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JP2005029535A - Antiseptic bactericide, and cosmetic, medicine and food compounded therewith - Google Patents

Antiseptic bactericide, and cosmetic, medicine and food compounded therewith Download PDF

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JP2005029535A
JP2005029535A JP2003272667A JP2003272667A JP2005029535A JP 2005029535 A JP2005029535 A JP 2005029535A JP 2003272667 A JP2003272667 A JP 2003272667A JP 2003272667 A JP2003272667 A JP 2003272667A JP 2005029535 A JP2005029535 A JP 2005029535A
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antiseptic
alkanediol
octanediol
tea tree
tree oil
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JP3965628B2 (en
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Hironari Okamoto
裕也 岡本
Fumihiro Okada
文裕 岡田
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Mandom Corp
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02Acyclic compounds
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/16Emollients or protectives, e.g. against radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations

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Abstract

<P>PROBLEM TO BE SOLVED: To obtain an antiseptic bactericide improved in the antibacterial power of 1,2-octanediol by compounding 1,2-octanediol with tea tree oil, and provide cosmetics, medicines and foods compounded with the antiseptic bactericide. <P>SOLUTION: The antiseptic bactericide contains a 5-10C alkanediol and the tea tree oil as active components. The cosmetics, medicines and foods are compounded with the antiseptic bactericide. The 1,2-alkanediol is preferably 1,2-hexanediol or 1,2-octanediol, especially preferably 1,2-octanediol. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

本発明は防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品に係り、その目的は、炭素数5〜10の1,2−アルカンジオールとティーツリー油とを有効成分として配合することにより、1,2−アルカンジオールが本来有する抗菌力を増強する防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品を提供することにある。   The present invention relates to an antiseptic disinfectant and cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant, and its purpose is to combine 1,2-alkanediol having 5 to 10 carbon atoms and tea tree oil as active ingredients. Accordingly, an object of the present invention is to provide an antiseptic and bactericidal agent that enhances the antibacterial activity inherent to 1,2-alkanediol, and cosmetics, pharmaceuticals and foods containing the antiseptic and bactericidal agent.

化粧品(医薬部外品を含む)、医薬品及び食品などには、防腐殺菌剤として、パラベン、安息香酸類、サリチル酸類等が用いられている。しかしながら、上記した従来の防腐殺菌剤は皮膚刺激性が高いなど安全性が低いため、使用濃度範囲が制限されやすいといった欠点を有していた。例えば、パラベンや安息香酸塩の使用制限濃度は1%、安息香酸やサリチル酸の使用制限濃度は0.2%とされている。また、これら防腐殺菌剤はpHによる影響を受け易いため、防腐殺菌効果の安定性が悪く、界面活性剤などの他の配合成分との併用によりその防腐抗菌効果が著しく低下する場合があるといった問題も有していた。また、近年これらの防腐殺菌剤に対してアレルギー反応を起こす人が増えているために生活者の安全性に対する指向がより高まり、防腐殺菌剤を全く配合していないか、或いはその配合量を低減させた化粧料、医薬品及び食品の需要が高まっている。   Parabens, benzoic acids, salicylic acids, and the like are used as antiseptic fungicides in cosmetics (including quasi drugs), pharmaceuticals, and foods. However, the above-mentioned conventional antiseptic disinfectant has a drawback that the concentration range in use is easily limited because of low safety such as high skin irritation. For example, the use restriction concentration of paraben and benzoate is 1%, and the use restriction concentration of benzoic acid and salicylic acid is 0.2%. In addition, since these antiseptic fungicides are easily affected by pH, the stability of the antiseptic disinfection effect is poor, and the antibacterial antibacterial effect may be significantly reduced when used in combination with other components such as surfactants. Also had. In recent years, the number of people who cause allergic reactions to these antiseptics has increased, so consumers are more likely to be safe and have no or no preservatives. There is a growing demand for cosmetics, pharmaceuticals and foods.

防腐殺菌剤を低減又は排除する技術として、1,2−アルカンジオールからなる防腐殺菌剤(特許文献1参照)や、1,2−オクタンジオールからなる洗浄性又は非洗浄性化粧料用保湿静菌剤(特許文献2参照)などが開示されている。しかし、1,2−オクタンジオールなどの1,2−アルカンジオールを単独で防腐殺菌剤として用いた場合、非イオン性界面活性剤が存在すると高配合量を必要とする場合があった。また、1,2−アルカンジオールは、特有の原料臭を有することから、化粧料に配合した際の臭いの問題を有していた。   As a technique for reducing or eliminating the antiseptic disinfectant, an antiseptic disinfectant composed of 1,2-alkanediol (see Patent Document 1), and a moisturizing bacteriostatic agent for cleansing or non-detergent cosmetics composed of 1,2-octanediol An agent (see Patent Document 2) is disclosed. However, when a 1,2-alkanediol such as 1,2-octanediol is used alone as an antiseptic disinfectant, a high blending amount may be required in the presence of a nonionic surfactant. Moreover, since 1,2-alkanediol has a peculiar raw material odor, it has a problem of odor when blended in cosmetics.

また、1,2−アルカンジオールを用いた防腐殺菌剤に関する技術として、1,2−ペンタンジオールと2−フェノキシエタノールを組み合わせて配合した外用組成物(特許文献3参照)や、1,2−アルカンジオールとパラベンからなる防腐殺菌剤(特許文献4参照)が開示されている。しかし、これらは、防腐剤と1,2−ペンタンジオールなどの1,2−アルカンジオールを併用して防腐剤の効果を向上させようとするものであって、防腐剤自体を完全に排除しようとするものではなく、また、1,2−アルカンジオールが有する抗菌力を増強させようとするものでもない。   Moreover, as a technique related to an antiseptic fungicide using 1,2-alkanediol, an external composition (see Patent Document 3) in which 1,2-pentanediol and 2-phenoxyethanol are combined and 1,2-alkanediol is used. And an antiseptic disinfectant composed of paraben (see Patent Document 4). However, these are intended to improve the effect of the preservative by using a preservative and a 1,2-alkanediol such as 1,2-pentanediol in an attempt to completely eliminate the preservative itself. It is not intended to enhance the antibacterial activity of 1,2-alkanediol.

特開平11−322591号公報Japanese Patent Laid-Open No. 11-322591 特開2001−48720号公報JP 2001-48720 A 特開平10−53510号公報JP-A-10-53510 特開平11−310506号公報JP 11-310506 A

本発明は前記従来技術に鑑みてなされたものであって、1,2−アルカンジオールとティーツリー油とを有効成分として共に用いると、1,2−アルカンジオールが本来有する抗菌力を増強することができる防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品を提供することを課題とする。   The present invention has been made in view of the prior art, and when 1,2-alkanediol and tea tree oil are used together as active ingredients, the antibacterial activity inherent in 1,2-alkanediol is enhanced. It is an object of the present invention to provide an antiseptic and bactericidal agent that can be used and cosmetics, pharmaceuticals, and foods that contain the antiseptic and bactericide.

すなわち、請求項1に係る発明は、炭素数5〜10の1,2−アルカンジオールと、ティーツリー油とを有効成分として含有することを特徴とする防腐殺菌剤に関する。
請求項2に係る発明は、前記1,2−アルカンジオールが、1,2−ヘキサンジオール及び/又は1,2−オクタンジオールであることを特徴とする請求項1に記載の防腐殺菌剤に関する。
請求項3に係る発明は、前記1,2−アルカンジオールが、1,2−オクタンジオールであることを特徴とする請求項1に記載の防腐殺菌剤に関する。
請求項4に係る発明は、防腐殺菌剤として請求項1〜3のいずれかに記載の防腐殺菌剤を配合したことを特徴とする化粧料、医薬品又は食品に関する。
That is, the invention according to claim 1 relates to an antiseptic fungicide characterized by containing 1,2-alkanediol having 5 to 10 carbon atoms and tea tree oil as active ingredients.
The invention according to claim 2 relates to the antiseptic fungicide according to claim 1, wherein the 1,2-alkanediol is 1,2-hexanediol and / or 1,2-octanediol.
The invention according to claim 3 relates to the antiseptic fungicide according to claim 1, wherein the 1,2-alkanediol is 1,2-octanediol.
The invention which concerns on Claim 4 is related with cosmetics, a pharmaceutical, or a foodstuff which mix | blended the antiseptic disinfectant in any one of Claims 1-3 as an antiseptic disinfectant.

1,2−アルカンジオールが本来有する抗菌力が増強された防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品を提供することができる。   It is possible to provide an antiseptic and bactericidal agent with enhanced antibacterial activity inherent to 1,2-alkanediol, and cosmetics, pharmaceuticals and foods containing the antiseptic and bactericidal agent.

本発明に係る防腐殺菌剤は、1,2−アルカンジオールとティーツリー油を有効成分として含有する。   The antiseptic disinfectant according to the present invention contains 1,2-alkanediol and tea tree oil as active ingredients.

本発明に係る第一の成分は、炭素数5〜10の直鎖状のアルキル鎖を有する1,2−アルカンジオールであり、具体的には、1,2−ペンタンジオール、1,2−ヘキサンジオール、1,2−ヘプタンジオール、1,2−オクタンジオール、1,2−ノナンジオール、1,2−デカンジオールである。これらのうち、1,2−ヘキサンジオール、1,2−オクタンジオールを用いるのが好ましく、1,2−オクタンジオールを用いるのがより好ましい。尚、本発明においては、これらの1種を単独で、又は2種以上を組み合わせて用いることもできる。   The first component according to the present invention is 1,2-alkanediol having a linear alkyl chain having 5 to 10 carbon atoms, specifically 1,2-pentanediol, 1,2-hexane. Diol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, and 1,2-decanediol. Of these, 1,2-hexanediol and 1,2-octanediol are preferably used, and 1,2-octanediol is more preferably used. In addition, in this invention, these 1 type can also be used individually or in combination of 2 or more types.

本発明に係る防腐殺菌剤の第二の成分は、ティーツリー油である。ティーツリー油とは、オーストラリア原産の植物であるティーツリー(Melaleuca alternifolia)の葉、樹皮、または樹木から水蒸気蒸留又は有機溶媒によって抽出される精油である。このようなティーツリー油は、市販されているティーツリー油(ティーツリーオイル)を用いることもできる。   The second component of the antiseptic disinfectant according to the present invention is tea tree oil. Tea tree oil is an essential oil extracted from leaves, bark or trees of tea tree (Melaleuca alternifolia), a plant native to Australia, by steam distillation or organic solvent. Commercially available tea tree oil (tea tree oil) can also be used as such tea tree oil.

本発明に係る防腐殺菌剤においては、第一の成分である1,2−アルカンジオールと第二の成分であるティーツリー油の含有量は特に限定されないが、重量比で0.1:1〜10:1、好ましくは0.2:1〜5:1となるように配合する。1,2−アルカンジオールをティーツリー油の含有量の10重量倍を超えて配合すると、また0.1重量倍未満の場合、抗菌力の増強効果が期待できないために好ましくない。   In the antiseptic fungicide according to the present invention, the content of 1,2-alkanediol as the first component and tea tree oil as the second component is not particularly limited, but is 0.1: 1 to 1 by weight. It mix | blends so that it may be 10: 1, Preferably 0.2: 1-5: 1. If 1,2-alkanediol is added in excess of 10 times the content of tea tree oil, and if it is less than 0.1 times, it is not preferable because an antibacterial effect cannot be expected.

本発明に係る防腐殺菌剤は、第一の成分である炭素数5〜10の1,2−アルカンジオールと、第二の成分であるティーツリー油とを含有するから、後述する試験に示されるように、第一の成分と第二の成分との相乗効果によって、抗菌力の優れた増強作用が発揮される。したがって、パラベン、安息香酸類、サリチル酸類のような従来から用いられる防腐殺菌剤を低配合又は配合する必要がなく、極めて安全性の高い防腐殺菌剤を得ることができる。   The antiseptic disinfectant according to the present invention contains 1,2-alkanediol having 5 to 10 carbon atoms, which is the first component, and tea tree oil, which is the second component. As described above, the synergistic effect of the first component and the second component exerts an excellent antibacterial activity. Therefore, it is not necessary to blend or blend conventionally used antiseptics such as parabens, benzoic acids, and salicylic acids, and an extremely safe antiseptic can be obtained.

本発明の防腐殺菌剤は、化粧料、医薬品及び食品などに配合して使用することができる。具体的には、洗顔剤、化粧水、乳液、スキンクリーム、ファンデーション、マスカラ、ネールエナメル、口紅等の皮膚用化粧料、シャンプー、ヘアトリートメント、育毛・養毛剤、ヘアクリーム、ヘアフォーム、パーマネントウェーブ剤などの頭髪用化粧料、しみやそばかすなどの特定の使用目的を有した薬用化粧料(医薬部外品)、にきび治療薬、うがい薬、トローチ等の医薬品、チューインガム、キャンディー、飲料水等の食品に好適に用いることができる。   The antiseptic disinfectant of the present invention can be used by blending it in cosmetics, pharmaceuticals, foods and the like. Specifically, facial cleanser, lotion, milky lotion, skin cream, foundation, mascara, nail enamel, lipstick and other skin cosmetics, shampoo, hair treatment, hair growth / hair restorer, hair cream, hair foam, permanent wave agent, etc. Cosmetics for specific hair use such as hair cosmetics, stains and freckles (quasi-drugs), acne medicines, gargles, lozenges, and other foods such as chewing gum, candy, and drinking water It can be used suitably.

本発明の防腐殺菌剤を用いて化粧料、医薬品又は食品を調製する場合、本発明の効果を損なわない範囲内であれば、化粧料、医薬品又は食品に通常用いられる成分を適宜任意に配合することができる。例えば、化粧料(医薬部外品を含む)や医薬品の場合、油脂、ロウ類、高級脂肪酸、低級アルコール、高級アルコール、ステロール類、脂肪酸エステル、保湿剤、界面活性剤、高分子化合物、無機顔料、色素、酸化防止剤、紫外線吸収剤、ビタミン類、収斂剤、美白剤、動植物抽出物、金属イオン封鎖剤、精製水等を例示することができる。また、食品の場合は、動植物油、多糖類、甘味料、着色料、ガムベース等を例示することができる。   When preparing cosmetics, pharmaceuticals or foods using the antiseptic disinfectant of the present invention, the components usually used in cosmetics, pharmaceuticals or foods are optionally arbitrarily blended as long as the effects of the present invention are not impaired. be able to. For example, in the case of cosmetics (including quasi-drugs) and pharmaceuticals, fats and oils, waxes, higher fatty acids, lower alcohols, higher alcohols, sterols, fatty acid esters, humectants, surfactants, polymer compounds, inorganic pigments , Pigments, antioxidants, ultraviolet absorbers, vitamins, astringents, whitening agents, animal and plant extracts, sequestering agents, purified water, and the like. In the case of food, animal and vegetable oils, polysaccharides, sweeteners, colorants, gum bases and the like can be exemplified.

化粧料、医薬品又は食品に本発明の防腐殺菌剤を配合する場合、配合量は特に限定されないが、組成物中0.01〜20重量%、好ましくは0.05〜5重量%である。配合量が0.01重量%未満の場合、抗菌効果に劣るために、また、20重量%を超えて配合したとしてもそれ以上の効果が望めないからである。   When the antiseptic disinfectant of the present invention is blended in cosmetics, pharmaceuticals or foods, the blending amount is not particularly limited, but is 0.01 to 20% by weight, preferably 0.05 to 5% by weight in the composition. This is because when the amount is less than 0.01% by weight, the antibacterial effect is inferior, and even if the amount exceeds 20% by weight, no further effect can be expected.

実施例1
(共試菌)
共試菌としてStaphylococcus aureus IFO13276(黄色ブドウ状球菌)を用いた。
Example 1
(Co-test)
Staphylococcus aureus IFO13276 (Staphylococcus aureus) was used as a co-test fungus.

(接種用菌液の調製)
接種用菌液としては、寒天培地で35℃で培養後、更にブイヨン培地に移植して35℃で培養した。得られた培養液をブイヨン培地で約10個/mlに希釈したものを接種用菌液とした。
(Preparation of bacterial solution for inoculation)
As a bacterial solution for inoculation, after culturing at 35 ° C. on an agar medium, it was further transplanted to a bouillon medium and cultured at 35 ° C. A solution obtained by diluting the obtained culture solution to about 10 8 cells / ml with a bouillon medium was used as a bacterial solution for inoculation.

(被験物質の希釈系列の調製)
20w/w%エチルセルソルブを希釈溶媒とし、5w/v%の1,2−オクタンジオール液(母液)を調製した。この母液を倍倍希釈して、10段階の希釈系列を調製した。また、ティーツリー油(ヴェ・マン・フィス香料社製)及び1,2−オクタンジオールとティーツリー油の等量混合物についても、同様にして、それぞれ10段階の希釈系列を調製した。
(Preparation of dilution series of test substance)
A 20 w / w% ethyl cellosolve was used as a diluent solvent to prepare a 5 w / v% 1,2-octanediol liquid (mother liquid). This mother liquor was diluted twice to prepare a 10-stage dilution series. Similarly, a 10-stage dilution series was prepared for tea tree oil (manufactured by We Mann Fis Fragrance) and an equivalent mixture of 1,2-octanediol and tea tree oil.

(最小発育阻止濃度(MIC)の測定)
上記被験物質を含む希釈系列を加えた各寒天培地をシャーレに入れ、それぞれについて、上記接種用菌液を約1cmの長さに画線した。培養は35℃で行い、2日後の菌の生育の有無を判定した。このとき、生育が認められなかった最小の濃度をMICとして求めた。その結果、1,2−オクタンジオールは2250μg/ml、ティーツリー油は5000μg/ml、1,2−オクタンジオールとティーツリー油の等重量混合物は2500μg/mlであった。
尚、MICによって、抗菌力を評価することができる。被験物質の濃度が薄いときには微生物への影響はないが、濃度を増していくと発育抑制が起こる。この程度は、濃度に依存して発育抑制が進み、ついには発育が停止する。このときの濃度がMICとして表される。したがって、MIC以上の濃度になると、微生物は死滅していくことになる。
(Measurement of minimum inhibitory concentration (MIC))
Each agar medium to which a dilution series containing the test substance was added was placed in a petri dish, and the inoculum for the inoculum was streaked to a length of about 1 cm. The culture was performed at 35 ° C., and the presence or absence of growth of the bacteria after 2 days was determined. At this time, the minimum concentration at which no growth was observed was determined as MIC. As a result, 1,2-octanediol was 2250 μg / ml, tea tree oil was 5000 μg / ml, and an equal weight mixture of 1,2-octanediol and tea tree oil was 2500 μg / ml.
In addition, antibacterial power can be evaluated by MIC. When the test substance concentration is low, there is no effect on microorganisms, but growth increases when the concentration is increased. This degree of growth proceeds depending on the concentration, and finally the growth stops. The concentration at this time is expressed as MIC. Therefore, when the concentration is higher than MIC, the microorganisms are killed.

(二元最小発育阻止濃度)
得られた1,2−オクタンジオール、ティーツリー油、及び1,2−オクタンジオールとティーツリー油の等重量混合物の各MICを、1,2−オクタンジオール及びティーツリー油の配合量に対してプロットし、二元最小発育阻止濃度図を求めた。結果を図1に示す。
尚、二元最小発育阻止濃度により、抗菌性を有する二種類の物質を配合した場合の作用効果を判定することができる。具体的には、抗菌性を有する二種類の物質を配合した場合、それにより生ずる作用は、相乗作用、相加作用、拮抗作用に大別される。相乗作用とは、二薬剤が相乗的に作用し、本来有する抗菌力が更に増強される作用である。相加作用とは、各薬剤の抗菌力が合わさった作用である。拮抗作用とは、一薬剤が他剤の抗菌力を打ち消す場合の作用である。そして、二元最小発育阻止濃度図による方法は、例えば、図2に示すように、A物質とB物質について、それぞれの割合を変えてMICを測定し、グラフから判定する方法である。これによると、A物質のみにおけるMIC(点A)とB物質のみにおけるMIC(点B)とをプロットした点を結び、両物質を併用したときのMICが、この線上より内側にある場合(点C)は、併用により抗菌力が増強された相乗作用であると、線上(点D)にある場合は相加作用であると、線上より外側にある場合(点E)は、一方又は双方の抗菌力を打ち消し抗菌力を減少させる拮抗作用であると判定することができる。
(Dual minimum inhibitory concentration)
Each MIC of the obtained 1,2-octanediol, tea tree oil, and an equal weight mixture of 1,2-octanediol and tea tree oil was determined with respect to the blending amount of 1,2-octanediol and tea tree oil. Plotting was performed to obtain a binary minimum inhibitory concentration diagram. The results are shown in FIG.
In addition, the effect at the time of mix | blending two types of substances which have antimicrobial property can be determined with a binary minimum growth inhibitory density | concentration. Specifically, when two types of substances having antibacterial properties are blended, the action caused by the substances is roughly classified into a synergistic action, an additive action, and an antagonistic action. The synergistic action is an action in which two drugs act synergistically to further enhance the inherent antibacterial power. The additive action is an action in which the antibacterial powers of the respective drugs are combined. Antagonism is an action when one drug counteracts the antibacterial activity of another drug. The method based on the binary minimum growth inhibition concentration diagram is, for example, a method of determining from the graph by measuring the MIC for each of the A substance and B substance while changing their ratios as shown in FIG. According to this, when MIC (point A) only for substance A and MIC (point B) only for substance B are connected, the MIC when both substances are used is inside this line (point C) is a synergistic effect in which the antibacterial activity is enhanced by the combined use, if it is on the line (point D), if it is an additive action, if it is outside the line (point E), either or both It can be determined that the antagonistic action counteracts the antibacterial activity and decreases the antibacterial activity.

(抗菌効果の評価)
図1の結果から、1,2−オクタンジオールとティーツリー油との組合せにより、抗菌力の相乗効果が認められた。
(Evaluation of antibacterial effect)
From the result of FIG. 1, the synergistic effect of antibacterial activity was recognized by the combination of 1,2-octanediol and tea tree oil.

以下、本発明の防腐殺菌剤を配合した化粧料、医薬品及び食品の配合例を示す。尚、配合量は重量%である。
(配合例1:保湿クリーム)
モノラウリン酸デカグリセリル 1.0
モノステアリン酸ポリオキシエチレン
グリセリル(15E.O.) 1.0
水素添加大豆リン脂質 1.0
ステアリン酸 4.0
セタノール 2.0
ベヘニルアルコール 2.0
パラフィン 3.0
スクワラン 12.0
ホホバ油 4.0
メチルポリシロキサン 0.2
1,3−ブチレングリコール 3.0
L−アルギニン 0.1
キサンタンガム 0.001
1,2−オクタンジオール 0.25
ティーツリー油 0.1
精製水 残分
合 計 100.0
Hereinafter, formulation examples of cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant of the present invention will be shown. In addition, a compounding quantity is weight%.
(Formulation example 1: moisturizing cream)
Decaglyceryl monolaurate 1.0
Polyoxyethylene monostearate
Glyceryl (15E.O.) 1.0
Hydrogenated soybean phospholipid 1.0
Stearic acid 4.0
Cetanol 2.0
Behenyl alcohol 2.0
Paraffin 3.0
Squalane 12.0
Jojoba oil 4.0
Methyl polysiloxane 0.2
1,3-butylene glycol 3.0
L-Arginine 0.1
Xanthan gum 0.001
1,2-octanediol 0.25
Tea tree oil 0.1
Purified water residue
Total 100.0

(配合例2:親水性軟膏)
アスコルビン酸 0.5
ポリオキシエチレンセチルエーテル 2.0
水素添加大豆リン脂質 1.0
ステアリン酸 4.0
グリセリンモノステアレート 10.0
流動パラフィン 10.0
ワセリン 4.0
セタノール 5.0
プロピレングリコール 5.0
1,2−ヘキサンジオール 0.5
ティーツリー油 0.2
精製水 残分
合 計 100.0
(Formulation example 2: hydrophilic ointment)
Ascorbic acid 0.5
Polyoxyethylene cetyl ether 2.0
Hydrogenated soybean phospholipid 1.0
Stearic acid 4.0
Glycerol monostearate 10.0
Liquid paraffin 10.0
Vaseline 4.0
Cetanol 5.0
Propylene glycol 5.0
1,2-hexanediol 0.5
Tea tree oil 0.2
Purified water residue
Total 100.0

(配合例3:飲料)
アスコルビン酸 0.5
ブドウ糖液糖 33.0
グレープフルーツ果汁 64.0
1,2−ペンタンジオール 0.5
ティーツリー油 0.1
酸味料 適量
合 計 100.0
(Formulation Example 3: Beverage)
Ascorbic acid 0.5
Glucose liquid sugar 33.0
Grapefruit juice 64.0
1,2-pentanediol 0.5
Tea tree oil 0.1
Sour seasoning
Total 100.0

以上詳述した如く、本発明の防腐殺菌剤は、1,2−アルカンジオールが本来有する抗菌力を増強する効果を奏する。よって、従来の防腐殺菌剤を配合する必要がなくなり、高い安全性を得ることもできる。
また、本発明の防腐殺菌剤を配合した化粧料、医薬品及び食品は、パラベン、安息香酸、サリチル酸等の従来の防腐剤を含有する必要がなく、しかも本発明の防腐殺菌剤は優れた増強された抗菌活性を有しているので、防腐殺菌剤自体を低配合量とすることができ、極めて安全性の高いものである。
As described above in detail, the antiseptic disinfectant of the present invention has an effect of enhancing the antibacterial power inherent to 1,2-alkanediol. Therefore, it is not necessary to add a conventional antiseptic disinfectant, and high safety can be obtained.
Further, cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant of the present invention do not need to contain conventional antiseptics such as parabens, benzoic acid and salicylic acid, and the antiseptic disinfectant of the present invention is excellently enhanced. Since the antibacterial activity is high, the antiseptic disinfectant itself can be blended in a low amount, which is extremely safe.

実施例1の二元最小発育阻止濃度図である。2 is a binary minimum growth inhibitory concentration diagram of Example 1. FIG. 二元最小発育阻止濃度から、抗菌性を有する二種類の物質を配合した場合により生じる作用効果を判定する方法の一例を示す図である。It is a figure which shows an example of the method of judging the effect produced by the case where 2 types of substances which have antimicrobial property are mix | blended from binary minimum growth inhibitory density | concentration.

Claims (4)

炭素数5〜10の1,2−アルカンジオールと、ティーツリー油とを有効成分として含有することを特徴とする防腐殺菌剤。 An antiseptic disinfectant comprising, as active ingredients, 1,2-alkanediol having 5 to 10 carbon atoms and tea tree oil. 前記1,2−アルカンジオールが、1,2−ヘキサンジオール及び/又は1,2−オクタンジオールであることを特徴とする請求項1に記載の防腐殺菌剤。 The antiseptic disinfectant according to claim 1, wherein the 1,2-alkanediol is 1,2-hexanediol and / or 1,2-octanediol. 前記1,2−アルカンジオールが、1,2−オクタンジオールであることを特徴とする請求項1に記載の防腐殺菌剤。 The antiseptic disinfectant according to claim 1, wherein the 1,2-alkanediol is 1,2-octanediol. 防腐殺菌剤として請求項1〜3のいずれかに記載の防腐殺菌剤を配合したことを特徴とする化粧料、医薬品又は食品。
A cosmetic, pharmaceutical product or food comprising the antiseptic agent according to any one of claims 1 to 3 as an antiseptic agent.
JP2003272667A 2003-07-10 2003-07-10 Antiseptic disinfectant and cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant Expired - Lifetime JP3965628B2 (en)

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