HK1040187B - 苯磺酰(硫)脲與β-受體阻滯劑聯合在製備用於心臟迷走神經機能障礙治療和預防的藥物中的用途 - Google Patents

苯磺酰(硫)脲與β-受體阻滯劑聯合在製備用於心臟迷走神經機能障礙治療和預防的藥物中的用途

Info

Publication number: HK1040187B
Authority: HK; Hong Kong
Prior art keywords: dysfunctions; benzenesulfonyl; ureas; prophylaxis; thio
Prior art date: 1998-09-10

Application number

HK02101438.6A

Other languages

English (en)

Other versions

HK1040187A1 (en

Inventor

K‧沃斯

H‧C‧恩格勒特

H‧波恩

H‧高戈萊恩

H‧海特施

U‧格拉奇

Original Assignee

薩諾費-阿文蒂斯德國有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-10

Filing date

2002-02-26

Publication date

2005-09-02

1998-09-10 Priority claimed from DE1998141534 external-priority patent/DE19841534A1/de

1999-01-14 Priority claimed from DE1999101061 external-priority patent/DE19901061A1/de

2002-02-26 Application filed by 薩諾費-阿文蒂斯德國有限公司 filed Critical 薩諾費-阿文蒂斯德國有限公司

2002-05-31 Publication of HK1040187A1 publication Critical patent/HK1040187A1/xx

2005-09-02 Publication of HK1040187B publication Critical patent/HK1040187B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/54—Silicon-containing compounds
- C08K5/5406—Silicon-containing compounds containing elements other than oxygen or nitrogen

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Polymers & Plastics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

HK02101438.6A 1998-09-10 2002-02-26 苯磺酰(硫)脲與β-受體阻滯劑聯合在製備用於心臟迷走神經機能障礙治療和預防的藥物中的用途 HK1040187B (zh)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE1998141534 DE19841534A1 (de)	1998-09-10	1998-09-10	Verwendung von Benzolsulfonyl(thio)harnstoffen zur Behandlung und Prophylaxe von Dysfunktionen des autonomen Nervensystems und Verwendung von Benzolsulfonyl(thio)harnstoffen in Kombination mit Betarezeptoren-Blockern
DE1999101061 DE19901061A1 (de)	1999-01-14	1999-01-14	Verwendung von Benzolsulfonyl(thio)harnstoffen zur Behandlung von Prophylaxe von Dysfunktionen des autonomen Nervensystems und Verwendung von Benzolsulfonyl(thio)harnstoffen in Kombination mit Betarezeptoren-Blockern
PCT/EP1999/006450 WO2000015204A2 (en)	1998-09-10	1999-09-02	Use of benzenesulfonyl(thio)ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl(thio)ureas in combination with beta-receptor blockers

Publications (2)

Publication Number	Publication Date
HK1040187A1 HK1040187A1 (en)	2002-05-31
HK1040187B true HK1040187B (zh)	2005-09-02

Family

ID=26048790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK02101438.6A HK1040187B (zh)	1998-09-10	2002-02-26	苯磺酰(硫)脲與β-受體阻滯劑聯合在製備用於心臟迷走神經機能障礙治療和預防的藥物中的用途

Country Status (27)

Country	Link
US (1)	US6414030B1 (zh)
EP (1)	EP1117409B1 (zh)
JP (1)	JP4733268B2 (zh)
KR (1)	KR100981592B1 (zh)
CN (1)	CN1195524C (zh)
AR (1)	AR020411A1 (zh)
AT (1)	ATE287718T1 (zh)
AU (1)	AU762832B2 (zh)
BR (1)	BR9913572A (zh)
CA (1)	CA2343009C (zh)
CZ (1)	CZ301165B6 (zh)
DE (1)	DE69923464T2 (zh)
DK (1)	DK1117409T3 (zh)
ES (1)	ES2235507T3 (zh)
HK (1)	HK1040187B (zh)
HU (1)	HU228988B1 (zh)
ID (1)	ID28854A (zh)
IL (2)	IL141414A0 (zh)
MY (1)	MY121798A (zh)
NO (1)	NO330215B1 (zh)
NZ (1)	NZ510424A (zh)
PL (1)	PL194986B1 (zh)
PT (1)	PT1117409E (zh)
RU (1)	RU2247562C2 (zh)
TR (1)	TR200100692T2 (zh)
TW (1)	TWI238817B (zh)
WO (1)	WO2000015204A2 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19917233A1 (de) *	1999-04-16	2000-10-19	Aventis Pharma Gmbh	Kristalline Formen des Natriumsalzes des 5-Chlor-2-methoxy-N-(2-(4-methoxy-3-methylaminothiocarbonylaminosulfonyl-phenyl)-ethyl)- benzamids
DE19923086A1 (de)	1999-05-20	2000-11-23	Aventis Pharma Gmbh	Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US7620611B1 (en) *	1999-07-20	2009-11-17	Trilithic, Inc.	Neural networks for ingress monitoring
DE10054482A1 (de)	2000-11-03	2002-05-08	Aventis Pharma Gmbh	Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054481A1 (de) *	2000-11-03	2002-05-08	Aventis Pharma Gmbh	Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10129704A1 (de) *	2001-06-22	2003-01-02	Aventis Pharma Gmbh	Verwendung von Benzolsulfonyl(thio)harnstoffen in der Behandlung des septischen Schocks
CN1330630C (zh) *	2004-03-10	2007-08-08	中国药科大学	新的磺酰(硫)脲衍生物、其制备方法及含有它们的药物组合物
DE102004061017A1 (de) *	2004-12-18	2006-06-22	Sanofi-Aventis Deutschland Gmbh	Piperidinsulfonylharnstoffe und -thioharnstoffe, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
WO2008148468A1 (en) *	2007-06-05	2008-12-11	Sanofi-Aventis	Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them

Family Cites Families (8)

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Publication number	Priority date	Publication date	Assignee	Title
DE1185180B (de) *	1963-10-19	1965-01-14	Hoechst Ag	Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1518874C3 (de) *	1964-10-07	1975-03-13	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
DE3009047A1 (de)	1980-03-08	1981-09-24	C.H. Boehringer Sohn, 6507 Ingelheim	Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung
GB8716972D0 (en) *	1987-07-17	1987-08-26	Pfizer Ltd	Treatment of cardiac arrhythmias
ES2098069T3 (es)	1993-02-23	1997-04-16	Hoechst Ag	Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y su utilizacion como agentes farmaceuticos.
DE19505397A1 (de) *	1995-02-17	1996-08-22	Hoechst Ag	Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
WO1996028437A1 (en)	1995-03-10	1996-09-19	Hoechst Marion Roussel, Inc.	Novel process for preparing 2,3-dihydro-benzofuranol derivatives
FR2746013B1 (fr)	1996-03-18	1998-05-29	Sanofi Sa	Utilisation de composes antiarythmiques dans la prevention de la mortalite post infarctus

1999
- 1999-09-02 ID IDW20010566A patent/ID28854A/id unknown
- 1999-09-02 PT PT99944585T patent/PT1117409E/pt unknown
- 1999-09-02 CZ CZ20010858A patent/CZ301165B6/cs not_active IP Right Cessation
- 1999-09-02 IL IL14141499A patent/IL141414A0/xx active IP Right Grant
- 1999-09-02 AT AT99944585T patent/ATE287718T1/de active
- 1999-09-02 WO PCT/EP1999/006450 patent/WO2000015204A2/en active IP Right Grant
- 1999-09-02 DE DE69923464T patent/DE69923464T2/de not_active Expired - Lifetime
- 1999-09-02 BR BR9913572-8A patent/BR9913572A/pt not_active Application Discontinuation
- 1999-09-02 NZ NZ510424A patent/NZ510424A/xx not_active IP Right Cessation
- 1999-09-02 CA CA2343009A patent/CA2343009C/en not_active Expired - Fee Related
- 1999-09-02 DK DK99944585T patent/DK1117409T3/da active
- 1999-09-02 RU RU2001109434/15A patent/RU2247562C2/ru not_active IP Right Cessation
- 1999-09-02 KR KR1020017003067A patent/KR100981592B1/ko not_active IP Right Cessation
- 1999-09-02 EP EP99944585A patent/EP1117409B1/en not_active Expired - Lifetime
- 1999-09-02 CN CNB998107794A patent/CN1195524C/zh not_active Expired - Fee Related
- 1999-09-02 JP JP2000569788A patent/JP4733268B2/ja not_active Expired - Fee Related
- 1999-09-02 HU HU0103534A patent/HU228988B1/hu not_active IP Right Cessation
- 1999-09-02 AU AU57444/99A patent/AU762832B2/en not_active Ceased
- 1999-09-02 TR TR2001/00692T patent/TR200100692T2/xx unknown
- 1999-09-02 ES ES99944585T patent/ES2235507T3/es not_active Expired - Lifetime
- 1999-09-02 PL PL347215A patent/PL194986B1/pl unknown
- 1999-09-08 AR ARP990104515A patent/AR020411A1/es not_active Application Discontinuation
- 1999-09-09 MY MYPI99003906A patent/MY121798A/en unknown
- 1999-11-25 TW TW088115446A patent/TWI238817B/zh not_active IP Right Cessation
2001
- 2001-02-13 IL IL141414A patent/IL141414A/en not_active IP Right Cessation
- 2001-03-05 NO NO20011117A patent/NO330215B1/no not_active IP Right Cessation
- 2001-11-09 US US09/986,626 patent/US6414030B1/en not_active Expired - Lifetime
2002
- 2002-02-26 HK HK02101438.6A patent/HK1040187B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
RU2247562C2 (ru)	2005-03-10
HUP0103534A3 (en)	2003-09-29
CN1319014A (zh)	2001-10-24
WO2000015204A2 (en)	2000-03-23
DK1117409T3 (da)	2005-05-30
DE69923464T2 (de)	2006-05-11
US6414030B1 (en)	2002-07-02
PT1117409E (pt)	2005-04-29
AU5744499A (en)	2000-04-03
CN1195524C (zh)	2005-04-06
CZ2001858A3 (en)	2001-06-13
JP4733268B2 (ja)	2011-07-27
EP1117409A2 (en)	2001-07-25
IL141414A (en)	2006-07-05
HUP0103534A2 (hu)	2002-05-29
CA2343009A1 (en)	2000-03-23
ATE287718T1 (de)	2005-02-15
PL347215A1 (en)	2002-03-25
JP2002524497A (ja)	2002-08-06
DE69923464D1 (de)	2005-03-03
MY121798A (en)	2006-02-28
PL194986B1 (pl)	2007-07-31
NO20011117D0 (no)	2001-03-05
NO330215B1 (no)	2011-03-07
US20020082300A1 (en)	2002-06-27
HU228988B1 (hu)	2013-07-29
ID28854A (id)	2001-07-05
CZ301165B6 (cs)	2009-11-25
KR100981592B1 (ko)	2010-09-13
IL141414A0 (en)	2002-03-10
HK1040187A1 (en)	2002-05-31
ES2235507T3 (es)	2005-07-01
TR200100692T2 (tr)	2001-07-23
WO2000015204A3 (en)	2000-07-13
AR020411A1 (es)	2002-05-08
AU762832B2 (en)	2003-07-03
TWI238817B (en)	2005-09-01
KR20010086396A (ko)	2001-09-10
CA2343009C (en)	2011-03-15
EP1117409B1 (en)	2005-01-26
NO20011117L (no)	2001-05-02
BR9913572A (pt)	2001-05-22
NZ510424A (en)	2003-06-30

Publication	Publication Date	Title
HK1040187B (zh)	2005-09-02	苯磺酰(硫)脲與β-受體阻滯劑聯合在製備用於心臟迷走神經機能障礙治療和預防的藥物中的用途
HUP0004439A3 (en)	2001-12-28	1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
IL135315A0 (en)	2001-05-20	4(3)-substituted-4(3)-aminomethyl-(thio)pyran or -piperidine derivatives (gabapentin analogues), their preparation and their use in the treatment of neurological disorders
PL343074A1 (en)	2001-07-30	Moistened cosmetic eye treatment pads
EP0326034A3 (en)	1990-11-07	Combination for the treatment of nervous cells and fibers illnesses and disorders
HUP0103236A2 (hu)	2002-02-28	Bőr- és szövetápoló és/vagy kezelő készítmény
HK1050126A1 (zh)	2003-06-13	治療人食管異常組織的方法和系統
IL164882A0 (en)	2005-12-18	Selective nerve fiber stimulation for treating heart conditions
IL128573A0 (en)	2000-01-31	Treatment of upper airway allergic responses with a combination of histamine receptor antagonists
HUP9900406A3 (en)	2002-04-29	Antagonists of the oncogenic activity of the protein mdm2, and use thereof in the treatment of cancers
IL112895A0 (en)	1995-06-29	Treatment of obsessive-compulsive disorders with 5-ht2 antagonists
PL356093A1 (en)	2004-06-14	Hydroxyeicosatetraenoate salts, compositions and methods of use in treating dry eye disorders
AU5774699A (en)	2000-03-06	Human stearoyl-coa desaturase-related compositions and methods for treating skin disorders
EP0233762A3 (en)	1989-05-10	Use of aromatic diamines for the treatment of angina, and diamines therefor
HUP0302052A3 (en)	2005-12-28	Use of fviia or a tissue factor antagonist for regulating gene expression and cell migration or chemotaxis
HK1075673A1 (en)	2005-12-23	Dopaminergic neurons and proliferation-competent precursor cells for treating parkinson's disease
ZA886249B (en)	1989-04-26	Use of a compound for the treatment of sleep disorders and depression
EP1019054A4 (en)	2000-11-29	TREATMENT OF SKIN DISEASES
AU4057189A (en)	1990-03-23	Treatment of glaucoma and related disorders in the human eye with pyridinylmethyl (sulfinyl or thio)benzimidazoles
CN117414244A (zh)	2024-01-19	一种战创伤头颈胸支具
EP1183075A4 (en)	2002-07-10	FACE OR NASAL MASK FOR NON-INVASIVE VENTILATION OF PATIENTS IN GENERAL
TW388387U (en)	2000-04-21	Structure improvement of emergency belt with auxiliary respiratory emergency treatment
GB9815188D0 (en)	1998-09-09	Treatment of skin disorders
SI0848720T1 (en)	2004-04-30	Antagonists of the oncogenic activity of the protein mdm2, and use thereof in the treatment of cancers
HU9900288V0 (en)	2000-01-28	Helper counterfoil for online and other long-distance making a bet

Legal Events

Date	Code	Title	Description
2016-03-24	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20150902