HUE047238T2 - Szérumalbuminhoz kötõdõ fehérjék - Google Patents
Szérumalbuminhoz kötõdõ fehérjékInfo
- Publication number
- HUE047238T2 HUE047238T2 HUE12727658A HUE12727658A HUE047238T2 HU E047238 T2 HUE047238 T2 HU E047238T2 HU E12727658 A HUE12727658 A HU E12727658A HU E12727658 A HUE12727658 A HU E12727658A HU E047238 T2 HUE047238 T2 HU E047238T2
- Authority
- HU
- Hungary
- Prior art keywords
- serum albumin
- binding proteins
- albumin binding
- proteins
- serum
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161500464P | 2011-06-23 | 2011-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE047238T2 true HUE047238T2 (hu) | 2020-04-28 |
Family
ID=46298413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12727658A HUE047238T2 (hu) | 2011-06-23 | 2012-06-14 | Szérumalbuminhoz kötõdõ fehérjék |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9573992B2 (hu) |
| EP (3) | EP2723771B1 (hu) |
| JP (3) | JP6324887B2 (hu) |
| CN (2) | CN106046168A (hu) |
| AU (1) | AU2012271974B2 (hu) |
| CA (1) | CA2839779C (hu) |
| CY (1) | CY1122691T1 (hu) |
| DK (1) | DK2723771T3 (hu) |
| ES (1) | ES2759936T3 (hu) |
| HR (2) | HRP20170535T4 (hu) |
| HU (1) | HUE047238T2 (hu) |
| IN (1) | IN2014CN00414A (hu) |
| LT (1) | LT2723771T (hu) |
| PL (1) | PL2723771T3 (hu) |
| PT (1) | PT2723771T (hu) |
| SI (1) | SI2723771T1 (hu) |
| WO (1) | WO2012175400A1 (hu) |
Families Citing this family (65)
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| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP2723771B1 (en) * | 2011-06-23 | 2019-09-11 | Ablynx NV | Serum albumin binding proteins |
| EP2723769B2 (en) | 2011-06-23 | 2022-06-15 | Ablynx NV | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
| CN103889451B (zh) * | 2011-09-30 | 2016-06-29 | 埃博灵克斯股份有限公司 | 与C-Met相关的生物物质 |
| WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
| SI3248986T1 (sl) | 2014-05-16 | 2022-04-29 | Ablynx Nv | Variabilne domene imunoglobulina |
| ES2900852T3 (es) | 2014-05-16 | 2022-03-18 | Ablynx Nv | Métodos de detección y/o medición de anticuerpos anti-fármaco, en particular anticuerpos anti-fármaco que se presentan durante el tratamiento |
| NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
| PL3233910T3 (pl) | 2014-12-19 | 2020-06-01 | Ablynx N.V. | Dimery nanociał połączone cysteiną |
| WO2016120843A1 (en) | 2015-01-29 | 2016-08-04 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa | Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders |
| IL274151B (en) | 2015-05-21 | 2022-07-01 | Harpoon Therapeutics Inc | Trispecific binding proteins and methods of use |
| NO2768984T3 (hu) | 2015-11-12 | 2018-06-09 | ||
| SI3374392T1 (sl) | 2015-11-13 | 2022-04-29 | Ablynx Nv | Izboljšane variabilne domene imunoglobulina, ki vežejo serumski albumin |
| JP6768800B2 (ja) | 2015-11-18 | 2020-10-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｃｔｌａ４結合性物質 |
| CN109071639B (zh) | 2015-11-18 | 2022-07-08 | 默沙东公司 | Pd1/ctla4结合剂 |
| UA121914C2 (uk) | 2015-11-18 | 2020-08-10 | Мерк Шарп І Доум Корп. | Молекула, що зв'язує pd1 і lag3 |
| AU2016357460B2 (en) * | 2015-11-18 | 2023-07-27 | Ablynx Nv | Improved serum albumin binders |
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| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| SG11201810327XA (en) * | 2016-05-20 | 2018-12-28 | Harpoon Therapeutics Inc | Single domain serum albumin binding protein |
| US20190195866A1 (en) | 2016-06-23 | 2019-06-27 | Ablynx N.V. | Improved pharmacokinetic assays for immunoglobulin single variable domains |
| CN117700549A (zh) | 2016-11-16 | 2024-03-15 | 埃博灵克斯股份有限公司 | 能够结合CD123和TCRα/β的T细胞募集多肽 |
| JP7417421B2 (ja) | 2016-12-07 | 2024-01-18 | アブリンクス エン．ヴェー． | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
| CN107674122A (zh) * | 2016-12-28 | 2018-02-09 | 天津天锐生物科技有限公司 | 一种识别人血清白蛋白的单域抗体 |
| CN110191896B (zh) | 2017-01-17 | 2023-09-29 | 埃博灵克斯股份有限公司 | 改进的血清白蛋白结合物 |
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| BR112019023855B1 (pt) | 2017-05-12 | 2021-11-30 | Harpoon Therapeutics, Inc | Proteínas de ligação à mesotelina |
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| WO2010042815A2 (en) | 2008-10-09 | 2010-04-15 | Duke University | Vhh antibody fragments for use in the detection and treatment of cancer |
| CN105646643A (zh) | 2008-10-29 | 2016-06-08 | 阿布林克斯公司 | 单域抗原结合性分子的纯化方法 |
| MX2011010151A (es) * | 2009-03-27 | 2011-12-14 | Glaxo Group Ltd | Fusiones y conjugados de farmaco. |
| WO2011064382A1 (en) | 2009-11-30 | 2011-06-03 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
| KR20120102125A (ko) | 2009-12-18 | 2012-09-17 | 사노피 | Ｇｐｖｉ에 대한 신규한 길항제 항체 및 그의 ｆａｂ 단편 및 그의 용도 |
| PE20130527A1 (es) | 2010-03-03 | 2013-05-09 | Boehringer Ingelheim Int | Polipeptidos de union a a-beta biparatopicos |
| US9068011B2 (en) | 2010-03-10 | 2015-06-30 | Genmab A+S | Monoclonal antibodies against c-Met |
| EP2621953B1 (en) | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Biological materials related to c-met |
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP2723771B1 (en) * | 2011-06-23 | 2019-09-11 | Ablynx NV | Serum albumin binding proteins |
| US20150344568A1 (en) | 2011-06-23 | 2015-12-03 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP2723769B2 (en) | 2011-06-23 | 2022-06-15 | Ablynx NV | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP2987806A3 (en) | 2011-08-17 | 2016-07-13 | Glaxo Group Limited | Modified single variable domain antibodies with reduced binding to anti-drug-antibodies |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
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2012
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- 2012-06-14 LT LT12727658T patent/LT2723771T/lt unknown
- 2012-06-14 JP JP2014516279A patent/JP6324887B2/ja active Active
- 2012-06-14 CN CN201610392570.9A patent/CN106046168A/zh active Pending
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- 2012-06-14 IN IN414CHN2014 patent/IN2014CN00414A/en unknown
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- 2012-06-14 EP EP23159592.7A patent/EP4218933A1/en active Pending
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- 2012-06-14 CN CN201280030647.8A patent/CN103619878B/zh active Active
- 2012-06-14 SI SI201231696T patent/SI2723771T1/sl unknown
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2017
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- 2018-04-11 JP JP2018076201A patent/JP6843090B2/ja active Active
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- 2019-11-29 HR HRP20192160TT patent/HRP20192160T1/hr unknown
- 2019-12-10 CY CY20191101299T patent/CY1122691T1/el unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| DK2723771T3 (da) | 2019-12-02 |
| US20140228546A1 (en) | 2014-08-14 |
| CY1122691T1 (el) | 2021-03-12 |
| JP7304375B2 (ja) | 2023-07-06 |
| JP6843090B2 (ja) | 2021-03-17 |
| CA2839779A1 (en) | 2012-12-27 |
| US20170210789A1 (en) | 2017-07-27 |
| CN103619878A (zh) | 2014-03-05 |
| PT2723771T (pt) | 2019-12-11 |
| AU2012271974B2 (en) | 2017-01-12 |
| EP4218933A1 (en) | 2023-08-02 |
| ES2759936T3 (es) | 2020-05-12 |
| EP2723771A1 (en) | 2014-04-30 |
| JP6324887B2 (ja) | 2018-05-16 |
| WO2012175400A1 (en) | 2012-12-27 |
| HRP20170535T4 (hr) | 2022-08-19 |
| EP3466972A1 (en) | 2019-04-10 |
| HRP20192160T1 (hr) | 2020-02-21 |
| CA2839779C (en) | 2020-10-06 |
| EP2723771B1 (en) | 2019-09-11 |
| CN106046168A (zh) | 2016-10-26 |
| LT2723771T (lt) | 2019-12-10 |
| IN2014CN00414A (hu) | 2015-04-03 |
| HRP20170535T1 (hr) | 2017-06-16 |
| CN103619878B (zh) | 2016-10-26 |
| PL2723771T3 (pl) | 2020-04-30 |
| US9573992B2 (en) | 2017-02-21 |
| JP2021088585A (ja) | 2021-06-10 |
| JP2018127478A (ja) | 2018-08-16 |
| AU2012271974A1 (en) | 2013-12-12 |
| SI2723771T1 (sl) | 2019-12-31 |
| JP2014520129A (ja) | 2014-08-21 |
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