each fixed point was determined by measuring the temperature up to 30 minutes every 3 minutes after drinking the sample or the control with the temperature measured before drinking as the reference point, and obtaining the temperature difference from the reference point.

(Test results)
From the fluctuation value obtained by measuring the fixed-point temperature, compare the maximum value between 10 and 30 minutes after drinking between the sample and the control, and subtract the numerical value when drinking the sample from the value when drinking the sample. Value.

  Table 1 shows the results of a drinking effect test of 5-decenoic acid and a 6-decenoic acid mixture.

  From the results shown in Table 1, when the sample was drunk, the temperature was significantly increased compared to the control, and 5-decenoic acid and the 6-decenoic acid mixture had the effect of increasing body temperature at the peripheral site by oral ingestion. It could be confirmed.

  Next, Table 2 shows the results of the drinking effect test of isobutyl angelate.

  From the results in Table 2, it was confirmed that when the sample was taken, the temperature increased significantly compared to the control, and isobutyl angelate had the effect of increasing the body temperature at the peripheral site by ingestion.

  Next, Table 3 shows the results of the drinking effect test of 3-methylpentyl angelate.

  From the results in Table 3, it was confirmed that when the sample was drunk, the temperature was significantly increased as compared with the control, and 3-methylpentylangelate had an effect of increasing body temperature at the peripheral site by ingestion.

  Next, Table 4 shows the results of a drinking effect test of roman chamomile oil.

  From the results in Table 4, it was confirmed that the temperature was significantly increased when the sample was drunk compared with the control, and that roman chamomile oil had an effect of increasing body temperature at the peripheral site by oral ingestion.

(Test method)
A drinking test was conducted by replacing the sample in the test of Example 1 with a beverage having the following formulation. As the body temperature increasing agent of the present invention, roman chamomile oil and isobutyl angelate were used in combination. Moreover, the control did not contain the above-mentioned body temperature increasing agent of the present invention, and other ingredients prepared the same beverage.

Beverage formulation example ――――――――――――――――――――――
Fructose glucose liquid sugar 60.0
Apple transparent fruit juice 4.3
Citric acid 2.3
Trisodium citrate 0.8
Ascorbic acid 0.2
Sucralose 0.03
Acesulfame potassium 0.02
Perfume 0.99
Roman chamomile oil 0.009
Isobutyl angelate 0.001
Water balance ――――――――――――――――――――――
1000.0g

(Test results)
As in Example 1, the maximum value between 10 and 30 minutes after drinking is compared between the sample and the control from the fluctuation value obtained by measuring the fixed point temperature, and the value at the time of drinking the sample is compared with the value at the time of drinking the sample. A value obtained by subtracting the value was used as a comparison value.

  Table 5 shows the drinking test results for the prescription example near water.

  From the results in Table 5, when the sample was drunk, the temperature increased significantly compared to the control, and by ingesting a drink added with roman chamomile oil and isobutyl angelate, an effect of increasing body temperature at the peripheral site was obtained. It was confirmed that

  The compound used as an active ingredient of the body temperature increasing agent or peripheral region body temperature lowering improving agent of the present invention is a compound that has been used as a fragrance and has extremely little irritation and can be widely added to foods and drinks. In addition, since the compound group of the present invention can be easily synthesized, mass production is possible.

Claims (2)

A body temperature increasing agent containing, as an active ingredient, at least one compound selected from 5-decenoic acid and 6-decenoic acid. A peripheral region body temperature lowering improving agent comprising as an active ingredient at least one compound selected from 5-decenoic acid and 6-decenoic acid.