HK1049657A1 - 用於製備具有多種治療特性的三取代的咪唑化合物的亞胺中間體 - Google Patents

用於製備具有多種治療特性的三取代的咪唑化合物的亞胺中間體

Info

Publication number: HK1049657A1
Authority: HK; Hong Kong
Prior art keywords: preparation; imidazole compounds; therapeutic properties; multiple therapeutic; imine intermediates
Prior art date: 1993-07-16

Application number

HK03100345.9A

Other languages

English (en)

Inventor

Leroy Adams Jerry

William Sheldrake Peter

Francis Gallagher Timothy

Shanker Garigipati Ravi

Elliot Bender Paul

Charles Boehm Jeffrey

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-16

Filing date

1998-12-16

Publication date

2003-05-23

1998-12-16 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2003-05-23 Publication of HK1049657A1 publication Critical patent/HK1049657A1/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Neurology (AREA)
Rheumatology (AREA)
Virology (AREA)
Oncology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Immunology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)

HK03100345.9A 1993-07-16 1998-12-16 用於製備具有多種治療特性的三取代的咪唑化合物的亞胺中間體 HK1049657A1 (zh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9273393A	1993-07-16	1993-07-16

Publications (1)

Publication Number	Publication Date
HK1049657A1 true HK1049657A1 (zh)	2003-05-23

Family

ID=22234840

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
HK98113635A HK1012392A1 (en)	1993-07-16	1998-12-16	Tri-substituted imidazoles having multiple therapeutic properties
HK03100345.9A HK1049657A1 (zh)	1993-07-16	1998-12-16	用於製備具有多種治療特性的三取代的咪唑化合物的亞胺中間體
HK03100350.1A HK1049659A1 (zh)	1993-07-16	1998-12-16	具有多種治療特性的三-取代咪唑化合物製備用異氰化物的中間體
HK03100349.5A HK1049658A1 (zh)	1993-07-16	1998-12-16	具有多種治療特性的三-取代咪唑化合物製備用甲酰胺中間體

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
HK98113635A HK1012392A1 (en)	1993-07-16	1998-12-16	Tri-substituted imidazoles having multiple therapeutic properties

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
HK03100350.1A HK1049659A1 (zh)	1993-07-16	1998-12-16	具有多種治療特性的三-取代咪唑化合物製備用異氰化物的中間體
HK03100349.5A HK1049658A1 (zh)	1993-07-16	1998-12-16	具有多種治療特性的三-取代咪唑化合物製備用甲酰胺中間體

Country Status (31)

Country	Link
EP (5)	EP1229035A1 (zh)
JP (4)	JPH09500137A (zh)
CN (2)	CN1050126C (zh)
AP (1)	AP484A (zh)
AT (2)	ATE236896T1 (zh)
AU (1)	AU694130C (zh)
BR (2)	BR9407079A (zh)
CA (1)	CA2167311A1 (zh)
CZ (1)	CZ11996A3 (zh)
DE (2)	DE69432463T2 (zh)
DK (1)	DK0708768T3 (zh)
DZ (1)	DZ1798A1 (zh)
ES (2)	ES2237650T3 (zh)
FI (1)	FI960177A0 (zh)
HK (4)	HK1012392A1 (zh)
HU (1)	HUT75313A (zh)
IL (2)	IL110296A (zh)
MA (1)	MA23270A1 (zh)
MY (1)	MY116478A (zh)
NO (4)	NO316881B1 (zh)
NZ (2)	NZ329994A (zh)
PL (4)	PL181721B1 (zh)
PT (1)	PT708768E (zh)
RU (1)	RU2140918C1 (zh)
SG (1)	SG52368A1 (zh)
SI (1)	SI0708768T1 (zh)
SK (1)	SK282342B6 (zh)
TW (1)	TW330934B (zh)
UA (1)	UA63875C2 (zh)
WO (1)	WO1995002591A1 (zh)
ZA (1)	ZA945193B (zh)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3857751A (en) *	1971-11-15	1974-12-31	Tufdura Ltd	Composite sheet capable of withstanding impingement by particulate materials
US5916891A (en)	1992-01-13	1999-06-29	Smithkline Beecham Corporation	Pyrimidinyl imidazoles
US5840746A (en) *	1993-06-24	1998-11-24	Merck Frosst Canada, Inc.	Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases
US5670527A (en) *	1993-07-16	1997-09-23	Smithkline Beecham Corporation	Pyridyl imidazole compounds and compositions
US5593992A (en) *	1993-07-16	1997-01-14	Smithkline Beecham Corporation	Compounds
US5616601A (en) *	1994-07-28	1997-04-01	Gd Searle & Co	1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
US6613789B2 (en)	1994-07-28	2003-09-02	G. D. Searle & Co.	Heterocyclo-substituted imidazoles for the treatment of inflammation
JPH10512264A (ja) *	1995-01-12	1998-11-24	スミスクライン・ビーチャム・コーポレイション	新規化合物
GB9500580D0 (en) *	1995-01-12	1995-03-01	Merck Sharp & Dohme	Therapeutic agents
EP0809492A4 (en) *	1995-02-17	2007-01-24	Smithkline Beecham Corp	IL-8 RECEPTOR ANTAGONISTS
US5739143A (en) *	1995-06-07	1998-04-14	Smithkline Beecham Corporation	Imidazole compounds and compositions
US5658903A (en) *	1995-06-07	1997-08-19	Smithkline Beecham Corporation	Imidazole compounds, compositions and use
US6369068B1 (en)	1995-06-07	2002-04-09	Smithkline Beecham Corporation	Amino substituted pyrimidine containing compounds
US5717100A (en) *	1995-10-06	1998-02-10	Merck & Co., Inc.	Substituted imidazoles having anti-cancer and cytokine inhibitory activity
US6083949A (en) *	1995-10-06	2000-07-04	Merck & Co., Inc.	Substituted imidazoles having anti-cancer and cytokine inhibitory activity
DE19540027A1 (de) *	1995-10-27	1997-04-30	Gruenenthal Gmbh	Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe
ZA9610687B (en) *	1995-12-22	1997-09-29	Smithkline Beecham Corp	Novel synthesis.
ZA97175B (en) *	1996-01-11	1997-11-04	Smithkline Beecham Corp	Novel substituted imidazole compounds.
AP9700912A0 (en)	1996-01-11	1997-01-31	Smithkline Beecham Corp	Novel cycloalkyl substituted imidazoles
ES2205167T3 (es) *	1996-01-11	2004-05-01	Smithkline Beecham Corporation	Nuevos compuestos de imidazol sustituidos.
US6046208A (en) *	1996-01-11	2000-04-04	Smithkline Beecham Corporation	Substituted imidazole compounds
JP2001508395A (ja) *	1996-01-11	2001-06-26	スミスクライン・ビーチャム・コーポレイション	新規シクロアルキル置換イミダゾール
EP1005343A4 (en) *	1996-03-08	2000-06-07	Smithkline Beecham Corp	USE OF CSAIDS AS ANGIOGENESIS INHIBITORS
WO1997035856A1 (en) *	1996-03-25	1997-10-02	Smithkline Beecham Corporation	Novel treatment for cns injuries
EP0906307B1 (en) *	1996-06-10	2005-04-27	Merck & Co., Inc.	Substituted imidazoles having cytokine inhibitory activity
EP0956018A4 (en)	1996-08-21	2000-01-12	Smithkline Beecham Corp	IMIDAZOLE COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE
US6608060B1 (en)	1996-12-18	2003-08-19	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
US6147080A (en) *	1996-12-18	2000-11-14	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
US5945418A (en) *	1996-12-18	1999-08-31	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
US5929076A (en) *	1997-01-10	1999-07-27	Smithkline Beecham Corporation	Cycloalkyl substituted imidazoles
US6187799B1 (en)	1997-05-23	2001-02-13	Onyx Pharmaceuticals	Inhibition of raf kinase activity using aryl ureas
CA2294057A1 (en)	1997-06-13	1998-12-17	Smithkline Beecham Corporation	Novel pyrazole and pyrazoline substituted compounds
AU8154998A (en)	1997-06-19	1999-01-04	Smithkline Beecham Corporation	Novel aryloxy substituted pyrimidine imidazole compounds
US7301021B2 (en)	1997-07-02	2007-11-27	Smithkline Beecham Corporation	Substituted imidazole compounds
US6562832B1 (en)	1997-07-02	2003-05-13	Smithkline Beecham Corporation	Substituted imidazole compounds
US6489325B1 (en)	1998-07-01	2002-12-03	Smithkline Beecham Corporation	Substituted imidazole compounds
AU8381098A (en)	1997-07-02	1999-01-25	Smithkline Beecham Corporation	Novel cycloalkyl substituted imidazoles
TW517055B (en) *	1997-07-02	2003-01-11	Smithkline Beecham Corp	Novel substituted imidazole compounds
US6362193B1 (en)	1997-10-08	2002-03-26	Smithkline Beecham Corporation	Cycloalkenyl substituted compounds
AU9449398A (en) *	1997-10-10	1999-05-03	Imperial College Innovations Ltd.	Use of csaidtm compounds for the management of uterine contractions
JP3337992B2 (ja) *	1997-11-04	2002-10-28	ファイザー製薬株式会社	５−置換ピコリン酸化合物及びその製造方法
AU1924699A (en) *	1997-12-19	1999-07-12	Smithkline Beecham Corporation	Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses
GB9809869D0 (en) *	1998-05-09	1998-07-08	Medical Res Council	Inhibition of protein kinases
NZ526958A (en)	1998-05-22	2004-12-24	Smithkline Beecham Corp	Novel 2-alkyl substituted imidazole compounds
US6858617B2 (en)	1998-05-26	2005-02-22	Smithkline Beecham Corporation	Substituted imidazole compounds
EP1109918B1 (en)	1998-06-24	2006-10-04	University of Dundee	Mitogen- and stress-activated protein kinases that contain two kinase domains and uses thereof
AU4395399A (en) *	1998-07-02	2000-01-24	Sankyo Company Limited	Five-membered heteroaryl compounds
US6207687B1 (en) *	1998-07-31	2001-03-27	Merck & Co., Inc.	Substituted imidazoles having cytokine inhibitory activity
WO2000010563A1 (en)	1998-08-20	2000-03-02	Smithkline Beecham Corporation	Novel substituted triazole compounds
ES2212657T3 (es)	1998-11-04	2004-07-16	Smithkline Beecham Corporation	Pirazinas sustituidas piridin-4-il o pirimidin-4-il.
US6239279B1 (en)	1998-12-16	2001-05-29	Smithkline Beecham Corporation	Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
CA2359244C (en)	1999-01-13	2013-10-08	Bayer Corporation	.omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US8124630B2 (en)	1999-01-13	2012-02-28	Bayer Healthcare Llc	ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US20020065296A1 (en)	1999-01-13	2002-05-30	Bayer Corporation	Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors
US7122666B2 (en)	1999-07-21	2006-10-17	Sankyo Company, Limited	Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
US6759410B1 (en)	1999-11-23	2004-07-06	Smithline Beecham Corporation	3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
ES2249309T3 (es)	1999-11-23	2006-04-01	Smithkline Beecham Corp	Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p39 kinasa.
US7053098B1 (en)	1999-11-23	2006-05-30	Smithkline Beecham Corporation	3,4-Dihydro-(1H) quinazolin-2-one compounds as CSBP/P38 kinase inhibitors
ATE281439T1 (de)	1999-11-23	2004-11-15	Smithkline Beecham Corp	3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US6627647B1 (en) *	2000-03-23	2003-09-30	Boehringer Ingelheim Pharmaceuticals, Inc.	Substituted 1-(4-aminophenyl)imidazoles and their use as anti-inflammatory agents
FR2823751B1 (fr) *	2001-04-24	2003-05-23	Oreal	Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
FR2823747B1 (fr) *	2001-04-24	2003-05-23	Oreal	Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
WO2002094267A1 (fr) *	2001-05-24	2002-11-28	Sankyo Company, Limited	Preparation pharmaceutique pour prevenir ou traiter l'arthrite
AU2003209116A1 (en)	2002-02-11	2003-09-04	Bayer Pharmaceuticals Corporation	Aryl ureas with angiogenesis inhibiting activity
SI1580188T1 (sl)	2002-02-11	2012-02-29	Bayer Healthcare Llc	Aril sečnine kot kinazni inhibitorji
RU2217196C2 (ru) *	2002-02-28	2003-11-27	Небольсин Владимир Евгеньевич	Способ индукции дифференцировки клеток
JP4481011B2 (ja)	2002-03-05	2010-06-16	トランステックファーマ，インコーポレイテッド	リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体
AU2003291227A1 (en)	2002-11-05	2004-06-07	Smithkline Beecham Corporation	Antibacterial agents
JP2007511203A (ja)	2003-05-20	2007-05-10	バイエル、ファーマシューテイカルズ、コーポレイション	キナーゼ阻害活性を有するジアリール尿素
ME00294B (me)	2003-07-23	2011-05-10	Bayer Pharmaceuticals Corp	Fluoro supstituisana omega-karaboksiaril difenil urea za liječenje i prevenciju bolesti i stanja bolesti
PL1864665T3 (pl) *	2005-03-11	2012-10-31	Zenyaku Kogyo Kk	Środek immunosupresyjny obejmujący związek heterocykliczny jako składnik aktywny
US8580833B2 (en)	2009-09-30	2013-11-12	Transtech Pharma, Inc.	Substituted imidazole derivatives and methods of use thereof
PT2493876E (pt) *	2009-10-28	2014-03-20	Pfizer	Derivados de imidazol como inibidores de caseína cinase
CN104387301B (zh) *	2014-11-11	2016-05-04	常州大学	一种2-氟-4-甲基苯磺酰甲基异腈的合成方法
CN113350353A (zh)	2015-03-23	2021-09-07	墨尔本大学	呼吸性疾病的治疗
CN110753688A (zh) *	2017-05-03	2020-02-04	墨尔本大学	用于治疗呼吸系统疾病的化合物
CN110531023B (zh) *	2019-10-08	2024-06-14	安徽理工大学	一种薄层色谱分析仪
CN114112812B (zh) *	2021-10-29	2024-05-24	华北电力大学	相变颗粒测试装置、固-液相变机理可视化实验台及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3707475A (en) *	1970-11-16	1972-12-26	Pfizer	Antiinflammatory imidazoles
US3929807A (en) *	1971-05-10	1975-12-30	Ciba Geigy Corp	2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
KR930703321A (ko) *	1990-12-13	1993-11-29	스튜어트 알. 슈터	신규한 사이토킨 억제성 소염 의약
EP0563286A4 (en) *	1990-12-13	1995-01-11	Smithkline Beecham Corp	Novel csaids
MX9300141A (es) *	1992-01-13	1994-07-29	Smithkline Beecham Corp	Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.

1994
- 1994-07-12 IL IL11029694A patent/IL110296A/xx not_active IP Right Cessation
- 1994-07-13 AP APAP/P/1994/000654A patent/AP484A/en active
- 1994-07-13 DZ DZ940081A patent/DZ1798A1/fr active
- 1994-07-14 MA MA23584A patent/MA23270A1/fr unknown
- 1994-07-14 MY MYPI94001844A patent/MY116478A/en unknown
- 1994-07-15 UA UA96010110A patent/UA63875C2/uk unknown
- 1994-07-15 EP EP02076581A patent/EP1229035A1/en not_active Withdrawn
- 1994-07-15 PL PL94332408A patent/PL181721B1/pl unknown
- 1994-07-15 SG SG1996003561A patent/SG52368A1/en unknown
- 1994-07-15 ES ES02079534T patent/ES2237650T3/es not_active Expired - Lifetime
- 1994-07-15 ZA ZA945193A patent/ZA945193B/xx unknown
- 1994-07-15 EP EP02079534A patent/EP1291346B1/en not_active Expired - Lifetime
- 1994-07-15 PT PT94923503T patent/PT708768E/pt unknown
- 1994-07-15 WO PCT/US1994/007969 patent/WO1995002591A1/en not_active Application Discontinuation
- 1994-07-15 CZ CZ96119A patent/CZ11996A3/cs unknown
- 1994-07-15 AT AT94923503T patent/ATE236896T1/de not_active IP Right Cessation
- 1994-07-15 HU HU9503855A patent/HUT75313A/hu unknown
- 1994-07-15 EP EP94923503A patent/EP0708768B1/en not_active Expired - Lifetime
- 1994-07-15 EP EP02076582A patent/EP1227092A3/en not_active Withdrawn
- 1994-07-15 CN CN94193161A patent/CN1050126C/zh not_active Expired - Fee Related
- 1994-07-15 ES ES94923503T patent/ES2197167T3/es not_active Expired - Lifetime
- 1994-07-15 AU AU73354/94A patent/AU694130C/en not_active Ceased
- 1994-07-15 NZ NZ329994A patent/NZ329994A/xx unknown
- 1994-07-15 DE DE69432463T patent/DE69432463T2/de not_active Expired - Fee Related
- 1994-07-15 NZ NZ269457A patent/NZ269457A/en unknown
- 1994-07-15 PL PL94332405A patent/PL181723B1/pl unknown
- 1994-07-15 SK SK47-96A patent/SK282342B6/sk unknown
- 1994-07-15 AT AT02079534T patent/ATE291576T1/de not_active IP Right Cessation
- 1994-07-15 BR BR9407079A patent/BR9407079A/pt not_active Application Discontinuation
- 1994-07-15 SI SI9430449T patent/SI0708768T1/xx unknown
- 1994-07-15 RU RU96103386/04A patent/RU2140918C1/ru not_active IP Right Cessation
- 1994-07-15 EP EP02076580A patent/EP1227091A3/en not_active Withdrawn
- 1994-07-15 DK DK94923503T patent/DK0708768T3/da active
- 1994-07-15 JP JP7504744A patent/JPH09500137A/ja active Pending
- 1994-07-15 PL PL94332406A patent/PL181694B1/pl unknown
- 1994-07-15 DE DE69434316T patent/DE69434316T2/de not_active Expired - Fee Related
- 1994-07-15 PL PL94312614A patent/PL181705B1/pl unknown
- 1994-07-15 CA CA002167311A patent/CA2167311A1/en not_active Abandoned
- 1994-10-04 TW TW083109192A patent/TW330934B/zh active
1996
- 1996-01-15 NO NO960173A patent/NO316881B1/no not_active IP Right Cessation
- 1996-01-15 FI FI960177A patent/FI960177A0/fi unknown
1997
- 1997-05-13 BR BR1100546-7A patent/BR1100546A/pt active IP Right Grant
1998
- 1998-05-04 IL IL12431898A patent/IL124318A0/xx unknown
- 1998-06-17 CN CN98115012A patent/CN1218801A/zh active Pending
- 1998-12-16 HK HK98113635A patent/HK1012392A1/xx not_active IP Right Cessation
- 1998-12-16 HK HK03100345.9A patent/HK1049657A1/zh unknown
- 1998-12-16 HK HK03100350.1A patent/HK1049659A1/zh unknown
- 1998-12-16 HK HK03100349.5A patent/HK1049658A1/zh unknown
2001
- 2001-02-19 NO NO20010837A patent/NO20010837D0/no not_active Application Discontinuation
- 2001-02-19 NO NO20010839A patent/NO20010839D0/no not_active Application Discontinuation
- 2001-02-19 NO NO20010838A patent/NO20010838D0/no not_active Application Discontinuation
2003
- 2003-12-10 JP JP2003412029A patent/JP2004099622A/ja active Pending
- 2003-12-10 JP JP2003412024A patent/JP2004149541A/ja active Pending
- 2003-12-10 JP JP2003412020A patent/JP2004083600A/ja active Pending

Also Published As

Publication number	Publication date
HK1049658A1 (zh)	2003-05-23
DK0708768T3 (da)	2003-08-04
EP1227092A3 (en)	2002-08-07
CN1218801A (zh)	1999-06-09
IL110296A0 (en)	1994-10-21
EP0708768B1 (en)	2003-04-09
DZ1798A1 (fr)	2002-02-17
EP0708768A1 (en)	1996-05-01
TW330934B (en)	1998-05-01
HK1049659A1 (zh)	2003-05-23
EP1227092A2 (en)	2002-07-31
CA2167311A1 (en)	1995-01-26
NO10837A (no)	1996-01-15
JPH09500137A (ja)	1997-01-07
NO316881B1 (no)	2004-06-14
ZA945193B (en)	1995-04-20
NO20010839D0 (no)	2001-02-19
PL312614A1 (en)	1996-04-29
EP0708768A4 (en)	1996-08-21
CZ11996A3 (en)	1996-10-16
NZ329994A (en)	1999-07-29
PL181694B1 (pl)	2001-09-28
PL181723B1 (pl)	2001-09-28
JP2004083600A (ja)	2004-03-18
UA63875C2 (en)	2004-02-16
EP1227091A2 (en)	2002-07-31
HK1012392A1 (en)	1999-07-30
IL124318A0 (en)	1998-12-06
NO10839A (no)	1996-01-15
EP1227091A3 (en)	2002-08-07
NZ269457A (en)	1998-08-26
AP9400654A0 (en)	1994-07-31
EP1229035A1 (en)	2002-08-07
AU705568B2 (en)	1999-05-27
PT708768E (pt)	2003-08-29
IL110296A (en)	1999-12-31
FI960177A (fi)	1996-01-15
HUT75313A (en)	1997-05-28
DE69432463T2 (de)	2004-02-12
NO20010838D0 (no)	2001-02-19
FI960177A0 (fi)	1996-01-15
AU694130B2 (en)	1998-07-16
MA23270A1 (fr)	1995-04-01
MY116478A (en)	2004-02-28
SI0708768T1 (en)	2003-10-31
NO960173D0 (no)	1996-01-15
RU2140918C1 (ru)	1999-11-10
CN1129447A (zh)	1996-08-21
CN1050126C (zh)	2000-03-08
BR1100546A (pt)	2004-08-31
SK282342B6 (sk)	2002-01-07
SK4796A3 (en)	1997-01-08
AU7185098A (en)	1998-08-27
DE69432463D1 (de)	2003-05-15
ATE236896T1 (de)	2003-04-15
NO20010837D0 (no)	2001-02-19
HU9503855D0 (en)	1996-02-28
ATE291576T1 (de)	2005-04-15
AP484A (en)	1996-04-23
AU7335494A (en)	1995-02-13
ES2197167T3 (es)	2004-01-01
PL181721B1 (en)	2001-09-28
PL181705B1 (pl)	2001-09-28
AU694130C (en)	2002-12-05
ES2237650T3 (es)	2005-08-01
JP2004149541A (ja)	2004-05-27
DE69434316D1 (de)	2005-04-28
SG52368A1 (en)	1998-09-28
WO1995002591A1 (en)	1995-01-26
NO960173L (no)	1996-01-15
NO10838A (no)	1996-01-15
BR9407079A (pt)	1996-08-27
EP1291346B1 (en)	2005-03-23
JP2004099622A (ja)	2004-04-02
DE69434316T2 (de)	2006-03-09
EP1291346A1 (en)	2003-03-12

Publication	Publication Date	Title
HK1049657A1 (zh)	2003-05-23	用於製備具有多種治療特性的三取代的咪唑化合物的亞胺中間體
AU3428393A (en)	1993-07-28	Use of polyamines as ionic-channel regulating agents
ZA951107B (en)	1996-02-12	Substituted spiro compounds for the treatment of inflammation
AU6623894A (en)	1994-10-24	Therapeutic compounds
AU4293193A (en)	1994-11-21	Novel trisubstituted aromatic amines useful for the treatment of cognitive deficits
AU6092794A (en)	1994-08-15	Oxime-substituted therapeutic compounds
IL132532A (en)	2003-06-24	Intermediates for the preparation of substituted cephalosporins
AU1230595A (en)	1995-08-31	Process for the preparation of polyalkyl-1-oxa- diazaspirodecane compounds
ZA964010B (en)	1997-11-20	Use of pyrrole compounds as antifouling agents.
AU2964495A (en)	1996-03-14	Vicinal-substituted carbocyclic compounds as therapeutic agents
AU5095093A (en)	1994-04-26	Process for the preparation of tetrazoles
AU8463691A (en)	1992-03-26	Processes for the preparation of nitrogen-containing compounds
AU4712696A (en)	1996-09-04	The use of heterocyclic compounds
ZA968550B (en)	1998-04-14	Novel processes for the preparation of anti-malarial compounds.
AU4585993A (en)	1994-03-15	Use of angiotensin ii antagonists for the treatment of hyperlipidaeme
AU5643594A (en)	1994-09-29	Process for the preparation of organochlorosilanes
AU5371694A (en)	1994-05-24	Use of the tarchonanthus camphoratus
GB9415313D0 (en)	1994-09-21	The preparation of organic compounds
HK1013293A1 (en)	1999-08-20	Process for the preparation of methylchlorosilane
AU3964093A (en)	1993-11-18	Novel use of nitroimidazoles
GB9304071D0 (en)	1993-04-14	Process for the preparation of nitriles
AU7866894A (en)	1995-05-04	The use of inositoltrisphosphate for the preparing of medicaments
GB2275267B (en)	1996-10-16	Preparation of dicyanobenzenes by ammoxidation
GB9415312D0 (en)	1994-09-21	The preparation of organic compounds
AU2671895A (en)	1996-01-15	Bisquinolines for the treatment of malaria