HRP980240B1 - A new process for the preparation of a pharmacologically ve substance - Google Patents

A new process for the preparation of a pharmacologically ve substance

Info

Publication number: HRP980240B1
Authority: HR; Croatia
Prior art keywords: pharmacologically; substance; preparation; new process; new
Prior art date: 1997-05-13

Application number

HR980240A

Other languages

English (en)

Inventor

Maria Bakonyi

Matianna Csatarinee Nagy

Leventene Molnar

Antal Gajary

Edit Alattyani

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-13

Filing date

1998-05-06

Publication date

2003-02-28

1998-05-06 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

1999-02-28 Publication of HRP980240A2 publication Critical patent/HRP980240A2/hr

2003-02-28 Publication of HRP980240B1 publication Critical patent/HRP980240B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Saccharide Compounds (AREA)

HR980240A 1997-05-13 1998-05-06 A new process for the preparation of a pharmacologically ve substance HRP980240B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU9700885A HU222283B1 (hu)	1997-05-13	1997-05-13	Eljárás tieno[3,2-c]piridin-származékok előállítására

Publications (2)

Publication Number	Publication Date
HRP980240A2 HRP980240A2 (en)	1999-02-28
HRP980240B1 true HRP980240B1 (en)	2003-02-28

Family

ID=90014236

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR980240A HRP980240B1 (en)	1997-05-13	1998-05-06	A new process for the preparation of a pharmacologically ve substance

Country Status (38)

Country	Link
US (1)	US6180793B1 (xx)
EP (1)	EP0981529B1 (xx)
KR (1)	KR100428238B1 (xx)
CN (1)	CN1109036C (xx)
AR (1)	AR014349A1 (xx)
AT (1)	ATE212025T1 (xx)
AU (1)	AU735702B2 (xx)
BR (1)	BR9809112B1 (xx)
CA (1)	CA2289623C (xx)
CO (1)	CO4950564A1 (xx)
CZ (1)	CZ292820B6 (xx)
DE (1)	DE69803176T2 (xx)
DK (1)	DK0981529T3 (xx)
DZ (1)	DZ2487A1 (xx)
EE (1)	EE03925B1 (xx)
EG (1)	EG21973A (xx)
ES (1)	ES2172141T3 (xx)
HK (1)	HK1027350A1 (xx)
HR (1)	HRP980240B1 (xx)
HU (1)	HU222283B1 (xx)
ID (1)	ID23018A (xx)
IL (1)	IL132774A0 (xx)
IS (1)	IS1883B (xx)
ME (1)	ME01636B (xx)
MY (1)	MY121299A (xx)
NO (1)	NO325419B1 (xx)
NZ (1)	NZ501577A (xx)
PL (1)	PL194859B1 (xx)
PT (1)	PT981529E (xx)
RS (1)	RS49626B (xx)
RU (1)	RU2172315C1 (xx)
SA (1)	SA98190583B1 (xx)
SK (1)	SK283700B6 (xx)
TR (1)	TR199902783T2 (xx)
TW (1)	TW552263B (xx)
UA (1)	UA66359C2 (xx)
WO (1)	WO1998051689A1 (xx)
ZA (1)	ZA983921B (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
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FR2769313B1 (fr) *	1997-10-06	2000-04-21	Sanofi Sa	Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
HU226421B1 (en)	1998-11-09	2008-12-29	Sanofi Aventis	Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
IN191030B (xx) *	2001-01-24	2003-09-13	Cadila Healthcare Ltd
US6495691B1 (en)	2001-07-06	2002-12-17	Brantford Chemicals Inc.	Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en)	2001-12-18	2004-07-27	Teva Pharmaceutical Industries Ltd.	Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en)	2002-01-11	2006-07-11	Teva Pharmaceutical Industries, Ltd.	Polymorphs of clopidogrel hydrogensulfate
ITMI20020933A1 (it) *	2002-05-03	2003-11-03	Danimite Dipharma S P A	Procedimento per la sintesi di clopidogrel
US6800759B2 (en) *	2002-08-02	2004-10-05	Teva Pharmaceutical Industries Ltd.	Racemization and enantiomer separation of clopidogrel
IL166593A0 (en)	2002-08-02	2006-01-15		Racemization and enantiomer separation of clopidogrel
US6812363B2 (en) *	2002-10-15	2004-11-02	Usv Limited	Racemization of optically active 2-substituted phenyl glycine esters
WO2004081015A1 (en) *	2003-03-10	2004-09-23	Hetero Drugs Limited	Amorphous clopidogrel hydrogen sulfate
AU2003238664A1 (en)	2003-03-12	2004-09-30	Cadila Healthcare Limited	Polymorphs and amorphous form of (s) - (+) -clopidogrel bisulfate
GB0321256D0 (en) *	2003-09-11	2003-10-08	Generics Uk Ltd	Novel crystalline compounds
DE602004025267D1 (de)	2003-11-03	2010-03-11	Cadila Healthcare Ltd	Verfahren zur herstellung form i von (s)-(+)- clopidogrelbisulfat
CA2457459A1 (en) *	2004-02-11	2005-08-11	Brantford Chemicals Inc.	Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
KR100553398B1 (ko)	2004-03-12	2006-02-16	한미약품 주식회사	티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
US20060154957A1 (en) *	2004-09-21	2006-07-13	Nina Finkelstein	Crystalline clopidogrel hydrobromide and processes for preparation thereof
MX2007010267A (es) *	2005-02-24	2007-09-11	Teva Pharma	Base de clopidogrel adecuada para formulacion farmaceutica y preparacion de ella.
KR100681512B1 (ko)	2005-03-08	2007-02-09	주식회사 한서켐	클로피도그렐의 신규한 제조 중간체 및 이를 이용한 클로피도그렐의 제조방법
KR101235117B1 (ko)	2005-12-26	2013-02-20	에스케이케미칼주식회사	광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
CN102014899A (zh) *	2006-04-27	2011-04-13	因-斯韦特实验室有限公司	硫酸氢氯吡格雷多晶型物的制备方法
US20090247569A1 (en) *	2006-08-03	2009-10-01	Claude Singer	Process for Preparing Clopidogrel Bisulphate
US8247558B2 (en)	2006-09-04	2012-08-21	Ranbaxy Laboratories Limited	Process for the preparation of clopidogrel and its pharmaceutically acceptable salts
EP1980563A1 (en)	2007-04-09	2008-10-15	BATTULA, Srinivasa Reddy	Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
EP2107061A1 (en)	2008-04-02	2009-10-07	Krka Tovarna Zdravil, D.D., Novo Mesto	Process for the preparation of optically enriched clopidogrel
US20090264460A1 (en) *	2008-04-21	2009-10-22	Mamta Mishra	Clopidogrel pharmaceutical formulations
KR100990949B1 (ko)	2008-06-09	2010-10-29	엔자이텍 주식회사	클로피도그렐 및 그의 유도체의 제조방법
CN102186858A (zh) *	2008-10-24	2011-09-14	桑多斯股份公司	制备s-氯吡格雷的方法
US8563690B2 (en) *	2008-11-03	2013-10-22	The Board Of Trustees Of The University Of Illinois	Modulation of platelet aggregation
CN101544655B (zh) *	2009-05-05	2012-07-04	上海医药集团股份有限公司	噻吩并[3，2-c]吡啶衍生物的制备方法
CN101863899B (zh) *	2010-06-21	2013-03-20	常州制药厂有限公司	一种提高氯吡格雷樟脑磺酸盐拆分收率的方法
KR20170004283A (ko)	2015-07-02	2017-01-11	류종렬	그립부가 개선된 쉐이크 핸드형 탁구 라켓
KR20170004282A (ko)	2015-07-02	2017-01-11	류종렬	수도 지지부가 구비된 쉐이크 핸드형 탁구 라켓

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2530247B1 (fr) *	1982-07-13	1986-05-16	Sanofi Sa	Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2608607B1 (fr)	1986-12-23	1989-04-28	Sanofi Sa	Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues
FR2623810B2 (fr) *	1987-02-17	1992-01-24	Sanofi Sa	Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2652575B1 (fr) *	1989-09-29	1992-01-24	Sanofi Sa	Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664596B1 (fr) *	1990-07-10	1994-06-10	Sanofi Sa	Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.

1997
- 1997-05-13 HU HU9700885A patent/HU222283B1/hu active IP Right Grant
1998
- 1998-05-06 HR HR980240A patent/HRP980240B1/xx not_active IP Right Cessation
- 1998-05-08 ZA ZA983921A patent/ZA983921B/xx unknown
- 1998-05-11 ME MEP-1999-587A patent/ME01636B/me unknown
- 1998-05-11 NZ NZ501577A patent/NZ501577A/en not_active IP Right Cessation
- 1998-05-11 AT AT98921670T patent/ATE212025T1/de active
- 1998-05-11 TR TR1999/02783T patent/TR199902783T2/xx unknown
- 1998-05-11 WO PCT/HU1998/000048 patent/WO1998051689A1/en active IP Right Grant
- 1998-05-11 CA CA002289623A patent/CA2289623C/en not_active Expired - Fee Related
- 1998-05-11 ES ES98921670T patent/ES2172141T3/es not_active Expired - Lifetime
- 1998-05-11 SK SK1516-99A patent/SK283700B6/sk not_active IP Right Cessation
- 1998-05-11 KR KR10-1999-7010466A patent/KR100428238B1/ko not_active IP Right Cessation
- 1998-05-11 DK DK98921670T patent/DK0981529T3/da active
- 1998-05-11 BR BRPI9809112-3A patent/BR9809112B1/pt not_active IP Right Cessation
- 1998-05-11 CN CN98805036A patent/CN1109036C/zh not_active Expired - Lifetime
- 1998-05-11 PT PT98921670T patent/PT981529E/pt unknown
- 1998-05-11 DE DE69803176T patent/DE69803176T2/de not_active Expired - Lifetime
- 1998-05-11 EE EEP199900488A patent/EE03925B1/xx unknown
- 1998-05-11 RS YUP-587/99A patent/RS49626B/sr unknown
- 1998-05-11 CZ CZ19993939A patent/CZ292820B6/cs not_active IP Right Cessation
- 1998-05-11 RU RU99126506/04A patent/RU2172315C1/ru active
- 1998-05-11 EP EP98921670A patent/EP0981529B1/en not_active Expired - Lifetime
- 1998-05-11 AU AU74448/98A patent/AU735702B2/en not_active Expired
- 1998-05-11 IL IL13277498A patent/IL132774A0/xx not_active IP Right Cessation
- 1998-05-11 US US09/423,549 patent/US6180793B1/en not_active Expired - Lifetime
- 1998-05-11 PL PL336693A patent/PL194859B1/pl unknown
- 1998-05-12 DZ DZ980098A patent/DZ2487A1/xx active
- 1998-05-12 MY MYPI98002116A patent/MY121299A/en unknown
- 1998-05-12 EG EG52098A patent/EG21973A/xx active
- 1998-05-13 AR ARP980102220A patent/AR014349A1/es active IP Right Grant
- 1998-05-13 CO CO98026855A patent/CO4950564A1/es unknown
- 1998-06-12 TW TW087109424A patent/TW552263B/zh not_active IP Right Cessation
- 1998-09-27 SA SA98190583A patent/SA98190583B1/ar unknown
- 1998-11-05 UA UA99126785A patent/UA66359C2/uk unknown
- 1998-11-05 ID IDW991592A patent/ID23018A/id unknown
1999
- 1999-11-11 IS IS5244A patent/IS1883B/is unknown
- 1999-11-12 NO NO19995533A patent/NO325419B1/no not_active IP Right Cessation
2000
- 2000-10-10 HK HK00106408A patent/HK1027350A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69803176T2 (de)	2002-08-22
PT981529E (pt)	2002-06-28
CZ393999A3 (cs)	2000-04-12
CN1255924A (zh)	2000-06-07
ATE212025T1 (de)	2002-02-15
IS5244A (is)	1999-11-11
KR20010012511A (ko)	2001-02-15
PL336693A1 (en)	2000-07-03
EE9900488A (et)	2000-06-15
CN1109036C (zh)	2003-05-21
JP2001525819A (ja)	2001-12-11
SK283700B6 (sk)	2003-12-02
ZA983921B (en)	1998-11-09
IL132774A0 (en)	2001-03-19
WO1998051689A1 (en)	1998-11-19
RS49626B (sr)	2007-08-03
RU2172315C1 (ru)	2001-08-20
NO325419B1 (no)	2008-04-21
EP0981529A1 (en)	2000-03-01
ME01636B (me)	2007-08-03
PL194859B1 (pl)	2007-07-31
US6180793B1 (en)	2001-01-30
EG21973A (en)	2002-05-31
NZ501577A (en)	2001-10-26
KR100428238B1 (ko)	2004-04-30
HUP9700885A2 (hu)	1999-09-28
TW552263B (en)	2003-09-11
EE03925B1 (et)	2002-12-16
CO4950564A1 (es)	2000-09-01
SK151699A3 (en)	2000-07-11
HUP9700885D0 (en)	1997-07-28
TR199902783T2 (xx)	2000-04-21
NO995533D0 (no)	1999-11-12
UA66359C2 (uk)	2004-05-17
MY121299A (en)	2006-01-28
HU222283B1 (hu)	2003-05-28
AU7444898A (en)	1998-12-08
DE69803176D1 (de)	2002-02-21
HK1027350A1 (en)	2001-01-12
HRP980240A2 (en)	1999-02-28
EP0981529B1 (en)	2002-01-16
HUP9700885A3 (en)	2000-06-28
AU735702B2 (en)	2001-07-12
CA2289623C (en)	2007-01-30
DK0981529T3 (da)	2002-04-22
NO995533L (no)	1999-12-13
JP4256478B2 (ja)	2009-04-22
IS1883B (is)	2003-08-15
BR9809112A (pt)	2000-08-01
CA2289623A1 (en)	1998-11-19
CZ292820B6 (cs)	2003-12-17
SA98190583B1 (ar)	2006-08-19
BR9809112B1 (pt)	2010-10-05
AR014349A1 (es)	2001-02-28
ID23018A (id)	1999-12-30
ES2172141T3 (es)	2002-09-16
DZ2487A1 (fr)	2004-07-30
YU58799A (sh)	2002-06-19

Publication	Publication Date	Title
HRP980240B1 (en)	2003-02-28	A new process for the preparation of a pharmacologically ve substance
ZA986046B (en)	1999-02-01	A process for the preparation of polyethylene
ZA981829B (en)	1998-09-03	Process for the preparation of a catalyst composition
EG22337A (en)	2002-12-31	Process for preparing novel pharmaceutical compounds
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HUP0003737A3 (en)	2002-01-28	New process for the preparation of omeprazole
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IL133140A0 (en)	2001-03-19	Novel process for the preparation of 4-aryl-piperidines
IL133932A0 (en)	2001-04-30	A process for the preparation of cyclopropylacetylene
AU4174196A (en)	1996-06-17	Process for the preparation of a pharmacologically active chemical combination
ZA986048B (en)	1999-02-01	A process for the preparation of polyethylene
IL131205A0 (en)	2001-01-28	Process for preparing pharmaceutical compounds
HUP0001751A3 (en)	2001-02-28	A process for the preparation of 1,4,7,10-tetraazacyclododecane
ZA987741B (en)	1998-10-08	Process for the preparation of oxazaphosphorine-2-amines
PL343277A1 (en)	2001-08-13	Process for the preparation of a tetrapeptide
EE200000401A (et)	2001-10-15	Farmatseutilise preparaadi valmistamismeetod
HK1024690A1 (en)	2000-10-20	A new process for the preparation of 3-n,n-dicycobutylamino-8-fluoro-3, 4-dihydro-2h-1-benzopyran-5-carboxamide
HUP0001757A3 (en)	2002-12-28	Improved process for the preparation of halo-4-phenoxyquinolines
AU6832098A (en)	1998-10-30	A process for the preparation of tetraazamacrocycles
IL135553A0 (en)	2001-05-20	Process for the preparation of azacycloalkyalkanoyl pseudotetrapeptides
EG21226A (en)	2001-03-31	Process for preparing of new pharmaceutical compound
GB9807032D0 (en)	1998-06-03	Process for the preparation of (S)-3-carbethoxy-3-benzylpiperidine
IL132237A0 (en)	2001-03-19	Process for the preparation of 3-isochromanome
HUP0003321A3 (en)	2002-02-28	Process for the preparation of 2-alkylthiobenzonitrile derivatives
AU3840199A (en)	1999-11-23	Process for the preparation of a pharmaceutical intermediate

Legal Events

Date	Code	Title	Description
1999-02-28	A1OB	Publication of a patent application
1999-06-02	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2003-01-30	PNAN	Change of the applicant name, address/residence	Owner name: SANOFI SYNTHELABO, FR Owner name: SANOFI-SYNTHELABO, FR
2003-02-28	B1PR	Patent granted
2005-03-18	PNAN	Change of the applicant name, address/residence	Owner name: SANOFI-AVENTIS, FR Owner name: SANOFI, 40, FR
2017-04-06	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20170406 Year of fee payment: 20
2018-05-15	PB20	Patent expired after termination of 20 years	Effective date: 20180506