JP2002332234A5 - - Google Patents

Download PDF

Info

Publication number: JP2002332234A5
Authority: JP; Japan
Prior art keywords: formula; formulation; voriconazole; present; cyclodextrin derivative
Prior art date: 2002-03-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2002088076A

Other languages

English (en)

Other versions

JP5089004B2 (ja

JP2002332234A (ja

Filing date

2002-03-27

Publication date

2008-05-22

1997-06-21 Priority claimed from GBGB9713149.4A external-priority patent/GB9713149D0/en

2002-03-27 Application filed filed Critical

2002-11-22 Publication of JP2002332234A publication Critical patent/JP2002332234A/ja

2008-05-22 Publication of JP2002332234A5 publication Critical patent/JP2002332234A5/ja

2012-12-05 Application granted granted Critical

2012-12-05 Publication of JP5089004B2 publication Critical patent/JP5089004B2/ja

2018-06-02 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Description

【特許請求の範囲】
【請求項１】ボリコナゾールと、式I；
【化１】

［式中、Ｒ^1a-g、Ｒ^2a-g、及びＲ^3a-gは独立的にＯＨ又はＯ（ＣＨ₂）₄ＳＯ₃Ｈを表す；但し、Ｒ^1a-gの少なくとも１つはＯ（ＣＨ₂）₄ＳＯ₃Ｈを表す］で示されるシクロデキストリン誘導体又はその製薬的に許容される塩とを含む薬剤製剤であって、
当該式Ｉのシクロデキストリン誘導体が１：１から１：１０までのボリコナゾール：シクロデキストリン誘導体のモル比率で存在し、および、
当該製剤は凍結乾燥されている、
当該製剤。
【請求項２】式Ｉの分子当りのＯ（ＣＨ₂）₄ＳＯ₃Ｈ基の平均数は６．１〜６．９の範囲内である、請求項１記載の製剤。
【請求項３】存在する各Ｏ（ＣＨ₂）₄ＳＯ₃Ｈがアルカリ金属塩の形状である、請求項１又は請求項２に記載の製剤。

JP2002088076A 1997-06-21 2002-03-27 ボリコナゾールを含有する薬剤製剤 Expired - Lifetime JP5089004B2 (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9713149.4A GB9713149D0 (en)	1997-06-21	1997-06-21	Pharmaceutical formulations
GB9713149.4		1997-06-21

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
JP11503686A Division JP2000513029A (ja)	1997-06-21	1998-06-02	ボリコナゾールを含有する薬剤製剤

Publications (3)

Publication Number	Publication Date
JP2002332234A JP2002332234A (ja)	2002-11-22
JP2002332234A5 true JP2002332234A5 (ja)	2008-05-22
JP5089004B2 JP5089004B2 (ja)	2012-12-05

Family

ID=10814734

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
JP11503686A Withdrawn JP2000513029A (ja)	1997-06-21	1998-06-02	ボリコナゾールを含有する薬剤製剤
JP2002088076A Expired - Lifetime JP5089004B2 (ja)	1997-06-21	2002-03-27	ボリコナゾールを含有する薬剤製剤

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
JP11503686A Withdrawn JP2000513029A (ja)	1997-06-21	1998-06-02	ボリコナゾールを含有する薬剤製剤

Country Status (48)

Country	Link
US (1)	US6632803B1 (ja)
EP (1)	EP1001813B8 (ja)
JP (2)	JP2000513029A (ja)
KR (1)	KR100372988B1 (ja)
CN (1)	CN1125653C (ja)
AP (1)	AP912A (ja)
AR (1)	AR015900A1 (ja)
AT (1)	ATE238812T1 (ja)
AU (1)	AU724799B2 (ja)
BG (1)	BG64584B1 (ja)
BR (1)	BRPI9809468B8 (ja)
CA (1)	CA2295035C (ja)
CO (1)	CO4940450A1 (ja)
CZ (1)	CZ289570B6 (ja)
DE (1)	DE69814091T2 (ja)
DK (1)	DK1001813T3 (ja)
DZ (1)	DZ2523A1 (ja)
EA (1)	EA001924B1 (ja)
EG (1)	EG23910A (ja)
ES (1)	ES2195355T3 (ja)
GB (1)	GB9713149D0 (ja)
HK (1)	HK1027966A1 (ja)
HR (1)	HRP980341B1 (ja)
HU (1)	HU228338B1 (ja)
ID (1)	ID22939A (ja)
IL (1)	IL132918A (ja)
IS (1)	IS2004B (ja)
MA (1)	MA26508A1 (ja)
ME (1)	ME00907B (ja)
MY (1)	MY118151A (ja)
NO (1)	NO313125B1 (ja)
NZ (1)	NZ501066A (ja)
OA (1)	OA11232A (ja)
PA (1)	PA8453201A1 (ja)
PE (1)	PE84899A1 (ja)
PL (1)	PL191295B1 (ja)
PT (1)	PT1001813E (ja)
RS (1)	RS49633B (ja)
SA (1)	SA98190159B1 (ja)
SI (1)	SI1001813T1 (ja)
SK (1)	SK282946B6 (ja)
TN (1)	TNSN98090A1 (ja)
TR (1)	TR199903191T2 (ja)
TW (1)	TW406023B (ja)
UA (1)	UA57083C2 (ja)
UY (1)	UY25055A1 (ja)
WO (1)	WO1998058677A1 (ja)
ZA (1)	ZA985364B (ja)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9818258D0 (en) *	1998-08-21	1998-10-14	Pfizer Ltd	Antifungal compositions
PE20020300A1 (es)	2000-08-22	2002-05-10	Pharmacia Corp	Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
AR031135A1 (es)	2000-10-10	2003-09-10	Upjohn Co	Composiciones de antibiotico topico para el tratamiento de infecciones oculares
GEP20063996B (en) *	2002-08-20	2006-12-11	Bristol Myers Squibb Co	Aripiprazole complex formulation and use thereof
GB0327390D0 (en) *	2003-11-25	2003-12-31	Pfizer Ltd	Pharmaceutical formulations
BRPI0416870A (pt) *	2003-12-08	2007-01-30	Univ Arizona	composições anticáncer sinergìticas
CA2572223C (en)	2004-06-25	2014-08-12	The Johns Hopkins University	Angiogenesis inhibitors
US20100204178A1 (en)	2006-10-02	2010-08-12	James Cloyd	Novel parenteral carbamazepine formulation
WO2007047253A2 (en) *	2005-10-11	2007-04-26	Eastman Chemical Company	Pharmaceutical formulations of cyclodextrins and antifungal azole compounds
AR061889A1 (es)	2006-07-13	2008-10-01	Medichem Sa	Proceso mejorado para la preparacion de voriconazol
CN1919846B (zh) *	2006-09-14	2013-01-02	大道隆达（北京）医药科技发展有限公司	伏立康唑及其药用盐、中间体的一种新定向合成制备方法
BG1110U1 (bg) *	2007-06-19	2008-09-30	Рудолф ПОДЛИПСКИ	Отоплителен съд за експресно локално загряване навода
EP2018866A1 (en) *	2007-07-27	2009-01-28	Sandoz AG	Pharmaceutical compositions containing voriconazole
US8192721B2 (en) *	2007-12-13	2012-06-05	Verrow Pharmaceuticals, Inc.	Compositions useful for reducing toxicity associated with gadolinium-based contrast agents
US20110224232A1 (en) *	2008-05-06	2011-09-15	Board Of Regents, The University Of Texas System	Treatment of Pulmonary Fungal Infection With Voriconazole via Inhalation
BRPI0914863A2 (pt) *	2008-06-06	2017-05-30	Glenmark Pharmaceuticals Ltd	formulação tópica estável, e, uso da mesma
CN101390825B (zh) *	2008-10-01	2010-12-29	山东省眼科研究所	一种伏立康唑眼内释药系统
ME01133B (me)	2008-10-21	2013-03-20	Onyx Therapeutics Inc	Kombinovana terapija sa peptidnim epoksiketonima
CN101444510B (zh) *	2008-12-31	2011-03-09	南京卡文迪许生物工程技术有限公司	含有伏立康唑的药物制剂及其制备方法
WO2011020605A1 (en)	2009-08-19	2011-02-24	Ratiopharm Gmbh	Process for the production of coevaporates and complexes comprising voriconazole and cyclodextrin
WO2011064558A2 (en)	2009-11-30	2011-06-03	Cipla Limited	Pharmaceutical composition
CA2802929C (en)	2010-06-29	2019-01-08	David Monteith	Posaconazole intravenous solution formulations stabilized by substituted beta-cyclodextrin
EP2409699B1 (en) *	2010-07-23	2014-04-30	Combino Pharm, S.L.	Stable compositions of voriconazole
CN102058519B (zh) *	2010-11-19	2013-01-02	苏州特瑞药业有限公司	一种伏立康唑缓释栓剂及其制备方法
WO2012171561A1 (en)	2011-06-15	2012-12-20	Synthon Bv	Stabilized voriconazole composition
EP2561863A1 (en)	2011-08-22	2013-02-27	Farmaprojects, S.A.U.	Pharmaceutical compositions comprising voriconazole
US20130202681A1 (en) *	2012-01-05	2013-08-08	Frederick Timothy Guilford	Liposomally encapsulated reduced glutathione for management of cancer and disruption of cancer energy cycles
US8853248B2 (en)	2012-04-05	2014-10-07	Hubert Maehr	(1,2,3-triazolyl)sulfonyl derivatives
RS65647B1 (sr)	2012-05-08	2024-07-31	Onyx Therapeutics Inc	Postupci za kompleksiranje ciklodekstrina za formulaciju peptidnih inhibitora proteazoma
EP2846769A1 (en)	2012-05-11	2015-03-18	Cipla Limited	Pharmaceutical composition
US20150352112A1 (en)	2013-01-11	2015-12-10	Xellia Pharmaceuticals Aps	Voriconazole inclusion complexes
EP2968595A2 (en)	2013-03-14	2016-01-20	Fresenius Kabi USA LLC	Voriconazole formulations
GB201312737D0 (en)	2013-07-17	2013-08-28	Univ Greenwich	Cyclodextrin
CN103690968A (zh) *	2013-11-21	2014-04-02	石药集团中奇制药技术（石家庄）有限公司	一种伏立康唑组合物及其制备方法
PT109117B (pt) *	2016-01-28	2019-02-01	Hovione Farm Sa	Complexação de ingredientes ativos farmacêuticos
WO2018091668A1 (en)	2016-11-18	2018-05-24	Aicuris Anti-Infective Cures Gmbh	Novel formulations of amidine substituted beta-lactam compounds on the basis of modified cyclodextrins and acidifying agents, their preparation and use as antimicrobial pharmaceutical compositions
WO2018149359A1 (zh) *	2017-02-17	2018-08-23	武汉朗来科技发展有限公司	三氮唑抗菌衍生物、其药物组合物和用途
CN113750034A (zh) *	2020-06-05	2021-12-07	中南大学湘雅三医院	耳用温敏凝胶及其制备方法
CN116570558B (zh) *	2023-06-21	2023-12-26	广州仁恒医药科技股份有限公司	一种伏立康唑眼用纳米缓释组合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3346123A1 (de)	1983-12-21	1985-06-27	Janssen Pharmaceutica, N.V., Beerse	Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
DE3347421A1 (de)	1983-12-29	1985-07-11	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von fluorarmen alkaliphosphatloesungen
GB8819308D0 (en)	1988-08-13	1988-09-14	Pfizer Ltd	Triazole antifungal agents
KR0166088B1 (ko) *	1990-01-23	1999-01-15	.	수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) *	1990-01-23	1994-12-27	University Of Kansas	Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
US5278175A (en) *	1990-02-02	1994-01-11	Pfizer Inc.	Triazole antifungal agents
GB9002375D0 (en) *	1990-02-02	1990-04-04	Pfizer Ltd	Triazole antifungal agents
GB9512961D0 (en)	1995-06-26	1995-08-30	Pfizer Ltd	Antifungal agents
GB9602080D0 (en)	1996-02-02	1996-04-03	Pfizer Ltd	Pharmaceutical compounds

1997
- 1997-06-21 GB GBGB9713149.4A patent/GB9713149D0/en active Pending
1998
- 1998-02-06 UA UA99126910A patent/UA57083C2/uk unknown
- 1998-05-05 TW TW087106918A patent/TW406023B/zh not_active IP Right Cessation
- 1998-06-02 ID IDW991429A patent/ID22939A/id unknown
- 1998-06-02 PL PL337692A patent/PL191295B1/pl unknown
- 1998-06-02 DK DK98930793T patent/DK1001813T3/da active
- 1998-06-02 ES ES98930793T patent/ES2195355T3/es not_active Expired - Lifetime
- 1998-06-02 CN CN98806446A patent/CN1125653C/zh not_active Expired - Lifetime
- 1998-06-02 DE DE69814091T patent/DE69814091T2/de not_active Expired - Lifetime
- 1998-06-02 WO PCT/EP1998/003477 patent/WO1998058677A1/en active IP Right Grant
- 1998-06-02 IL IL13291898A patent/IL132918A/en not_active IP Right Cessation
- 1998-06-02 EA EA199900937A patent/EA001924B1/ru not_active IP Right Cessation
- 1998-06-02 TR TR1999/03191T patent/TR199903191T2/xx unknown
- 1998-06-02 JP JP11503686A patent/JP2000513029A/ja not_active Withdrawn
- 1998-06-02 CA CA002295035A patent/CA2295035C/en not_active Expired - Lifetime
- 1998-06-02 CZ CZ19994096A patent/CZ289570B6/cs not_active IP Right Cessation
- 1998-06-02 SK SK1593-99A patent/SK282946B6/sk not_active IP Right Cessation
- 1998-06-02 SI SI9830469T patent/SI1001813T1/xx unknown
- 1998-06-02 NZ NZ501066A patent/NZ501066A/xx not_active IP Right Cessation
- 1998-06-02 US US09/402,289 patent/US6632803B1/en not_active Expired - Lifetime
- 1998-06-02 BR BRPI9809468A patent/BRPI9809468B8/pt active IP Right Grant
- 1998-06-02 RS YUP-681/99A patent/RS49633B/sr unknown
- 1998-06-02 ME MEP-1999-681A patent/ME00907B/me unknown
- 1998-06-02 HU HU0003323A patent/HU228338B1/hu unknown
- 1998-06-02 AT AT98930793T patent/ATE238812T1/de active
- 1998-06-02 AU AU81104/98A patent/AU724799B2/en not_active Expired
- 1998-06-02 PT PT98930793T patent/PT1001813E/pt unknown
- 1998-06-02 KR KR10-1999-7012034A patent/KR100372988B1/ko not_active IP Right Cessation
- 1998-06-02 EP EP98930793.9A patent/EP1001813B8/en not_active Expired - Lifetime
- 1998-06-10 PA PA19988453201A patent/PA8453201A1/es unknown
- 1998-06-15 SA SA98190159A patent/SA98190159B1/ar unknown
- 1998-06-17 MA MA25117A patent/MA26508A1/fr unknown
- 1998-06-17 TN TNTNSN98090A patent/TNSN98090A1/fr unknown
- 1998-06-17 DZ DZ980133A patent/DZ2523A1/xx active
- 1998-06-18 AR ARP980102924A patent/AR015900A1/es active IP Right Grant
- 1998-06-18 AP APAP/P/1998/001268A patent/AP912A/en active
- 1998-06-19 HR HR980341A patent/HRP980341B1/xx not_active IP Right Cessation
- 1998-06-19 PE PE1998000539A patent/PE84899A1/es not_active IP Right Cessation
- 1998-06-19 UY UY25055A patent/UY25055A1/es not_active IP Right Cessation
- 1998-06-19 ZA ZA9805364A patent/ZA985364B/xx unknown
- 1998-06-20 MY MYPI98002792A patent/MY118151A/en unknown
- 1998-06-20 EG EG70998A patent/EG23910A/xx active
- 1998-06-23 CO CO98035641A patent/CO4940450A1/es unknown
1999
- 1999-11-12 NO NO19995565A patent/NO313125B1/no not_active IP Right Cessation
- 1999-11-15 IS IS5248A patent/IS2004B/is unknown
- 1999-11-15 BG BG103882A patent/BG64584B1/bg unknown
- 1999-12-10 OA OA9900277A patent/OA11232A/en unknown
2000
- 2000-11-17 HK HK00107329A patent/HK1027966A1/xx not_active IP Right Cessation
2002
- 2002-03-27 JP JP2002088076A patent/JP5089004B2/ja not_active Expired - Lifetime

Publication	Publication Date	Title
JP2002332234A5 (ja)	2008-05-22
JP2003531118A5 (ja)	2010-03-04
JP2006526031A5 (ja)	2006-12-28
JP2007503202A5 (ja)	2009-03-12
JP2005508905A5 (ja)	2005-12-22
JP2007510619A5 (ja)	2007-11-29
JP2006515626A5 (ja)	2007-06-14
JP2002541233A5 (ja)	2009-07-02
JP2009500423A5 (ja)	2010-08-26
JP2007511546A5 (ja)	2007-11-29
JP2005532287A5 (ja)	2009-08-27
JP2002543183A5 (ja)	2008-01-24
JP2002533472A5 (ja)	2006-12-21
JP2002527396A5 (ja)	2006-12-14
JP2006514012A5 (ja)	2006-12-14
EP1772142A3 (en)	2011-09-14	Organic compounds
JP2005511697A5 (ja)	2006-01-12
JP2003509349A5 (ja)	2006-05-25
JP2001526218A5 (ja)	2006-03-30
JP2002506864A5 (ja)	2006-04-27
JP2004533444A5 (ja)	2005-12-22
JP2002525323A5 (ja)	2007-01-11
JP2003503449A5 (ja)	2007-08-16
JP2000159790A5 (ja)	2006-12-07
JP2008513510A5 (ja)	2011-01-06