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HK1117532A1 - Novel deuterated benzo [d][1,3]-dioxol derivatives as serotonin reuptake inhibitors - Google Patents

Novel deuterated benzo [d][1,3]-dioxol derivatives as serotonin reuptake inhibitors

Info

Publication number
HK1117532A1
HK1117532A1 HK08111437.0A HK08111437A HK1117532A1 HK 1117532 A1 HK1117532 A1 HK 1117532A1 HK 08111437 A HK08111437 A HK 08111437A HK 1117532 A1 HK1117532 A1 HK 1117532A1
Authority
HK
Hong Kong
Prior art keywords
compound
reuptake inhibitors
isotopologues
serotonin reuptake
novel deuterated
Prior art date
Application number
HK08111437.0A
Other languages
English (en)
Inventor
Roger Tung
Original Assignee
Concert Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concert Pharmaceuticals Inc filed Critical Concert Pharmaceuticals Inc
Publication of HK1117532A1 publication Critical patent/HK1117532A1/xx

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pulmonology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
HK08111437.0A 2005-07-29 2008-10-16 Novel deuterated benzo [d][1,3]-dioxol derivatives as serotonin reuptake inhibitors HK1117532A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70407305P 2005-07-29 2005-07-29
PCT/US2006/029599 WO2007016431A2 (en) 2005-07-29 2006-07-28 Novel benzo [d] [1,3]-dioxol derivatives

Publications (1)

Publication Number Publication Date
HK1117532A1 true HK1117532A1 (en) 2009-01-16

Family

ID=37709249

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08111437.0A HK1117532A1 (en) 2005-07-29 2008-10-16 Novel deuterated benzo [d][1,3]-dioxol derivatives as serotonin reuptake inhibitors

Country Status (13)

Country Link
US (5) US20080287495A1 (xx)
EP (1) EP1910322B1 (xx)
JP (1) JP5301991B2 (xx)
KR (1) KR101380190B1 (xx)
CN (1) CN101273024A (xx)
AU (1) AU2006275595B2 (xx)
BR (1) BRPI0615973A2 (xx)
CA (1) CA2616383C (xx)
EA (1) EA014432B1 (xx)
ES (1) ES2396365T3 (xx)
HK (1) HK1117532A1 (xx)
WO (1) WO2007016431A2 (xx)
ZA (1) ZA200800785B (xx)

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US8450492B2 (en) 2013-05-28
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CA2616383C (en) 2015-06-09
US20100222589A1 (en) 2010-09-02
US20070191432A1 (en) 2007-08-16
KR20080039949A (ko) 2008-05-07
AU2006275595A1 (en) 2007-02-08
AU2006275595B2 (en) 2012-08-16
EP1910322A4 (en) 2010-09-22
BRPI0615973A2 (pt) 2011-05-31
KR101380190B1 (ko) 2014-04-11
EP1910322B1 (en) 2012-09-05
EA200800490A1 (ru) 2008-08-29
EA014432B1 (ru) 2010-12-30
CA2616383A1 (en) 2007-02-08
WO2007016431A3 (en) 2007-07-12
CN101273024A (zh) 2008-09-24
US20140018390A1 (en) 2014-01-16
JP5301991B2 (ja) 2013-09-25
US7678914B2 (en) 2010-03-16
US20080287495A1 (en) 2008-11-20
ES2396365T3 (es) 2013-02-21
ZA200800785B (en) 2009-01-28
JP2009502963A (ja) 2009-01-29
WO2007016431A2 (en) 2007-02-08

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