Nothing Special   »   [go: up one dir, main page]

HK1094800A1 - Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino [4,5-c]pyrrole - Google Patents

Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino [4,5-c]pyrrole

Info

Publication number
HK1094800A1
HK1094800A1 HK07102138.2A HK07102138A HK1094800A1 HK 1094800 A1 HK1094800 A1 HK 1094800A1 HK 07102138 A HK07102138 A HK 07102138A HK 1094800 A1 HK1094800 A1 HK 1094800A1
Authority
HK
Hong Kong
Prior art keywords
oxepino
dibenz
pyrrole
tetrahydro
trans
Prior art date
Application number
HK07102138.2A
Other languages
English (en)
Inventor
Gerardus Johannes Kemperman
Jacobus Johannes Maria Van Der Linden
Michael R Reeder
Original Assignee
Organon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon filed Critical Organon
Publication of HK1094800A1 publication Critical patent/HK1094800A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK07102138.2A 2005-04-07 2007-02-26 Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino [4,5-c]pyrrole HK1094800A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05102742 2005-04-07

Publications (1)

Publication Number Publication Date
HK1094800A1 true HK1094800A1 (en) 2007-04-13

Family

ID=35511130

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07102138.2A HK1094800A1 (en) 2005-04-07 2007-02-26 Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino [4,5-c]pyrrole

Country Status (28)

Country Link
EP (2) EP2154134B1 (xx)
JP (1) JP2008534657A (xx)
KR (1) KR20070116973A (xx)
CN (2) CN1861604B (xx)
AR (1) AR063188A1 (xx)
AT (1) ATE447564T1 (xx)
AU (1) AU2006231281B2 (xx)
BR (1) BRPI0610677A2 (xx)
CA (1) CA2603181A1 (xx)
CY (1) CY1109722T1 (xx)
DE (1) DE602006010132D1 (xx)
DK (1) DK1710241T3 (xx)
ES (1) ES2333980T3 (xx)
HK (1) HK1094800A1 (xx)
HR (1) HRP20100031T1 (xx)
IL (1) IL186354A0 (xx)
MX (1) MX2007012446A (xx)
NO (1) NO20075152L (xx)
NZ (1) NZ562125A (xx)
PL (1) PL1710241T3 (xx)
PT (1) PT1710241E (xx)
RS (1) RS51341B (xx)
RU (1) RU2397164C2 (xx)
SI (1) SI1710241T1 (xx)
TW (1) TW200716589A (xx)
UA (2) UA93044C2 (xx)
WO (1) WO2006106136A1 (xx)
ZA (2) ZA200708493B (xx)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5027477B2 (ja) * 2005-10-21 2012-09-19 住友化学株式会社 ジベンゾオキセピノピロール化合物およびその中間体の製造方法ならびに新規中間体
TW200817414A (en) * 2006-07-05 2008-04-16 Organon Nv Process for the preparation of asenapine and intermediate products used in said process
WO2008078482A1 (ja) * 2006-12-22 2008-07-03 Sumitomo Chemical Company, Limited アセナピン合成中間体の製造方法
US7875729B2 (en) * 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
JP5245428B2 (ja) * 2007-07-06 2013-07-24 住友化学株式会社 トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体
JP2011508751A (ja) * 2008-01-04 2011-03-17 ナームローゼ・フエンノートチヤツプ・オルガノン アセナピンの調製方法および前記方法において使用される中間生成物
RU2012102247A (ru) 2009-06-24 2013-07-27 Мсд Осс Б.В. Инъекционные композиции, содержащие асенапин и способ лечения с их применением
CN101851242B (zh) * 2010-05-25 2013-07-24 上海皓元生物医药科技有限公司 阿塞那平中间体的制备方法
ES2466767T3 (es) * 2010-07-29 2014-06-11 Laboratorios Lesvi, S.L. Nuevo proceso para la preparación de asenapina
WO2012038975A2 (en) * 2010-09-22 2012-03-29 Msn Laboratories Limited Process for the preparation of (3ars,12brs)-5-chloro-2-methyl-2,3,3a12b-tetrahydro-1hdibenzo[2,3:6,7] oxepino [4,5-c]pyrrole maleate and it's pharmaceutical composition thereof
ES2575544T3 (es) 2010-12-24 2016-06-29 Medichem, S.A. Procedimientos para la preparación de 5-cloro-2-metil-2,3,3a,12b-tetrahidro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pirrol
ITMI20110734A1 (it) * 2011-05-02 2012-11-03 Olon Spa Sali cristallini di asenapina
WO2013024492A2 (en) * 2011-07-01 2013-02-21 Megafine Pharma (P) Ltd. A process for the preparation of asenapine and novel salts thereof
CN102952144A (zh) * 2011-08-29 2013-03-06 上海华拓医药科技发展股份有限公司 阿森纳平马来酸盐的晶型、制备方法及其药物组合物
WO2013080069A1 (en) * 2011-11-28 2013-06-06 Ranbaxy Laboratories Limited Process for the preparation of asenapine intermediate
CN102746209A (zh) * 2012-06-20 2012-10-24 盛世泰科生物医药技术(苏州)有限公司 一种3-（2-（4-氯苯氧基）苯基）-1-甲基-2,4-二酮的合成方法
CN103965206A (zh) * 2013-01-29 2014-08-06 北京京卫燕康药物研究所有限公司 一种阿色纳品马来酸盐的新晶型及制备方法
CN103113379A (zh) * 2013-03-12 2013-05-22 盛世泰科生物医药技术(苏州)有限公司 阿塞那平马来酸盐的合成工艺
CN103254202A (zh) * 2013-05-19 2013-08-21 甘肃皓天化学科技有限公司 阿塞纳平的制备方法
CN103342707B (zh) * 2013-06-28 2015-09-02 甘肃皓天化学科技有限公司 用于制备阿塞纳平中间体的制备方法
CN104447771A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的马来酸阿塞那平化合物
CN103864802B (zh) * 2014-03-31 2016-08-17 四川科伦药业股份有限公司 马来酸阿塞那平的制备方法
CN105693735A (zh) * 2016-01-15 2016-06-22 万特制药(海南)有限公司 马来酸阿塞那平一种制备方法
CA3047354A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
JP7236389B2 (ja) 2016-12-20 2023-03-09 エルテーエス ローマン テラピー－ジステーメ アーゲー アセナピンを含有する経皮治療システム
EP3644973B1 (en) 2017-06-26 2021-03-24 LTS LOHMANN Therapie-Systeme AG Transdermal therapeutic system containing asenapine and silicone acrylic hybrid polymer
CN109200025A (zh) * 2017-06-29 2019-01-15 哈尔滨莱博通药业有限公司 一种阿森纳平马来酸盐舌下片
MX2020014286A (es) 2018-06-20 2021-03-25 Lts Lohmann Therapie Systeme Ag Sistema terapeutico transdermico que contiene asenapina.
CN110183457A (zh) * 2019-06-27 2019-08-30 浙江天顺药业有限公司 一种阿塞那平及其制备方法
CN112194665A (zh) * 2020-10-20 2021-01-08 连云港杰瑞药业有限公司 一种合成阿塞那平中间体的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
CA2182981C (en) 1994-03-02 2006-10-17 Leonardus Petrus Carla Delbressine Sublingual or buccal pharmaceutical composition
WO1999032108A1 (en) 1997-12-19 1999-07-01 Akzo Nobel N.V. Org-5222 in the treatment of depression

Also Published As

Publication number Publication date
CN1861604B (zh) 2011-08-31
ZA200708493B (en) 2009-09-30
TW200716589A (en) 2007-05-01
EP2154134A1 (en) 2010-02-17
SI1710241T1 (sl) 2010-02-26
JP2008534657A (ja) 2008-08-28
CN101175741A (zh) 2008-05-07
CA2603181A1 (en) 2006-10-12
CN101175741B (zh) 2011-06-22
RU2397164C2 (ru) 2010-08-20
BRPI0610677A2 (pt) 2012-10-30
RS51341B (en) 2011-02-28
PT1710241E (pt) 2009-12-10
HRP20100031T1 (hr) 2010-02-28
KR20070116973A (ko) 2007-12-11
WO2006106136A1 (en) 2006-10-12
RU2007141161A (ru) 2009-05-20
EP2154134B1 (en) 2012-10-24
DK1710241T3 (da) 2010-03-01
AU2006231281A1 (en) 2006-10-12
ATE447564T1 (de) 2009-11-15
CY1109722T1 (el) 2014-04-09
NO20075152L (no) 2007-11-01
ES2333980T3 (es) 2010-03-03
CN1861604A (zh) 2006-11-15
ZA200708490B (en) 2008-10-29
DE602006010132D1 (de) 2009-12-17
UA93043C2 (ru) 2011-01-10
UA93044C2 (xx) 2011-01-10
MX2007012446A (es) 2007-11-07
EP1710241A1 (en) 2006-10-11
AU2006231281B2 (en) 2011-04-28
IL186354A0 (en) 2008-01-20
EP1710241B1 (en) 2009-11-04
PL1710241T3 (pl) 2010-04-30
NZ562125A (en) 2010-08-27
AR063188A1 (es) 2009-01-14

Similar Documents

Publication Publication Date Title
IL186354A0 (en) INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF TRANS -5-CHLORO-2-METHYL-2,3,3a,12b-TETRAHYDRO-1H -DIBENZ[2,3:6,7] OXEPINO [4,5-c] PYRROLE
HK1163672A1 (en) Processes for the preparation of compounds
IL192362A0 (en) Processes for preparing intermediate compounds useful for the preparation of ezetimibe
EP1893625A4 (en) PROCESS FOR THE PREPARATION OF 9-DEAZAPURINE DERIVATIVES
HK1108580A1 (en) A process for the preparation of [1,4,5]-oxadiazepine derivatives
ZA200610587B (en) 1-Heterocyclyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones
IL189181A0 (en) Novel 4-amino-thieno[3,2-c]pyridine-7-
IL213474A0 (en) Processes for the preparation of cyclopropyl-amide derivatives
IL191568A0 (en) Novel process for the preparation of 5-amino-3h-thiazolo[4,5-d]pyrimidin-2-one
IL187441A0 (en) Derivatives of 6,7-dihydro-5h-imidazo[1,2-a] imidazole-3-sulfonic acid
EP1781677A4 (en) PROCESS FOR PREPARING A D-ERYTHRO-2,2-DIFLUORO-2-DEOXY-1-OXORIBOSE DERIVATIVE
HK1105634A1 (en) Heteroatoms-containing tricyclic compounds
EP1928827A4 (en) PYRROLE DERIVATIVES AS THERAPEUTIC AGENTS
ZA200703495B (en) Process for the preparation of irbesartan hydrochloride
IL176471A0 (en) Process for the preparation of triazolopyrimidines
GB0427589D0 (en) Process for the preparation of a substituted porphyrin
IL178960A0 (en) Process for the preparation of pyridin-2-ylmethylsulphinyl-1h-benzimidazol compounds
GB0521727D0 (en) Methods for the preparation of organic compounds
GB0521726D0 (en) Methods for the preparation of organic compounds
GB0521728D0 (en) Methods for the preparation of organic compounds
IL186457A0 (en) Process for the preparation of 9,10-dehydro-12,13-desoxyepothilone derivatives
HU0401379D0 (en) Process for the preparation of risperidon
IL189370A0 (en) PROCESS FOR PRODUCING IMIDAZO[1,2-b]PYRIDAZINE COMPOUND
ZA200706203B (en) Processes and compounds for the preparation of substituted naphthylindole derivatives
PT1600446E (pt) Novos derivados de 3,3-dimetil-5-ciano-benzoxepina úteis para a preparação de derivados de 5-formil-benzoxepina

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130406