FR2556963A1 - DENTIFRICE COMPOSITION AND ITS USE IN A DISPENSER - Google Patents

Abstract

THE INVENTION CONCERNS A TOOTHPASTE COMPOSITION WHICH HAS ADVANTAGEOUS RHEOLOGICAL PROPERTIES FOR BEING EFFECTIVELY INTRODUCED INTO A DISPENSER ACTUATED MECHANICALLY OR BY PRESSURE DIFFERENCE AND TO BE EXTRUDED THEREFORE. THIS COMPOSITION CONTAINS A TRIHYDRATED ALPHA-ALUMINO AS A POLISHING AGENT AND A NUMBER OF ACTIVE INGREDIENTS AND A MIXTURE OF GELING AGENTS CONSTITUTES A CELLULOSIC GELING AGENT SUCH AS SODIUM SALT OF CARBOXYMETHYOTAHYANTHANIUM ETHYANTHYANTHANIUM ETHYANTHYANTHANIUM ETHYANTHYOTAHELLULOSE OR CARBOXYANTHYANTHYANTHYANTHYANTHANIUM SODIUM SALT OF X-CARBOXYANTHYANTHYOTAHELLULOSE OR CARBOXYANTHYANTHYANTHYOTAHELLULOSE OR SODIUM SALT.

Description

i

  The present invention relates to a composition of

  tifrice and in particular a composition of toothpaste pre-

  having favorable rheological properties

  to be introduced effectively into a dispenser of den-

  tifrice operated mechanically or by pressure difference,

  and being expelled by extrusion.

  A toothpaste is usually recognizable by its

  creamy consistency or gel and it can be designated couram-

  by toothpaste, toothpaste or, in some cases, toothpaste in clear gel or opacified gel. In fact, it can be characterized as a semi-solid, for example by being substantially solid when standing in shape on

  the bristles of a toothbrush and essentially liquid,

  eg during manufacture with stirring or when introduced into a container or is subject to

  pressure to be extruded from its container.

  The creamy consistency of toothpastes is generally

  conferred by a gelling agent or binder. previously,

  the gelling agents were chosen mainly to

  to cilitate the dispersion of the toothpaste in the oral cavity.

  Many gelling agents such as cellulosic materials

  seaweed derivatives, gums and clays meet this criterion. However, some gelling agents, while

  being generally of interest for conditioned toothpastes

  in flexible tubes, have drawbacks when packaged in actuated distributors

  mechanically or by pressure difference.

  Toothpastes containing conventional polishing agents

  such as alpha-alumina trihydrate and

  conventional gelling agents such as the sodium salt of the carboxy

  Methylcellulose or hydroxyethylcellulose or mixtures thereof can be advantageously introduced into flexible tubes or mechanically actuated or pressure differential dispensers and extruded therefrom. However, when the toothpaste contains many active ingredients, there may be difficulties when introducing a toothpaste into a dispenser mechanically operated or pressure differential and / or when trying to expel by extrusion. In particular, it may appear

  leaks from dispenser ports during the

  pleating or conveying and the product may be difficult to extrude into ribbon-satisfactory form from a rheological point of view.

  Dentifrices that are thick or tend to

  may become increasingly difficult to extrapolate

  lO der by the consumer from a toothpaste tube after a while. In other words, the consumer may have to increase the pressure exerted on a toothpaste tube containing such toothpaste during the period of use.

  to soften or liquefy the mass of semi-toothpaste

  solid to extrude it. This was not a major problem previously because the formulations can be adjusted to use less gelling agent to achieve a balance so that the toothpaste is not too soft at the beginning of use or too thick at the end and in any case, consumers easily adjusted the degree of pressure needed to extrude the necessary amount

  toothpaste on the bristles of a toothbrush.

  Toothpastes that are fluid after extrusion of a tube have also been accepted into use if they harden into a stronger form on the bristles of the toothbrush in seconds. Thus, the type of gelling agent could vary greatly for toothpastes packaged in tubes. Indeed, Copenhagen Pectin Factory Ltd. of Little Skensved, Denmark, a subsidiary of Hercules Inc. of Wilmington, Delaware, U.S.A. proposed his product Genuvisco

  Type 0819, an iota-carrageenan (i-carrageenan).

  possible toothpaste. The i-carrageenan dis-

  available from Marine Colloids Division of FMC Corp. of Springfield, New Jersey, under the designation Viscarin TP-5 has also been proposed as a possible thickener for toothpaste containing dicalcium phosphate or silica. In addition, i-carrageenan has been described as a

  thickener at the same time as the k-carrageenan and an alginate

  alkali metal nate for a toothpaste containing galac-

  tane-galactose in the Japanese Patent Publication No. 56 115711, in the name of Lion Toothpaste Ltd: When using a toothpaste dispenser, which operates mechanically or by pressure difference, the

  conventional techniques for reducing the thickening of

  tifrice can not be quite satisfactory because, compared to a toothpaste introduced into a flexible tube, when using a dispenser, the toothpaste must be relatively fluid during the introduction, but resumes its consistency and keeps it during transport , storage

  and the use. In other words, toothpaste, after introducing

  essentially resumes the consistency it had before

  the liquefaction effect during shear

  during transport, storage and use. Conventional gelling agents such as the sodium salt of the

  carboxymethylcellulose, hydroxyethylcellulose, or their

  langes, can be advantageously used for denture

  frice containing alpha-alumina trihydrate as a

  polishing, to be introduced into a dispenser. How-

  when such a toothpaste contains many sources of active ingredients, for example at least two sources of fluorine, a desensitizing agent such as allantoic (C7H6N403) and a vasodilator such as pyridyl-carbinol,

N CH _ OH

  difficulties arise when toothpaste is introduced

  in a mechanically operated dispenser or by means of

  pressure. In particular, toothpaste may

  the space between a rod and a piston used

  especially in a mechanically operated distributor-

  leakage occurs at the level of the distribution orifices

  tor. In addition, the toothpaste ribbon extruded from a

  mechanically or by pressure difference may be irregular or discontinuous. Since he is

  particularly advantageous to prepare a toothpaste

  alpha-alumina trihydrate as a polishing agent, which contains several active agents, such as those indicated above, because of the compatibility of these materials with

  the polishing agent, another gelling system is required.

  Contrary to what can be expected from most

  On the other types of gelling agents, a mixture of a cellulosic gelling agent and i-carrageenan gives an excellent toothpaste containing alpha-alumina trihydrate and several active ingredients, which must be introduced into

  a container actuated mechanically or by difference of pressure

  and be extruded from this container. It goes without saying that xanthan was not compatible with gelling agents

  cellulosic as it may contain cellulase.

  An advantage of the present invention is to provide

  a toothpaste that is easily introduced into a

  toothpaste carrier operated mechanically or by difference

  pressure and is extruded easily from such a dispenser.

  Other advantages will emerge from the description which

go follow.

  According to some of its aspects, the present invention

  a toothpaste in a mechanically operated dispenser

  by pressure difference, comprising about 80% by weight of an aqueous humectant vehicle, about

  0.1 to 5% by weight of a mixture of gelling agents, approximately

  20 to 75% by weight of alpha-alumina trihydrate as a polishing agent, sodium fluoride and sodium monofluorophosphate. amount providing about 300 to 10,000 ppm of fluorine, about 0.05 to 0.5% by weight of allantoin as

  desensitizing agent and about 0.05 to 0.5% by weight of py-

  ridyl-carbinol as a vasodilator, said gelling agent mixture being a mixture of a cellulosic gelling agent or xanthan with i-carrageenan in a ratio by weight

  cellulosic gelling agent or xanbhane to i-carra-

  ghennane from about 5: 1 to about 1: 5.

  In the formulation of toothpaste, the vehicle

  comprises a liquid phase commensurate with the gelling agent to form an extrudable creamy mass of

  desired degree. The liquid phase of the toothpaste mainly comprises

  usually water and a humectant such as polyols

  taking glycerol, sorbitol, maltitol, xylitol, low molecular weight polyethylene glycol (for example

  400 or 600), propylene glycol, etc., including their

  ges. It is generally advantageous to use, as the liquid phase, water and a humectant such as glycerine,

  sorbitol or polyethylene glycol, generally in

  about 10 to 55% by weight of water and about 20 to 50% by weight of humectant. The toothpaste contains alpha-alumina trihydrate as a polishing agent in amounts of about 20 to about weight percent. Alpha-alumina trihydrate is usually

  prepared by the Bayer process and used in the form of

  cells smaller than about 40 microns, mainly

  between 3 and 20 microns. Other police officers

  Smoothing can be incorporated such as insoluble sodium metaphosphate, dicalcium phosphate, calcined alumina, silica or calcium carbonate in minor proportion by

  compared to alpha-alumina trihydrate.

  The gelling agent mixture of the present invention

  toothpaste is present in a proportion of approximately

  0.1 to 5% by weight. It contains either a gelling agent

  cellulose, either xanthan, mixed with i-carrageenan

  wherein the weight ratio of said cellulosic gelling agent xanthan to i-carrageenan is from about 1 to about 1: 5, preferably from about 1: 1 to about 1: 3, and the total mixture is of gelling agents represents

  preferably about 0.2 to 3% by weight.

  As mentioned above, iota-carrageenan is marketed and sold under the designation Genuvisco type 0819 and Viscarin TP-5 and has been recommended for use in a toothpaste. Such an application in a toothpaste is described in the Japanese patent published under the

  N 56 115711 from Lion Toothpaste Ltd. in which the i-carra-

  ghenane is mentioned as a possible component of a system

  at the same time as k-carrageenan and

  alkali metal ginate. In the U.S. Patent No. 4,353,890, icarrageenan is described as a product of

  replacement of k-carrageenan as a gelling agent

  toothpaste, and in this patent the dentine paste

  frice is subjected to microwave radiation to reduce

  re the general tendency of carrageenan to become fluid during manufacture. Carrageenan may be the only gelling agent or it may be mixed with other gelling agents. In the present invention, the toothpaste containing i-carrageenan to be introduced into a

  distributor actuated mechanically or by difference of pressure

  It does not require microwave radiation.

  The prior art generally described above does not indicate that gelling systems consisting of cellulosic gelling agent and icarrageenan can confer

  toothpastes containing alpha-alumina trihydrate

  me polishing agent and many active ingredients, the properties necessary for an effective introduction into a

  distributor actuated mechanically or by difference of pressure

  and for extrusion from such a distributor:

  Note that the U.S. Patent. N 0 029 760 de-

  written an oral composition in which i-carrageenan is described as an antigingivite agent replacing other carrageenins. Carrageenans are highly depolymerized derivatives of carrageenans. Carrageenans

  do not seem to provide any anti-swelling effect.

  Toothpastes are commonly manufactured by a procedure

  cold dice, for example at about 25 C, or by a method of

  hot, for example at about 60 ° C. I-carrageenan can e-

  be used in cold-process techniques or

  yielded hot. Since xanthan is manufactured by a

  cold treatment, it can be easily mixed when

  that it is used with i-carrageenan and be incorporated together with it in the toothpaste by a cold treatment. I-carrageenan can only be used with

hot weather.

  The physical properties of the i-carrageenan Genuvisco type 0819 are indicated below: 1. Viscosity of a 0.30% solution of GENUVISCO type 0819 in a lean solvent prepared using a hot process (60 C):

  Viscosity = 110 17 mPa.s at 32 rpm.

  Viscosity = 70 ll mPa.s at 64 rpm.

  Viscosity = 45 + 7 mPa.s at 128 rpm.

  Measured on Rotovisco RV 3 HAAKE at 25 C.

  2. Viscosity of a 0.30% solution of GENUVISCO type 0819 in a poor solvent prepared using a cold process (25 C): Viscosity = 450 + 60 mPa.s measured on a viscosimeter

Brookfield LVT at 25 C.

  Viscosity = 85 - 13 mPa.s at 32 rpm.

  Viscosity = 55 + 8 mPa.s at 64 rpm.

  Viscosity = 37 + 6 mPa.s at 128 rpm.

  Measured on Rotovisco RV3 HAAKE at 25 C.

  3. Particle size: Less than 1% of gum on a

  0.075 mm test sieves (DIN 80, sieves with

meshes 0.074 mm).

  4. Moisture content: Less than 12%.

  5. pH: 8.5 + 1.5 in a 0.5% solution in distilled water

distilled at 25 C.

6. Color: White to cream.

  Viscarin TP-5 i-carrageenan presents the properties

physical types:

Color: light havana to havanne.

  Particle size: More than 95.0% passing through a

mesh screen of 250 nm.

  Moisture content: maximum 12.0 Z (Moisture equilibrium

Cenco).

  pH: 7.0 to 9.5, 1.5% solution, 30 C.

  Examples of cellulosic gelling agents are

  The present invention comprises an alkali metal salt of carboxymethylcellulose, methylcellulose, hydroxymethylcellulose and hydroxypropylcellulose. The sodium salt of carboxymethylcellulose is preferred. The mixed gel system is present in a proportion of about 0.1 to 5% by weight of the toothpaste, and

  the weight ratio of cellulosic gelling agent to i-car-

  Ragandan is from about 5: 1 to about 1: 5, preferably from about 1: 1 to about 1: 3, and more preferably

  it is about 1: 1. Thus, a preferred toothpaste

  tif may contain about 0.9 to 1.2% of the total gel

  ranging from about 0.3 to about 0.9 of each of the gel

  cellulosic filler and i-carrageenan, the ratio by weight

  between the two being between about 1: 1 and 1: 3.

  It is evident that the sodium salt qualities of carboxymethylcellulose that can be used include the following:

TABLE I

  SUPPLIER CMC QUALITY VISCOSITY (MP) Hercules 7MXF 300-500 Hercules 7MFD 300-500 Hercules 9M31F 900-1200 Hercules 9M31XF 900-1200 Hercules 12M31XF 900-1200 Hercules 7MF 300-500 Hercules 12M31PD 900-1200 Hercules 7M8SXF 200-800 Wolff Walsrode Walocel CRT 1000 PA 07 700-1200 Nyma Nymcel ZMF.33 * 50-80 Enka Akucell AC 1642 * 80-120 Enka Akucell AC 1632 * 60-120 Cros Cellogen HP-SA 700-900 Uddeholm Cekol MVEP 500 -800 Hoechst Tylose CB 200 ** 120-260 * 1% Solution (Brookfield; 25 C) ** Hoeppler Viscometer (2%; 20 C) In addition, hydroxyethylcellulose grades that can be used include the following: :

TABLE 2

  SUPPLIER QUALITY OF HEC VISCOSITE (m.Pa.s.)

  Hercules Natrosol 250M and MR 4500-6500.

  Hercules Natrosol 250 HR * 1500-2500 and 250 H * Hercules Natrosol 250 HHR * 3400-5000 and 250 HH BP Chemicals Cellobond 5000 A 4200-5600 -BP Chemicals Cellobond 7000 A 6000-7000 Hoechst Tylose H 4000.P ** 3000- 5000 Hoechst Tylose H 10000 P ** 7000-12000 * 1% Solution (Brookfield-25 C) ** Hoeppler Viscometer (2%; 25 C) I-Carrageenan and Cellulosic Gelling Agent

  can be mixed together mechanically before being

  with the liquid phase of the dental cream vehicle,

  or they can be mixed separately with the

  quide, by heat treatment techniques (for example

  about 60 ° C) or cold treatment (for example,

25 C).

  Xanthan gum is a fermentation product prepared by the action of bacteria of the genus Xanthomonas on

  10 carbohydrates. Four species of Xanthomonas,

  see X. campestris, X. phaseoli, X.malvocearum and X.carotae

  are mentioned in the literature as being the produc-

  the most efficient gums. Although the Chinese structure

  exact dose is not determined, it is usually

  as a heteropolysaccharide having a molecular weight of

  a few millions. It contains D-glucose, D-mannose and D-glucuronic acid in a molar ratio

  2.8: 3: 2.0. The molecule contains 4.7% acetyl and approximately

  3% pyruvate. The proposed chemical structure can be found in Industrial Gums, by McNeely and Kang, edited by

  R. Whistler, CH. XXI. 2nd Edition, New York, 1973. The

  cessation of growth, isolation and purification of the

  Xanthan gum is also found in this publication.

  Another description of xanthan gum is found in

  Manufacturing Chemist, May 1960, pages 206-208 (comprising

  the mention on page 208 of the potential use of gom-

  my described for the formulation of toothpastes).

  I-carrageenan and xanthan can be mixed

  together mechanically before being mixed with the

  gets liquid from the dental cream vehicle, or they can

  be mixed separately with the liquid phase, by means of

  cold treatment (eg about 25 C).

  The toothpaste is packaged in a container

  which it can be easily extruded, for example a distri-

  tooth cream scorer mechanically or mechanically operated

  pressure. The rheological properties are very

  when using a dispensing container

  mechanically of the type described in the patent application

  tannic N 2 070'695A, published on September 9, 1981. This recital

  distributor comprises a dispensing mouthpiece, a tensioning element, a central rod, a piston and an element

manual order.

  The dispensing container operated by difference of

  pressure may be aerosol or vacuum type. Distributions

  appropriate scorers operated by differential pressure

  those comprising a collapsible bag containing the product,

  placed inside a rigid container which contains a flui-

  thruster. In such dispensing containers, the function

  the valve allows to release only the product, the

  propellant fluid being separated from the product by the impermea

  ble fluids. Dispensers of this type are described in U.S. patents. Nos. 3,828,977 and 3,838,796. These are the so-called Sepro distributors. The so-called Exxel containers

also use pressure.

  Another type of dispenser is the container

  barrier piston disclosed in U.S. Patent No. 4,171,757.

  This container comprises a valve, a compartment containing the product and a substantially fluid-tight barrier piston which separates the propellant fluid from the contained product.

(the container says Diamond).

  The dentifrice contains as active agents a mixture of sodium fluoride and sodium monofluorophosphate to provide about 300 to 10,000 ppm of fluorine, for example about 750 to 2000 ppm, and in particular about 1400 to

  2000 ppm, for example about 1400 to 1670 ppm. We use

  a binary fluoride system consisting of sodium monofluorophosphate and sodium fluoride, in which about 30 to 40% of the fluorine (e.g.

  %) are provided by sodium fluoride.

  Sodium monofluorophosphate, Na2PO3F, as commercially available can vary widely

  as to its purity. It can be used in any purity

  provided that impurities do not adversely affect

  the desired properties. In general, purity is advantageous

  at least 80 Z. For the best results

  It should be at least 85%, and preferably at least 90% by weight, of sodium monofluorophosphate, the remainder being mainly impurities or by-products of manufacture, such as sodium fluoride. and phosphate

  of water-soluble sodium. In other words, monofluorophos-

  used sodium phere must have a total content of

  greater than 12%, preferably greater than 12.7%, a content of not more than 1.5%, preferably not more than 1.2% free sodium fluoride; preferably from

  minus 12.1%, all calculated as fluoride.

  As indicated above, the sodium fluoride in the binary mixture is a separate component, containing fluorine, sodium monofluorophosphate. About 225-800 ppm of fluorine is preferably supplied to the dental cream by the

sodium fluoride.

  The additional active agent is provided to the dentifrice by the presence of about 0.05 to 0.5% by weight, preferably

  about 0.08 to 0.2%, allantoic as a desensitizing agent,

  reading. This agent fights the sensitivity of the periodontal tissue.

  that injured and promotes his healing. The allantoin can be ob-

  held by ABM Industrial Products Ltd.of Woodley, Stock-

Port, Cheshire, Great Britain.

* Pyridyl-carbinol (active agent) in proportion to

  0.05 to 0.5% by weight, preferably from about 0.08 to

  0.2% gives the toothpaste a vasodilating effect.

  When using a toothpaste containing alpha-

  alumina trihydrate as a polishing agent, the dual system

  fluoride, al-lantone as desensitizing agent and pyridylcarbinol as vasodilator, described above,

  introduction and extrusion with the aid of distributors

  mechanically or by pressure difference are

  effective and rheologically advantageous

  with the gel system of the invention.

  The filling is carried out by conventional techniques

  c. For example, when using an

  mechanically born of the type disclosed in published UK Patent Application No. 2,070,695A, a predetermined amount of the toothpaste is extruded through a spout or nozzle to fill the dispenser which is open at its base and which contains a

  central stem. A piston with a diameter corresponding to the diameter

  internal distributor and having a central opening

  trale allowing the introduction of the central rod is slid into place. The dispenser is then closed tightly

using a background disc.

  Any suitable surfactant or detersive material may be incorporated into the dentifrice compositions. These compatible materials are advantageous for conferring other detergent, foaming and antibacterial properties according to the particular type of surfactant material and are chosen

  in a similar way. These detergents are hydrophilic compounds

  soluble in general, and can be of anionic structure,

  nonionic or cationic. It is usually better to

  use synthetic or hydrosoluble organic detergents

  without soap. Appropriate detergent materials are

  and include, for example, the water-soluble salts of monosulfate monoglyceride of higher fatty acid detergent

  (eg sodium salt, monoglycerol monosulfate

  of coconut fatty acid), a higher alkyl sulfate

  (eg sodium lauryl sulphate), an alkylaryl sulphoxide

  nate (for example sodium dodecylbenzene sulfonate,

  1, 2-dihydroxypropane-type higher fatty acid esters

  sulfonate), etc. Other surfactants include higher aliphatic acyl amides substantially saturated with acids.

  aliphatic amino carboxylic acids such as those

  12 to 16 carbon atoms in the acyl radical. The door

  amino acid is usually derived from monoamino acids.

  lower saturated aliphatic carboxylic acids having

  2 to 6 carbon atoms, generally monocarboxylic acids

  lic. Suitable compounds are fatty acid amides

  glycine, sarcosine, alanine, 3-aminopropa-

  noTe and valine having about 12 to 16 carbon atoms in the acyl group. However, it is preferable to use N-lauroyl-, myristoylet palmitoyl-sarcosides to obtain

the best effects.

  Amides can be used in the form of

  free acid or, preferably, in the form of their salts

  water-soluble substances, for example alkali metal salts, amines

  monium, amine and alkylolamine. Particular examples are sodium and potassium N-lauroyl, myristoyl and palmitoyl sarcosides, ammonium and ethanolamine N-lauroylglycide, and alanine. For convenience, the reference to an "amino-carboxylic acid compound", "sarcoside", etc., refers to water-soluble carboxylates having a group

free carboxylic acid.

  These materials are used in pure form or practically

  pure. They must be as deprived as possible

  of soap or similar higher fatty acid having

  this to reduce the activity of these compounds. In general practice

  the proportion of such higher fatty acids is lower than

  than 15% by weight of the amide and insufficient for

  harmful, and preferably less than

% of said amide. Various other materials can be incorporated into the toothpastes of

  the present invention. Examples

  they are coloring and bleaching agents, preservatives

  such as methyl p-hydroxybenzoate or benzene

  sodium zoate, stabilizers, silicones,

  chlorophylls, and ammoniated materials such as

  diammonic phosphate and their mixtures. These adjuvants are incorporated in the present compositions in proportion

  does not adversely affect the properties or characteristics

  desired and are advantageously chosen and used

in classical proportions.

  For some applications, it may be desirable to incorporate antibacterial agents into the compositions

  of the present invention. Examples of antibacterial agents

  Examples which can be used in amounts of from about 0.01% to about 5%, preferably from about 0.05% to about 1.0% by weight of the dentifrice composition include the following: N1 -4 (chlorobenzyl) -N5 (2,4-dichlorobenzyl) biguanide; p-chlorophenyl biguanide; 4chlorobenzhydryl biguanide; 4-chlorobenzhydrylguanylurée; N-3lauroxypropyl-N5-p-chlorobenzylbiguanide; 1,6-di-p-chlorophenylbiguanide;

  1- (lauryldimethylammonium) -8- (p-chloro) dichloride

  benzyldimethylammonium) octane; 5,6-dichloro-2-guanidinobenzimidazole; Nlp-chlorophenyl-N5-laurylbiguanide; amino-1,3-bis (2-ethylhexyl) -5-methylhexahydropyrimidine;

  and their addition salts with non-toxic acids.

  To aromatize the compositions of the present invention,

  any flavoring or sweetening matter may be used

  appropriate corantes. Examples of aromatic constituents

  Suitable oils include flavoring oils, for example spearmint, peppermint,

  wintergreen, sassafras, cloves, sage, eucalyptus

  tus, marjoram, cinnamon, lemon and orange as well

  than methyl salicylate. Sweetening agents

  required include sucrose, lactose, maltose,

  sorbitol, sodium cyclamate, saccharide dipeptides

  sodium salt of the U.S. Patent No. 3,939,261 and the oxathiazine salts of U.S. No 3 932 606. Agents

  flavoring agents and sweeteners may form together

  about 0.01 to 5% or more of the composition.

  Toothpastes must have a pH that can be used in

  convenient. A pH range of 3 to 10.5 is particularly suitable

  is lying. The reference to pH is used to designate the pH determination directly on the toothpaste. If you wish, you can

  add materials such as benzoic acid or

  to adjust the pH, for example, between 4 and 8.5.

  The following non-limiting examples illustrate

  the nature of the present invention. All quantities of the various ingredients are expressed in weight except

otherwise stated.

Example 1

  The following toothpaste is prepared by a conventional method.

  It is used in a cold press (room temperature) and introduced into the mechanically actuated dispenser described in British Patent No. 2,070,695A. Parts Sorbitol (70%) 23,000 Sodium salt of saccharin 0.170 icarrageenan (Genuvisco 0819) 0.500 Sodium salt of carboxymethylcellulose (7MFD) 0.500 methyl p-hydroxybenzoate 0.080 Allantoin 0.150 Sodium fluorine O0.100 Sodium monofluorophosphate 0.760 Pyridyl carbinol 0.100 Alpha-alumina trihydrate (Alcoa C-333) 51,000 Benzo acid 0.140 Sodium lauryl sulphate 1.667 Titanium dioxide 0.500 Aroma 1,200 Deionized Water 20,133 Toothpaste effectively fills the dispenser

  and shows no leakage during storage at 43 C

  plush: 1 month. It is well extruded from the distributor

  after 1 month of storage at 43 C.

  Similar satisfactory results are obtained when

  that the toothpaste is modified so that it contains 0.55 par-

  of i-carrageenan and 0.55 parts of sodium carbonate salt.

  boxymethylcellulose in one case and 0.45 part of i-carrageenan

  nane and 0.45 part of sodium salt of carboxymethylcellulose

  in a second case, with corresponding adjustment of the water content. In fact, with these dentifrices, there is no leakage and good extrusionability after

  a storage at 43 C for 3 months.

  We still get good results when everyone

  of the three toothpastes described above is modified in a way

  re to contain 50,000 parts of alpha-alumina trihydrate in

  a series of these toothpastes and 52,000 parts of alpha-alumina

  do not trihydrate in the second set of these dentifrices, with

  corresponding adjustment of the water contents.

Example 2

  The following toothpaste is prepared by a cold process

  and introduced into the same dispenser as in Example 1.

  Parts Sorbitol (70%) 23,000 Sodium salt of saccharin 0.170 icarraghenan (Genuvisco 0819) 0.666 Sodium salt of carboxymethylcellulose (7MFD) 0.334 methyl p-hydroxybenzoate 0.080 Allantoin 0.150 Sodium fluoride 0.100 Sodium monofluorophosphate 0.760 Pyridyl carbinol 0.100 Alpha alumina trihydrate (Alcoa C-333) 51,500 Benzoic acid 0.140 Sodium lauryl sulphate 1.667 Titanium dioxide 0, 500 Aroma 1,200 Deionized water 19,633 The toothpaste effectively fills the dispenser and does not leak and is well extracted from the dispenser

  after a storage period of 1 month at 43 C.

  Similar advantageous effects are obtained when the toothpastes of the examples are introduced into a dispenser

  operated by pressure difference.

  When the sodium salt of carboxymethyl-

  cellulose as the sole gelling agent, extrusion is poor

  is. When using hydroxyethylcellulose as sole agent

  gelling, there is a leak. However, when

  bind the hydroxyethylcellulose with the i-carrageenan,

  holds a satisfactory filling and extrusion.

Example 3

  The following dentifrice is prepared by a conventional method.

  cold temperature (room temperature) and introduces it into the mechanically actuated

N 2 070 695A.

  Parts Sorbitol (70%) 23,000 Sodium salt of saccharin 0.170 icarraghenan (Genuvisco 0819) 0.500 Xanthan (Keltrol) 0.500 methyl hydroxybenzoate 0.080 AllantoTne 0.150 Sodium fluoride 0.100 Sodium monofluorophosphate 0.760 Pyridyl carbinol 0.100 Alphaaluminum trihydrate (Alcoa C- 333) 51,000 Benzoic Acid 0.140 Sodium Lauryl Sulfate 1.667 Titanium Dioxide 0.500 Flavor 1,200 Deionized Water 20,133 The toothpaste effectively fills the dispenser - and does not leak during storage at 43 ° C for more than 1 month. I1 extruders well from the distributor after a

1 month storage at 43 C.

  Similar satisfactory results are obtained when

  that the toothpaste is modified so that it contains 0.55 part of icarraghenan and 0.55 part of xanthan-in one case and 0.45 part of icarragenenane and 0.45 part of xanthan in a second case, with corresponding adjustment of water content. Indeed, the absence of leakage and good extrudability after storage at 43 C for 3 months are observed with the toothpaste containing 0.45 part of xanthan and

0.45 part of i-carrageenan.

  Satisfactory results are also observed when

  that each of the three toothpastes described above is modified

  to contain 50,000 parts of tri-alpha-alumina

  hydrated in a first set of these dentifrices and 52,000 parts of alpha-alumina trihydrate in the second set of these dentifrices, with corresponding adjustment of

water content.

  Phosphoric acid can be used in place of

  benzoic acid and obtain similar results.

Example 4

  The following toothpaste is prepared by a method of

  cold and introduces it into the same distributor as in the E-

xample 3.

  Parts Sorbitol (70%) 23,000 Sodium saccharin 0.170 icarraghenan (Genuvisco 0819) 0.750 Xanthan (Keltrol) 0.250 methylhydroxybenzoate 0.080 AllantoTne 0.150 Sodium fluoride 0.100 Sodium monofluorophosphate 0.760 Pyridyl-carbinol 0.100 Alphaaluminum trihydrate (Alcoa C- 333) 51,000 Benzoic Acid 0.140 Sodilum Lauryl Sulfate 1.667 Titanium Dioxide 0.500 Aroma 1.200 Deionized Water 20.133 The toothpaste effectively fills the dispenser and is leak free and is easy to extract from the dispenser

  after storage for 3 months at 43 C.

  The same advantageous results are obtained with 50,000 parts of alphaaluminum trihydrate. Each variant provides

  also similar results with a gel system con-

  holding (a) 0.825 part of i-carrageenan and 0.275 part of xanthan and (b) 0.675 part of i-carrageenan and 0.225 part

of xanthan.

  Similar advantageous effects are obtained when

  the toothpastes of the examples are introduced into a distri-

  scorer operated by pressure difference.

Claims (7)

R E V E N D I C A T I 0 N S   1 - Toothpaste in a machine operated dispenser   or by pressure difference, characterized in that   it comprises about 20 to 80% by weight of a vehicle   aqueous, about 0.1 to 5% by weight of a mixture of   gelling agents, about 20 to 75% by weight of triethyl alpha-alumina   as a polishing agent, sodium fluoride and   sodium monofluorophosphate in proportions providing   about 300 to 10,000 ppm of fluorine, about 0.05 to 0.5% by weight of allantoin as a desensitizing agent and about 0.05 to 0.5% by weight of pyridyl carbinol as a vasodilator,   the gelling agent mixture being a mixture of a general agent   cellulosic or xanthan leavening agent with i-carrageenan in a weight ratio of cellulosic gelling agent to   i-carrageenan from about 5: 1 to about 1: 5.   2 - Toothpaste according to claim 1, characterized   in that the weight ratio of the cellulosic gelling agent   or xanthan to i-carrageenan is about 3: 1 to about   viron 1: 3 and the gelling agent mixture is present in the   portion of about 0.2 to 3% by weight.   3 - dentifrice according to claim 2, characterized in that the cellulose gelling agent is present and is   sodium salt of carboxymethylcellulose.   4 - Toothpaste according to claim 2, characterized in that xanthan is present.   Toothpaste according to claim 2, characterized   in that the weight ratio of the cellulosic gelling agent   that xanthan to i-carrageenan is about 1: 1.   6 - dentifrice according to claim 1, characterized in that sodium fluoride and sodium monofluorophosphate are present in proportions providing at least 750   at 2000 ppm of fluorine, and about 30 to 40% of the fluorine is by sodium fluoride.   7 - Toothpaste according to claim 1, characterized   in that the toothpaste is contained in an active distributor mechanically.   8 - Process for preparing a dispenser containing   a toothpaste comprising about 20 to 80% by weight of a   aqueous humectant, about 0.1 to 5% by weight of a   gelling agents, about 20 to 75% by weight of   phaalumin trihydrate as a polishing agent, sodium fluoride and sodium monofluorophosphate in proportions providing about 300 to 1000 ppm of fluorine, about 0.05 to 0.5% by weight of allantoin as a desensitizing agent and about 0.05 to 0.5% by weight of pyridylcarbinol as agent   vasodilator, said gelling mixture being a mixture of   cellulose gelling agent and i-carrageenan in a   weight of the cellulosic gelling agent at i-carrageen   from about 5: 1 to about 1: 5, characterized in that   extrude into a mechanically actuated dispenser a quantity   predetermined amount of said toothpaste by means of a nozzle for   fill a dispenser which is open at its base and which   holds a central stem and, sliding in place around   said central rod, a piston having a corresponding diameter   the inner diameter of the dispenser and a central opening   treated to receive said central rod and then closed   the dispenser sealingly by means of a bottom disc.