JP4535744B2 - Antiseptic disinfectant and cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant - Google Patents
Antiseptic disinfectant and cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant Download PDFInfo
- Publication number
- JP4535744B2 JP4535744B2 JP2004039215A JP2004039215A JP4535744B2 JP 4535744 B2 JP4535744 B2 JP 4535744B2 JP 2004039215 A JP2004039215 A JP 2004039215A JP 2004039215 A JP2004039215 A JP 2004039215A JP 4535744 B2 JP4535744 B2 JP 4535744B2
- Authority
- JP
- Japan
- Prior art keywords
- antiseptic
- antiseptic disinfectant
- cosmetics
- octanediol
- pharmaceuticals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002421 anti-septic effect Effects 0.000 title claims description 48
- 239000000645 desinfectant Substances 0.000 title claims description 37
- 239000002537 cosmetic Substances 0.000 title claims description 18
- 235000013305 food Nutrition 0.000 title claims description 17
- 239000003814 drug Substances 0.000 title description 22
- 239000000284 extract Substances 0.000 claims description 25
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims description 24
- 229940031723 1,2-octanediol Drugs 0.000 claims description 23
- 240000004784 Cymbopogon citratus Species 0.000 claims description 23
- 235000017897 Cymbopogon citratus Nutrition 0.000 claims description 23
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
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- 230000001580 bacterial effect Effects 0.000 description 12
- 239000000126 substance Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 10
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- 239000000243 solution Substances 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
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- 239000000417 fungicide Substances 0.000 description 4
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- 241000894007 species Species 0.000 description 4
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- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
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- 230000000855 fungicidal effect Effects 0.000 description 2
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- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
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- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
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- 238000002360 preparation method Methods 0.000 description 2
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- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
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- CUBCNYWQJHBXIY-UHFFFAOYSA-N benzoic acid;2-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1O CUBCNYWQJHBXIY-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
本発明は防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品に係り、その目的は、1,2−オクタンジオールとレモングラス抽出エキスとを有効成分として含有することにより、1,2−オクタンジオールが本来有する抗菌力を増強することができる防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品を提供することにある。 The present invention relates to an antiseptic fungicide and cosmetics, pharmaceuticals and foods containing the antiseptic fungicide, and its purpose is to contain 1,2-octanediol and lemongrass extract as active ingredients, An object of the present invention is to provide an antiseptic and bactericidal agent capable of enhancing the antibacterial power inherent to 2-octanediol, and cosmetics, pharmaceuticals and foods containing the antiseptic and bactericidal agent.
化粧品(医薬部外品を含む)、医薬品及び食品などには、防腐殺菌剤として、パラベン、安息香酸類、サリチル酸類等が用いられている。しかしながら、上記した従来の防腐殺菌剤は皮膚刺激性が高いなど安全性が低いため、使用濃度範囲が制限されやすいといった欠点を有していた。例えば、パラベンや安息香酸塩の使用制限濃度は1%、安息香酸やサリチル酸の使用制限濃度は0.2%とされている。また、これら防腐殺菌剤はpHによる影響を受け易いため、防腐殺菌効果の安定性が悪く、界面活性剤などの他の配合成分との併用によりその防腐抗菌効果が著しく低下する場合があるといった問題も有していた。また、近年これらの防腐殺菌剤に対してアレルギー反応を起こす人が増えているために生活者の安全性に対する指向がより高まり、これら防腐殺菌剤を全く配合していないか、或いはその配合量を低減させた化粧料、医薬品及び食品の需要が高まっている。 Parabens, benzoic acids, salicylic acids, and the like are used as antiseptic fungicides in cosmetics (including quasi drugs), pharmaceuticals, and foods. However, the above-mentioned conventional antiseptic disinfectant has a drawback that the concentration range in use is easily limited because of low safety such as high skin irritation. For example, the use restriction concentration of paraben and benzoate is 1%, and the use restriction concentration of benzoic acid and salicylic acid is 0.2%. In addition, since these antiseptic fungicides are easily affected by pH, the stability of the antiseptic disinfection effect is poor, and the antibacterial antibacterial effect may be significantly reduced when used in combination with other components such as surfactants. Also had. In recent years, the number of people who have allergic reactions to these antiseptic disinfectants has increased, so the consumer safety has become more and more important. There is an increasing demand for reduced cosmetics, pharmaceuticals and foods.
そこで、従来の防腐殺菌剤を低減できる技術として、1,2−ペンタンジオールと2−フェノキシエタノールを組み合わせて配合した外用組成物(特許文献1参照)や、1,2−アルカンジオールとパラベンからなる防腐殺菌剤(特許文献2参照)が開示されている。しかし、これらは、従来の防腐剤と1,2−アルカンジオールを併用して防腐剤の効果を向上させようとするものであって、従来の防腐剤自体を完全に排除しようとするものではなく、また、1,2−アルカンジオールが有する抗菌力を増強させようとするものでもなかった。 Therefore, as a technique capable of reducing the conventional antiseptic disinfectant, an external composition (see Patent Document 1) that is a combination of 1,2-pentanediol and 2-phenoxyethanol, or an antiseptic comprising 1,2-alkanediol and parabens. A disinfectant (see Patent Document 2) is disclosed. However, these are intended to improve the effect of the preservative by using a conventional preservative and 1,2-alkanediol together, and are not intended to completely eliminate the conventional preservative itself. Also, it was not intended to enhance the antibacterial activity of 1,2-alkanediol.
一方、従来の防腐殺菌剤を排除できる技術として、1,2−アルカンジオールからなる防腐殺菌剤(特許文献3参照)や、1,2−オクタンジオールからなる洗浄性又は非洗浄性化粧料用保湿静菌剤(特許文献4参照)などが開示されている。しかし、1,2−オクタンジオールなどの1,2−アルカンジオールを単独で防腐殺菌剤として用いた場合、充分な効果性を得るためには高配合量を必要とする場合があり、また、1,2−アルカンジオールは特有の原料臭を有することから、低配合量でも充分な防腐殺菌効果を発揮できる技術が望まれている。 On the other hand, as a technique that can eliminate the conventional antiseptic disinfectant, an antiseptic disinfectant composed of 1,2-alkanediol (see Patent Document 3) and a moisturizing agent for cleansing or non-detergency cosmetics composed of 1,2-octanediol. A bacteriostatic agent (see Patent Document 4) and the like are disclosed. However, when 1,2-alkanediol such as 1,2-octanediol is used alone as an antiseptic disinfectant, a high blending amount may be required to obtain sufficient effectiveness. Since 2-alkanediol has a peculiar raw material odor, a technology capable of exhibiting a sufficient antiseptic sterilization effect even at a low blending amount is desired.
本発明は前記従来技術に鑑みてなされたものであって、1,2−オクタンジオールと、レモングラス抽出エキスとを共に用いると、幅広い菌種に対して1,2−オクタンジオールが本来有する抗菌力を増強することができる防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品を提供することを課題とする。 The present invention has been made in view of the prior art, and when 1,2-octanediol and lemongrass extract are used together, the antibacterial nature of 1,2-octanediol has a wide variety of bacterial species. It is an object of the present invention to provide an antiseptic / bacterial agent capable of enhancing strength and cosmetics, pharmaceuticals and foods containing the antiseptic / bacterial agent.
すなわち、請求項1の係る発明は、1,2−オクタンジオールと、レモングラス抽出エキスとを含有することを特徴とする防腐殺菌剤に関する。
請求項2に係る発明は、防腐殺菌剤として請求項1に記載の防腐殺菌剤を配合したことを特徴とする化粧料に関する。
請求項3に係る発明は、防腐殺菌剤として請求項1に記載の防腐殺菌剤を配合したことを特徴とする医薬品に関する。
請求項4に係る発明は、防腐殺菌剤として請求項1に記載の防腐殺菌剤を配合したことを特徴とする食品に関する。
That is, the invention according to claim 1 relates to an antiseptic disinfectant characterized by containing 1,2-octanediol and a lemongrass extract.
According to a second aspect of the present invention relates to a cosmetic, characterized in that blended with antiseptic disinfectant according to claim 1 as an antiseptic disinfectant.
The invention according to claim 3 relates to a pharmaceutical comprising the antiseptic disinfectant according to claim 1 as an antiseptic disinfectant.
The invention according to claim 4 relates to a food comprising the antiseptic disinfectant according to claim 1 as an antiseptic disinfectant.
本発明の防腐殺菌剤は、1,2−オクタンジオールが本来有する抗菌力を増強させるという効果を奏する。また、本発明に係る防腐殺菌剤を配合した化粧料、医薬品及び食品は、サリチル酸、安息香酸、パラベンなどの従来の防腐殺菌剤を含有する必要がなく、しかも本発明に係る防腐殺菌剤は優れた抗菌活性を有しているので、防腐殺菌剤自体を低配合とすることができるという効果を奏する。 The antiseptic disinfectant of the present invention has an effect of enhancing the antibacterial activity inherent in 1,2-octanediol. Further, cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant according to the present invention do not need to contain conventional antiseptic disinfectants such as salicylic acid, benzoic acid and parabens, and the antiseptic disinfectant according to the present invention is excellent. Since the antibacterial activity is high, the preservative disinfectant itself can be made low.
本発明に係る防腐殺菌剤は、1,2−オクタンジオールとレモングラス抽出エキスとを有効成分として含有する。 The antiseptic disinfectant according to the present invention contains 1,2-octanediol and lemongrass extract as active ingredients.
本発明に係る第1の成分は、1,2−オクタンジオールであり、より具体的には、1、2−n−オクタンジオールである。1,2−オクタンジオールは、それ自体単独でも抗菌活性を有するが、後述する第2の成分と組合わせることにより、抗菌活性が相乗的に増強される。 The first component according to the present invention is 1,2-octanediol, and more specifically 1,2-n-octanediol. 1,2-octanediol itself has antibacterial activity, but the antibacterial activity is synergistically enhanced by combining with the second component described later.
本発明に係る第2の成分は、レモングラス抽出エキスである。レモングラスは、Cymbopogon citratus Stapf又はC.flexuosus Stapfの学名であるイネ科の植物である。 The second component according to the present invention is a lemongrass extract. Lemongrass is a gramineous plant that is the scientific name of Cymbopogon citratus Stapf or C.flexuosus Stapf.
レモングラス抽出エキスは、レモングラスの葉部、根部、茎部などの各部位を単独で或いは適宜混合して、無水又は含水の有機溶媒、或いは水などで抽出して調製することができるが、市販のレモングラス抽出エキスをそのまま用いることもできる。 Lemongrass extract extract can be prepared by extracting each part of lemongrass leaves, roots, stems, etc. alone or appropriately, and extracting with anhydrous or hydrous organic solvent, water, etc. Commercially available lemongrass extract can be used as it is.
抽出溶媒としては、水のほかに、極性有機溶媒として、メタノール、エタノール、イソプロピルアルコール、n−プロピルアルコール、イソブタノール、n−ヘキサノール、メチルアミルアルコール、2−エチルブタノール、n−オクタノール等の炭素数1〜8の一価アルコール、あるいは、エチレングリコール、プロピレングリコール、1、3−ブチレングリコール、ヘキシレングリコール、エチレングリコールモノメチルエーテル、エチレングリコールモノエチルエーテル、プロピレングリコールモノメチルエーテル、プロピレングリコールモノエチルエーテル、等の炭素数2〜6の多価アルコールあるいはその誘導体、アセトン、メチルアセトン、エチルメチルケトン、イソブチルメチルケトン、メチル−n−プロピルケトン等の炭素数3から6のケトン、あるいは、酢酸エチル、酢酸イソプロピル等の炭素数4〜5のエステル、あるいは、エチルエーテル、イソプロピルエーテル、n−ブチルエーテル等の炭素数4〜8のエーテルが挙げられる。また、非極性有機溶媒としては、石油エーテル、あるいは、n−ブタン、n−ペンタン、n−ヘキサン、n−オクタン等の炭素数4〜8の脂肪族炭化水素、あるいは、四塩化炭素、クロロホルム、ジクロロエタン、トリクロロエチレン等の炭素数1〜2の脂肪族炭化水素のハロゲン化物、あるいは、ベンゼン、トルエン等の炭素数6〜7の芳香族炭化水素等が挙げられ、水やエタノールが好ましく用いられる。 As an extraction solvent, in addition to water, polar organic solvents such as methanol, ethanol, isopropyl alcohol, n-propyl alcohol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol, n-octanol, etc. 1-8 monohydric alcohols, or ethylene glycol, propylene glycol, 1,3-butylene glycol, hexylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, etc. Carbons such as C 2-6 polyhydric alcohols or derivatives thereof, acetone, methyl acetone, ethyl methyl ketone, isobutyl methyl ketone, methyl n-propyl ketone, etc. 3 to 6 ketone or ethyl acetate, esters of 4-5 carbon atoms such as isopropyl acetate, or ethyl ether, isopropyl ether, ethers of 4 to 8 carbon atoms such as n- butyl ether. Nonpolar organic solvents include petroleum ether, aliphatic hydrocarbons having 4 to 8 carbon atoms such as n-butane, n-pentane, n-hexane, and n-octane, carbon tetrachloride, chloroform, Examples thereof include halogenated aliphatic hydrocarbons having 1 to 2 carbon atoms such as dichloroethane and trichloroethylene, and aromatic hydrocarbons having 6 to 7 carbon atoms such as benzene and toluene, and water and ethanol are preferably used.
本発明に係る防腐殺菌剤においては、第1の成分である1,2−オクタンジオールと第2の成分であるレモングラス抽出エキスの含有量は特に限定されないが、重量比で0.1:1〜10:1、好ましくは0.2:1〜5:1となるように配合する。1,2−オクタンジオールをレモングラス抽出エキスの含有量の10重量倍を超えて配合すると、また0.1重量倍未満の場合、抗菌力の増強効果が期待できないために好ましくない。 In the antiseptic disinfectant according to the present invention, the content of 1,2-octanediol as the first component and the lemongrass extract as the second component is not particularly limited, but 0.1: 1 by weight. -10: 1, preferably 0.2: 1 to 5: 1. If 1,2-octanediol is added in an amount exceeding 10 times the content of the lemongrass extract extract, and less than 0.1 times the amount, it is not preferable because an antibacterial effect cannot be expected.
本発明に係る防腐殺菌剤は、第1の成分である1,2−オクタンジオールと、第2の成分であるレモングラス抽出エキスとを含有するから、後述する実施例に示されるように、幅広い菌種に対して第1の成分と第2の成分との相乗効果によって、抗菌力の優れた増強作用が発揮される。したがって、パラベン、安息香酸類、サリチル酸類のような従来から用いられる防腐殺菌剤を低配合又は配合する必要がなく、極めて安全性の高い防腐殺菌剤を得ることができる。 Since the antiseptic disinfectant according to the present invention contains 1,2-octanediol as the first component and lemongrass extract as the second component, it is widely used as shown in the examples described later. Due to the synergistic effect of the first component and the second component on the bacterial species, an enhancing action with excellent antibacterial activity is exhibited. Therefore, it is not necessary to blend or blend conventionally used antiseptics such as parabens, benzoic acids, and salicylic acids, and an extremely safe antiseptic can be obtained.
本発明の防腐殺菌剤は、化粧料、医薬品及び食品などに配合して使用することができる。具体的には、洗顔剤、化粧水、乳液、スキンクリーム、ファンデーション、マスカラ、ネールエナメル、口紅等の皮膚用化粧料、シャンプー、ヘアトリートメント、育毛・養毛剤、ヘアクリーム、ヘアフォーム、パーマネントウェーブ剤などの頭髪用化粧料、しみやそばかすなどの特定の使用目的を有した薬用化粧料(医薬部外品)、にきび治療薬、うがい薬、トローチ等の医薬品、チューインガム、キャンディー、飲料水等の食品に好適に用いることができる。 The antiseptic disinfectant of the present invention can be used by blending it in cosmetics, pharmaceuticals, foods and the like. Specifically, facial cleanser, lotion, milky lotion, skin cream, foundation, mascara, nail enamel, lipstick and other skin cosmetics, shampoo, hair treatment, hair growth / hair restorer, hair cream, hair foam, permanent wave agent, etc. Cosmetics for specific hair use such as hair cosmetics, stains and freckles (quasi-drugs), acne medicines, gargles, lozenges, and other foods such as chewing gum, candy, and drinking water It can be used suitably.
本発明の防腐殺菌剤を用いて化粧料、医薬品又は食品を調製する場合、本発明の効果を損なわない範囲内であれば、上記した成分の他、化粧料、医薬品又は食品に通常用いられる成分を適宜任意に配合することができる。例えば、化粧料(医薬部外品を含む)や医薬品の場合、油脂、ロウ類、高級脂肪酸、低級アルコール、高級アルコール、ステロール類、脂肪酸エステル、保湿剤、界面活性剤、高分子化合物、無機顔料、色素、酸化防止剤、紫外線吸収剤、ビタミン類、収斂剤、美白剤、動植物抽出物、金属イオン封鎖剤、精製水等を例示することができる。また、食品の場合は、動植物油、多糖類、甘味料、着色料、ガムベース等を例示することができる。 When preparing cosmetics, pharmaceuticals or foods using the antiseptic disinfectant of the present invention, in addition to the above-described components, components usually used for cosmetics, pharmaceuticals or foods as long as the effects of the present invention are not impaired. Can be blended as appropriate. For example, in the case of cosmetics (including quasi-drugs) and pharmaceuticals, fats and oils, waxes, higher fatty acids, lower alcohols, higher alcohols, sterols, fatty acid esters, humectants, surfactants, polymer compounds, inorganic pigments , Pigments, antioxidants, ultraviolet absorbers, vitamins, astringents, whitening agents, animal and plant extracts, sequestering agents, purified water, and the like. In the case of food, animal and vegetable oils, polysaccharides, sweeteners, colorants, gum bases and the like can be exemplified.
化粧料、医薬品又は食品に本発明の防腐殺菌剤を配合する場合、配合量は特に限定されないが、組成物中0.01〜20重量%、好ましくは0.05〜5重量%である。配合量が0.01重量%未満の場合、抗菌効果に劣るために、また、20重量%を超えて配合したとしてもそれ以上の効果が望めないからである。 When the antiseptic disinfectant of the present invention is blended in cosmetics, pharmaceuticals or foods, the blending amount is not particularly limited, but is 0.01 to 20% by weight, preferably 0.05 to 5% by weight in the composition. This is because when the amount is less than 0.01% by weight, the antibacterial effect is inferior, and even if the amount exceeds 20% by weight, no further effect can be expected.
実施例1
(共試菌)
共試菌として、グラム陰性菌であるEscherichia coli IFO3972(大腸菌)、グラム陽性菌としてStaphylococcus aureus IFO13276(黄色ブドウ状球菌)、酵母としてCandida albicans IFO1594(口腔カンジダ症菌)、カビとしてAspergillus niger IFO9455(クロカビ)を用いた。
Example 1
(Co-test)
As test bacteria, Escherichia coli IFO3972 (E. coli), Gram-negative bacteria, Staphylococcus aureus IFO13276 (Staphylococcus aureus) as gram-positive bacteria, Candida albicans IFO1594 (oral candidiasis) as yeast, Aspergillus niger IFO9455 as mold ) Was used.
(接種用菌液の調製)
接種用菌液としては、大腸菌及び黄色ブドウ状球菌の場合、寒天培地で35℃で培養後、更にブイヨン培地に移植して35℃で培養した。得られた培養液をブイヨン培地で約108個/mlに希釈したものを接種用菌液とした。
また、口腔カンジダ症菌の場合、30℃で同様に培養して約107個/mlに希釈したものを、クロカビの場合は、25℃で培養後にTween 80(ポリオキシエチレン(20)ソルビタンモノオレエート)2%加生理食塩水に胞子を懸濁させ約106個/mlに調製したものを接種用菌液とした。
(Preparation of bacterial solution for inoculation)
In the case of Escherichia coli and Staphylococcus aureus, the bacterial solution for inoculation was cultured at 35 ° C. on an agar medium, then transplanted to a bouillon medium and cultured at 35 ° C. A solution obtained by diluting the obtained culture solution to about 10 8 cells / ml with a bouillon medium was used as a bacterial solution for inoculation.
In the case of oral candidiasis, the same culture at 30 ° C. and diluted to about 10 7 cells / ml are used. In the case of black mold, Tween 80 (polyoxyethylene (20) sorbitan mono) is cultured at 25 ° C. (Oleate) What was prepared by suspending spores in 2% physiological saline and preparing about 10 6 cells / ml was used as a bacterial solution for inoculation.
(被験物質の希釈系列の調製)
20w/w%エチルセルソルブを希釈溶媒とし、5、4、3、2.5、2.25、2、1.75、1.5、1.25、1w/v%の1,2−オクタンジオール液を調製した。
また、レモングラス抽出エキス(長谷川香料社製)及び1,2−オクタンジオールとレモングラス抽出エキスの等量混合物については、5w/v%の液を倍倍希釈して希釈系列を調製した。
(Preparation of dilution series of test substance)
5, 4-, 3, 2.5, 2.25, 2, 1.75, 1.5, 1.25, 1 w / v% 1,2-octane using 20 w / w% ethyl cellosolve as a diluent solvent A diol solution was prepared.
Moreover, about the lemongrass extract (made by Hasegawa Koryo Co., Ltd.) and 1,2-octanediol and the mixture of equal amounts of lemongrass extract, a dilution series was prepared by doubling a 5 w / v% solution.
(最小発育阻止濃度(MIC)の測定)
上記被験物質を含む希釈系列1mLに対して各寒天培地9mLをシャーレに入れ、それぞれについて、上記接種用菌液を約1cmの長さに画線した。培養は、大腸菌及び黄色ブドウ状球菌については、35℃で行い、2日後の菌の生育の有無を判定した。また、酵母及びカビについては、25℃で培養を行い、3日後の菌の生育の有無を判定した。このとき、生育が認められなかった最小の濃度をMICとして求めた。結果を表1に示す。
(Measurement of minimum inhibitory concentration (MIC))
For each 1 mL of the dilution series containing the test substance, 9 mL of each agar medium was placed in a petri dish, and for each, the inoculum bacterial solution was streaked to a length of about 1 cm. Cultivation was performed at 35 ° C. for Escherichia coli and Staphylococcus aureus, and the presence or absence of bacterial growth after 2 days was determined. Moreover, about yeast and mold, it culture | cultivated at 25 degreeC and the presence or absence of the growth of a microbe after 3 days was determined. At this time, the minimum concentration at which no growth was observed was determined as MIC. The results are shown in Table 1.
尚、MICによって、抗菌力を評価することができる。被験物質の濃度が薄いときには微生物への影響はないが、濃度を増していくと発育抑制が起こる。この程度は、濃度に依存して発育抑制が進み、ついには発育が停止する。このときの濃度がMICとして表される。したがって、MIC以上の濃度になると、微生物は死滅していくことになる。 In addition, antibacterial power can be evaluated by MIC. When the test substance concentration is low, there is no effect on microorganisms, but growth increases when the concentration is increased. This degree of growth proceeds depending on the concentration, and finally the growth stops. The concentration at this time is expressed as MIC. Therefore, when the concentration is higher than MIC, the microorganisms are killed.
(二元最小発育阻止濃度)
得られた1,2−オクタンジオール、レモングラス抽出エキス、及び1,2−オクタンジオールとレモングラス抽出エキスの等重量混合物の各MICを、1,2−オクタンジオール及びレモングラス抽出エキスの配合量に対してプロットし、二元最小発育阻止濃度図を求めた。結果を図1〜図4に示す。
尚、二元最小発育阻止濃度により、抗菌性を有する二種類の物質を配合した場合の作用効果を判定することができる。具体的には、抗菌性を有する二種類の物質を配合した場合、それにより生ずる作用は、相乗作用、相加作用、拮抗作用に大別される。相乗作用とは、二薬剤が相乗的に作用し、本来有する抗菌力が更に増強される作用である。相加作用とは、各薬剤の抗菌力が合わさった作用である。拮抗作用とは、一薬剤が他剤の抗菌力を打ち消す場合の作用である。そして、二元最小発育阻止濃度図による方法は、例えば、図5に示すように、A物質とB物質について、それぞれの割合を変えてMICを測定し、グラフから判定する方法である。これによると、A物質のみにおけるMIC(点A)とB物質のみにおけるMIC(点B)とをプロットした点を結び、両物質を併用したときのMICが、この線上より内側にある場合(点C)は、併用により抗菌力が増強された相乗作用であると、線上(点D)にある場合は相加作用であると、線上より外側にある場合(点E)は、一方又は双方の抗菌力を打ち消し抗菌力を減少させる拮抗作用であると判定することができる。
(Dual minimum inhibitory concentration)
Each MIC of the obtained 1,2-octanediol, lemongrass extract extract, and an equal weight mixture of 1,2-octanediol and lemongrass extract extract is blended with 1,2-octanediol and lemongrass extract extract. And a binary minimum growth inhibitory concentration diagram was obtained. The results are shown in FIGS.
In addition, the effect at the time of mix | blending two types of substances which have antimicrobial property can be determined with a binary minimum growth inhibitory density | concentration. Specifically, when two kinds of substances having antibacterial properties are blended, the action caused by the substances is roughly classified into a synergistic action, an additive action, and an antagonistic action. The synergistic action is an action in which the two drugs act synergistically to further enhance the inherent antibacterial power. The additive action is an action in which the antibacterial powers of the respective drugs are combined. Antagonism is an action when one drug counteracts the antibacterial activity of another drug. Then, the method based on the binary minimum growth inhibition concentration diagram is a method of determining from the graph by measuring the MIC for each of the A substance and the B substance while changing their ratios as shown in FIG. According to this, when MIC (point A) only for substance A and MIC (point B) only for substance B are connected, the MIC when both substances are used is inside this line (point C) is a synergistic effect in which the antibacterial activity is enhanced by the combined use, if it is on the line (point D), if it is an additive action, if it is outside the line (point E), one or both It can be determined that the antagonistic action counteracts the antibacterial activity and decreases the antibacterial activity.
(抗菌効果の評価)
図1〜図4の結果から、1,2−オクタンジオールとレモングラス抽出エキスとの組合せにより、幅広い菌種に対して抗菌力の相乗効果が認められた。
(Evaluation of antibacterial effect)
From the result of FIGS. 1-4, the synergistic effect of antibacterial activity was recognized with respect to a wide variety of bacterial species by the combination of 1,2-octanediol and lemongrass extract.
以下、本発明の防腐殺菌剤を配合した化粧料、医薬品及び食品の配合例を示す。尚、配合量は重量%である。
(配合例1:保湿クリーム)
モノラウリン酸デカグリセリル 1.0
モノステアリン酸ポリオキシエチレン(15)グリセリル 1.0
水素添加大豆リン脂質 1.0
ステアリン酸 4.0
セタノール 2.0
ベヘニルアルコール 2.0
パラフィン 3.0
スクワラン 12.0
ホホバ油 4.0
メチルポリシロキサン 0.2
1,3−ブチレングリコール 3.0
L−アルギニン 0.1
キサンタンガム 0.001
1,2−オクタンジオール 0.25
レモングラス抽出エキス 0.1
精製水 残分
合 計 100.0
Hereinafter, formulation examples of cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant of the present invention will be shown. In addition, a compounding quantity is weight%.
(Formulation example 1: moisturizing cream)
Decaglyceryl monolaurate 1.0
Polyoxyethylene (15) glyceryl monostearate 1.0
Hydrogenated soybean phospholipid 1.0
Stearic acid 4.0
Cetanol 2.0
Behenyl alcohol 2.0
Paraffin 3.0
Squalane 12.0
Jojoba oil 4.0
Methyl polysiloxane 0.2
1,3-butylene glycol 3.0
L-Arginine 0.1
Xanthan gum 0.001
1,2-octanediol 0.25
Lemongrass extract 0.1
Purified water residue
Total 100.0
(配合例2:親水性軟膏)
アスコルビン酸 0.5
ポリオキシエチレンセチルエーテル 2.0
水素添加大豆リン脂質 1.0
ステアリン酸 4.0
グリセリンモノステアレート 10.0
流動パラフィン 10.0
ワセリン 4.0
セタノール 5.0
プロピレングリコール 5.0
1,2−オクタンジオール 0.5
レモングラス抽出エキス 0.2
精製水 残分
合 計 100.0
(Formulation example 2: hydrophilic ointment)
Ascorbic acid 0.5
Polyoxyethylene cetyl ether 2.0
Hydrogenated soybean phospholipid 1.0
Stearic acid 4.0
Glycerol monostearate 10.0
Liquid paraffin 10.0
Vaseline 4.0
Cetanol 5.0
Propylene glycol 5.0
1,2-octanediol 0.5
Lemongrass extract 0.2
Purified water residue
Total 100.0
(配合例3:飲料)
アスコルビン酸 0.5
ブドウ糖液糖 33.0
グレープフルーツ果汁 64.0
1,2−オクタンジオール 0.5
レモングラス抽出エキス 0.1
酸味料 適量
合 計 100.0
(Formulation Example 3: Beverage)
Ascorbic acid 0.5
Glucose liquid sugar 33.0
Grapefruit juice 64.0
1,2-octanediol 0.5
Lemongrass extract 0.1
Sour seasoning
Total 100.0
本発明の防腐殺菌剤は、幅広い菌種に対して1,2−オクタンジオールが本来有する抗菌力を増強して優れた抗菌活性を有するとともに、高い安全性を有しているので、化粧料、医薬品及び食品などの防腐殺菌剤として好適に用いることができる。 The antiseptic disinfectant of the present invention has excellent antibacterial activity by enhancing the antibacterial activity inherent to 1,2-octanediol against a wide range of bacterial species, and has high safety. It can be suitably used as an antiseptic disinfectant for pharmaceuticals and foods.
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