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FR2822464B1 - Derives biguanides et leurs applications en therapeutique - Google Patents

Derives biguanides et leurs applications en therapeutique

Info

Publication number
FR2822464B1
FR2822464B1 FR0103846A FR0103846A FR2822464B1 FR 2822464 B1 FR2822464 B1 FR 2822464B1 FR 0103846 A FR0103846 A FR 0103846A FR 0103846 A FR0103846 A FR 0103846A FR 2822464 B1 FR2822464 B1 FR 2822464B1
Authority
FR
France
Prior art keywords
therapeutic applications
biguanide derivatives
biguanide
derivatives
hyperglycaemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0103846A
Other languages
English (en)
Other versions
FR2822464A1 (fr
Inventor
Gerard Moinet
Daniel Cravo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0103846A priority Critical patent/FR2822464B1/fr
Application filed by LIPHA SAS filed Critical LIPHA SAS
Priority to KR10-2003-7012150A priority patent/KR20030085558A/ko
Priority to CZ20032766A priority patent/CZ20032766A3/cs
Priority to AU2002308178A priority patent/AU2002308178B2/en
Priority to US10/472,229 priority patent/US7285681B2/en
Priority to AT02753575T priority patent/ATE449066T1/de
Priority to BR0208131-8A priority patent/BR0208131A/pt
Priority to SK1280-2003A priority patent/SK12802003A3/sk
Priority to MXPA03008404A priority patent/MXPA03008404A/es
Priority to CA2441309A priority patent/CA2441309C/fr
Priority to RU2003130070/04A priority patent/RU2276136C2/ru
Priority to DE60234424T priority patent/DE60234424D1/de
Priority to PCT/EP2002/003119 priority patent/WO2002074740A1/fr
Priority to EP02753575A priority patent/EP1370525B1/fr
Priority to ES02753575T priority patent/ES2336771T3/es
Priority to HU0303593A priority patent/HUP0303593A3/hu
Priority to CNB02806254XA priority patent/CN1228325C/zh
Priority to JP2002573749A priority patent/JP4418157B2/ja
Priority to PL02362528A priority patent/PL362528A1/xx
Publication of FR2822464A1 publication Critical patent/FR2822464A1/fr
Priority to NO20034171A priority patent/NO20034171D0/no
Priority to ZA200308146A priority patent/ZA200308146B/en
Priority to HK04104234A priority patent/HK1062172A1/xx
Publication of FR2822464B1 publication Critical patent/FR2822464B1/fr
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
FR0103846A 2001-03-21 2001-03-21 Derives biguanides et leurs applications en therapeutique Expired - Fee Related FR2822464B1 (fr)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FR0103846A FR2822464B1 (fr) 2001-03-21 2001-03-21 Derives biguanides et leurs applications en therapeutique
ES02753575T ES2336771T3 (es) 2001-03-21 2002-03-20 Derivados de biguanida.
CZ20032766A CZ20032766A3 (cs) 2001-03-21 2002-03-20 Derivát biguanidu, jeho použití a farmaceutický prostředek, který ho obsahuje
HU0303593A HUP0303593A3 (en) 2001-03-21 2002-03-20 Biguanide derivatives, pharmaceutical compositions containing them and their use
AT02753575T ATE449066T1 (de) 2001-03-21 2002-03-20 Biguanidderivate
BR0208131-8A BR0208131A (pt) 2001-03-21 2002-03-20 Derivados biguanida
SK1280-2003A SK12802003A3 (sk) 2001-03-21 2002-03-20 Derivát biguanidu, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje
MXPA03008404A MXPA03008404A (es) 2001-03-21 2002-03-20 Derivados de biguanida.
CA2441309A CA2441309C (fr) 2001-03-21 2002-03-20 Derives de biguanide
RU2003130070/04A RU2276136C2 (ru) 2001-03-21 2002-03-20 Производные бигуанида и фармацевтическая композиция на их основе
DE60234424T DE60234424D1 (en) 2001-03-21 2002-03-20 Biguanidderivate
PCT/EP2002/003119 WO2002074740A1 (fr) 2001-03-21 2002-03-20 Derives de biguanide
KR10-2003-7012150A KR20030085558A (ko) 2001-03-21 2002-03-20 비구아나이드 유도체
AU2002308178A AU2002308178B2 (en) 2001-03-21 2002-03-20 Biguanide derivatives
US10/472,229 US7285681B2 (en) 2001-03-21 2002-03-20 Biguanide derivatives
CNB02806254XA CN1228325C (zh) 2001-03-21 2002-03-20 双胍衍生物
JP2002573749A JP4418157B2 (ja) 2001-03-21 2002-03-20 ビグアニド誘導体
PL02362528A PL362528A1 (en) 2001-03-21 2002-03-20 Biguanide derivatives
EP02753575A EP1370525B1 (fr) 2001-03-21 2002-03-20 Derives de biguanide
NO20034171A NO20034171D0 (no) 2001-03-21 2003-09-19 Biguanidderivater
ZA200308146A ZA200308146B (en) 2001-03-21 2003-10-20 Biguanide derivatives.
HK04104234A HK1062172A1 (en) 2001-03-21 2004-06-11 Biguanide derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0103846A FR2822464B1 (fr) 2001-03-21 2001-03-21 Derives biguanides et leurs applications en therapeutique

Publications (2)

Publication Number Publication Date
FR2822464A1 FR2822464A1 (fr) 2002-09-27
FR2822464B1 true FR2822464B1 (fr) 2004-08-06

Family

ID=8861407

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0103846A Expired - Fee Related FR2822464B1 (fr) 2001-03-21 2001-03-21 Derives biguanides et leurs applications en therapeutique

Country Status (22)

Country Link
US (1) US7285681B2 (fr)
EP (1) EP1370525B1 (fr)
JP (1) JP4418157B2 (fr)
KR (1) KR20030085558A (fr)
CN (1) CN1228325C (fr)
AT (1) ATE449066T1 (fr)
AU (1) AU2002308178B2 (fr)
BR (1) BR0208131A (fr)
CA (1) CA2441309C (fr)
CZ (1) CZ20032766A3 (fr)
DE (1) DE60234424D1 (fr)
ES (1) ES2336771T3 (fr)
FR (1) FR2822464B1 (fr)
HK (1) HK1062172A1 (fr)
HU (1) HUP0303593A3 (fr)
MX (1) MXPA03008404A (fr)
NO (1) NO20034171D0 (fr)
PL (1) PL362528A1 (fr)
RU (1) RU2276136C2 (fr)
SK (1) SK12802003A3 (fr)
WO (1) WO2002074740A1 (fr)
ZA (1) ZA200308146B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101417988B (zh) * 2007-10-24 2011-04-27 山东轩竹医药科技有限公司 双胍哌嗪类二肽酰肽酶ⅳ抑制剂
KR101041428B1 (ko) * 2008-10-13 2011-06-14 한국화학연구원 Ｎ1-2-티오펜-2-일에틸-ｎ2-치환된 바이구아나이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물
WO2010103040A1 (fr) 2009-03-10 2010-09-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Activateurs de protéine kinases activées par le 5'-adénosine monophosphate (ampk), destinés au traitement de l'hypertension pulmonaire
KR101136045B1 (ko) * 2009-11-16 2012-04-18 한국화학연구원 Ｎ1-(펜에틸)-ｎ2-치환된 바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물
NL1037643C2 (en) * 2010-01-22 2011-07-25 Karel Paul Bouter Nutritional product comprising a biguanide.
KR101324283B1 (ko) * 2010-04-27 2013-11-01 한올바이오파마주식회사 바이구아나이드 화합물의 신규 염, 그의 제조방법, 그를 포함하는 약제학적 조성물
WO2013188452A1 (fr) * 2012-06-11 2013-12-19 The Regents Of The University Of California Composés et procédés de traitement du cancer
KR102216701B1 (ko) 2014-11-20 2021-02-18 이뮤노메트테라퓨틱스 인코포레이티드 바이구아나이드 화합물 및 이의 용도
ES2903088T3 (es) 2015-04-30 2022-03-31 Immunomet Therapeutics Inc Compuestos de guanidina y su uso
CN105125689B (zh) * 2015-09-21 2018-01-19 株洲千金药业股份有限公司 一种含有妇科千金片药渣的足浴粉及其制备方法
US10344002B2 (en) 2016-09-26 2019-07-09 Nusirt Sciences, Inc. Compositions and methods for treating metabolic disorders
CN113354561B (zh) * 2021-04-17 2023-03-28 中山大学 双胍衍生物及其应用与制剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB852584A (en) * 1956-05-31 1960-10-26 Us Vitamin Corp Biguanide compositions
US2937173A (en) * 1959-05-06 1960-05-17 Us Vitamin Pharm Corp Indolino and tetrahydroquinolino triazines
US3879541A (en) * 1970-03-03 1975-04-22 Bayer Ag Antihyperglycemic methods and compositions
DE2009743A1 (de) * 1970-03-03 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Substituierte Biguanide mit antihyperglykämischer Wirkung
US3960949A (en) * 1971-04-02 1976-06-01 Schering Aktiengesellschaft 1,2-Biguanides
EP0034002A3 (fr) * 1980-01-22 1981-09-23 Beecham Group Plc Dérivés de carboxamidine
JPS6141367A (ja) * 1984-08-02 1986-02-27 三菱瓦斯化学株式会社 繊維または繊維製品の過酸化水素による漂白法
FR2696740B1 (fr) * 1992-10-13 1994-12-30 Dospharma Sa Dérivés prodrogués de la diméthylbiguanide et applications comme médicaments.

Also Published As

Publication number Publication date
HUP0303593A3 (en) 2007-03-28
CN1496347A (zh) 2004-05-12
SK12802003A3 (sk) 2004-02-03
JP4418157B2 (ja) 2010-02-17
MXPA03008404A (es) 2004-01-29
JP2004523580A (ja) 2004-08-05
AU2002308178B2 (en) 2007-03-01
ES2336771T3 (es) 2010-04-16
US20040092495A1 (en) 2004-05-13
RU2276136C2 (ru) 2006-05-10
DE60234424D1 (en) 2009-12-31
ZA200308146B (en) 2005-01-20
CA2441309C (fr) 2010-06-15
NO20034171L (no) 2003-09-19
ATE449066T1 (de) 2009-12-15
CA2441309A1 (fr) 2002-09-26
EP1370525B1 (fr) 2009-11-18
HK1062172A1 (en) 2004-10-21
EP1370525A1 (fr) 2003-12-17
KR20030085558A (ko) 2003-11-05
CN1228325C (zh) 2005-11-23
HUP0303593A2 (hu) 2004-03-01
CZ20032766A3 (cs) 2004-01-14
BR0208131A (pt) 2004-03-02
US7285681B2 (en) 2007-10-23
PL362528A1 (en) 2004-11-02
RU2003130070A (ru) 2005-04-10
WO2002074740A1 (fr) 2002-09-26
FR2822464A1 (fr) 2002-09-27
NO20034171D0 (no) 2003-09-19

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20141128