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IL144958A0 - Camptothecin derivatives having antitumor activity - Google Patents

Camptothecin derivatives having antitumor activity

Info

Publication number
IL144958A0
IL144958A0 IL14495800A IL14495800A IL144958A0 IL 144958 A0 IL144958 A0 IL 144958A0 IL 14495800 A IL14495800 A IL 14495800A IL 14495800 A IL14495800 A IL 14495800A IL 144958 A0 IL144958 A0 IL 144958A0
Authority
IL
Israel
Prior art keywords
antitumor activity
camptothecin derivatives
camptothecin
derivatives
antitumor
Prior art date
Application number
IL14495800A
Other languages
English (en)
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of IL144958A0 publication Critical patent/IL144958A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL14495800A 1999-03-09 2000-03-08 Camptothecin derivatives having antitumor activity IL144958A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99830124A EP1044977B1 (en) 1999-03-09 1999-03-09 Camptothecin derivatives having antitumor activity

Publications (1)

Publication Number Publication Date
IL144958A0 true IL144958A0 (en) 2002-06-30

Family

ID=8243303

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14495800A IL144958A0 (en) 1999-03-09 2000-03-08 Camptothecin derivatives having antitumor activity
IL144958A IL144958A (en) 1999-03-09 2001-08-16 Derivatives of camphutothcin, processes for their preparation, distillate preparations containing them and their use in the preparation of drugs for the treatment of tumors

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL144958A IL144958A (en) 1999-03-09 2001-08-16 Derivatives of camphutothcin, processes for their preparation, distillate preparations containing them and their use in the preparation of drugs for the treatment of tumors

Country Status (39)

Country Link
US (2) US6242457B1 (me)
EP (1) EP1044977B1 (me)
JP (1) JP4610743B2 (me)
KR (1) KR100702085B1 (me)
CN (1) CN1139592C (me)
AR (1) AR022860A1 (me)
AT (1) ATE216998T1 (me)
AU (1) AU774174B2 (me)
BG (1) BG65032B1 (me)
BR (1) BR0008840B1 (me)
CA (1) CA2362760C (me)
CO (1) CO5180590A1 (me)
CZ (1) CZ304465B6 (me)
DE (1) DE69901379T2 (me)
DK (1) DK1044977T3 (me)
EA (1) EA003605B1 (me)
EE (1) EE04679B1 (me)
EG (1) EG23999A (me)
ES (1) ES2175919T3 (me)
HK (1) HK1031222A1 (me)
HR (1) HRP20010667B1 (me)
HU (1) HU229506B1 (me)
IL (2) IL144958A0 (me)
IS (1) IS2003B (me)
ME (2) MEP4008A (me)
MX (1) MXPA01009081A (me)
NO (1) NO328363B1 (me)
NZ (1) NZ513393A (me)
PE (1) PE20001485A1 (me)
PL (1) PL222208B1 (me)
PT (1) PT1044977E (me)
RS (1) RS50405B (me)
SI (1) SI1044977T1 (me)
SK (1) SK287561B6 (me)
TN (1) TNSN00045A1 (me)
TR (1) TR200102603T2 (me)
TW (1) TWI272272B (me)
WO (1) WO2000053607A1 (me)
ZA (1) ZA200107408B (me)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE376824T1 (de) 1999-01-13 2007-11-15 Alchemia Oncology Pty Ltd Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
FR2794123B1 (fr) * 1999-05-28 2001-07-27 Aventis Pharma Sa Preparation de derives de la camptothecine et de la nothapodytine
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
US20040029906A1 (en) * 2001-07-31 2004-02-12 Michael Christman Inhibitors of dna polymerase sigma
MXPA04001828A (es) * 2001-08-27 2005-03-07 Meditech Res Ltd Protocolos terapeuticos mejorados.
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
ITRM20020305A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
ITRM20030344A1 (it) 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
AU2005226932B2 (en) * 2004-03-26 2009-07-09 Novartis Ag Use of camptothecin derivates for the treatment of proliferative diseases in a fixed dosing regimen
JP5170741B2 (ja) 2004-04-27 2013-03-27 ウェルスタット バイオロジクス コーポレイション ウイルスおよびカンプトテシン類を使用する癌の処置
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
PL1827437T3 (pl) * 2004-12-15 2013-06-28 Sigma Tau Ind Farmaceuti Połączenia środków terapeutycznych do leczenia raka
PL1828196T3 (pl) * 2004-12-21 2013-02-28 Sigma Tau Ind Farmaceuti Stereoselektywny sposób wytwarzania i krystaliczne formy kamptotecyny
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
JP5190958B2 (ja) 2005-07-14 2013-04-24 ウェルスタット バイオロジクス コーポレイション ウイルス、フルオロピリミジンおよびカンプトテシンを使用した癌の処置
JP5465431B2 (ja) * 2005-07-27 2014-04-09 アルケミア オンコロジー ピーティーワイ リミテッド ヒアルロナンを用いる治療プロトコル
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
MX2008001970A (es) * 2005-08-10 2008-03-24 Novartis Ag Formulaciones para 7-(t-butoxi)iminometil camptotecin.
JP5627181B2 (ja) * 2005-09-07 2014-11-19 アルケミア オンコロジー ピーティーワイ リミテッド ヒアルロナンおよび治療用抗体を含む治療用組成物ならびに治療方法
CN101340910B (zh) 2005-12-21 2012-12-12 希格马托制药工业公司 抗药性肿瘤的治疗
CA2642717C (en) * 2006-02-17 2015-08-18 Novacea, Inc. Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs
KR101394768B1 (ko) 2006-03-30 2014-05-21 드라이스 파마슈티컬스 아이엔씨 캄토테신-세포 투과 펩티드 결합체 및 이를 포함하는 약학 조성물
CN101652125A (zh) * 2007-02-01 2010-02-17 希格马托制药工业公司 包含喜树碱衍生物的药物组合物
WO2008098701A1 (en) * 2007-02-13 2008-08-21 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
BRPI0815051A2 (pt) 2007-08-01 2015-02-10 Sigma Tau Ind Farmaceuti Tratamento de tumores pediátricos
EP2096113A1 (en) * 2008-02-05 2009-09-02 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 9-substituted camptothecin derivatives as antitumor compounds
TWI482621B (zh) 2009-12-23 2015-05-01 Sigma Tau Ind Farmaceuti 青蒿素基藥物與其他化學治療劑的抗癌組合物
US10517961B2 (en) 2015-09-25 2019-12-31 ZY Therapeutics, Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
EP0612248B1 (en) * 1991-11-15 2003-08-20 Smithkline Beecham Corporation Composition containing cisplatin and topotecan as antitumor agent.
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
WO1998007727A1 (en) * 1996-08-19 1998-02-26 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives

Also Published As

Publication number Publication date
CZ20013077A3 (cs) 2002-01-16
HUP0200210A2 (hu) 2002-05-29
KR20010102519A (ko) 2001-11-15
DK1044977T3 (da) 2002-07-08
BG105810A (en) 2002-06-28
HRP20010667B1 (en) 2003-06-30
IS6031A (is) 2001-07-31
US20010008939A1 (en) 2001-07-19
CZ304465B6 (cs) 2014-05-21
BR0008840A (pt) 2002-01-08
JP2002539128A (ja) 2002-11-19
RS50405B (sr) 2009-12-31
NZ513393A (en) 2003-04-29
HUP0200210A3 (en) 2004-03-29
CN1139592C (zh) 2004-02-25
BG65032B1 (bg) 2006-12-29
AU774174B2 (en) 2004-06-17
AU3160400A (en) 2000-09-28
CN1343209A (zh) 2002-04-03
IL144958A (en) 2009-08-03
SI1044977T1 (en) 2002-08-31
DE69901379T2 (de) 2002-11-07
EE04679B1 (et) 2006-08-15
CA2362760A1 (en) 2000-09-14
WO2000053607A1 (en) 2000-09-14
TNSN00045A1 (fr) 2005-11-10
US6589939B2 (en) 2003-07-08
EP1044977B1 (en) 2002-05-02
ATE216998T1 (de) 2002-05-15
EE200100466A (et) 2002-12-16
HK1031222A1 (en) 2001-06-08
TR200102603T2 (tr) 2002-01-21
SK11642001A3 (sk) 2002-01-07
DE69901379D1 (de) 2002-06-06
CO5180590A1 (es) 2002-07-30
ZA200107408B (en) 2002-05-29
EP1044977A1 (en) 2000-10-18
NO20014128L (no) 2001-08-24
JP4610743B2 (ja) 2011-01-12
CA2362760C (en) 2009-08-18
HRP20010667A2 (en) 2002-08-31
BR0008840B1 (pt) 2011-12-27
EG23999A (en) 2008-03-19
NO20014128D0 (no) 2001-08-24
TWI272272B (en) 2007-02-01
NO328363B1 (no) 2010-02-01
PT1044977E (pt) 2002-09-30
PL355094A1 (en) 2004-03-22
PE20001485A1 (es) 2000-12-07
ES2175919T3 (es) 2002-11-16
ME00017B (me) 2010-06-10
YU64301A (sh) 2005-07-19
SK287561B6 (sk) 2011-02-04
EA200100954A1 (ru) 2002-04-25
AR022860A1 (es) 2002-09-04
US6242457B1 (en) 2001-06-05
MEP4008A (xx) 2010-02-10
HU229506B1 (en) 2014-01-28
PL222208B1 (pl) 2016-07-29
IS2003B (is) 2005-04-15
MXPA01009081A (es) 2002-08-30
EA003605B1 (ru) 2003-06-26
KR100702085B1 (ko) 2007-04-02

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