JP2007268194A - Iontophoresis device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an iontophoresis device, provided with an electrode structure having a polarization electrode, which actuates securely. <P>SOLUTION: In the iontophoresis device, an action side electrode 24 is composed of an action side collector 24A connected to a DC power source 12, an action side bonding agent layer 24C disposed on the front surface of the action side collector 24A, and an action side polarization electrode 24B, disposed on a front surface of the action side bonding agent layer 24C, and electrically connected and bonded to the action side collector 24A by the action side bonding agent layer 24C. For the action side bonding agent layer 24C, conductive bonding agent should preferably be used. For the action side polarization electrode 24B, viscous fluid including chemical should preferably be impregnated. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an iontophoresis device for administering drug ions to a living body by applying a voltage.

  As described in Patent Document 1, the iontophoresis device as described above has a working electrode structure and a non-working electrode structure, and a chemical ion from an ion exchange membrane of the working electrode structure. Is administered in vivo via the skin or mucous membrane.

  As an electrode structure of such an iontophoresis device, the present applicant has proposed an electrode structure having a polarizable electrode, which is not known, but an iontophoresis using this electrode structure. In the apparatus, conduction may be insufficient.

WO03037425

  The present invention has been made in view of such problems, and an object of the present invention is to provide an iontophoresis device having an electrode structure having a polarizable electrode and having good conduction and reliable operation. .

  The present inventor has investigated the cause of insufficient conduction of an iontophoresis device provided with an electrode structure having a polarizable electrode. As a result, in the electrode structure having a polarizable electrode, when a viscous liquid containing an electrolyte such as a drug or sodium chloride contained in the polarizable electrode penetrates to the contact interface between the current collector and the polarizable electrode, It has been found that the electrical connection between the current collector and the polarizable electrode is insufficient, which causes insufficient conduction.

  The present invention has been completed based on this finding. That is, the said subject is achieved by the following examples.

  (1) A pair of electrode structures and a DC power source connected to the pair of electrode structures, and drug ions held in one of the pair of electrode structures are converted into voltage from the DC power source. The iontophoresis device for administration to a living body, wherein at least one of the pair of electrode structures is disposed on a current collector connected to the DC power source and on the front surface of the current collector An iontophoresis device comprising an electrode comprising an adhesive layer and a polarizable electrode disposed on the front surface of the adhesive layer and bonded to the current collector by the adhesive layer.

  (2) The iontophoresis device according to (1), wherein the polarizable electrode contains activated carbon.

  (3) The iontophoresis device according to (2), wherein the activated carbon is activated carbon fiber.

  (4) The iontophoresis device according to any one of (1) to (3), wherein the current collector contains at least one of carbon and silver as a conductive substance.

  (5) The iontophoresis according to any one of (1) to (4), wherein the adhesive layer is provided at a plurality of mutually separated locations on the front surface of the current collector. Lesis device.

  (6) The iontophoresis according to any one of (1) to (4), wherein the adhesive layer is provided over the entire surface between the current collector and the polarizable electrode. apparatus.

  (7) The iontophoresis device according to any one of (1) to (6), wherein the adhesive layer is made of a conductive adhesive.

  (8) The iontophoresis device according to (7), wherein the conductive adhesive has at least one of an epoxy resin and a phenol resin.

  (9) Of the pair of electrode structures, the electrode structure holding the drug ions is a working electrode structure, and the working electrode structure is provided with a working electrode as the electrode. The working electrode is connected to the DC power source, the working adhesive layer disposed on the front surface of the working current collector, and the working adhesive layer on the front surface. A working polarizable electrode disposed and adhered to the working current collector by the working adhesive layer, wherein the working polarizable electrode is impregnated with a viscous liquid containing the drug ion. The iontophoresis device according to any one of (1) to (8).

  (10) The electrode structure having the electrolyte solution holding portion is a non-working side electrode structure, and the non-working side electrode structure is provided with a non-working side electrode as the electrode, and the non-working side electrode The electrode is disposed on the non-working side current collector connected to the DC power source, the non-working side adhesive layer disposed on the front surface of the non-working side current collector, and the front surface of the non-working side adhesive layer. And a non-working side polarizable electrode adhered to the non-working side current collector by the non-working side adhesive layer, and the non-working side polarizable electrode is impregnated with a viscous liquid containing the electrolytic solution. The iontophoresis device according to any one of (1) to (9), wherein

  In the iontophoresis device according to the present invention, the working electrode, the non-working electrode, or the current collector in which the working electrode and the non-working electrode are connected to a DC power source, and the front surface of the current collector And an adhesive layer disposed on the front surface of the adhesive layer and adhered to the current collector by the adhesive layer, and the polarizable electrode is formed by the adhesive layer. Since it is bonded to the current collector, electrical contact between the current collector and the polarizable electrode in the working side electrode, the non-working side electrode, or the working side electrode and the non-working side electrode Is maintained well. For this reason, the iontophoresis device according to the present invention includes an electrode structure having a polarizable electrode and has good conduction and reliable operation.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

  As shown in FIG. 1, an iontophoresis device 10 according to an embodiment of the present invention includes a DC power source 12, a working electrode structure 20, and a non-working electrode structure 40. . The working electrode structure 20 is connected to one of the anode and the cathode of the DC power source 12 by a working conductor 19A (see FIG. 2), and the non-working electrode structure 40 is DC by a non-working conductor 19B (see FIG. 2). Connected to the other of the anode and the cathode of the power source 12.

  The iontophoresis device 10 has such a configuration, and administers drug ions held in the working electrode structure 20 to a living body by a voltage from the DC power supply 12.

  In the iontophoresis device 10, the working electrode structure 20 and the non-working electrode structure 40 are base ends each made of a resin sheet, in which constituent members such as a polarizable electrode and a chemical solution holding unit are overlapped. It is configured to be sandwiched between the support 14 and the intermediate support 16 or housed in a through hole formed in the intermediate support 16 and the tip support 18. The proximal support body 14 and the intermediate support body 16 have the same size, and the distal end support body 18 is formed larger than these.

  The base end support body 14, the intermediate support body 16 and the front end support body 18 are all provided with adhesive layers 14A, 16A and 18A on the lower surface in FIG. Layer 18A is adapted to adhere to the skin or mucous membrane.

  Here, the intermediate support 16 includes a working intermediate support 16B that forms part of the working electrode structure 20, and a non-working intermediate support 16C that forms part of the non-working electrode structure 40. It is set as one sheet-like member which consists of these.

  Similarly, the tip support 18 includes a working tip support 18B that forms part of the working electrode structure 20, and a non-working tip support 18C that forms part of the non-working electrode structure 40. It is set as one sheet-like member which consists of these.

  The working electrode structure 20 includes a working electrode 24 connected to an anode or a cathode having the same polarity as the drug ions in the DC power source 12, and a separator 26 disposed on the front surface of the working electrode 24. A second ion-selective membrane 28 that is disposed in front of the separator 26 and selectively allows ions having opposite signs to the drug ions to pass therethrough, and is disposed in front of the second ion-selective membrane 28, A drug solution holding unit 30 that holds the drug and a first ion-selective membrane 32 that is disposed in front of the drug solution holding unit 30 and selectively allows the same kind of ions as the drug ions to pass through are laminated in this order. It is configured.

  The working electrode 24 is connected to the DC power source 12 and is formed by printing on the front surface of the resin sheet 36, and the working side adhesive disposed on the front surface of the working current collector 24A. An agent layer 24C, and a working-side polarizable electrode 24B disposed on the front surface of the working-side adhesive layer 24C and electrically connected to and adhered to the working-side current collector 24A by the working-side adhesive layer 24C. It is composed of From the viewpoint of conductivity, a conductive adhesive may be used for the working side adhesive layer 24C. The working current collector 24A is formed by applying a conductive paint containing conductive powder. As the conductive powder in the conductive paint, any conductive powder can be used. For example, carbon powder, silver powder, or a mixture of carbon powder and silver powder can be used.

  In addition, “electrically connected” includes not only the case where they are in direct physical contact but also the case where they are connected via a conductor such as a conductive adhesive (the same applies hereinafter).

  The intermediate support 16 (working-side intermediate support 16B) is made of a resin material having a thickness substantially equal to that of the working-side polarizable electrode 24B, and has substantially the same shape as the planar shape of the working-side polarizable electrode 24B. The working side intermediate through hole 21A is provided, and the working side polarizable electrode 24B is accommodated in the working side intermediate through hole 21A.

  Further, the tip support 18 (working-side tip support 18B) is made of a resin material having a thickness substantially equal to that of the chemical solution holding part 30, and the working-side tip having substantially the same shape as the planar shape of the working-side polarizable electrode 24B. There is a through-hole 22A, and the chemical solution holding part 30 is accommodated in the working-side tip through-hole 22A.

  The non-working side electrode structure 40 includes a non-working side electrode 44 connected to an anode or a cathode having a polarity opposite to that of the drug ion in the DC power source 12 from the base support 14 side, and the non-working side electrode. 44, disposed on the front surface of the electrode 44, and selectively passes through an electrode-side electrolyte holding unit 46 that holds the electrolyte, a tip-side electrolyte holding unit 48 that holds the same electrolyte, and ions having the opposite sign to the drug ions The third ion selective film 50 to be formed is laminated in this order.

  The non-working side electrode 44 is connected to the DC power source 12, and the non-working side current collector 44 </ b> A formed by printing on the front surface of the resin sheet 36 apart from the working side current collector 24 </ b> A of the working side electrode 24. The non-working side adhesive layer 44C disposed on the front surface of the non-working side current collector 44A and the non-working side adhesive layer 44C are disposed on the front surface of the non-working side adhesive layer 44C. The non-working side polarizable electrode 44B is electrically connected to and bonded to the current collector 44A. From the viewpoint of conductivity, a conductive adhesive may be used for the non-working side adhesive layer 44C. The non-working side current collector 44A is formed by applying a conductive paint containing conductive powder. As the conductive powder in the conductive paint, any conductive powder can be used. For example, carbon powder, silver powder, or a mixture of carbon powder and silver powder can be used.

  The non-working-side polarizable electrode 44B has a thickness substantially equal to that of the intermediate support 16 (non-working-side intermediate support 16C) and is formed on the intermediate support 16 (non-working-side intermediate support 16C). It is stored in the through hole 41A. Further, the tip side electrolyte solution holding portion 48 has a thickness substantially equal to that of the tip support body 18 (non-working side tip support body 18C), and is inactive formed on the tip support body 18 (non-working side tip support body 18C). It is accommodated in the side tip through hole 42A.

  As shown in enlarged views in FIGS. 2 and 3, on the front surface of the resin sheet 36, the working current collector 24A and the non-working current collector 44A, and the working conductor 19A and the non-working conductor 19B are provided. The working side current collector 24A and the non-working side current collector 44A are respectively connected to the working side conducting wire 19A and the non-working side conducting wire 19B which are formed by continuously printing in a film shape. Yes. These working side conducting wire 19A and non-working side conducting wire 19B are made of the same material as the working side current collector 24A and the non-working side current collector 44A, respectively.

  These working-side conducting wire 19A and non-working-side conducting wire 19B are connected to the DC power source 12 via a connector 19C at their tips. Further, in the working side conducting wire 19A and the non-working side conducting wire 19B, an insulating film 19D made of, for example, a polyimide film is adhered to the side surface opposite to the resin sheet 36. The insulating film 19D has a length that covers a range where the working side conductive wire 19A and the non-working side conductive wire 19B are in contact with the resin sheet 36 and a certain range of a protruding portion from the resin sheet 36.

  In this embodiment, the iontophoresis device 10 is configured by stacking the circular members shown in FIGS. 1 and 4 in the thickness direction and integrally as shown in FIG.

  Reference numeral 56 in FIGS. 1 and 4 denotes an adhesive, which is an intermediate portion between the working film and non-working current collectors 24A and 44A between the insulating film 19D and the intermediate support 16. The working and non-working side current collectors 24A and 44A are electrically isolated from the working side and the non-working side.

  Reference numeral 58 in FIGS. 1 and 4 denotes a release liner that covers the first ion selective membrane 32 and the third ion selective membrane 50 and is releasably attached to the front surface of the tip support 18.

  Next, materials, components, etc. will be described for each of the above components.

  The chemical liquid holding unit 30 is configured by impregnating a PP (polypropylene) non-woven fabric with a viscous liquid containing a drug. In addition, the drug impregnated in the drug solution holding unit 30 contains positive or negative ions (drugs that dissociate into drug ions (including drug precursors)) by dissolving in a solvent such as water. Examples of drugs that dissociate medicinal ingredients into positive ions include lidocaine hydrochloride, which is an anesthetic, morphine hydrochloride, which is an anesthetic, and drugs that dissociate medicinal ingredients into negative ions include vitamins. A certain ascorbic acid etc. can be illustrated.

  In addition to the above, hormones, DNA, RNA, proteins, amino acids, minerals, and liposomes are also included.

  The electrode side electrolyte solution holding part 46 in the non-working side electrode structure 40 is obtained by impregnating a PP non-woven fabric with a viscous liquid containing an electrolyte solution (detailed later). The tip side electrolyte solution holding part 48 is also made by impregnating a PP nonwoven fabric with a viscous liquid containing the same electrolyte solution.

  The electrolyte used in the electrode-side electrolyte holding unit 46 and the tip-side electrolyte holding unit 48 is mainly composed of an electrolyte, and this electrolyte is oxidized or oxidized rather than water electrolysis (oxidation at the anode and reduction at the cathode). It is particularly preferable to use electrolytes that are easily reduced, for example, pharmaceutical agents such as ascorbic acid (vitamin C) and sodium ascorbate, organic acids such as lactic acid, oxalic acid, malic acid, succinic acid, fumaric acid and / or salts thereof. Preferably, it is possible to suppress the generation of oxygen gas and hydrogen gas, and by blending a plurality of types of electrolytes that become buffer electrolytes when dissolved in a solvent, the pH during energization can be reduced. Variations can be suppressed.

  The viscous liquid containing the drug or the electrolyte as described above can be obtained by chemically treating, for example, water (ion-exchanged water), HPC (hydroxypropyl cellulose) (for example, H-Type of Nippon Soda Co., Ltd.), or cellulose insoluble in water. It can be produced by mixing 2% by mass or more of a sticky material such as Metrose (for example, 90SH-10000SR manufactured by Shin-Etsu Chemical Co., Ltd.) which is treated to give a water-soluble polymer.

Both the working side polarizable electrode 24B in the working side electrode 24 and the non-working side polarizable electrode 44B in the non-working side electrode 44 are mainly composed of a conductive base material formed of activated carbon, preferably activated carbon fiber or carbon fiber paper. Configured as an ingredient. When only activated carbon fibers are used as the working side and non-working side polarizable electrodes 24B and 44B, a layer may be formed by combining cloth and felt made of activated carbon fibers. In this case, the working-side polarizable electrode 24B may be impregnated with a viscous liquid containing the same drug as the drug held in the drug solution holding unit 30, and the non-working-side polarizable electrode 44B It is preferable to impregnate a viscous liquid containing the same electrolytic solution as the electrolytic solution held in the electrolytic solution holding part 46. Further, for example, a layer in which activated carbon is dispersed in a binder polymer may be laminated on the conductive substrate. As the activated carbon, one having a specific surface area of 10 m ² / g or more may be used.

  Both the working current collector 24A in the working electrode 24 and the non-working side current collector 44A in the non-working side electrode 44 are obtained by printing a PET (polyethylene terephthalate) material mixed with carbon and an adhesive. It is a printed electrode.

  The material for the working current collector 24A and the non-working current collector 44A may be any material as long as it has conductivity. In addition to carbon, a conductive metal such as gold, platinum, silver, copper, or zinc may be used. It may be used. In addition, a conductive material itself such as carbon or gold may be used as the current collector without printing. The same applies to the materials of the working conductor 19A and the non-working conductor 19B. Further, the working side current collector 24A and the working side conducting wire 19A may be made of different materials, and similarly, the non-working side current collector 44A and the non-working side conducting wire 19B may be made of different materials. .

  The separator 26 is obtained by impregnating a PP non-woven fabric with a viscous liquid containing the same drug as the drug held in the drug solution holding unit 30. The separator 26 includes a working side polarizable electrode 24 </ b> B and a second ion selective membrane 28. By interposing them in between, physical contact between the two is prevented.

  The first ion selective membrane 32 is configured to include an ion exchange resin into which an ion exchange group is introduced so as to selectively pass ions having the same sign as the drug ions.

  The second ion selective membrane 28 is configured to contain an ion exchange resin into which an ion exchange group has been introduced so as to selectively pass ions having opposite signs to drug ions.

  Similar to the second ion selective membrane 28, the third ion selective membrane 50 is configured to include an ion exchange resin into which ion exchange groups are introduced so as to selectively pass ions having opposite signs to the drug ions. ing.

  As the DC power source 12, a button battery or a thin battery disclosed in, for example, Japanese Patent Application Laid-Open No. 11-067236, US Patent Publication No. 2004 / 0185667A1, US Pat. No. 6,855,441, or the like can be used. The structure of the present embodiment is not limited.

  In addition, the working and non-working side electrodes, the chemical solution holding portion, the ion selective membrane, and the first to fourth through holes can take a circular, quadrangular, hexagonal, or other shape.

  Next, the effect of this embodiment will be described.

  In this iontophoresis device 10, both the working side electrode 24 and the non-working side electrode 44 are composed of a current collector and a polarizable electrode, so that the electrode reaction during energization in the conventional iontophoresis device is performed. In the state where the electrode reaction is reduced, or the electrolyte solution or the drug can be energized. As a result, generation of gas such as oxygen gas, chlorine gas or hydrogen gas, or Generation of undesirable ions such as hydrogen ions, hydroxyl ions and hypochlorous acid can be suppressed or reduced.

  The penetration mechanism of drug ions into the skin in the iontophoresis device 10 is considered as follows. That is, when the working side current collector 24A is connected to the DC power source 12 by the working side conducting wire 19A and a DC voltage having the same polarity as that of drug ions is applied, a DC voltage is applied to the working side polarizable electrode 24B. An electric double layer is formed at the interface between the viscous liquid containing sucrose and the working-side polarizable electrode 24B, and the drug ions move to the skin side by an electric force and pass through the first ion-selective membrane 32 in the skin. It is a mechanism that penetrates into

  Next, the working side electrode 24 and the non-working side electrode 44 will be further described with reference to FIG.

  As shown in an enlarged view in FIG. 3, in the working side electrode 24, a working side adhesive layer 24C is provided over the entire surface between the working side polarizable electrode 24B and the working side current collector 24A. Electrical connection between the polarizable electrode 24B and the working current collector 24A is ensured. A conductive adhesive is used as the working side adhesive layer 24C.

  As the conductive adhesive, any adhesive that does not adversely affect the living body can be used. For example, a conductive material such as silver powder, copper powder, or carbon fiber mixed with a resin that does not adversely affect the living body. An adhesive can be used. As the resin, it is preferable to use an epoxy resin or a phenol resin from the viewpoint of chemical resistance. For example, when the working side polarizable electrode 24B is impregnated with a viscous liquid containing lidocaine hydrochloride as a chemical solution, the lidocaine hydrochloride exhibits an acidity, and when impregnated with a viscous liquid containing a sodium chloride solution as an electrolyte solution, it exhibits alkalinity. Because there are things.

  As described above, the working-side polarizable electrode 24B may be impregnated with a viscous liquid containing the same drug as the drug held in the drug solution holding unit 30, and the non-working-side polarizable electrode 44B The viscous liquid containing the same electrolytic solution as the electrolytic solution held in the electrode-side electrolytic solution holding part 46 is preferably impregnated, but the working-side adhesive is provided between the working-side polarizable electrode 24B and the working-side current collector 24A. When the layer 24C is provided over the entire surface using a conductive adhesive, it is unlikely that a viscous liquid including a chemical solution penetrates to the contact interface between the working side polarizable electrode 24B and the working side current collector 24A. The electrical contact between the side polarizable electrode 24B and the working current collector 24A is kept good.

  In the non-working side electrode 44, a non-working side adhesive layer 44C is provided over the entire surface using a conductive adhesive between the non-working side polarizable electrode 44B and the non-working side current collector 44A. Electrical connection between the non-working side polarizable electrode 44B and the non-working side current collector 44A is ensured. Thus, the non-working side electrode 44 has the same configuration as the working side electrode 24.

  Next, main parts of an iontophoresis device according to another embodiment will be described with reference to FIGS.

  When the conductive adhesive is used over the entire surface as in the above-described embodiment, the amount of the adhesive that decreases the surface area of the polarizable electrode increases, so that the working side portion formed when a DC voltage is applied is increased. There is also a possibility that the amount of reduction in the area of the electric double layer at the interface between the polar electrode 24B and the viscous liquid containing the drug solution will increase, and the amount of reduction in the electrical force that drives the drug ions into the skin may also increase.

  Therefore, in this embodiment, as shown in FIGS. 6 and 7, working-side adhesive layers 24D corresponding to the working-side adhesive layer 24C are provided at a plurality of locations separated from each other, and working-side bonding is performed. The agent layer 24D does not cover the entire surface facing the working side polarizable electrode 24B and the working side current collector 24A.

  As described above, when the working-side adhesive layer is provided at a plurality of locations separated from each other on the front surface of the working-side current collector 24A and becomes 24D in FIGS. 6 and 7, the working-side polarizable electrode 24B and Compared with the case where the working-side adhesive layer 24C is provided over the entire surface between the working-side current collector 24A, the amount of the adhesive that decreases the surface area of the polarizable electrode is reduced. The amount of decrease in the area of the electric double layer at the interface between the working-side polarizable electrode 24B formed and the viscous liquid containing the drug solution is also smaller than when the entire surface is covered, and the electric ions that drive drug ions into the skin. The amount of decrease in force is also small. In addition, the heating with respect to the adhesive may be less than in the case of covering the entire surface, the manufacture is easy, and the cost is reduced.

  Further, the same effect can be obtained when the non-working side adhesive layer is provided at a plurality of locations separated from each other on the front surface of the non-working side current collector 44A to be 44D in FIGS.

  In addition, since it is considered that organic solvent components harmful to the human body are used in the conductive adhesive to dissolve the resin-based components, when the conductive adhesive is cured, it is heated and dried under reduced pressure conditions. It is preferable to remove the organic solvent component.

1 is an exploded perspective view showing an iontophoresis device according to an embodiment of the present invention. The top view which expands and shows the working side electrode and non-working side electrode part in the iontophoresis apparatus which concerns on one Embodiment of this invention Enlarged sectional view taken along line III-III in FIG. 1 is an exploded sectional view showing an iontophoresis device according to an embodiment of the present invention. Sectional drawing which shows the assembly state of the iontophoresis apparatus which concerns on one Embodiment of this invention. Sectional drawing which expands and shows the principal part of the iontophoresis apparatus which concerns on other embodiment of this invention. The top view which expands and shows the principal part of the iontophoresis apparatus which concerns on other embodiment of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 ... Iontophoresis apparatus 12 ... DC power supply 14 ... Base end support 16 ... Intermediate support 16B ... Working side intermediate support 16C ... Non-working side intermediate support 18 ... Tip support 18B ... Action side tip support 18C ... non-working side tip support 14A, 16A, 18A ... adhesive layer 19A ... working side lead 19B ... non-working side lead 19C ... connector 19D ... insulating film 20 ... working side electrode structure 21A ... working side intermediate through hole 22A ... working Side tip through-hole 24 ... working side electrode 24A ... working side current collector 24B ... working side polarizable electrode 24C, 24D ... working side adhesive layer 25, 45 ... tapered surface 26 ... separator 28 ... second ion selective membrane 30 ... Chemical solution holding part 32 ... First ion selective membrane 36 ... Resin sheet 40 ... Non-working side electrode structure 41A ... Non-working side intermediate through hole 42A ... Non-working side tip penetration 44 ... Non-working side electrode 44A ... Non-working side current collector 44B ... Non-working side polarizable electrode 44C, 44D ... Non-working side adhesive layer 46 ... Electrode side electrolyte holding part 48 ... Tip side electrolyte holding part 50 ... Third ion selective membrane 56 ... Adhesive 58 ... Release liner

Claims (10)

A pair of electrode structures and a direct current power source connected to the pair of electrode structures, and drug ions held in one of the pair of electrode structures are converted into a living body by a voltage from the direct current power source. An iontophoresis device for administration to
At least one of the pair of electrode structures is disposed on a current collector connected to the DC power source, an adhesive layer disposed on the front surface of the current collector, and on a front surface of the adhesive layer. An iontophoresis device comprising: a polarizable electrode bonded to the current collector by an agent layer. In claim 1,
The iontophoresis device, wherein the polarizable electrode contains activated carbon. In claim 2,
An iontophoresis device, wherein the activated carbon is activated carbon fiber. In any one of Claims 1 thru | or 3,
The iontophoresis device, wherein the current collector contains at least one of carbon and silver as a conductive substance. In any one of Claims 1 thru | or 4,
The iontophoresis device, wherein the adhesive layer is provided at a plurality of locations separated from each other on the front surface of the current collector. In any one of Claims 1 thru | or 4,
The iontophoresis device, wherein the adhesive layer is provided over the entire surface between the current collector and the polarizable electrode. In any one of Claims 1 thru | or 6.
The iontophoresis device, wherein the adhesive layer is made of a conductive adhesive. In claim 7,
An iontophoresis device, wherein the conductive adhesive comprises at least one of an epoxy resin and a phenol resin. In any one of Claims 1 thru | or 8.
Of the pair of electrode structures, the electrode structure that holds the drug ions is a working electrode structure, and the working electrode structure is provided with a working electrode as the electrode,
The working electrode is disposed on the working current collector connected to the DC power source, on the working adhesive layer disposed on the front surface of the working current collector, and on the front surface of the working adhesive layer. The working-side polarizable electrode adhered to the working-side current collector by the working-side adhesive layer,
An iontophoresis device, wherein the working-side polarizable electrode is impregnated with a viscous liquid containing the drug ions. In any one of Claims 1 thru | or 9,
Of the pair of electrode structures, the electrode structure that does not hold the drug ions is a non-working-side electrode structure that has an electrolyte solution holding unit that holds an electrolyte solution. Is provided with a non-working side electrode as the electrode,
The non-working side electrode includes a non-working side current collector connected to the DC power source, a non-working side adhesive layer disposed on the front surface of the non-working side current collector, and the non-working side adhesive layer. A non-working side polarizable electrode disposed on the front surface and adhered to the non-working side current collector by the non-working side adhesive layer;
An iontophoresis device, wherein the non-working side polarizable electrode is impregnated with a viscous liquid containing the electrolytic solution.

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