JP3057601B2 - Method for producing protein-enriched royal jelly tablets - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a method for producing a royal jelly tablet in which the discoloration to brown or brown due to oxidation is prevented, quality deterioration due to decomposition of the components caused by gastric juice is suppressed, and the protein content is enhanced.

[0002]

2. Description of the Related Art Royal jelly, also called royal milk, is a substance secreted by the worker bee from the pharyngeal gland in the head, and is stored in a nest on a nest box as bait for queen bees. This is completely different from the honey that worker bees collect flower nectar and store in the hive.It contains proteins, vitamins and various minerals, etc., and nutrients necessary for maintaining human health are It is well-balanced.

The components of royal jelly have a water content of 62-70.
%, Crude protein 12-15%, crude fat 3-5%, carbohydrate about 15%, ash about 1.5%, appearance is a white paste-like fluid with an exciting sour taste. Trace components include various amino acids, phosphate conjugates, vitamins, fatty acids,
Contains minerals (March 25, 1992, published by Dobunshoin, 6th edition, 8th edition, edited by Yoshito Sakurai, "Pochette General Food Dictionary", page 1020).

[0004] As described above, royal jelly is used as a health food because it is useful for maintaining health. However, in the air, a part of the contained components is oxidized, so that the color changes from brown to brown. Since the quality is remarkably deteriorated, various proposals have been made to maintain the freshness. That is, it is known that, when royal jelly is preserved by drying to reduce the moisture content, handling is easy and there is little deterioration. It has also been proposed that royal jelly be granulated using gelatin or the like for convenient use, or encapsulated in capsules. Also,
For storage at room temperature, those to which propolis is added are also known (Japanese Patent Publication No. 3-49543, Japanese Unexamined Patent Publication No. Hei 4-49543).
36159, JP-B-4-21457, JP-B4-39305, and JP-B5-87216).

[0005]

However, simply granulated or encapsulated products inevitably suffer from deterioration in quality due to oxidation in the air, and when taken, some of the components contained in royal jelly due to gastric juice. Has been degraded and its nutritional value has been reduced. The present inventor has previously proposed a royal jelly tablet which has solved the above-mentioned problems in the prior art, has no deterioration in quality even after long-term storage, and has no loss of nutritional value even when taken, and a method for producing the same. Invention of Japanese Patent Application No. 9-1957). In the invention of the prior application, the above-mentioned problems in the prior art have been solved, but there is a need for further improvements to enhance the effect of royal jelly and to facilitate production.

[0006]

Means for Solving the Problems In order to achieve the above-mentioned object, the present inventors have conducted intensive studies and as a result, the protein content has been enhanced by mixing collagen powder with royal jelly powder as a raw material prior to tableting. At the same time, they have found that plain tablets are easy to mold and that the yield is improved, and the present invention has been completed.

[0007] That is, the present invention based on the above-mentioned findings provides a granular mixture formed by mixing and stirring a dry powder royal jelly, a collagen powder, an excipient and a lubricant at a low temperature until it can be tableted. Dried by moisture ,
This granulated mixture is subjected to a humidity of 40% or less and
A plain tablet surface generated by tabletting at 20 ° C. or less, Chez
Use a rack alcohol solution to form the coating
After that, alcohol-soluble tampa extracted from grain
Apply an alcohol solution of a mixture of wood and shellac
After subjecting the coating process to impart enteric Te performs glycocalyx seat, after glycocalyx seat, dense glycocalyx coating humidified conditions Kasho
The present invention further provides a method for producing a royal jelly tablet in which the protein content is enhanced, characterized by performing a glossing treatment on the sugar-coated layer.

[0008]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The construction and operation of the present invention will be described.
An object of the present invention is to prevent the quality of royal jelly as a health food from deteriorating, to enhance the protein content, to facilitate tableting, and to improve the quality stability of the product.

[0009] The reduction in quality is to prevent browning of the tablet due to oxidation and to prevent decomposition of nutrient components by gastric juice upon taking. According to the experimental results of how gastric juice acts on royal jelly, the present inventor requested the Osaka City University School of Medicine, a part of the protein in royal jelly is degraded, and the nutritive value is reduced by that It became clear.

In order to produce high quality royal jelly products, attention must be paid to the deterioration of components from the stage of raw material collection. The royal jelly, which is a main component of the raw material used in the present invention, is collected one day earlier than a case where it is normally collected from a beekeeper's mount so that the component quality is not deteriorated. The collected royal jelly was immediately cooled with ice water,
When the royal jelly reaches the temperature of the ice water (almost 0 ° C.), it is rapidly frozen at −5 to −20 ° C. in order to prevent deterioration, and then is transported to the factory. In a factory, frozen royal jelly is once naturally thawed, then freeze-dried at an ultra-low temperature of -30 to -40 ° C to remove moisture and to be pulverized.

Next, as a pretreatment for forming a tablet, a royal jelly powder is mixed with a collagen powder, an excipient and a lubricant, and the mixture is stirred. Collagen is the protein most contained in the animal body and is reported to be used for medical use, cosmetics, and the like ("Food and Science", January 1997, Vol. 39, No. 1). 95-99, "Special Feature / Effective Use of New Food Materials: Properties and Use of Fermented Collagen Peptides"). According to the above-mentioned literature, it has been confirmed that the effect of addition is recognized when used in combination with another protein, rather than when used alone. Lactose is used as an excipient. In addition to lactose, crystalline cellulose and corn starch can also be used, and two or more of these may be used in combination. In addition, a vegetable hardened fat is blended with the lubricant.
Hardened soybean oil and the like are suitable, but not limited thereto, and sucrose, sugar esters or fatty acid esters can also be used. Lubricants may be added together with excipients to obtain granules depending on their properties, or may be added during tableting.

The proportion of royal jelly is 100 parts by weight, collagen is 20 to 150 parts by weight, and excipients are 150 parts by weight.
It is preferable that the amount of the lubricant is 0.5 to 1.2 parts by weight. If the amount is less than this range, the yield of tableting will be poor, and if it is too large, the ratio of nutrients will decrease, and the original purpose will not be achieved. As an auxiliary component, for example, by adding an appropriate amount of bone calcium powder, the calcium component can be strengthened. Further, catechin may be blended to prevent oxidation.

When heat is applied during mixing and stirring, the quality of royal jelly deteriorates. Therefore, while lowering the temperature, stirring is performed while reducing the humidity and ventilation drying until the tableting by the tableting machine becomes possible. Even if ventilation is performed at 40 ° C. due to low humidity, the temperature of the processed material is about 20 ° C. and is hardly affected by the temperature. The mixed and stirred raw material becomes granules suitable for tableting. Granule size is 100
A diameter range of ２０００2000 μm is preferred.

The tableting machine may be a general-purpose tableting machine generally used for tablet production in the pharmaceutical industry. For tableting, the above granular raw material is tableted at a humidity of 40% or less and a temperature of 25 ° C. or less, and the uncoated tablet is stored in a closed container containing a desiccant. The tablet size varies depending on the ratio of the royal jelly in the compounding ingredients, but is determined by the royal jelly content per tablet.

Next, the uncoated tablet manufactured by compression is resistant to moisture.
Shellac Coat before enteric coating treatment to improve
Do the singing. Shellac is a stolen Asian bean
Larvae parasitic on plants of the family Laceae or Mulaceae
Is a natural resin secreted by
It is soluble in organic solvents . It is gloss of western confectionery such as chocolate
And used as a citrus coating agent.

Shellac coating, uncoated tablet 60kg
About 3.5 to 5 liters of shellac
Disperse the solution (8-12% ethanol solution) in 3-5 times
After clothing, 15-45 ° C at 35-45 ° C by shelf dryer
Allow to dry for at least a minute. Coating thickness is 25-35μm
It is. Uncoated tablets with shellac coating are ventilated
The property is almost lost, and in subsequent processes,
Quality deterioration is prevented.

Subsequently, in order to prevent degradation of royal jelly by gastric juice, a treatment for imparting enteric properties is performed.
To make an uncoated tablet enteric-coated, its surface is coated with an alcohol-soluble protein alcohol solution extracted from cereals. As the grain, wheat, corn, soybean and the like are suitable.

For enteric film formation, a solution extracted from a protein fraction of a grain (eg, wheat or corn gluten meal) with an alcohol is used.
The extract is used as a solution of a predetermined concentration after removing and purifying insoluble foreign substances by ordinary purification means such as filtration. 60 ~
A concentration of 5 to 10 parts by weight of the dissolved component (solid state) in 100 parts by weight of 90% alcohol is suitable. In order to improve the familiarity with the shellac coating layer described above ,
Dissolve and use an appropriate amount (eg equal amount) of shellac at the same time
I do.

In order to form the enteric coating on the tablet, after the shellac coating plain tablets were placed in a film coating pan (FM pan), cereals, such as proteins 3 alcohol soluble extracted from corn
13-17 liters of an ethanol solution containing 6%, glycerin fatty acid ester 0.5-1% and shellac 3-6% is used as a coating solution, and the supply air temperature is 50-60.
° C, air volume 10-12 m ³ / min, pan rotation speed 8-10 times / min, spray pressure 3.5-5 kg / m ² 4-6
Time film coating. Its coating thickness is 35-40 μm.

For tablets coated with an enteric coating, granulated sugar, gelatin, gum arabic, lactose,
Sugar coating is performed using a sugar coating material containing calcium calcium powder and catechin as necessary. The mixing ratio of the sugar coating material is as follows: granulated sugar 40-50%, gelatin 1-2%, gum arabic 1-2%, bone calcium powder 7-1 when added
1%, catechin 3-5%, lactose residue. There is no problem even if bone calcium powder and catechin are not used. After the sugar coating is put on the enteric film coating, it is humidified under a constant humidity condition, so that the crystal on the sugar coating surface is made dense to prevent cracking. If this humidification treatment is not performed, fine cracks may occur on the surface of the sugar coating layer.

Subsequently, the sugar coating layer is subjected to a glossing treatment.
Carnauba wax, for example, is used as a brightening agent.
Carnauba wax is a natural waxy substance obtained from the leaves of wax palm and is commonly used for brightening sweets. The luster disappears instantly when steamed, because it is a natural product. The sugar-coated tablet containing royal jelly thus completed has a moisture content of 0.5.
１1%, hardness is 15 kg or more.

[0022]

EXAMPLES Examples of the present invention will be described, but the present invention is not limited by these examples. Example 1 Crude royal jelly collected at Sanken Wei Ri Bee Garden (Xinying Town, Tainan County, Taiwan) and kept in ice water (0 ° C.) for 2 to 3 hours immediately after collection to obtain ice water temperature -15 ° C. was used as a raw material. After the material was naturally thawed, it was freeze-dried in vacuum at -38 ° C and 150 hectopascals to obtain a powder. Particle size is 150-20
The range was 0 μm.

Into 100 kg of the powder, collagen powder (trade name “Nippi Peptide PRA” manufactured by Nippi Co., Ltd.) is added.
20 kg, lactose 42 kg as an excipient, and hardened soybean oil 0.8 kg as a lubricant were mixed, and the humidity was 25 ° C or less and the humidity was 60%
The mixture was sufficiently stirred below to obtain granules for tablet formation. The particle size of the granules was distributed within 1000-2000 μm. The granules were air-dried at a humidity of 30% or less until they could be compressed. The water content was 1%.

Tableting machine manufactured by Hata Seisakusho Co., Ltd. (Model D3)
550 under the condition of humidity of 60% and temperature of 25 ° C. or less.
An uncoated tablet of 265 mg / piece was produced at a rate of pieces / minute and stored in a sealed container containing a desiccant. The uncoated tablets are selected, and shellac coating is performed except for defective products . Sierra
6.6 coatings per 100 kg of uncoated tablet
Liter of shellac solution (10% ethanol solution)
Sprinkle in three portions, then use a shelf dryer to apply 40
Dry at 15 ° C for at least 15 hours. Coating thickness is 30
μm. It said the plain tablet To enteric performs alcohol-soluble corn protein 5% on its surface, 0.7% glycerol fatty acid ester, a coated using an alcoholic solution 24 l containing 5% shellac. Coating is a film coating pan (FM
Bread) and put the uncoated tablet in, supply air temperature 56 ° C, air volume 11m
³ / min, pan rotation speed 9.25 times / min, spray pressure 4k
Film coating was performed for 5 hours under the condition of g / m ² . The coating thickness was 37 μm.

The tablets coated with the enteric coating are sugar-coated using 14 kg of a sugar coating material consisting of granulated sugar, gelatin, gum arabic and lactose. The mixing ratio of sugar coating material is 45% granulated sugar and 1.5% gelatin.
%, Gum arabic 1.5% and lactose residue. After the sugar coating is applied, the crystal on the surface of the sugar coating layer is made dense by humidification at a humidity of 95% to prevent cracks.

Next, the sugar coating layer is subjected to a glossing treatment using carnauba wax. The powder of carnauba wax is mixed and stirred, adhered to the surface of the sugar coating layer and waxed.
Dragees containing finished royal jelly weigh 500
mg, 9 mm on a side, 7 mm in thickness, chamfered equilateral triangular shape. One tablet contained 165 mg of royal jelly, 100 mg of collagen powder, 69.44 mg of lactose, and 0.56 mg of soybean oil and fat. The water content was 0.8% and the hardness was 15 kg or more. When the lock shape is round, the size is 11 mm in diameter and 7 mm in thickness.

The properties of the sugar-coated tablets containing the collagen-containing royal jelly thus produced were tested. A disintegration test was performed using an artificial gastric fluid (first fluid) and an artificial intestinal fluid (second fluid) under the conditions specified in the General Pharmacopoeia General Test Method. In the first liquid, all six sugar-coated tablets containing royal jelly did not dissolve for more than 60 minutes. Subsequently,
When the sample tested with the first liquid was immersed in the second liquid,
One after 2 minutes and 40 seconds, two after 23 minutes, one after 24 minutes and 30 seconds, one after 24 minutes and 40 seconds, and the last one after 49 minutes and 20 seconds. As a result, it was confirmed that the royal jelly sugar-coated tablets produced by the present invention were not dissolved by gastric juice and had excellent enteric properties.

As a storage test, a temperature of 40 ° C. and a humidity of 75
%, And the change in water content and the change in the content of 10-hydroxy-δ-2-decenoic acid in royal jelly were examined. As a result, at the start of storage, the water content was 2.6% and the decenoic acid was 1.79%, but after 4 weeks, the water content was 2.6%, the decenoic acid was 1.59%, and after 8 weeks, the water content was 3.3. % And decenoic acid were 1.46%. Four weeks of the above conditions correspond to one year at room temperature, and eight weeks correspond to two years. From these results, it is clear that the collagen-containing royal jelly sugar-coated tablet produced according to the present invention can maintain stable quality for a long period of time.

[0029]

Since the present invention is constituted as described above, the manufactured royal jelly-coated sugar tablets containing collagen have excellent enteric properties without being dissolved by gastric juice and maintain stable quality for a long period of time. In addition, the combination of collagen has an excellent effect that the hardness after tableting is high, the yield is improved, and the synergistic properties of royal jelly and collagen proteins can also be expected, which is extremely useful as a health food.

Continuation of the front page (58) Field surveyed (Int.Cl. ⁷ , DB name) A23L 1/04-1/09 A61K 9/00-9/72 A61K 47/00-47/48 A61K 35/64 JICST file (JOIS)

Claims (5)

(57) [Claims] A granulated mixture formed by mixing and stirring a dry powder royal jelly, a collagen powder, an excipient and a lubricant is dried by dehumidification at a low temperature until a tabletable state is obtained. The granular mixture is controlled by a tableting machine to a humidity of 40% or less.
The surface of the uncoated tablet produced by tableting at a temperature of 20 ° C. or lower was coated with an alcoholic shellac solution.
Soluble in alcohol extracted from cereal grains
Alcohol solution of a mixture of protein and shellac
After applying a coating process to impart enteric properties by applying a coating, sugar coating is performed, and after coating, the coating film is coated under humidified conditions.
A method for producing a royal jelly tablet in which a protein content is enhanced, wherein a densification treatment is performed, and a gloss coating treatment is further performed on the sugar-coated layer. 2. The method according to claim 1, wherein the excipient is lactose, crystalline cellulose, or corn starch, or a combination thereof, and the lubricant is any of vegetable hardened oil, sucrose, fatty acid ester, glycerin fatty acid ester or a combination thereof. Item 4. A method for producing a royal jelly tablet in which the protein content is enhanced according to Item 1. 3. A cereal, wheat, corn, manufacturing method of royal jelly tablet with enhanced protein fraction according to claim 1 or 2, wherein either of the soybean. 4. A coating layer is, granulated sugar, gelatin, claim 1, which is formed by gum arabic and lactose, 2 or
Or a method for producing a royal jelly tablet enriched in protein content according to claim 3 . 5. The method for producing a royal jelly tablet enriched in protein according to claim 1, wherein carnauba wax is used for glossing.