DE69803176D1 - Verfahren zur herstellung von einer pharmacologisch aktiven substanz - Google Patents

Verfahren zur herstellung von einer pharmacologisch aktiven substanz

Info

Publication number: DE69803176D1
Authority: DE; Germany
Prior art keywords: producing; active substance; pharmacologically active; pharmacologically; substance
Prior art date: 1997-05-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69803176T

Other languages

English (en)

Other versions

DE69803176T2 (de

Inventor

Maria Bakonyi

Nagy Marianna Csatarine

Leventene Molnar

Antal Gajary

Edit Alattyani

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Sanofi Synthelabo SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-13

Filing date

1998-05-11

Publication date

2002-02-21

1998-05-11 Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA

2002-02-21 Application granted granted Critical

2002-02-21 Publication of DE69803176D1 publication Critical patent/DE69803176D1/de

2002-08-22 Publication of DE69803176T2 publication Critical patent/DE69803176T2/de

2018-05-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Saccharide Compounds (AREA)

DE69803176T 1997-05-13 1998-05-11 Verfahren zur herstellung von einer pharmacologisch aktiven substanz Expired - Lifetime DE69803176T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9700885A HU222283B1 (hu)	1997-05-13	1997-05-13	Eljárás tieno[3,2-c]piridin-származékok előállítására
PCT/HU1998/000048 WO1998051689A1 (en)	1997-05-13	1998-05-11	A new process for the preparation of a pharmacologically active substance

Publications (2)

Publication Number	Publication Date
DE69803176D1 true DE69803176D1 (de)	2002-02-21
DE69803176T2 DE69803176T2 (de)	2002-08-22

Family

ID=90014236

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69803176T Expired - Lifetime DE69803176T2 (de)	1997-05-13	1998-05-11	Verfahren zur herstellung von einer pharmacologisch aktiven substanz

Country Status (38)

Country	Link
US (1)	US6180793B1 (de)
EP (1)	EP0981529B1 (de)
KR (1)	KR100428238B1 (de)
CN (1)	CN1109036C (de)
AR (1)	AR014349A1 (de)
AT (1)	ATE212025T1 (de)
AU (1)	AU735702B2 (de)
BR (1)	BR9809112B1 (de)
CA (1)	CA2289623C (de)
CO (1)	CO4950564A1 (de)
CZ (1)	CZ292820B6 (de)
DE (1)	DE69803176T2 (de)
DK (1)	DK0981529T3 (de)
DZ (1)	DZ2487A1 (de)
EE (1)	EE03925B1 (de)
EG (1)	EG21973A (de)
ES (1)	ES2172141T3 (de)
HK (1)	HK1027350A1 (de)
HR (1)	HRP980240B1 (de)
HU (1)	HU222283B1 (de)
ID (1)	ID23018A (de)
IL (1)	IL132774A0 (de)
IS (1)	IS1883B (de)
ME (1)	ME01636B (de)
MY (1)	MY121299A (de)
NO (1)	NO325419B1 (de)
NZ (1)	NZ501577A (de)
PL (1)	PL194859B1 (de)
PT (1)	PT981529E (de)
RS (1)	RS49626B (de)
RU (1)	RU2172315C1 (de)
SA (1)	SA98190583B1 (de)
SK (1)	SK283700B6 (de)
TR (1)	TR199902783T2 (de)
TW (1)	TW552263B (de)
UA (1)	UA66359C2 (de)
WO (1)	WO1998051689A1 (de)
ZA (1)	ZA983921B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2769313B1 (fr) *	1997-10-06	2000-04-21	Sanofi Sa	Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
HU226421B1 (en)	1998-11-09	2008-12-29	Sanofi Aventis	Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
IN191030B (de) *	2001-01-24	2003-09-13	Cadila Healthcare Ltd
US6495691B1 (en)	2001-07-06	2002-12-17	Brantford Chemicals Inc.	Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en)	2001-12-18	2004-07-27	Teva Pharmaceutical Industries Ltd.	Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en)	2002-01-11	2006-07-11	Teva Pharmaceutical Industries, Ltd.	Polymorphs of clopidogrel hydrogensulfate
ITMI20020933A1 (it) *	2002-05-03	2003-11-03	Danimite Dipharma S P A	Procedimento per la sintesi di clopidogrel
US6800759B2 (en) *	2002-08-02	2004-10-05	Teva Pharmaceutical Industries Ltd.	Racemization and enantiomer separation of clopidogrel
IL166593A0 (en)	2002-08-02	2006-01-15		Racemization and enantiomer separation of clopidogrel
US6812363B2 (en) *	2002-10-15	2004-11-02	Usv Limited	Racemization of optically active 2-substituted phenyl glycine esters
WO2004081015A1 (en) *	2003-03-10	2004-09-23	Hetero Drugs Limited	Amorphous clopidogrel hydrogen sulfate
AU2003238664A1 (en)	2003-03-12	2004-09-30	Cadila Healthcare Limited	Polymorphs and amorphous form of (s) - (+) -clopidogrel bisulfate
GB0321256D0 (en) *	2003-09-11	2003-10-08	Generics Uk Ltd	Novel crystalline compounds
DE602004025267D1 (de)	2003-11-03	2010-03-11	Cadila Healthcare Ltd	Verfahren zur herstellung form i von (s)-(+)- clopidogrelbisulfat
CA2457459A1 (en) *	2004-02-11	2005-08-11	Brantford Chemicals Inc.	Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
KR100553398B1 (ko)	2004-03-12	2006-02-16	한미약품 주식회사	티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
US20060154957A1 (en) *	2004-09-21	2006-07-13	Nina Finkelstein	Crystalline clopidogrel hydrobromide and processes for preparation thereof
MX2007010267A (es) *	2005-02-24	2007-09-11	Teva Pharma	Base de clopidogrel adecuada para formulacion farmaceutica y preparacion de ella.
KR100681512B1 (ko)	2005-03-08	2007-02-09	주식회사 한서켐	클로피도그렐의 신규한 제조 중간체 및 이를 이용한 클로피도그렐의 제조방법
KR101235117B1 (ko)	2005-12-26	2013-02-20	에스케이케미칼주식회사	광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
CN102014899A (zh) *	2006-04-27	2011-04-13	因-斯韦特实验室有限公司	硫酸氢氯吡格雷多晶型物的制备方法
US20090247569A1 (en) *	2006-08-03	2009-10-01	Claude Singer	Process for Preparing Clopidogrel Bisulphate
US8247558B2 (en)	2006-09-04	2012-08-21	Ranbaxy Laboratories Limited	Process for the preparation of clopidogrel and its pharmaceutically acceptable salts
EP1980563A1 (de)	2007-04-09	2008-10-15	BATTULA, Srinivasa Reddy	Verfahren zur Herstellung von Methyl (+)-(S)-Alpha-(O-Chlorophenyl)-6,7-Dihydrothieno-[3,2-C]pyridine-5(4H) Acetat
EP2107061A1 (de)	2008-04-02	2009-10-07	Krka Tovarna Zdravil, D.D., Novo Mesto	Herstellungsverfahren für optisch angereichertes Clopidogrel
US20090264460A1 (en) *	2008-04-21	2009-10-22	Mamta Mishra	Clopidogrel pharmaceutical formulations
KR100990949B1 (ko)	2008-06-09	2010-10-29	엔자이텍 주식회사	클로피도그렐 및 그의 유도체의 제조방법
CN102186858A (zh) *	2008-10-24	2011-09-14	桑多斯股份公司	制备s-氯吡格雷的方法
US8563690B2 (en) *	2008-11-03	2013-10-22	The Board Of Trustees Of The University Of Illinois	Modulation of platelet aggregation
CN101544655B (zh) *	2009-05-05	2012-07-04	上海医药集团股份有限公司	噻吩并[3，2-c]吡啶衍生物的制备方法
CN101863899B (zh) *	2010-06-21	2013-03-20	常州制药厂有限公司	一种提高氯吡格雷樟脑磺酸盐拆分收率的方法
KR20170004283A (ko)	2015-07-02	2017-01-11	류종렬	그립부가 개선된 쉐이크 핸드형 탁구 라켓
KR20170004282A (ko)	2015-07-02	2017-01-11	류종렬	수도 지지부가 구비된 쉐이크 핸드형 탁구 라켓

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2530247B1 (fr) *	1982-07-13	1986-05-16	Sanofi Sa	Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2608607B1 (fr)	1986-12-23	1989-04-28	Sanofi Sa	Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues
FR2623810B2 (fr) *	1987-02-17	1992-01-24	Sanofi Sa	Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2652575B1 (fr) *	1989-09-29	1992-01-24	Sanofi Sa	Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664596B1 (fr) *	1990-07-10	1994-06-10	Sanofi Sa	Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.

1997
- 1997-05-13 HU HU9700885A patent/HU222283B1/hu active IP Right Grant
1998
- 1998-05-06 HR HR980240A patent/HRP980240B1/xx not_active IP Right Cessation
- 1998-05-08 ZA ZA983921A patent/ZA983921B/xx unknown
- 1998-05-11 ME MEP-1999-587A patent/ME01636B/de unknown
- 1998-05-11 NZ NZ501577A patent/NZ501577A/en not_active IP Right Cessation
- 1998-05-11 AT AT98921670T patent/ATE212025T1/de active
- 1998-05-11 TR TR1999/02783T patent/TR199902783T2/xx unknown
- 1998-05-11 WO PCT/HU1998/000048 patent/WO1998051689A1/en active IP Right Grant
- 1998-05-11 CA CA002289623A patent/CA2289623C/en not_active Expired - Fee Related
- 1998-05-11 ES ES98921670T patent/ES2172141T3/es not_active Expired - Lifetime
- 1998-05-11 SK SK1516-99A patent/SK283700B6/sk not_active IP Right Cessation
- 1998-05-11 KR KR10-1999-7010466A patent/KR100428238B1/ko not_active IP Right Cessation
- 1998-05-11 DK DK98921670T patent/DK0981529T3/da active
- 1998-05-11 BR BRPI9809112-3A patent/BR9809112B1/pt not_active IP Right Cessation
- 1998-05-11 CN CN98805036A patent/CN1109036C/zh not_active Expired - Lifetime
- 1998-05-11 PT PT98921670T patent/PT981529E/pt unknown
- 1998-05-11 DE DE69803176T patent/DE69803176T2/de not_active Expired - Lifetime
- 1998-05-11 EE EEP199900488A patent/EE03925B1/xx unknown
- 1998-05-11 RS YUP-587/99A patent/RS49626B/sr unknown
- 1998-05-11 CZ CZ19993939A patent/CZ292820B6/cs not_active IP Right Cessation
- 1998-05-11 RU RU99126506/04A patent/RU2172315C1/ru active
- 1998-05-11 EP EP98921670A patent/EP0981529B1/de not_active Expired - Lifetime
- 1998-05-11 AU AU74448/98A patent/AU735702B2/en not_active Expired
- 1998-05-11 IL IL13277498A patent/IL132774A0/xx not_active IP Right Cessation
- 1998-05-11 US US09/423,549 patent/US6180793B1/en not_active Expired - Lifetime
- 1998-05-11 PL PL336693A patent/PL194859B1/pl unknown
- 1998-05-12 DZ DZ980098A patent/DZ2487A1/xx active
- 1998-05-12 MY MYPI98002116A patent/MY121299A/en unknown
- 1998-05-12 EG EG52098A patent/EG21973A/xx active
- 1998-05-13 AR ARP980102220A patent/AR014349A1/es active IP Right Grant
- 1998-05-13 CO CO98026855A patent/CO4950564A1/es unknown
- 1998-06-12 TW TW087109424A patent/TW552263B/zh not_active IP Right Cessation
- 1998-09-27 SA SA98190583A patent/SA98190583B1/ar unknown
- 1998-11-05 UA UA99126785A patent/UA66359C2/uk unknown
- 1998-11-05 ID IDW991592A patent/ID23018A/id unknown
1999
- 1999-11-11 IS IS5244A patent/IS1883B/is unknown
- 1999-11-12 NO NO19995533A patent/NO325419B1/no not_active IP Right Cessation
2000
- 2000-10-10 HK HK00106408A patent/HK1027350A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69803176T2 (de)	2002-08-22
PT981529E (pt)	2002-06-28
CZ393999A3 (cs)	2000-04-12
CN1255924A (zh)	2000-06-07
ATE212025T1 (de)	2002-02-15
IS5244A (is)	1999-11-11
KR20010012511A (ko)	2001-02-15
PL336693A1 (en)	2000-07-03
EE9900488A (et)	2000-06-15
CN1109036C (zh)	2003-05-21
JP2001525819A (ja)	2001-12-11
SK283700B6 (sk)	2003-12-02
ZA983921B (en)	1998-11-09
IL132774A0 (en)	2001-03-19
WO1998051689A1 (en)	1998-11-19
RS49626B (sr)	2007-08-03
RU2172315C1 (ru)	2001-08-20
NO325419B1 (no)	2008-04-21
EP0981529A1 (de)	2000-03-01
ME01636B (de)	2007-08-03
PL194859B1 (pl)	2007-07-31
US6180793B1 (en)	2001-01-30
EG21973A (en)	2002-05-31
NZ501577A (en)	2001-10-26
KR100428238B1 (ko)	2004-04-30
HUP9700885A2 (hu)	1999-09-28
TW552263B (en)	2003-09-11
EE03925B1 (et)	2002-12-16
CO4950564A1 (es)	2000-09-01
SK151699A3 (en)	2000-07-11
HUP9700885D0 (en)	1997-07-28
TR199902783T2 (xx)	2000-04-21
NO995533D0 (no)	1999-11-12
UA66359C2 (uk)	2004-05-17
MY121299A (en)	2006-01-28
HU222283B1 (hu)	2003-05-28
AU7444898A (en)	1998-12-08
HK1027350A1 (en)	2001-01-12
HRP980240A2 (en)	1999-02-28
EP0981529B1 (de)	2002-01-16
HUP9700885A3 (en)	2000-06-28
AU735702B2 (en)	2001-07-12
CA2289623C (en)	2007-01-30
DK0981529T3 (da)	2002-04-22
NO995533L (no)	1999-12-13
JP4256478B2 (ja)	2009-04-22
IS1883B (is)	2003-08-15
HRP980240B1 (en)	2003-02-28
BR9809112A (pt)	2000-08-01
CA2289623A1 (en)	1998-11-19
CZ292820B6 (cs)	2003-12-17
SA98190583B1 (ar)	2006-08-19
BR9809112B1 (pt)	2010-10-05
AR014349A1 (es)	2001-02-28
ID23018A (id)	1999-12-30
ES2172141T3 (es)	2002-09-16
DZ2487A1 (fr)	2004-07-30
YU58799A (sh)	2002-06-19

Publication	Publication Date	Title
DE69803176D1 (de)	2002-02-21	Verfahren zur herstellung von einer pharmacologisch aktiven substanz
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DE69801560D1 (de)	2001-10-11	Verfahren zur herstellung einer katalysatorzusammenstellung
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DE69840320D1 (de)	2009-01-22	Verfahren zur Herstellung einer Gateelektrode
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DE69821428D1 (de)	2004-03-11	Verfahren zur herstellung einer alpha-monoglucosylhesperidin-reichen substanz
DE59807129D1 (de)	2003-03-13	Verfahren zur herstellung von metallocenen
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DE59807082D1 (de)	2003-03-06	Verfahren zur herstellung von metallocenen
DE69803652D1 (de)	2002-03-14	Verfahren zur herstellung von cyclopentadienylverbindungen
ATE219056T1 (de)	2002-06-15	Verfahren zur herstellung von alpha- bromolactamderivaten
DE69808068D1 (de)	2002-10-24	Verfahren zur herstellung von indolderivaten
DE69840327D1 (de)	2009-01-22	Verfahren zur herstellung einer gate-elektrode
DE69819191D1 (de)	2003-11-27	Verfahren zur herstellung von pentafluorethan
ATE225797T1 (de)	2002-10-15	Verfahren zur herstellung von oxazaphosphorin-2- aminen
DE59802764D1 (de)	2002-02-21	Verfahren zur herstellung von phosphabenzolverbindungen
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Legal Events

Date	Code	Title	Description
2003-02-13	8364	No opposition during term of opposition
2005-04-28	8327	Change in the person/name/address of the patent owner	Owner name: SANOFI-AVENTIS, PARIS, FR
2013-02-05	R082	Change of representative	Ref document number: 981529 Country of ref document: EP Representative=s name: BEETZ & PARTNER PATENT- UND RECHTSANWAELTE, DE

Date

Code

Title

Description

2003-02-13

8364

No opposition during term of opposition

2005-04-28

8327

Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR

2013-02-05

R082

Change of representative

Ref document number: 981529

Country of ref document: EP

Representative=s name: BEETZ & PARTNER PATENT- UND RECHTSANWAELTE, DE