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HK1058363A1 - Farnesyl transferase i8nhibiting 1,2-annelated quinoline enantiomer - Google Patents

Farnesyl transferase i8nhibiting 1,2-annelated quinoline enantiomer

Info

Publication number
HK1058363A1
HK1058363A1 HK04101163A HK04101163A HK1058363A1 HK 1058363 A1 HK1058363 A1 HK 1058363A1 HK 04101163 A HK04101163 A HK 04101163A HK 04101163 A HK04101163 A HK 04101163A HK 1058363 A1 HK1058363 A1 HK 1058363A1
Authority
HK
Hong Kong
Prior art keywords
farnesyl transferase
quinoline enantiomer
annelated quinoline
annelated
enantiomer
Prior art date
Application number
HK04101163A
Other languages
English (en)
Inventor
Marc Gaston Venet
Patrick Rene Angibaud
David William End
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1058363A1 publication Critical patent/HK1058363A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK04101163A 2000-06-22 2004-02-18 Farnesyl transferase i8nhibiting 1,2-annelated quinoline enantiomer HK1058363A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00202181 2000-06-22
PCT/EP2001/006747 WO2001098302A1 (en) 2000-06-22 2001-06-13 Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer

Publications (1)

Publication Number Publication Date
HK1058363A1 true HK1058363A1 (en) 2004-05-14

Family

ID=8171675

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04101163A HK1058363A1 (en) 2000-06-22 2004-02-18 Farnesyl transferase i8nhibiting 1,2-annelated quinoline enantiomer

Country Status (34)

Country Link
US (3) US20030114471A1 (hu)
EP (1) EP1296984B1 (hu)
JP (1) JP4919575B2 (hu)
KR (2) KR100831940B1 (hu)
CN (1) CN1207296C (hu)
AR (1) AR030704A1 (hu)
AT (1) ATE294804T1 (hu)
AU (3) AU6396201A (hu)
BG (1) BG65894B1 (hu)
BR (1) BRPI0111743B8 (hu)
CA (1) CA2410232C (hu)
CZ (1) CZ295278B6 (hu)
DE (1) DE60110592T2 (hu)
EA (1) EA005065B1 (hu)
EE (1) EE04966B1 (hu)
EG (1) EG24180A (hu)
ES (1) ES2241830T3 (hu)
HK (1) HK1058363A1 (hu)
HR (1) HRP20020989B1 (hu)
HU (1) HU229095B1 (hu)
IL (2) IL153560A0 (hu)
IS (1) IS2596B (hu)
JO (1) JO2361B1 (hu)
MX (1) MXPA02012845A (hu)
MY (1) MY127734A (hu)
NO (1) NO324494B1 (hu)
NZ (1) NZ522481A (hu)
PA (1) PA8519501A1 (hu)
PL (1) PL209521B1 (hu)
SA (1) SA01220349B1 (hu)
SK (1) SK285699B6 (hu)
UA (1) UA73572C2 (hu)
WO (1) WO2001098302A1 (hu)
ZA (1) ZA200210305B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003018135A1 (en) 2001-08-24 2003-03-06 Wyeth Holdings Corporation Method of using 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones for inhibition of farnesyl-protein transferase
AU2003229688B2 (en) 2002-04-15 2009-07-30 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles or triazoles
US20050003422A1 (en) 2003-07-01 2005-01-06 Mitch Reponi Methods for assessing and treating cancer
US10076512B2 (en) 2014-05-01 2018-09-18 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
US11311519B2 (en) 2014-05-01 2022-04-26 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
JP2017536403A (ja) * 2014-12-04 2017-12-07 アイガー・バイオファーマシューティカルズ・インコーポレイテッドＥｉｇｅｒ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． デルタ肝炎ウイルス感染の治療
EP3285768B1 (en) 2015-04-21 2020-12-30 Eiger Biopharmaceuticals, Inc. Pharmaceutical compositions comprising lonafarnib and ritonavir
PL3277842T3 (pl) 2015-08-17 2019-12-31 Kura Oncology, Inc. Sposoby leczenia pacjentów z nowotworem z użyciem inhibitorów farnezylotransferazy
WO2018085518A2 (en) 2016-11-03 2018-05-11 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1519765A (en) * 1974-09-05 1978-08-02 Ici Ltd Pesticidal dihydrotetrazolo(1,5a) quinazolines compositions and processes
US4141979A (en) * 1976-12-23 1979-02-27 Pfizer Inc. Tetrazolo[a]quinazol-5-ones antiallergy and antiulcer agents
GB9513577D0 (en) * 1995-07-04 1995-09-06 Brotherwood Rodney J Improvements in passenger carrying vehicles
TW349948B (en) * 1995-10-31 1999-01-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 2-quinolone derivatives
NZ320244A (en) * 1995-12-08 1999-06-29 Janssen Pharmaceutica Nv Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives
EP0891334A1 (en) 1996-04-03 1999-01-20 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
TW591030B (en) * 1997-03-10 2004-06-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
RU2205831C2 (ru) * 1997-04-25 2003-06-10 Янссен Фармацевтика Н.В. Хиназолиноны, ингибирующие фарнезилтрансферазу
PT988038E (pt) 1997-06-02 2002-12-31 Janssen Pharmaceutica Nv Derivados (imidazol-5-il)metil-2-quinolinona como inibidores da proliferacao de celulas dos musculos lisos
IL140720A0 (en) 1998-07-06 2002-02-10 Janssen Pharmaceutica Nv Farnesyl protein transferase inhibitors for treating arthropathies
CZ300968B6 (cs) * 1998-07-06 2009-09-30 Janssen Pharmaceutica N. V. Farmaceutická kompozice mající radiosenzibilizacní vlastnosti obsahující inhibitor farnesyl-protein transferasy
SK2442001A3 (en) * 1998-08-27 2002-10-08 Pfizer Prod Inc Alkynyl-substituted quinolin-2-ones, pharmaceutical compositions, their use in the treatment and method for producing thereof
DE69923849T2 (de) * 1998-08-27 2006-01-12 Pfizer Products Inc., Groton Quinolin-2-on-derivate verwendbar als antikrebsmittel
SK286072B6 (sk) * 1998-12-23 2008-02-05 Janssen Pharmaceutica N. V. 1,2-anelované chinolínové deriváty, spôsob ich prípravy, medziprodukty, farmaceutický prostriedok aich použitie
US6462201B1 (en) * 1998-12-29 2002-10-08 Isp Investments Inc. Process for the production of N-vinyl-2-pyrrolidone by vinylation
EE200100425A (et) * 1999-02-11 2002-12-16 Pfizer Products Inc. Heteroarüül-asendatud kinoliin-2-ooni derivaadid kui vähivastased vahendid
HN2000000266A (es) 2000-01-21 2001-05-21 Pfizer Prod Inc Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
AU2001231763A1 (en) * 2000-02-24 2001-09-03 Janssen Pharmaceutica N.V. Dosing regimen
AU2001293835A1 (en) 2000-09-25 2002-04-02 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
AU2002220559A1 (en) 2000-09-25 2002-04-02 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives

Also Published As

Publication number Publication date
NO324494B1 (no) 2007-10-29
HRP20020989B1 (en) 2011-05-31
EP1296984B1 (en) 2005-05-04
HRP20020989A2 (en) 2005-02-28
AU6396201A (en) 2002-01-02
JO2361B1 (en) 2006-12-12
NO20026032D0 (no) 2002-12-16
SK285699B6 (sk) 2007-06-07
UA73572C2 (en) 2005-08-15
EP1296984A1 (en) 2003-04-02
PL358918A1 (en) 2004-08-23
CN1437601A (zh) 2003-08-20
CZ295278B6 (cs) 2005-06-15
CA2410232C (en) 2008-10-07
CZ2003114A3 (cs) 2003-05-14
KR20030009463A (ko) 2003-01-29
JP4919575B2 (ja) 2012-04-18
PA8519501A1 (es) 2002-08-29
EG24180A (en) 2008-09-28
CN1207296C (zh) 2005-06-22
KR100831940B1 (ko) 2008-05-23
IS6590A (is) 2002-10-25
SK502003A3 (en) 2003-05-02
EA200300048A1 (ru) 2003-04-24
ZA200210305B (en) 2004-03-19
MXPA02012845A (es) 2003-05-15
IL153560A (en) 2011-06-30
KR100846370B1 (ko) 2008-07-15
HUP0300872A3 (en) 2004-11-29
AU2001263962B2 (en) 2006-07-20
AU2006220405B2 (en) 2009-05-21
DE60110592T2 (de) 2006-01-19
NZ522481A (en) 2004-09-24
US20080114009A1 (en) 2008-05-15
NO20026032L (no) 2002-12-16
BRPI0111743B1 (pt) 2019-03-26
US20030114471A1 (en) 2003-06-19
IS2596B (is) 2010-03-15
IL153560A0 (en) 2003-07-06
ES2241830T3 (es) 2005-11-01
EE04966B1 (et) 2008-02-15
US8329714B2 (en) 2012-12-11
US8318753B2 (en) 2012-11-27
BG107310A (bg) 2003-07-31
WO2001098302A1 (en) 2001-12-27
EA005065B1 (ru) 2004-10-28
BR0111743A (pt) 2003-07-08
EE200200695A (et) 2004-06-15
KR20070121847A (ko) 2007-12-27
BRPI0111743B8 (pt) 2021-05-25
AR030704A1 (es) 2003-09-03
AU2006220405A1 (en) 2006-10-12
CA2410232A1 (en) 2001-12-27
MY127734A (en) 2006-12-29
JP2004501153A (ja) 2004-01-15
HUP0300872A2 (hu) 2003-07-28
HU229095B1 (en) 2013-07-29
ATE294804T1 (de) 2005-05-15
SA01220349B1 (ar) 2007-01-23
DE60110592D1 (de) 2005-06-09
BG65894B1 (bg) 2010-04-30
PL209521B1 (pl) 2011-09-30
US20070259902A1 (en) 2007-11-08

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Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20210612