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HUP0302921A2 - Hatóanyag perkután bejuttatására alkalmas alkoholos gélkészítmény, valamint ebből egységdózist tartalmazó csomag - Google Patents

Hatóanyag perkután bejuttatására alkalmas alkoholos gélkészítmény, valamint ebből egységdózist tartalmazó csomag

Info

Publication number
HUP0302921A2
HUP0302921A2 HU0302921A HUP0302921A HUP0302921A2 HU P0302921 A2 HUP0302921 A2 HU P0302921A2 HU 0302921 A HU0302921 A HU 0302921A HU P0302921 A HUP0302921 A HU P0302921A HU P0302921 A2 HUP0302921 A2 HU P0302921A2
Authority
HU
Hungary
Prior art keywords
pharmaceutical composition
composition containing
active ingredient
subject
dosed
Prior art date
Application number
HU0302921A
Other languages
English (en)
Inventor
Robert E. Dudley
S. George Kottayil
Oliver Palatchi
Original Assignee
Laboratories Besins Iscovesco
Unimed Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24614189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0302921(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Laboratories Besins Iscovesco, Unimed Pharmaceuticals Inc. filed Critical Laboratories Besins Iscovesco
Publication of HUP0302921A2 publication Critical patent/HUP0302921A2/hu
Publication of HUP0302921A3 publication Critical patent/HUP0302921A3/hu
Publication of HU230401B1 publication Critical patent/HU230401B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Inorganic Chemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Emergency Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

A találmány tárgyát képezi gyógyászati készítmény, ami egy aktívhatóanyag perkután bejuttatására alkalmas és tartalmaz (a) egy 1-4szénatomos alkoholt; (b) egy penetrációfokozót; (c) egy aktívhatóanyagot; és (d) vizet. A találmány tárgyát képező gyógyászatikészítmény a vizsgálatok szerint előnyösen alkalmazható hipogonadizmus(csökkent ivarmirigy-működés) kezelésére férfiakon. Az ilyen céllalalkalmazott készítmény hatóanyagként tesztoszteront,penetrációfokozóként pedig előnyösen izopropil-mirisztátot tartalmaz.A találmány további tárgya egységdózis-csomag, amely tartalmaz (a) egyfóliából készült külső tasakot, amely rendelkezik egy belső és egykülső felülettel; (b) egy polietilénréteget, amely a belsőfóliafelületet borítja; és (c) egy gyógyászati készítményt, amely egyaktív hatóanyagot tartalmaz. Ó
HU0302921A 2000-08-30 2001-08-29 Hatóanyag perkután bejuttatására alkalmas alkoholos gélkészítmény, valamint ebből egységdózist tartalmazó csomag HU230401B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/651,777 2000-08-30
US09/651,777 US6503894B1 (en) 2000-08-30 2000-08-30 Pharmaceutical composition and method for treating hypogonadism
PCT/US2001/027202 WO2002017926A1 (en) 2000-08-30 2001-08-29 Pharmaceutical composition and method for treating hypogonadism

Publications (3)

Publication Number Publication Date
HUP0302921A2 true HUP0302921A2 (hu) 2004-01-28
HUP0302921A3 HUP0302921A3 (en) 2006-07-28
HU230401B1 HU230401B1 (hu) 2016-04-28

Family

ID=24614189

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302921A HU230401B1 (hu) 2000-08-30 2001-08-29 Hatóanyag perkután bejuttatására alkalmas alkoholos gélkészítmény, valamint ebből egységdózist tartalmazó csomag

Country Status (24)

Country Link
US (13) US6503894B1 (hu)
EP (3) EP2281553B1 (hu)
KR (1) KR100866715B1 (hu)
CN (3) CN1527714A (hu)
AT (1) ATE429920T1 (hu)
AU (2) AU9059801A (hu)
BR (1) BRPI0113670B8 (hu)
CY (1) CY1110907T1 (hu)
DE (1) DE60138553D1 (hu)
DK (1) DK1313482T3 (hu)
EA (1) EA009815B1 (hu)
ES (1) ES2326621T3 (hu)
HU (1) HU230401B1 (hu)
IL (2) IL154668A0 (hu)
MA (1) MA27127A1 (hu)
NO (1) NO335506B1 (hu)
NZ (1) NZ524473A (hu)
OA (1) OA12386A (hu)
PL (1) PL205875B1 (hu)
PT (1) PT1313482E (hu)
SI (1) SI1313482T1 (hu)
UA (1) UA76958C2 (hu)
WO (1) WO2002017926A1 (hu)
ZA (3) ZA200301705B (hu)

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HUP0302921A3 (en) 2006-07-28
US20030232072A1 (en) 2003-12-18
US20030050292A1 (en) 2003-03-13
ZA200301687B (en) 2004-09-13
BR0113670A (pt) 2004-11-09
EA200300313A1 (ru) 2004-08-26
UA76958C2 (en) 2006-10-16
HU230401B1 (hu) 2016-04-28
PT1313482E (pt) 2009-07-29
CN101081203A (zh) 2007-12-05
EA009815B1 (ru) 2008-04-28
US20130261097A1 (en) 2013-10-03
EP2281553B1 (en) 2020-12-02
KR20030064747A (ko) 2003-08-02
US20050113353A1 (en) 2005-05-26
CN101081203B (zh) 2010-09-29
US20140011788A1 (en) 2014-01-09
NZ524473A (en) 2006-09-29
US20150313914A1 (en) 2015-11-05
NO20030961D0 (no) 2003-02-28
PL205875B1 (pl) 2010-06-30
US20050112181A1 (en) 2005-05-26
US20130303501A1 (en) 2013-11-14
EP1313482B1 (en) 2009-04-29
DE60138553D1 (de) 2009-06-10
NO335506B1 (no) 2014-12-22
IL154668A0 (en) 2003-09-17
PL366117A1 (en) 2005-01-24
WO2002017926A1 (en) 2002-03-07
EP2070517A3 (en) 2009-07-29
EP1313482A1 (en) 2003-05-28
US20110172196A1 (en) 2011-07-14
ZA200301686B (en) 2004-04-19
CN101077350A (zh) 2007-11-28
ZA200301705B (en) 2004-07-08
US20020183296A1 (en) 2002-12-05
EP2281553A2 (en) 2011-02-09
OA12386A (en) 2006-04-17
DK1313482T3 (da) 2009-08-17
CN101077350B (zh) 2012-06-27
IL154668A (en) 2007-12-03
MA27127A1 (fr) 2005-01-03
EP2070517A2 (en) 2009-06-17
US9125816B2 (en) 2015-09-08
US9132089B2 (en) 2015-09-15
BRPI0113670B8 (pt) 2021-05-25
BRPI0113670B1 (pt) 2018-02-14
ATE429920T1 (de) 2009-05-15
US6503894B1 (en) 2003-01-07
SI1313482T1 (sl) 2009-10-31
CY1110907T1 (el) 2015-06-10
NO20030961L (no) 2003-04-25
US20110201586A1 (en) 2011-08-18
CN1527714A (zh) 2004-09-08
EP2281553A3 (en) 2012-11-14
KR100866715B1 (ko) 2008-11-03
AU9059801A (en) 2002-03-13
AU2001290598B2 (en) 2006-07-13
ES2326621T3 (es) 2009-10-16

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