Nothing Special   »   [go: up one dir, main page]

PE20001485A1 - Derivados de la camptotecina que tienen actividad antitumoral - Google Patents

Derivados de la camptotecina que tienen actividad antitumoral

Info

Publication number
PE20001485A1
PE20001485A1 PE2000000206A PE0002062000A PE20001485A1 PE 20001485 A1 PE20001485 A1 PE 20001485A1 PE 2000000206 A PE2000000206 A PE 2000000206A PE 0002062000 A PE0002062000 A PE 0002062000A PE 20001485 A1 PE20001485 A1 PE 20001485A1
Authority
PE
Peru
Prior art keywords
alkyl
cycloalkyl
alcoxy
heterocycle
alkenyl
Prior art date
Application number
PE2000000206A
Other languages
English (en)
Inventor
Paolo Carminati
Franco Zunino
Sergio Penco
Lucio Merlini
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of PE20001485A1 publication Critical patent/PE20001485A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE CAMPTOTECINA DE FORMULA I, DONDE R1 ES C(R5)=N-O(n)R4; R4 ES H, ALQUILO C1-C8, ALQUENILO C1-C8, CICLOALQUILO C3-C10, CICLOALQUILO C3-C10-ALQUILO C1-C8, ARILO C6-C14, HETEROCICLO, HETEROCICLO-ALQUILO C1-C8, ENTRE OTROS; R4 ES AROILO C6-C10, ARILSULFONILO C6-C10 OPCIONALMENTE SUSTITUIDO CON HALOGENO, OH, ALQUILO C1-C8, ALCOXI, FENILO, CIANO, NITRO, NR10R11; R10 Y R11 SON H, ALQUILO C1-C8; R4 ES POLIAMINOALQUILO, GLICOSILO; n ES 0-1; R5 ES H, ALQUILO C1-C8, ALQUENILO C1-C8, CICLOALQUILO C3-C10, CICLOALQUILO C3-C10-ALQUILO C1-C8, ENTRE OTROS; R2 Y R3 SON H, OH, ALCOXI C1-C8, CUANDO R5, R2 Y R3 SON H; n ES 1, ENTONCES R4 NO ES H. SON COMPUESTOS PREFERIDOS 7-METOXIIMINOMETILCAMPTOTECINA, 7-METOXIIMINOMETILO-10-HIDROXICAMPTOTECINA, 7-[N-(4-AMINOBUTILO)-2-AMINOETOXI]IMINOMETILCAMPTOTECINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION, A COMPUESTOS INTERMEDIOS Y A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE ADEMAS UN AGENTE ANTITUMORAL. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE TUMORES, INFECCIONES VIRALES, ACTIVIDAD ANTIPLASMODIO FALCIPARUM
PE2000000206A 1999-03-09 2000-03-08 Derivados de la camptotecina que tienen actividad antitumoral PE20001485A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99830124A EP1044977B1 (en) 1999-03-09 1999-03-09 Camptothecin derivatives having antitumor activity

Publications (1)

Publication Number Publication Date
PE20001485A1 true PE20001485A1 (es) 2000-12-07

Family

ID=8243303

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000206A PE20001485A1 (es) 1999-03-09 2000-03-08 Derivados de la camptotecina que tienen actividad antitumoral

Country Status (39)

Country Link
US (2) US6242457B1 (es)
EP (1) EP1044977B1 (es)
JP (1) JP4610743B2 (es)
KR (1) KR100702085B1 (es)
CN (1) CN1139592C (es)
AR (1) AR022860A1 (es)
AT (1) ATE216998T1 (es)
AU (1) AU774174B2 (es)
BG (1) BG65032B1 (es)
BR (1) BR0008840B1 (es)
CA (1) CA2362760C (es)
CO (1) CO5180590A1 (es)
CZ (1) CZ304465B6 (es)
DE (1) DE69901379T2 (es)
DK (1) DK1044977T3 (es)
EA (1) EA003605B1 (es)
EE (1) EE04679B1 (es)
EG (1) EG23999A (es)
ES (1) ES2175919T3 (es)
HK (1) HK1031222A1 (es)
HR (1) HRP20010667B1 (es)
HU (1) HU229506B1 (es)
IL (2) IL144958A0 (es)
IS (1) IS2003B (es)
ME (2) MEP4008A (es)
MX (1) MXPA01009081A (es)
NO (1) NO328363B1 (es)
NZ (1) NZ513393A (es)
PE (1) PE20001485A1 (es)
PL (1) PL222208B1 (es)
PT (1) PT1044977E (es)
RS (1) RS50405B (es)
SI (1) SI1044977T1 (es)
SK (1) SK287561B6 (es)
TN (1) TNSN00045A1 (es)
TR (1) TR200102603T2 (es)
TW (1) TWI272272B (es)
WO (1) WO2000053607A1 (es)
ZA (1) ZA200107408B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010113642A (ko) 1999-01-13 2001-12-28 추후기재 약물의 효능을 증대시키기 위한 조성물 및 증대 방법
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
FR2794123B1 (fr) * 1999-05-28 2001-07-27 Aventis Pharma Sa Preparation de derives de la camptothecine et de la nothapodytine
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US20040029906A1 (en) * 2001-07-31 2004-02-12 Michael Christman Inhibitors of dna polymerase sigma
CN1578677A (zh) * 2001-08-27 2005-02-09 美迪泰克研究有限公司 改良的治疗方案
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
ITRM20020305A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
RU2006137657A (ru) * 2004-03-26 2008-05-10 Новартис АГ (CH) Применение производных камптотецина для лечения пролиферативных заболеваний с использованием схемы лечения с фиксированной дозой
WO2005113018A2 (en) 2004-04-27 2005-12-01 Wellstat Biologics Corporation Cancer treatment using viruses and camptothecins
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
PT1827437E (pt) 2004-12-15 2012-01-12 Sigma Tau Ind Farmaceuti Combinação de agentes terapêuticos para o tratamento do cancro
JP5491699B2 (ja) 2004-12-21 2014-05-14 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 立体選択的方法およびカンプトテシンの結晶形態
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
KR20080039344A (ko) 2005-07-14 2008-05-07 웰스테트 바이올로직스 코포레이션 바이러스, 플루오로피리미딘 및 캄토테신을 이용한 암치료방법
EP1912658B1 (en) * 2005-07-27 2017-01-25 Alchemia Oncology Pty Limited Therapeutic protocols using hyaluronan
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
RU2008108894A (ru) * 2005-08-10 2009-09-20 Новартис АГ (CH) Композиции 7-(трет-бутокси)иминометилкамптотецина
EP1922077A4 (en) * 2005-09-07 2013-03-06 Alchemia Oncology Pty Ltd THERAPEUTIC COMPOSITIONS WITH HYALURON AND THERAPEUTIC ANTIBODIES AND TREATMENT PROCEDURES
JP5657205B2 (ja) * 2005-12-21 2015-01-21 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ 薬物耐性腫瘍の治療
CA2642717C (en) * 2006-02-17 2015-08-18 Novacea, Inc. Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs
US8410045B2 (en) 2006-03-30 2013-04-02 Drais Pharmaceuticals, Inc. Camptothecin-peptide conjugates and pharmaceutical compositions containing the same
CA2676986A1 (en) * 2007-02-01 2008-08-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Pharmaceutical composition comprising a campothecin derivative
WO2008098701A1 (en) * 2007-02-13 2008-08-21 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
US8829021B2 (en) 2007-08-01 2014-09-09 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Treatment of pediatric tumors
EP2096113A1 (en) 2008-02-05 2009-09-02 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 9-substituted camptothecin derivatives as antitumor compounds
TWI482621B (zh) 2009-12-23 2015-05-01 Sigma Tau Ind Farmaceuti 青蒿素基藥物與其他化學治療劑的抗癌組合物
WO2017053920A1 (en) 2015-09-25 2017-03-30 Zy Therapeutics Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPH07501079A (ja) * 1991-11-15 1995-02-02 スミスクライン・ビーチャム・コーポレイション 組合せ化学療法
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
BR9711319B1 (pt) * 1996-08-19 2009-08-11 derivados de camptotecina altamente lipofìlicos.

Also Published As

Publication number Publication date
US20010008939A1 (en) 2001-07-19
AU774174B2 (en) 2004-06-17
SK287561B6 (sk) 2011-02-04
DE69901379T2 (de) 2002-11-07
KR100702085B1 (ko) 2007-04-02
AU3160400A (en) 2000-09-28
AR022860A1 (es) 2002-09-04
HUP0200210A2 (hu) 2002-05-29
ME00017B (me) 2010-06-10
NO328363B1 (no) 2010-02-01
PT1044977E (pt) 2002-09-30
HU229506B1 (en) 2014-01-28
NZ513393A (en) 2003-04-29
RS50405B (sr) 2009-12-31
US6589939B2 (en) 2003-07-08
BR0008840B1 (pt) 2011-12-27
IS2003B (is) 2005-04-15
TWI272272B (en) 2007-02-01
NO20014128L (no) 2001-08-24
EP1044977A1 (en) 2000-10-18
EE200100466A (et) 2002-12-16
ATE216998T1 (de) 2002-05-15
MXPA01009081A (es) 2002-08-30
CZ304465B6 (cs) 2014-05-21
CA2362760A1 (en) 2000-09-14
BG65032B1 (bg) 2006-12-29
ES2175919T3 (es) 2002-11-16
US6242457B1 (en) 2001-06-05
BG105810A (en) 2002-06-28
SI1044977T1 (en) 2002-08-31
PL222208B1 (pl) 2016-07-29
CN1343209A (zh) 2002-04-03
EA200100954A1 (ru) 2002-04-25
WO2000053607A1 (en) 2000-09-14
EP1044977B1 (en) 2002-05-02
EA003605B1 (ru) 2003-06-26
JP2002539128A (ja) 2002-11-19
IS6031A (is) 2001-07-31
DE69901379D1 (de) 2002-06-06
SK11642001A3 (sk) 2002-01-07
DK1044977T3 (da) 2002-07-08
MEP4008A (xx) 2010-02-10
TNSN00045A1 (fr) 2005-11-10
PL355094A1 (en) 2004-03-22
HUP0200210A3 (en) 2004-03-29
HRP20010667B1 (en) 2003-06-30
CO5180590A1 (es) 2002-07-30
JP4610743B2 (ja) 2011-01-12
HRP20010667A2 (en) 2002-08-31
YU64301A (sh) 2005-07-19
EG23999A (en) 2008-03-19
KR20010102519A (ko) 2001-11-15
ZA200107408B (en) 2002-05-29
CA2362760C (en) 2009-08-18
CN1139592C (zh) 2004-02-25
TR200102603T2 (tr) 2002-01-21
BR0008840A (pt) 2002-01-08
HK1031222A1 (en) 2001-06-08
CZ20013077A3 (cs) 2002-01-16
IL144958A0 (en) 2002-06-30
EE04679B1 (et) 2006-08-15
IL144958A (en) 2009-08-03
NO20014128D0 (no) 2001-08-24

Similar Documents

Publication Publication Date Title
PE20001485A1 (es) Derivados de la camptotecina que tienen actividad antitumoral
AR005706A1 (es) Inhibidores egfr de 4-aminoquinzolina, procedimiento para su obtencion, composicion farmaceutica que los contiene, uso de los mismos para lapreparacion de un medicamento util como agente antineoplasico
ATE264846T1 (de) Substituierte benzimidazol-derivaten und ihre verwendung zur behandlung retroviraler infektionen
DE69529670D1 (de) Oxazolidinon derivate und diese enthaltende pharmazeutische zusammensetzungen
KR910006218A (ko) 2-아미도테트라린 치환유도체와 이 치환유도체를 포함하는 제약학적 조성물 및 이를 사용한 치료방법
KR950031074A (ko) 비-펩티드 타키키닌 수용체 길항물질
YU49443B (sh) Derivati benzimidazola, postupci za njihovo pripremanje i primena tih derivata u medicinskoj terapiji, naročito za lečenje ili sprečavanje virusnih infekcija
UY23835A1 (es) Procedimiento para la preparacion de compuesto de acilo
TR200101961T2 (tr) 1,2-halkalı kinolin türevleri
NO963053D0 (no) Kosmetiske eller farmasöytiske preparater inneholdende mangiferin eller derivater derav
ES2080297T3 (es) Derivados 17-g(b)-sustituido-4-aza-5g(a)-androstan-3-ona y procedimiento de preparacion de estos.
TR200200008T2 (tr) Fenofibratı ihtiva eden farmasötik bileşim ve bu bileşimin hazırlanması için yöntem
EA200200571A1 (ru) Новая композиция и ее применение
BR0214876A (pt) Formas de sal de e-2-metóxi-n-(3-(4-(3-metil-piridin-3-ilóxi)-fenilamino)qui nazolin-6-il)-alil)-acetamida, suas preparações e uso dos mesmos contra o câncer
PA8495101A1 (es) Derivados de 13-metileritromicina
PE20011066A1 (es) PIRIDO [2,3-d] PIRIMIDIN-2,7-DIAMINAS INHIBIDORES DE CINASAS
DE60024414D1 (de) Oxadiazolverbindungen und -zusammensetzungen zur abgabe von wirkstoffen
ES2084339T3 (es) Tetrahidropiridinas e hidroxipiperidinas sustituidas utiles como agentes para el sistema nervioso central.
PE20021018A1 (es) DERIVADOS DE ß - CARBOLINA
NO965444L (no) Triterpen-derivat samt medikamentell sammensetning omfattende dette
DE60014343D1 (de) N-(2-phenyl-4-amino-butyl)-1-naphthamide als neurokinin-1 rezeptorantagonisten
FR2782515B1 (fr) NOUVEAUX DERIVES DE L'INDANE-1-Ol, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
SE8105689L (sv) Terapeutiska medel
ATE32720T1 (de) 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung.
BR0014145A (pt) Compostos de benzimidazol substituìdo por alcóxi, preparações farmacêuticas contendo o mesmo, e métodos de uso do mesmo

Legal Events

Date Code Title Description
FG Grant, registration
FG Grant, registration
FD Application declared void or lapsed