IL107184A - Heterocyclic ether compounds that enhance cognitive function - Google Patents
Heterocyclic ether compounds that enhance cognitive functionInfo
- Publication number
- IL107184A IL107184A IL10718493A IL10718493A IL107184A IL 107184 A IL107184 A IL 107184A IL 10718493 A IL10718493 A IL 10718493A IL 10718493 A IL10718493 A IL 10718493A IL 107184 A IL107184 A IL 107184A
- Authority
- IL
- Israel
- Prior art keywords
- ether compounds
- heterocyclic ether
- cognitive function
- enhance cognitive
- cholinergic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95900592A | 1992-10-09 | 1992-10-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL107184A0 IL107184A0 (en) | 1994-01-25 |
IL107184A true IL107184A (en) | 1997-08-14 |
Family
ID=25501548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10718493A IL107184A (en) | 1992-10-09 | 1993-10-04 | Heterocyclic ether compounds that enhance cognitive function |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0663912B1 (xx) |
JP (1) | JP3098035B2 (xx) |
KR (1) | KR100311546B1 (xx) |
AT (1) | ATE210656T1 (xx) |
AU (1) | AU687017B2 (xx) |
CA (1) | CA2136075C (xx) |
DE (1) | DE69331329T2 (xx) |
DK (1) | DK0663912T3 (xx) |
ES (1) | ES2169727T3 (xx) |
IL (1) | IL107184A (xx) |
PT (1) | PT663912E (xx) |
WO (1) | WO1994008992A1 (xx) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5948793A (en) * | 1992-10-09 | 1999-09-07 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release |
US5852041A (en) * | 1993-04-07 | 1998-12-22 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acethylcholine receptors |
US5998404A (en) * | 1994-10-24 | 1999-12-07 | Eli Lilly And Company | Heterocyclic compounds and their use |
US5605908A (en) * | 1994-10-24 | 1997-02-25 | Eli Lilly And Company | Heterocyclic compounds and their use |
US5585388A (en) * | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
IL118279A (en) * | 1995-06-07 | 2006-10-05 | Abbott Lab | Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission |
JP2000500452A (ja) * | 1995-11-13 | 2000-01-18 | イーライ・リリー・アンド・カンパニー | 不安の処置法 |
US5794887A (en) | 1995-11-17 | 1998-08-18 | Komerath; Narayanan M. | Stagnation point vortex controller |
US6979695B2 (en) | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
US6437138B1 (en) | 1996-06-06 | 2002-08-20 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
BR9714677A (pt) * | 1996-12-10 | 2000-10-03 | Abbott Lab | "enantiÈmeros 3-piridila e seu uso como analgésicos" |
US6133253A (en) * | 1996-12-10 | 2000-10-17 | Abbott Laboratories | 3-Pyridyl enantiomers and their use as analgesics |
EP0978280A1 (en) * | 1997-04-26 | 2000-02-09 | Sumitomo Pharmaceuticals Company, Limited | 2-azabicyclo compounds |
US7214686B2 (en) | 1997-06-30 | 2007-05-08 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
US6624173B1 (en) | 1997-06-30 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions for treating and/or preventing CNS disorders |
US6525065B1 (en) | 1997-06-30 | 2003-02-25 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
CA2306477A1 (en) * | 1997-11-05 | 1999-05-20 | Neurosearch A/S | Azaring-ether derivatives and their use as nicotinic ach receptor modulators |
ATE262519T1 (de) * | 1997-12-19 | 2004-04-15 | Abbott Lab | Heterozyklische ether- und thioether-verbindungen,verwendbar zur steuerung von chemischer synaptischer transmission |
WO1999051216A2 (en) | 1998-04-02 | 1999-10-14 | R.J. Reynolds Tobacco Company | 3-pyridyloxyalkylamine or aryloxyalkylamine derivatives as cholinergic agonists |
CA2317567A1 (en) * | 1998-04-02 | 1999-10-14 | R.J. Reynolds Tobacco Company | Pharmaceutical compositions and methods for use |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
US6432975B1 (en) | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
US20010031771A1 (en) | 1999-05-24 | 2001-10-18 | Gary Maurice Dull | Pharmaceutical compositions and methods for use |
AU5483500A (en) * | 1999-07-09 | 2001-01-30 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods |
MXPA02002115A (es) * | 1999-09-14 | 2002-10-31 | Abbott Lab | Compuestos de eter 3-pirrolidiniloxi-3'-piridilico, utiles para controlar la transmision sinaptica quimica. . |
US6890935B2 (en) | 1999-11-01 | 2005-05-10 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
US6812314B2 (en) | 2001-10-17 | 2004-11-02 | University Of Florida | Thermally responsive polymer materials and uses thereof |
BR0214929A (pt) | 2001-12-14 | 2006-05-30 | Targacept Inc | métodos e composições para o tratamento de distúrbios do sistema nervoso central |
ES2355157T3 (es) | 2002-07-05 | 2011-03-23 | Targacept, Inc. | Compuestos diazaspirocíclico n-arilo y métodos de preparación y uso de las mismas. |
AU2003254016A1 (en) | 2002-07-19 | 2004-02-09 | Catholic Healthcare West | Methods and compositions relating to chimeric nicotinic receptor subunits |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
US7098331B2 (en) | 2003-03-05 | 2006-08-29 | Targacept, Inc. | Arylvinylazacycloalkane compounds and methods of preparation and use thereof |
ATE451368T1 (de) | 2003-10-15 | 2009-12-15 | Targacept Inc | Azabicyclische verbindungen zur linderung von schmerzen und zur behandlung von erkrankungen des zentralen nervensystems |
PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
US7780981B2 (en) | 2004-09-13 | 2010-08-24 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
EP1802601A1 (en) | 2004-09-20 | 2007-07-04 | Targacept, Inc. | Azaspiroalkene and azapiroalkane compounds with nicotinic cholinergic receptor activity |
UA88792C2 (xx) | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гідроксибензоатні солі метанікотинових сполук$гидроксибензоатные соли метаникотиновых соединений |
US7459469B2 (en) | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
WO2007024814A1 (en) | 2005-08-22 | 2007-03-01 | Targacept, Inc. | HETEROARYL-SUBSTiTUTED DIAZATRICYCLOALKANES, METHODS FOR ITS PREPARATION AND USE THEREOF |
GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
EP2133337A1 (en) | 2006-05-09 | 2009-12-16 | AstraZeneca AB | Salt forms of (2S)-(4E)-N-Methyl-5-[(5-Isopropoxy)pyridin-3-yl]-4-penten-2-amine |
TWI389889B (zh) | 2006-05-09 | 2013-03-21 | Targacept Inc | (2s)-(4e)-n-甲基-5-〔3-(5-異丙氧基吡啶)基〕-4-戊烯-2-胺之新穎多晶型 |
TWI454262B (zh) | 2006-11-02 | 2014-10-01 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
KR20090095608A (ko) * | 2006-11-29 | 2009-09-09 | 바스프 에스이 | 해충 방제용 피리딘 화합물 |
US20100028447A1 (en) | 2007-01-22 | 2010-02-04 | Targacept, Inc. | Intranasal, Buccal, And Sublingual Administration Of Metanicotine Analogs |
TW200845977A (en) | 2007-03-30 | 2008-12-01 | Targacept Inc | Sub-type selective azabicycloalkane derivatives |
KR20110075044A (ko) | 2007-04-02 | 2011-07-05 | 파킨슨즈 인스티튜트 | 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물 |
SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
JP5022494B2 (ja) | 2007-10-01 | 2012-09-12 | コメンティス,インコーポレーテッド | アルツハイマー病治療用のα7ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン−4−イルメチル1H−インドール−3−カルボキシレート誘導体 |
JP2012505834A (ja) * | 2008-10-14 | 2012-03-08 | サイコジェニックス・インコーポレーテッド | ニコチン性アセチルコリン受容体リガンドおよびその使用 |
US9145396B2 (en) | 2008-12-01 | 2015-09-29 | Targacept, Inc. | Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine |
NZ703381A (en) | 2008-12-01 | 2016-03-31 | Targacept Inc | Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine |
TW201024283A (en) | 2008-12-01 | 2010-07-01 | Targacept Inc | Synthesis and novel salt forms of (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine |
WO2010080757A2 (en) | 2009-01-07 | 2010-07-15 | Astrazeneca Ab | Combinations with an alpha-4beta-2 nicotinic agonist |
TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
MX2012006484A (es) | 2009-12-07 | 2012-08-01 | Targacept Inc | 3,6-diazabiciclo [3.1.1] heptanos como ligandos de receptores nicotinicos neuronales de acetilcolina. |
WO2011146009A1 (en) | 2010-05-20 | 2011-11-24 | Targacept Inc. | New process for the preparation of aryl substituted olefinic amines |
PE20130775A1 (es) | 2010-05-27 | 2013-07-21 | Targacept Inc | Antagonistas no competitivos de receptores nicotinicos |
WO2012125518A1 (en) | 2011-03-14 | 2012-09-20 | Targacept, Inc. | Salt forms of 3 - cyclopropylcarbonyl - 3, 6 - diazabicyclo [3.1.1] heptane |
WO2012129262A1 (en) | 2011-03-23 | 2012-09-27 | Targacept, Inc. | Treatment of attention deficit/hyperactivity disease |
TW201311698A (zh) | 2011-08-22 | 2013-03-16 | Targacept Inc | 作為神經元菸鹼乙醯膽鹼受體配位體之1,4-二氮雜雙環[3.2.2]壬烷 |
EP2776030B1 (en) * | 2011-11-11 | 2020-05-13 | Georgetown University | 2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof |
EP3166940A4 (en) | 2014-07-11 | 2018-04-25 | Alpharmagen, LLC | Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity |
WO2016123406A1 (en) | 2015-01-28 | 2016-08-04 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
US9724340B2 (en) | 2015-07-31 | 2017-08-08 | Attenua, Inc. | Antitussive compositions and methods |
CN105418477B (zh) * | 2015-12-22 | 2018-12-21 | 爱斯特(成都)生物制药股份有限公司 | 降低雷迪帕韦中间体中非对映异构体杂质含量的方法 |
AU2018205529B2 (en) | 2017-01-06 | 2023-08-10 | Morningside Venture Investments Limited | Transdermal drug delivery devices and methods |
CA3101966A1 (en) | 2018-05-29 | 2019-12-05 | Morningside Venture Investments Limited | Drug delivery methods and systems |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA848275B (en) * | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
CA1307790C (en) * | 1987-08-04 | 1992-09-22 | Ian Anthony Cliffe | Ethers |
YU84791A (xx) * | 1990-05-19 | 1994-06-10 | Boehringer Ingelheim Kg. | Biciklični 1-aza-cikloalkalni |
-
1993
- 1993-10-04 IL IL10718493A patent/IL107184A/xx not_active IP Right Cessation
- 1993-10-08 AT AT93923826T patent/ATE210656T1/de active
- 1993-10-08 WO PCT/US1993/009662 patent/WO1994008992A1/en active IP Right Grant
- 1993-10-08 CA CA002136075A patent/CA2136075C/en not_active Expired - Fee Related
- 1993-10-08 PT PT93923826T patent/PT663912E/pt unknown
- 1993-10-08 AU AU53557/94A patent/AU687017B2/en not_active Ceased
- 1993-10-08 JP JP06510167A patent/JP3098035B2/ja not_active Expired - Fee Related
- 1993-10-08 DK DK93923826T patent/DK0663912T3/da active
- 1993-10-08 DE DE69331329T patent/DE69331329T2/de not_active Expired - Lifetime
- 1993-10-08 KR KR1019940704340A patent/KR100311546B1/ko not_active IP Right Cessation
- 1993-10-08 EP EP93923826A patent/EP0663912B1/en not_active Expired - Lifetime
- 1993-10-08 ES ES93923826T patent/ES2169727T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU5355794A (en) | 1994-05-09 |
DK0663912T3 (da) | 2002-04-15 |
EP0663912B1 (en) | 2001-12-12 |
WO1994008992A1 (en) | 1994-04-28 |
ES2169727T3 (es) | 2002-07-16 |
EP0663912A4 (en) | 1995-02-17 |
PT663912E (pt) | 2002-06-28 |
IL107184A0 (en) | 1994-01-25 |
CA2136075C (en) | 2004-12-14 |
JP3098035B2 (ja) | 2000-10-10 |
AU687017B2 (en) | 1998-02-19 |
CA2136075A1 (en) | 1994-04-28 |
DE69331329D1 (de) | 2002-01-24 |
KR950701920A (ko) | 1995-05-17 |
ATE210656T1 (de) | 2001-12-15 |
DE69331329T2 (de) | 2002-08-08 |
JPH08502481A (ja) | 1996-03-19 |
KR100311546B1 (ko) | 2005-12-06 |
EP0663912A1 (en) | 1995-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |