JP2008167995A - Printing electrode member and iontophoresis device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To reduce bias in electric current density distribution in an electrode part. <P>SOLUTION: An electrode member includes: a sheet shape base body; a power feeding part printed on the base body with the use of a conductive material and electrically connected to an external part; and the electrode part printed on the base body with the use of the conductive material, wherein the electrode part and the power feeding part are arranged so that a straight line which connects the two outer circumferential points of the electrode part and traverses the power feeding part is drawn, and wherein the electrode part and the power feeding part are insulated in a part other than the contact part and its circumference. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a printed electrode member and an iontophoresis device including the printed electrode member. In particular, the present invention relates to an iontophoresis device for transdermally administering drug ions by iontophoresis, and a printed electrode member used therefor.

Known is a device that transdermally administers drug ions by iontophoresis to the surface of a living body such as skin or mucous membrane (hereinafter collectively referred to as “skin”) in a desired part of a human or animal body. (For example, see Patent Document 1). In addition, iontophoresis (iontophoresis) may be called iontophoresis, iontophoresis, ion osmosis therapy, etc.
JP 2000-229128 A

  13 and 14 schematically show printed electrode layers that can be used in the apparatus disclosed in Patent Document 1. FIG. 13 shows a plan view of the printed electrode member 50. In FIG. 13, the insulating protective layer 92 in the right power feeding unit 73 is omitted for the sake of explanation. 14 shows a side view of the printed electrode member 50 as viewed from the arrow A side in FIG. FIG. 14 is a side view enlarged in the thickness direction (vertical direction) to make it easy to see the arrangement of each part. The printed electrode member 50 is formed by coating a base 55 formed of a PET (polyethylene terephthalate) film and a conductive paint containing conductive powder such as carbon powder on the base 55 by a method such as printing. Insulating protective layer formed by coating, for example, an electrically insulating ink on the side opposite to the base 55 side of the power supply units 70 and 73 and the electrode portions 60 and 63 and the power supply units 70 and 73 by a method such as printing. 92. Here, when the printed electrode member 50 is used in an iontophoresis device, the electrode portions 60 and 63 come into contact with the electrolytic solution holding portions or the drug holding portions of the working side electrode portion and the non-working side electrode portion, respectively. At this time, the power feeding units 70 and 73 electrically connect the power source of the iontophoresis device and the electrode units 60 and 63, respectively, when the print electrode member 50 is used in the iontophoresis device.

  As shown in FIGS. 13 and 14, in the printed electrode member 50, each of the pair of power feeding portions 70 and 73 is electrically connected to each of the pair of electrode portions 60 and 63 at the outer peripheral portion thereof. Here, when power is supplied to the electrode units 60 and 63 from the power supply of the iontophoresis device, the electrode units 60 and 63 exhibit good conductivity but the resistance is not 0. In this plane, the current density in the vicinity of the portion connected to the power supply units 70 and 73 is the highest, and the current density decreases as the distance from the portion connected to the power supply units 70 and 73 increases. Such bias in the distribution of current density occurs when the iontophoresis is applied using an iontophoresis device and part of the part where the skin comes into contact with the working electrode part and the non-working electrode part. There may be undesirable effects such as concentration of electric current or reduction of drug administration efficiency.

  In order to solve the above problems, in the first embodiment of the present invention, a sheet-like base, a power feeding part printed on the base with a conductive material and electrically connected to the outside, and a conductive material on the base In an electrode member comprising a printed electrode part, the electrode part and the power supply part are arranged so that a straight line crossing the power supply part can be drawn by connecting two points on the outer periphery of the electrode part. And a printed electrode member that is insulated outside the periphery thereof. Thereby, the bias | inclination of the current density distribution in the electrode part of a printing electrode member can be made small.

  In the printed electrode member, the shortest distance between the straight line farthest from the contact part and the shortest distance between the contact parts among the straight lines crossing the power feeding part may be 3 mm or more. Further, the shortest distance between the straight line farthest from the contact part and the contact part among the straight lines crossing the power feeding part may be 5 mm or more, and may be 10 mm or more. Thereby, the bias | inclination of the current density distribution of an electrode part can be made smaller.

  In the above printed electrode member, the shortest distance between the contact portion and the straight line farthest from the contact portion among the straight lines crossing the power feeding portion is 1 / of the distance to the outer periphery of the electrode portion on the opposite side across the contact portion. It may be 4 or more. In addition, the shortest distance between the straight line farthest from the contact part and the contact part among the straight lines crossing the power supply part is ½ or more of the distance from the contact part to the outer periphery of the electrode on the opposite side across the contact part. It may be 1/1 or more. Thereby, the bias of the current density distribution of the electrode part can be further reduced.

  In the second embodiment of the present invention, a sheet-like substrate, a power feeding unit printed on the substrate with a conductive material and electrically connected to the outside, an electrode unit printed on the substrate with a conductive material, and an electrode In an electrode member including an insulating part that electrically insulates between the power feeding part and the electrode part except for the central part of the part, the power feeding part is superimposed on the electrode part, and the insulating part includes the power feeding part and the electrode part A printed electrode member is provided that includes an insulating layer printed therebetween. As a result, it is possible to electrically connect the electrode part and the power feeding part at the center of the electrode part while insulating the power feeding part and the electrode part without changing the shape of the electrode part. Can be further reduced.

  In a third aspect of the present invention, the working electrode structure includes a working electrode structure, a non-working electrode structure, and a power source connected to the working electrode structure and the non-working electrode structure. An iontophoresis device for administering drug ions held in a body to a living body by a voltage from a power source, wherein each of a working electrode structure and a non-working side electrode structure is electrically connected to a power source. The printed electrode member is connected to a sheet-like substrate, printed on the substrate with a conductive material, electrically connected to the outside, and printed on the substrate with a conductive material. The electrode part and the power supply part are arranged so that a straight line crossing the power supply part can be drawn by connecting two points on the outer periphery of the electrode part, and the electrode part and the power supply part are other than the contact part and the periphery thereof. Is insulated. According to such an iontophoresis device, since the bias of the current density distribution in the electrode portion of the printed electrode member is small, it is more uniform with respect to the skin in contact with the working electrode structure and the non-working electrode structure. Drug ions can be administered at a concentration.

  According to a fourth aspect of the present invention, the working electrode structure includes a working electrode structure, a non-working electrode structure, and a power source connected to the working electrode structure and the non-working electrode structure. An iontophoresis device for administering drug ions held in a body to a living body by a voltage from a power source, wherein each of a working electrode structure and a non-working electrode structure is electrically connected to a power source. The printed electrode member is connected to a sheet-like substrate, printed on the substrate with a conductive material, electrically connected to the outside, and printed on the substrate with a conductive material. And an insulating part that electrically insulates between the power feeding part and the electrode part except for the central part of the electrode part, the power feeding part is superimposed on the electrode part, and the insulating part is a power feeding part And an insulating layer printed between the electrode portions. Thereby, in the iontophoresis device, the electrode part and the power feeding part can be electrically connected at the center of the electrode part while insulating the power feeding part and the electrode part without changing the shape of the electrode part. The bias in the current density distribution of the part can be further reduced.

  The above summary of the invention does not enumerate all the necessary features of the present invention, and sub-combinations of these feature groups can also be the invention.

  In addition, the “drug” in the present specification, regardless of whether or not it is prepared, treats, recovers or prevents a disease, promotes or maintains health, diagnoses a medical condition or health condition, or promotes or maintains beauty. It means a substance administered to a living body for the purpose of.

  In addition, “drug ion” in the present specification means an ion generated by ion dissociation of a drug. Dissociation of a drug into drug ions may be caused by dissolving the drug in a solvent such as water, alcohols, acids, or alkalis, and may be caused by applying a voltage or adding an ionizing agent. There may be.

  In addition, the “medical solution” in the present specification refers to a fluid containing drug ions, and includes not only a solution in which a drug is dissolved in a solvent and a liquid state such as a stock solution in the case where the drug is in a liquid state, but also a drug. As long as at least a part of the drug dissociates into drug ions, it includes those in various states such as those in which the drug is suspended or emulsified in a solvent or the like, and those prepared in the form of an ointment or paste.

  In the present specification, “first conductivity type” means positive or negative electric polarity, and “second conductivity type” means a conductivity type (minus or plus) opposite to the first conductivity type.

  Hereinafter, the present invention will be described through embodiments of the invention. However, the following embodiments do not limit the invention according to the scope of claims, and all combinations of features described in the embodiments are included. It is not necessarily essential for the solution of the invention.

  FIG. 1 shows a top view of the iontophoresis device 10. FIG. 2 is a cross-sectional view taken along the line aa in FIG. As shown in FIGS. 1 and 2, the iontophoresis device 10 includes a printed electrode member 51, a working electrode structure 20, a non-working electrode structure 30, a first support 41, a second support 42, A third support 43 and a power source 80 are included. The printed electrode member 51 is electrically connected to the power supply 80, and the electrode portions 61 and 64 are directed toward the contact surface 45 with the skin so that the printed electrode member 51 is interposed between the first support body 41 and the second support body 42. Sandwiched between. Details of the printed electrode member 51 will be described later. Here, two openings of a predetermined shape (circular in this embodiment) are formed in the second support 42 and the third support 43, and the configuration of the working electrode structure 20 is formed in one of these two openings. Components are arranged on the other side, and components on the non-working side electrode structure 30 are arranged on the other side. The first support 41, the second support 42 and the third support 43 are made of a flexible material such as polyurethane foam so that the iontophoresis device 10 can be easily brought into contact with uneven skin. In addition, even when the user moves, the contact surface 45 can be made difficult to separate from the skin.

  The working electrode structure 20 includes a first electrolyte solution holding unit 21, a second conductivity type ion-selective membrane 22, a chemical solution holding unit 24, from the first support 41 side toward the contact surface 45 side. The first conductivity type ion-selective film 25 is provided in this order. The non-working side electrode structure 30 includes a second electrolyte solution holding unit 31, a first conductivity type ion-selective membrane 32, and a third electrolyte solution from the first support 41 side toward the contact surface 45 side. It has the holding | maintenance part 34 and the 2nd conductivity type ion selective film 35 in this order. The electrode part 61 of the printed electrode member 51 contacts the first electrolyte solution holding part 21 of the working electrode structure 20, and the electrode part 64 is the second electrolyte solution holding part 31 of the non-working electrode structure 30. Abut. Here, the 1st electrolyte solution holding | maintenance part 21 and the 2nd electrolyte solution holding | maintenance part 31 are examples of the connection object of the electrode parts 61 and 64, respectively.

  In the working-side electrode structure 20, the first electrolyte solution holding unit 21 is a carrier having an appropriate absorbability such as a woven or non-woven fabric of natural fibers, artificial fibers, a porous film, or a gel. Hold. As the electrolytic solution, a solution in which a compound that has an oxidation-reduction potential lower than the oxidation-reduction potential of water as compared with the electrolysis reaction of water (oxidation and reduction reaction of water) is dissolved is used.

  The second conductivity type ion-selective membrane 22 is provided on the contact surface 45 side of the first electrolyte solution holding unit 21 and selectively transmits ions of the second conductivity type. The medicinal solution holding unit 24 impregnates and holds a medicinal solution containing drug ions of the first conductivity type in a carrier having an appropriate absorbability such as a woven or non-woven fabric of natural fibers or artificial fibers, a porous membrane, or a gel. To do. The first conductivity type ion-selective film 25 is provided on the contact surface 45 side of the chemical solution holding part 24 and selectively transmits the first conductivity type ions.

  In the non-working side electrode structure 30, the second electrolyte solution holding unit 31 and the third electrolyte solution holding unit 34 are, for example, natural fibers, woven fabrics or nonwoven fabrics of artificial fibers, porous films, gels, or other suitable absorbability And holds the electrolyte solution. The first conductivity type ion-selective membrane 32 is provided on the contact surface 45 side of the second electrolyte solution holding unit 31 and selectively transmits the first conductivity type ions. The third electrolyte solution holding unit 34 is provided on the contact surface 45 side of the first conductivity type ion selective membrane 32. The second conductivity type ion-selective film 35 is provided on the contact surface 45 side of the third electrolyte solution holding part 34 and selectively transmits ions of the second conductivity type. In addition, the electrolyte solution held by the second electrolyte solution holding unit 31 and the third electrolyte solution holding unit 34 is the same as the electrolyte solution held by the first electrolyte solution holding unit 21 of the working electrode structure 20. A solution in which a compound easily oxidized and reduced having a redox potential lower than the redox potential of water as compared with the electrolysis reaction (water oxidation and reduction reaction) is used.

  An adhesive layer for enhancing the adhesion to the skin can be formed on the skin side of the first conductivity type ion selective membrane 25 and the second conductivity type ion selective membrane 35. Further, a peelable liner covering the contact surface 45, the first conductivity type ion-selective membrane 25, and the second conductivity type ion-selective membrane 35 can also be attached to the skin side of the adhesive layer. . As a result, it is possible to prevent foreign matter from being mixed and dried during storage of the iontophoresis device 10.

  The iontophoresis device 10 is configured so that the working-side electrode structure 20 and the non-operating state are supplied from the power source 80 in a state where the first-conductivity-type ion-selective membrane 25 and the second-conductivity-type ion-selective membrane 35 are in contact with the skin. When power for applying iontophoresis is supplied to the side electrode structure 30 (voltage is applied), the skin is interposed between the working electrode structure 20 and the non-working side electrode structure 30. The electric current flows through and enters the use state.

  Here, the specific configuration of the iontophoresis device 10 will be further described by taking as an example the case where the drug ion is an anion. In this case, the first conductivity type is negative and the second conductivity type is positive. That is, the electrode part 61 that contacts the first electrolyte solution holding part 21 of the working electrode structure 20 serves as a cathode, and the electrode part 64 that contacts the second electrolyte solution holding part 31 of the non-working electrode structure 30 serves as an anode. Become. In the working electrode structure 20, a cation exchange membrane is used for the second conductivity type ion selective membrane 22, and an anion exchange membrane is used for the first conductivity type ion selective membrane 25. In the non-working side electrode structure 30, an anion exchange membrane is used for the first conductivity type ion selective membrane 32, and a cation exchange membrane is used for the second conductivity type ion selective membrane 35.

  The iontophoresis device 10 has the following effects in a use state in which electricity is passed through the skin. That is, in the working electrode structure 20, the drug ions contained in the drug solution held by the drug solution holding unit 24 move to the opposite side (skin side) of the cathode electrode unit 61 by electrophoresis, and the drug solution holding unit 24 It permeates through the first conductivity type ion selective membrane 25 disposed on the skin side and in contact with the skin and quickly penetrates into the skin. On the other hand, cations in the living body do not pass through the first conductivity type ion selective membrane 25 and move to the chemical solution holding unit 24 side. Therefore, drug ions can be efficiently introduced into a living body by iontophoresis under a stable energized state. In addition, the cation paired with the drug ion, which is an anion, contained in the chemical solution holding part 24 moves to the electrode part 61 side and permeates the second conductivity type ion selective membrane 22 which is a cation exchange membrane. 1 Move to the electrolyte solution holding unit 21 side. Accordingly, in the energized state, the ion balance of the chemical solution holding unit 24 is not lost, and thus the pH is hardly changed. Therefore, since the energization resistance is difficult to increase, it is possible to suppress a decrease in drug ion transport efficiency.

  In the non-working side electrode structure 30, the compound dissolved in the electrolyte held by the third electrolyte holding unit 34 is a compound having a redox potential lower than that of water. At 64, no water electrolysis reaction occurs. Therefore, it is possible to prevent the energization resistance from increasing due to the contact between the electrode part 64 and the electrolyte solution held by the third electrolyte solution holding part 34 by bubbles (oxygen gas) generated by the electrolysis reaction of water. Can do.

  When the drug ion is a cation, the first conductivity type is positive and the second conductivity type is negative. Therefore, the electrical polarities of the electrode unit 61 and the electrode unit 64 in the iontophoresis device 10 shown in FIGS. 1 and 2 are reversed, and the second conductivity type ion selective film 22 and the first conductivity type are reversed. The types (ion selective characteristics) of the ion selective film 25, the first conductive type ion selective film 32, and the second conductive type ion selective film 35 are opposite to each other.

  FIG. 3 shows a plan view of the printed electrode member 51. FIG. 4 is a cross-sectional view taken along the line bb of FIG. FIG. 5 is a cross-sectional view taken along the line cc of FIG. In FIG. 3, the insulating protective layer 93 in the right power feeding portion 74 is omitted for the sake of explanation. Further, in the cross-sectional views after FIG. 4, the thickness of each component is exaggerated for the sake of explanation. As shown in FIGS. 3 to 5, the printed electrode member 51 includes a flexible base 56 formed of a PET (polyethylene terephthalate) film, and a pair of electrode portions 61 and 64 formed on the base 56. A pair of power feeding units 71 and 74 and an insulating protective layer 93 formed on the side opposite to the base 56 side of the power feeding units 71 and 74 are provided. The printed electrode member 51 is formed, for example, by applying a conductive paint containing a conductive material having conductivity such as silver and silver chloride or carbon on the substrate 56 by a method such as printing, and the electrode portions 61 and 64 and a pair of power feeding portions. 71 and 74 are formed, and an insulating protective layer 93 is formed by coating the power supply portions 71 and 74 with, for example, an electrically insulating ink by a method such as printing. Here, one end of the power supply units 71 and 74 is electrically connected to the central part of the electrode units 61 and 64, and the other end of the power supply units 71 and 74 is electrically connected to the power source 80 to be electrically connected. Connected to. In FIG. 4, the insulating protective layer 93 may enter between the power feeding unit 71 and the power feeding unit 74.

  Here, as shown in FIG. 3, the electrode unit 64 and the power supply unit 74 are arranged so that a straight line that crosses the power supply unit 74 by connecting two points X and X ′ on the outer periphery of the electrode unit 64 can be drawn. Further, the electrode portion 64 and the power feeding portion 74 are insulated by the separation portion 91 except for the contact portion Y and its periphery. In this case, the shortest distance between the contact portion Y and the straight line (XX ′) farthest from the contact portion Y among the straight lines traversing the power feeding portion 64 is the opposite side of the contact portion Y and the contact portion Y. It is preferably 1/4 or more of the distance to the electrode portion outer periphery Z, more preferably 1/2 or more, and further preferably 1/1 or more. In the form shown in FIG. 3, the shortest distance between the straight line (XX ′) farthest from the contact portion Y and the contact portion Y is the distance from the contact portion Y to the opposite electrode portion outer periphery Z that sandwiches the contact portion Y. About 1/1 of the distance. Further, the shortest distance between the straight line (XX ′) farthest from the contact portion Y and the contact portion Y is preferably 3 mm or more, more preferably 5 mm or more, and further preferably 10 mm or more.

  More specifically, as shown in FIGS. 3 and 5, in the printed electrode member 51, a separation portion 91 is provided between the power supply portion 71 and the electrode portion 61 in the vicinity of the center portion from the outer peripheral portion of the electrode portion 61. It is done. Similarly, a separation portion 91 is provided between the power feeding portion 74 and the electrode portion 64 in the vicinity of the center portion from the outer peripheral portion of the electrode portion 64. The spacing portion 91 is an example of the insulating portion of the present invention, and is formed by not printing the conductive paint. In addition to this, the insulating protective layer 93 may be extended and provided in the separation portion 91. The spacing portion 91 separates the power feeding portion 71 and the electrode portion 61 within the plane of the base body 56 except for the central portion of the electrode portion 61. Similarly, the separation portion 91 separates the power feeding portion 74 and the electrode portion 64 except for the central portion of the electrode portion 64. Therefore, one end opposite to the one electrically connected to the power supply outside the power feeding units 71 and 74 is electrically connected to the center of the electrode units 61 and 64, respectively.

  When electric power is supplied from the power source 80 connected to one end of the power feeding units 71 and 74 to the printed electrode member 51, current flows in the electrode units 61 and 64 from the central part toward the peripheral part. At this time, the distance between the part where the current flows in each of the electrode parts 61 and 64 (the part electrically connected to each of the power feeding parts 71 and 74) and the part farthest in the plane direction of the electrode parts 61 and 64 is 13 and FIG. 14, a portion where current flows in each of the electrode portions 60 and 63 of the printed electrode member 50 shown in FIGS. 13 and 14 (a portion electrically connected to the power feeding portions 70 and 73) and the surface of the electrode portions 60 and 63 therefrom. It is smaller than the distance from the farthest part in the direction. Therefore, the current density distribution in the electrode portions 61 and 64 of the printed electrode member 51 is less biased than the current density distribution in the electrode portions 60 and 63 of the printed electrode member 50.

  In the iontophoresis device 10, the electrode part 61 of the printed electrode member 51 is in contact with the first electrolyte holding part 21, and the electrode part 64 is in contact with the second electrolyte holding part 31. Yes. At this time, the insulating protective layer 93 is configured such that the power feeding unit 71 and the power feeding unit 74 and the first electrolytic solution are in regions where the power feeding unit 71 and the power feeding unit 74 overlap with the first electrolyte solution holding unit 21 and the second electrolyte solution holding unit 31, respectively. The holding unit 21 and the second electrolyte solution holding unit 31 are electrically insulated. Therefore, the power feeding unit 71 and the power feeding unit 74 are connected to the first electrolytic solution holding unit 21 and the second electrolytic solution holding unit from portions other than the portions that are electrically connected to the electrode unit 61 and the electrode unit 64 at their central portions, respectively. No power is supplied to 31. Therefore, the power feeding unit 71 and the power feeding unit 74 can reliably supply power to the center of each of the electrode unit 61 and the electrode unit 64.

  The iontophoresis device 10 may include a print electrode member 52 described below instead of the print electrode member 51. FIG. 6 shows a plan view of the printed electrode member 52. FIG. 7 is a sectional view taken along the line dd in FIG. FIG. 8 is a sectional view taken along the line ee of FIG. The printed electrode member 52 shown in FIGS. 6 to 8 is manufactured by a method such as printing according to the following procedure, for example. First, a pair of electrode portions 62 and 65 and a first insulating layer 95 are formed on a flexible substrate 57 formed of a PET (polyethylene terephthalate) film. Next, a pair of conductive portions 76 and 77 and a second insulating layer 96 are formed. Furthermore, the power feeding parts 72 and 75 are formed from above. Finally, an insulating protective layer 94 is formed on the power feeding units 72 and 75. Here, the electrode parts 62 and 65, the conductive parts 76 and 77, and the power feeding parts 72 and 75 are formed of a conductive paint containing a conductive material having conductivity such as silver and silver chloride or carbon, for example, and the first insulating layer 95, the second insulating layer 96, and the insulating protective layer 94 are formed of, for example, ink having electrical insulation.

  As shown in FIG. 7, the conductive portions 76 and 77 formed at the center of the electrode portions 62 and 65 are electrically connected by being in physical contact with the electrode portions 62 and 65. The power feeding portions 72 and 75 are formed from the outer peripheral portion to the central portion of the electrode portions 62 and 65, and one end thereof is connected to the conductive portions 76 and 77 in the central portion of the electrode portions 62 and 65, and the other end is connected to the power source 80. Each is electrically connected. The second insulating layer 96 is an example of an insulating portion of the present invention, and in a portion other than a portion electrically connected to the conductive portions 76 and 77 among portions overlapping the electrode portions 62 and 65 in the power feeding portions 72 and 75. The electrode parts 62 and 65 and the power feeding parts 72 and 75 are electrically insulated.

  When electric power is supplied from the power source 80 connected to one end of the power feeding units 72 and 75 to the printed electrode member 52 having the above-described configuration, in the electrode units 62 and 65, a current flows from the central portion toward the peripheral portion. Therefore, as in the case of the print electrode member 51 described above, the current density distribution in the electrode portions 62 and 65 of the print electrode member 52 is less biased than the current density distribution in the electrode portions 60 and 63 of the print electrode member 50. Further, the printed electrode member 52 may not be provided with the separating portion 91 like the printed electrode member 51 in a part of the electrode portions 62 and 65. Therefore, the electrode portions 62 and 65 of the print electrode member 52 have a greater degree of freedom in shape than the electrode portions 61 and 64 of the print electrode member 51, and the bias in the current density distribution can be further reduced.

  In the iontophoresis device 10 described above, when the printed electrode member 52 is used instead of the printed electrode member 51, the electrode portion 62 of the printed electrode member 52 is in contact with the first electrolyte solution holding portion 21, and The electrode part 65 is in contact with the second electrolyte solution holding part 31. At this time, the insulating protective layer 94 includes the power feeding unit 72 and the power feeding unit 75 in the region where the power feeding unit 72 and the power feeding unit 75 overlap the first electrolyte solution holding unit 21 and the second electrolyte solution holding unit 31, respectively. The holding unit 21 and the second electrolyte solution holding unit 31 are electrically insulated. Therefore, the power feeding unit 72 and the power feeding unit 75 supply power to the first electrolytic solution holding unit 21 and the second electrolytic solution holding unit 31 from portions other than the portions that are electrically connected to the conductive unit 76 and the conductive unit 77, respectively. There is no supply. Therefore, the power feeding unit 72 and the power feeding unit 75 can reliably supply power to the center of each of the electrode unit 62 and the electrode unit 65.

  The iontophoresis device 10 may include a printed electrode member 53 described below instead of the printed electrode member 51. FIG. 9 shows a plan view of the printed electrode member 53. FIG. 10 is a sectional view taken along the line ff of FIG. FIG. 11 is a cross-sectional view taken along the line gg of FIG. In the printed electrode member 53 shown in FIGS. 9 to 11, members having the same configurations and functions as those of the printed electrode member 52 shown in FIGS. 6 to 8 are denoted by the same reference numerals and description thereof is omitted.

  As shown in FIG. 9, the printed electrode member 53 has a shape in which the base body 57 is formed by connecting two rectangles with rounded corners, and the electrode parts 62 and 65 are each a rectangle with rounded corners. To the printed electrode member 52 shown in FIG. Further, four electrode portions 62 are arranged apart from each other. These four electrode portions 62 are electrically connected to each other by a power feeding portion 72 and a conductive portion 77 as shown in FIG. The configuration of the electrode unit 65 is the same, but the description is omitted.

  Here, as shown in FIG. 9, the electrode unit 65 and the power supply unit 75 are arranged so that a straight line that crosses the power supply unit 75 by connecting two points V and V ′ on the outer periphery of the electrode unit 65 can be drawn. Further, the electrode portion 65 and the power feeding portion 75 are insulated by the separation portion 91 except for the contact portion U and its periphery. In this case, the shortest distance between the contact portion Y and the straight line (VV ′) farthest from the contact portion U among the straight lines crossing the power feeding portion 75 is the opposite side of the contact portion Y and the contact portion Y. It is 1/1 or more of the distance to the electrode portion outer periphery W. Thereby, the bias of the current density distribution in the electrode portions 62 and 65 of the printed electrode member 53 is reduced.

  The iontophoresis device 10 using the printed electrode members 51, 52, and 53 described above has a working electrode structure 20 and a non-working electrode structure 30 as compared with the case where the printed electrode member 50 is used. The bias of the current density distribution in the usage state becomes smaller. Therefore, drug ions can be administered to the skin at a more uniform concentration.

  FIG. 12 shows a cross-sectional view of another example of the iontophoresis device 10. In the iontophoresis device 10, instead of the working electrode structure 20 and the non-working electrode structure 30 described above, a working electrode structure 26 and a non-working electrode structure 36 having the internal configuration shown in FIG. May be provided.

  The working-side electrode structure 26 of the iontophoresis device 10 shown in FIG. Similarly to the chemical solution holding unit 24 of the working electrode structure 20, the chemical solution holding unit 27 is a chemical solution containing the first conductive type drug ions, for example, natural fibers, woven or non-woven fabrics of artificial fibers, porous membranes, and the like. Alternatively, it is impregnated and held in a carrier having an appropriate absorbency such as a gel. In addition, the non-working side electrode structure 36 has an electrolyte solution holding part 37. Similarly to the second electrolytic solution holding unit 31 and the third electrolytic solution holding unit 34, the electrolytic solution holding unit 37 is a suitable absorbent such as a natural fiber, an artificial fiber woven or non-woven fabric, a porous film, or a gel. It is a carrier having a property and retains an electrolyte solution. Since the working electrode structure 26 and the non-working electrode structure 36 are simpler than the working electrode structure 20 and the non-working electrode structure 30, the number of components may be reduced. it can.

In the present embodiment, examples of drug ions used for iontophoresis include the following. Positively charged drug ions include anesthetic agents (such as procaine hydrochloride and lidocaine hydrochloride), gastrointestinal disease treatment agents (such as carnitine chloride), skeletal muscle relaxants (such as bancronium bromide), and antibiotics (tetracycline and kanamycin formulations). And gentamicin preparations). As negatively charged drug ions, vitamin (hereinafter abbreviated as V) agents (VB ₂ , VB ₁₂ , VC, VE, folic acid, etc.), corticosteroids (hydrocortisone water-soluble preparations, dexamethasone water-soluble preparations, prednisolone) Water-soluble preparations), antibiotics (penicillin-based water-soluble preparations, chromium-phenicol-based water-soluble preparations), and the like.

  Further, the voltage for applying iontophoresis may be a pulse voltage as in a low frequency treatment device, for example. Further, the voltage may be gradually increased or decreased. The current flowing through the body is preferably in the range of 0.01 to 5 mA, but can be increased or decreased depending on the area of the electrode portions 60, 61, 62, 63, 64, 65, the administration site, and individual differences between recipients, Set to a level that does not cause pain or heat.

  As mentioned above, although this invention was demonstrated using embodiment, the technical scope of this invention is not limited to the range as described in the said embodiment. It will be apparent to those skilled in the art that various modifications or improvements can be added to the above-described embodiment. It is apparent from the scope of the claims that the embodiments added with such changes or improvements can be included in the technical scope of the present invention.

A top view of the iontophoresis device 10 is shown. Sectional drawing in the aa cross section of FIG. 1 is shown. The top view of the printed electrode member 51 is shown. Sectional drawing in the bb cross section of FIG. 3 is shown. Sectional drawing in the cc cross section of FIG. 3 is shown. The top view of the printed electrode member 52 is shown. Sectional drawing in the dd cross section of FIG. 6 is shown. Sectional drawing in the ee cross section of FIG. 6 is shown. The top view of the printing electrode member 53 is shown. Sectional drawing in the ff cross section of FIG. 9 is shown. FIG. 11 is a cross-sectional view taken along the line gg of FIG. A sectional view of another example of the iontophoresis device 10 is shown. The top view of the printed electrode member 50 is shown. The side view which looked at the printed electrode member 50 from the arrow A side of FIG. 13 is shown.

Explanation of symbols

  10, 11 Iontophoresis device, 20, 26 Working electrode structure, 21 First electrolyte holding unit, 22 Second conductivity type ion selective membrane, 24, 27 Chemical solution holding unit, 25 First conductivity type Ion-selective membrane, 30, 36 Non-working side electrode structure, 31 Second electrolyte holding unit, 32 First conductivity type ion selective membrane, 34 Third electrolyte holding unit, 35 Second conductivity type ion selection Conductive film, 37 electrolyte holding part, 41 first support, 42 second support, 43 third support, 45 abutting surface, 50, 51, 52, 53 printed electrode member, 55, 56, 57, 58 Base, 60, 61, 62, 63, 64, 65, 66, 67 Electrode part, 70, 71, 72, 73, 74, 75 Power feeding part, 76, 77 Conductive part, 80 Power source, 91 Spacing part, 92, 93 , 94 insulating protective layer, 95 first insulating layer, 6 the second insulating layer

Claims (10)

A sheet-like substrate;
A power feeding unit printed on the base with a conductive material and electrically connected to the outside;
In an electrode member comprising an electrode portion printed with a conductive material on the substrate,
The electrode part and the power feeding part are arranged so that a straight line crossing the power feeding part can be drawn by connecting two points on the outer periphery of the electrode part,
A printed electrode member in which the electrode part and the power feeding part are insulated at portions other than the contact part and the periphery thereof.   2. The printed electrode member according to claim 1, wherein a shortest distance between the straight line farthest from the contact part and the contact part among the straight lines crossing the power feeding part is 3 mm or more.   The printed electrode member according to claim 2, wherein the shortest distance between the straight line farthest from the contact part and the shortest distance among the straight lines crossing the power feeding part is 5 mm or more.   The printed electrode member according to claim 3, wherein a shortest distance between a straight line farthest from the contact point and a shortest distance among the straight lines crossing the power feeding unit is 10 mm or more.   The shortest distance between the straight line farthest from the contact part and the contact part among the straight lines crossing the power feeding part is the distance to the outer periphery of the electrode part on the opposite side across the contact part and the contact part. The printed electrode member according to claim 1, which is ¼ or more.   The shortest distance between the straight line farthest from the contact part and the contact part among the straight lines crossing the power feeding part is the distance to the outer periphery of the electrode part on the opposite side across the contact part and the contact part. The printed electrode member according to claim 5, which is ½ or more.   Of the straight lines crossing the power feeding part, the shortest distance between the straight line farthest from the contact part and the contact part is 1 of the distance to the outer periphery of the electrode part on the opposite side across the contact part and the contact part. The printed electrode member according to claim 6, which is / 1 or more. A sheet-like substrate;
A power feeding unit printed on the base with a conductive material and electrically connected to the outside;
An electrode portion printed with a conductive material on the substrate;
In an electrode member comprising an insulating part that electrically insulates between the power feeding part and the electrode part except for the central part of the electrode part,
The power feeding part is superimposed on the electrode part,
The said insulating part is a printed electrode member containing the insulating layer printed between the said electric power feeding part and the said electrode part. A working electrode structure;
A non-working side electrode structure;
A power source connected to the working electrode structure and the non-working electrode structure;
An iontophoresis device for administering drug ions held in the working electrode structure to a living body by a voltage from the power source,
Each of the working side electrode structure and the non-working side electrode structure has a printed electrode member electrically connected to a power source,
The printed electrode member is:
A sheet-like substrate;
A power feeding unit printed on the base with a conductive material and electrically connected to the outside;
An electrode portion printed with a conductive material on the substrate;
The electrode part and the power feeding part are arranged so that a straight line crossing the power feeding part can be drawn by connecting two points on the outer periphery of the electrode part,
An iontophoresis device in which the electrode part and the power feeding part are insulated except for the contact part and the periphery thereof. A working electrode structure;
A non-working side electrode structure;
A power source connected to the working electrode structure and the non-working electrode structure;
An iontophoresis device for administering drug ions held in the working electrode structure to a living body by a voltage from the power source,
Each of the working side electrode structure and the non-working side electrode structure has a printed electrode member electrically connected to a power source,
The printed electrode member is:
A sheet-like substrate;
A power feeding unit printed on the base with a conductive material and electrically connected to the outside;
An electrode portion printed with a conductive material on the substrate;
In an electrode member comprising an insulating part that electrically insulates between the power feeding part and the electrode part except for the central part of the electrode part,
The power feeding part is superimposed on the electrode part,
The iontophoresis device, wherein the insulating unit includes an insulating layer printed between the power feeding unit and the electrode unit.

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