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FR2628633A1 - Strong, stable solutions of balsam of Peru - using over 90 per cent by vol ethanol as solvent - Google Patents

Strong, stable solutions of balsam of Peru - using over 90 per cent by vol ethanol as solvent Download PDF

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Publication number
FR2628633A1
FR2628633A1 FR8803352A FR8803352A FR2628633A1 FR 2628633 A1 FR2628633 A1 FR 2628633A1 FR 8803352 A FR8803352 A FR 8803352A FR 8803352 A FR8803352 A FR 8803352A FR 2628633 A1 FR2628633 A1 FR 2628633A1
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Prior art keywords
balsam
peru
solutions
volume
ethyl alcohol
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FR2628633B1 (en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin

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Abstract

Solutions of balsam of Peru, in ethanol of over 90% by volume, are new. The ethanol used is preferably 95%, the balsam content being 1-10%. Other components that may be present in these solutions include benzalkonium and benzethonium salts, which improve the antiseptic and viricidal properties of the balsam. The compositions may be formulated for inhalation or topical application to the skin and mucous membranes. USE/ADVANTAGE - Balsam of Peru is known to be useful in dermatology, traumatology, and in the treatment of respiratory mucosa. Solutions in 80% ethanol are known, but are not stable when the balsam content exceeds 1%. By using ethanol with a lower water content, stronger, stable solutions of the balsam, 5% or more, may be obtained.

Description

Solutions de baume du Pérou et utilisations de celles-ci.Peruvian balsam solutions and uses thereof.

La présente invention a pour objet des solutions de baume du Pérou et différentes utilisations de celles-ci. The present invention relates to Peru balsam solutions and different uses thereof.

Cn connaît selon l'art antérieur les vertus médicamenteuses du baume du Pérou. Il s'agit d'un complexe oléorésineux, extrait du Myroxylon pereiroe L., riche en vanilline. According to the prior art, the medicinal properties of Peru balsam are known. It is an oleoresin complex, extracted from Myroxylon pereiroe L., rich in vanillin.

Il existe déjà divers médicaments en contenant. Ledit baume du Pérou est notamment utilisé en dermatologie, en traumatologie... Il intervient également avantageusement dans le traitement des muqueuses respiratoires. Pou cette application, il existe des solutions pour inhalations, commercialisées sous la dénomination Balsofumine, et qui contiennent 1 % en poids dudit baume du Pérou dans de l'alcool à 80 c,Ó en volume. There are already various drugs containing it. Said balm from Peru is used in particular in dermatology, trauma ... It also intervenes advantageously in the treatment of respiratory mucous membranes. For this application, there are solutions for inhalations, marketed under the name Balsofumine, and which contain 1% by weight of said Peru balm in alcohol at 80 c, Ó by volume.

On a souhaité, pour en améliorer l'efficacité, préparer des solutions plus concentrées en ledit baume du Pérou. De telles solutions n'étaient pas stables. We wanted to improve the efficiency, prepare more concentrated solutions in said Peru balm. Such solutions were not stable.

Pour contourner ce problème de la conservation de solutions concentrées en baume du Pérou - notamment de formules pour inhalations - on a préconisé l'emploi de conditionnement -à plusieurs compartiments. Un tel conditionnement, pour la conservation séparée de fluides incompatiSles entre eux, et permettant leur mélange au moment de l'emploi, a notamment été décrit dans la demande de brevet FR 82 14525. To circumvent this problem of the conservation of solutions concentrated in balsam of Peru - in particular of formulas for inhalations - one recommended the use of conditioning - with several compartments. Such packaging, for the separate storage of fluids incompatible with each other, and allowing them to be mixed at the time of use, has in particular been described in patent application FR 82 14525.

Selon la présente invention, on propose des solutions stables de baume du Pérou, pouvant contenir plus de 1 % en poids et jusqu'à plus de 25 % en poids dudit baume du Pérou. According to the present invention, stable solutions of Peru balsam are proposed, which may contain more than 1% by weight and up to more than 25% by weight of said Peru balsam.

Les solutions selon l'invention sont des mélanges contenant ledit Baume du Pérou dissous en leur sein, mais peuvent également consister en lesdites solutions enrichies en un ou plusieurs composants actifs dudit Baume du Pérou qui aura été isolé, ou même en des solutions à base dudit ou desdits composants actifs. Dans la présente demande, il convient donc d'englober dans l'expression solutions de Baume du Pérou selon l'invention, les trois variantes précisées ci-dessus. The solutions according to the invention are mixtures containing said Peru Balm dissolved within them, but can also consist of said solutions enriched in one or more active components of said Peru Balm which will have been isolated, or even in solutions based on said or said active components. In the present application, it is therefore appropriate to include in the expression solutions of Peruvian balm according to the invention, the three variants specified above.

Les solutions selon l'invention sont caractérisées par la nature du solvant. Il s'agit d'alcool éthylique ou éthanol à plus de 90 % en volume ( > 900). The solutions according to the invention are characterized by the nature of the solvent. It is ethyl alcohol or ethanol at more than 90% by volume (> 900).

Avantageusement, le solvant intervenant dans les solutions de baume du Pérou selon l'invention est de l'alcool éthylique ou éthanol à au moins 95 % en volume (95 ). Selon une variante préférée, on utilise de l'alcool éthylique à 95 Ó en volume (95 ).  Advantageously, the solvent involved in the Peru balsam solutions according to the invention is ethyl alcohol or ethanol at least 95% by volume (95). According to a preferred variant, ethyl alcohol 95% by volume (95) is used.

Avec ledit solvant selon l'invention, il est possible d'obtenir des solutions stables de baume du Pérou contenant plus de 1/0 en poids dudit baume du Pérou ; voire 5 % ou plus de celui-ci.  With said solvent according to the invention, it is possible to obtain stable solutions of Peru balsam containing more than 1/0 by weight of said Peru balsam; even 5% or more of it.

Il est notamment tout à fait possible d'obtenir des solutions stables contenant 10 en poids dudit baume du Pérou. In particular, it is quite possible to obtain stable solutions containing 10 by weight of said Peru balm.

De telles solutions constituent l'objet de la présente invention
Elles sont obtenues par mélange, avec plus ou moins forte agitation, dudit baume du Pérou - qui se présente sous la forme d'un liquide sirupeux - et du solvant.Such solutions constitute the object of the present invention
They are obtained by mixing, with more or less strong agitation, said Peru balm - which is in the form of a syrupy liquid - and the solvent.

Audit mélange stable selon l'invention, on peut ajouter divers ingrédients. Audit stable mixture according to the invention, one can add various ingredients.

Comme indiqué ci-dessus, les solutions de baume du Pérou sont avantageusement utilisées en tant que formules pour inhalations. As indicated above, Peru balsam solutions are advantageously used as formulas for inhalations.

A partir des solutions concentrées selon l'invention, on peut donc obtenir de telles formules pour inhalations, particulièrement efficaces. From the concentrated solutions according to the invention, it is therefore possible to obtain such formulas for inhalations, which are particularly effective.

A titre d'exemple, on peut indiquer ci-après la composition d'une telle formule pour inhalations selon l'invention
10 g de baume du Pérou
0,5 g de menthol
20 g de teinture de benjoin
30 g de teinture d'eucalyptus
quantité suffisante pour 100 g d'alcool éthy
lique à 95 % en volume (950)
L'exemple ci-dessus a été donné à titre illustratif et ne limite aucunement la portée de la présente invention. A partir des solutions stables concentrées en baume du Pérou, selon l'invention, il est possible de préparer non seulement des formules pour inhalations, mais également toutes formes galéniques, notamment appli cables sur la peau, les muqueuses et leurs annexes (phanères)...By way of example, the composition of such a formula for inhalations according to the invention can be indicated below.
10 g Peru balsam
0.5 g menthol
20 g benzoin tincture
30 g eucalyptus tincture
sufficient quantity for 100 g of ethyl alcohol
95% by volume (950)
The above example has been given by way of illustration and does not in any way limit the scope of the present invention. From stable solutions concentrated in Peru balsam, according to the invention, it is possible to prepare not only formulas for inhalations, but also all galenical forms, in particular appli cables on the skin, the mucous membranes and their appendages (integuments). ..

Selon un autre objet de la présente invention, on a mis en évidence le fait que l'action antiseptique, virulicide des solutions selon l'invention était potentialisée par l'incorporation en leur sein de sel(s) de benzalkonium et/ou de benzéthonium. According to another object of the present invention, it has been demonstrated that the antiseptic, virulicidal action of the solutions according to the invention was potentiated by the incorporation within them of benzalkonium and / or benzethonium salt (s) .

Les solutions concentrées stables de baume du Pérou selon l'invention contiennent donc avantageusement du benzalkonium, du benzéthonium ou un mélange de ces produits. The stable concentrated solutions of Peruvian balm according to the invention therefore advantageously contain benzalkonium, benzethonium or a mixture of these products.

Ces produits interviennent sous forme de sels ou d'un mélange de sels. On les utilise de préférence sous forme de chlorure. These products come in the form of salts or a mixture of salts. They are preferably used in the form of chloride.

Ils étaient connus comme agents tensioactifs, agents conservateurs. Les propriétés antiseptiques, virulicides du benzalkonium étaient également connues. They were known as surfactants, preservatives. The antiseptic and virulicidal properties of benzalkonium were also known.

Toutefois, on notera que ces composés n'étaient jamais, selon l'art antérieur, intervenus dans des formulations pour inhalations. However, it will be noted that these compounds had never, according to the prior art, been used in formulations for inhalations.

Lesdits composés, sous forme de sels, interviennent genéralement à raison de 5 à 20 Ó en poids au sein des solutions selon l'invention. Il convient d'en mettre suffisamment pour que la potentialisation mentionnée ci-dessus se réalise, mais toutefois d'en limiter la quantité pour des problèmes de solubilisation, mais surtout pour éviter des problèmes d'irritation. Said compounds, in the form of salts, generally intervene at a rate of 5 to 20% by weight in the solutions according to the invention. It is advisable to put enough for the potentiation mentioned above to be carried out, but however to limit the amount for problems of solubilization, but especially to avoid problems of irritation.

Ainsi, des solutions selon l'invention peuvent contenir
10 g de baume du Pérou
10 g de chlorure de benzalkonium
0,5 g de menthol
20 g de teinture de benjoin
30 g de teinture d'eucalyptus
et une quantité suffisante pour 100 g
d'alcool éthylique à 95 % en volume (950) ou
10 g de baume du Pérou
10 g de chlorure de benzéthonium
0,5 g de menthol
20 g de teinture de benjoin
30 g de teinture d'eucalyptus
et une quantité suffisante pour 100 g
d'alcool éthylique à 95 % en volume (95 ). Thus, solutions according to the invention can contain
10 g Peru balsam
10 g benzalkonium chloride
0.5 g menthol
20 g benzoin tincture
30 g eucalyptus tincture
and an amount sufficient for 100 g
95% by volume ethyl alcohol (950) or
10 g Peru balsam
10 g benzethonium chloride
0.5 g menthol
20 g benzoin tincture
30 g eucalyptus tincture
and an amount sufficient for 100 g
95% by volume ethyl alcohol (95).

Comme précisé ci-dessus, les solutions selon l'invention peuvent intervenir dans la préparation de diverses formes galéniques et notamment dans la préparation de formules pour inhalations, de collutoires, de pommades, de suppositoires.. As specified above, the solutions according to the invention can be used in the preparation of various dosage forms and in particular in the preparation of formulas for inhalations, mouthwashes, ointments, suppositories, etc.

Leur utilisation à ces fins constitue un autre objet de la présente invention. Their use for these purposes constitutes another object of the present invention.

On rappelera enfin qu'un ou plusieurs composants actifs du Baume du Pérou, complexe oléorésineux, pourra être isolé, eventuellement purifié, identifié et venir enrichir les préparations originelles ou leur être préféré. Finally, it should be remembered that one or more active components of Peru Balsam, an oleoresin complex, can be isolated, possibly purified, identified and enriched or be preferred to the original preparations.

De telles solutions enrichies ou à base de composants actifs dudit Baume du Pérou, comme précisées ci-dessus, font partie de l'invention.  Such solutions enriched or based on active components of said Peruvian Balm, as specified above, form part of the invention.

Claims (11)

REVENDICATIONS 1. Solutions de baume du Pérou caractérisées en ce que le solvant utilisé est de l'alcool éthylique à plus de 90 % en volume  1. Peruvian balm solutions characterized in that the solvent used is ethyl alcohol of more than 90% by volume o ( > 90 ).  o (> 90). 2. Solutions de baume du Pérou selon la revendication 1, caractérisées en ce que Le solvant utilisé est de l'alcool éthylique à au moins 95 % en volume (95 ), de préférence de l'alcool éthylique à 95 % en volume (95 ).  2. Peru balsam solutions according to claim 1, characterized in that the solvent used is ethyl alcohol at least 95% by volume (95), preferably ethyl alcohol at 95% by volume (95 ). 3. Solutions selon L'une des revendications 1 ou 2, caractérisées en ce qu'elles contiennent -plus de 1 % en poids de baume du Pérou. 3. Solutions according to one of claims 1 or 2, characterized in that they contain more than 1% by weight of Peru balm. 4. Solutions selon a revendication 3, caractérisées en ce qu'elles contiennent, en poids, 5 X ou plus de baume du Pérou. 4. Solutions according to claim 3, characterized in that they contain, by weight, 5 X or more of Peru balm. 5. Solutions selon la revendication 4, caractérisées en ce qu'elles contiennent 10 % en poids de baume du Pérou. 5. Solutions according to claim 4, characterized in that they contain 10% by weight of Peru balm. 6. Solution selon L'une quelconque des revendications précédentes, caractérisée en ce qu'elle contient 6. Solution according to any one of the preceding claims, characterized in that it contains 10 g de baume du Pérou 10 g Peru balsam 0,5 g de menthol 0.5 g menthol 20 g de teinture de benjoin 20 g benzoin tincture 30 g de teinture d'eucalyptus 30 g eucalyptus tincture quantité suffisante pour 100 g d'alcool sufficient for 100 g of alcohol éthylique à 95 % en volume (95 ).  95% ethyl alcohol by volume (95). 7. Solutions selon l'une quelconque des revendications précédentes, caractérisées en ce qu'elles contiennent en outre du benzalkonium ; du benzéthonium ; ou un mélange de ces deux produits. 7. Solutions according to any one of the preceding claims, characterized in that they also contain benzalkonium; benzethonium; or a mixture of these two products. 8. Solutions selon la revendication 7, caractérisées en ce qu'elles contiennent de 5 à 20 % en poids de sel(s) de benzalkonium et/ou de benzéthonium. 8. Solutions according to claim 7, characterized in that they contain from 5 to 20% by weight of benzalkonium and / or benzethonium salt (s). 9. Solution selon l'une des revendications 7 ou 8, caractérisée en ce qu'elle contient 9. Solution according to one of claims 7 or 8, characterized in that it contains 10 g de baume du Pérou 10 g Peru balsam 10 g de chlorure de benzalkonium 10 g benzalkonium chloride 0,5 g de menthol 0.5 g menthol 20 g de teinture de benjoin  20 g benzoin tincture 30 g de teinture d'eucalyptus 30 g eucalyptus tincture et une quantité suffisante pour 100 g and an amount sufficient for 100 g d'alcool éthylique à 95 % en volume (95 ).  95% by volume ethyl alcohol (95). 10. Solution selon l'une des revendications 7 ou 8, caractérisée en ce qu'elle contient : 10. Solution according to one of claims 7 or 8, characterized in that it contains: 10 g de baume du Pérou 10 g Peru balsam 10 g de chlorure de benzéthonium 10 g benzethonium chloride 0,5 9 de menthol 0.5 9 menthol 20 g de teinture de benjoin 20 g benzoin tincture 3 g de teinture d'eucalyptus 3 g eucalyptus tincture quantité suffisante pour 100 g d'alcool sufficient for 100 g of alcohol éthylique à 95 x en volume (95 ).  95% ethyl alcohol (95). 11. Utilisation de solutions selon l'une quelconque des revendications précédentes pour la préparation de formules pour inhalations, de collutoires, de pommades, et suppositoires...  11. Use of solutions according to any one of the preceding claims for the preparation of formulas for inhalations, mouthwashes, ointments, and suppositories ...
FR8803352A 1988-03-15 1988-03-15 PERU BALM SOLUTIONS AND USES THEREOF Expired - Lifetime FR2628633B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR8803352A FR2628633B1 (en) 1988-03-15 1988-03-15 PERU BALM SOLUTIONS AND USES THEREOF

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8803352A FR2628633B1 (en) 1988-03-15 1988-03-15 PERU BALM SOLUTIONS AND USES THEREOF

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FR2628633A1 true FR2628633A1 (en) 1989-09-22
FR2628633B1 FR2628633B1 (en) 1991-07-26

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2532280A1 (en) * 1982-08-24 1984-03-02 Mercier Jean Packaging for the separate storage of mutually incompatible fluids which allows them to be mixed at the time of use
GB2128086A (en) * 1982-10-07 1984-04-26 Jaslien Singh Cosmetic composition and process
EP0175507A1 (en) * 1984-08-28 1986-03-26 Pharmaceutical Holdings Limited Pharmaceutical preparations

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2532280A1 (en) * 1982-08-24 1984-03-02 Mercier Jean Packaging for the separate storage of mutually incompatible fluids which allows them to be mixed at the time of use
GB2128086A (en) * 1982-10-07 1984-04-26 Jaslien Singh Cosmetic composition and process
EP0175507A1 (en) * 1984-08-28 1986-03-26 Pharmaceutical Holdings Limited Pharmaceutical preparations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DICTIONNAIRE VIDAL, 63ème édition, 1987 *

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