DK163276B - DENTAL DETAILS WITH GELING AGENT MIXTURE - Google Patents

Description

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The present invention relates to a dentifrice having desirable rheological properties suitable for effective filling of a mechanically operated or pressure differential toothpaste dispenser and for extrusion thereof.

A dentifrice is generally recognized by its creamy or gel consistency and can generally be referred to as a dental cream, a toothpaste or in some cases a 1.0 clear or opaque gel toothpaste. It can in fact be characterized as being semi-solid, being is substantially solid when placed on the bristles of a toothbrush, and substantially liquid, such as during manufacture, during stirring and filling on a container, or when subjected to pressure to extricate the dentifrice from its container.

The creamy consistency of dentifrices is typically imparted by a gelling agent or binder. In the past 20, gelling agents have been selected primarily for the purpose of achieving easy spreading of the dentifrice into the oral cavity.

Many gelling agents such as cellulose materials, polysaccharides from seaweed or algae, gums and clays meet this criterion. However, some gelling agents, although generally desirable for dentifrices packaged in flexible tubes, cause disadvantages when the dentifrices are packaged in mechanically operated or pressure differential dispensers.

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Dental care agents containing conventional polishing agents such as α-alumina trihydrate and conventional gelling agents such as sodium carboxymethyl cellulose or hydroxyethyl cellulose or mixtures thereof may be desirably loaded onto flexible tubes or mechanically operated or pressurized.

distinguish active dispensers and extrude from there. However, when the dentifrice contains many active ingredients, difficulties may occur when attempting to fill a dentifrice on a mechanically operated or pressure differential acting 2

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dispenser, and / or by attempting to extrude it therefrom.

In particular, leaks from openings in the dispensers may occur during filling or shipping, and the product may be difficult to extrude in rheologically acceptable strip form.

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Dental care products that are thickened or tend to thicken can become increasingly difficult for a consumer to squeeze out of a dental care tube over a period of time. In other words, the consumer may need to increase the pressure on a dentifrice tube containing such a dentifrice during use to soften or liquefy the semi-solid dentifrice mass to extrude it. This has not been a major problem so far, since compositions can be adjusted to use less gelling agent to strike a balance where the dentifrice is not too soft at the beginning of application and too thick at the end, and in each case consumers have readily adjusted. Be sure to apply the pressure needed to squeeze the desired amount of dentifrice onto a toothbrush's bristles.

Toothpaste, which is thin-fluid by squeezing from a tube, has also been accepted during use if it solidifies to a more solid form on toothpaste bristles within a few 25 seconds. Thus, the type of gelling agent could be widely varied for dentifrices packaged in tubes. Thus, Copenhagen Pectinfabrik A / S in Lille Skensved, Denmark, which is a subsidiary of Hercules Inc., Wilmington, Delaware, USA, has proposed its product "Genuvisco" type 0819, an iota-30 carrageenan (i-carrageenan), as a possible thickening agent for toothpaste. I-carrageenan, which is available from the Marine Colloids Division of the FMC Corporation in Springfield, New Jersey, as "Viscarin" TP-5, has also been suggested for any toothpastes associated with toothpaste containing dicalcium phosphate or silica. In addition, I-carrageenan has been referred to as a thickening component together with k-carrageenan and alkali metal alginate for a dentifrice containing galactan-3.

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Galactose in Japanese Patent Publication No. 56,115,117, published September 11, 1981, by Lion Dentifrice Ltd.

5 When using a dentifrice dispenser which is operated mechanically or by pressure difference, conventional techniques for reducing the thickening of the dentifrice may sometimes not be fully satisfactory when compared with a dentifrice filled on a flexible tube, since the dentifrice, when a dispenser is used, must be relatively thin. during filling, but regains its consistency and thus remains during shipping, storage and use periods. In other words, after filling, the dentifrice regains the consistency it had prior to the exerted shear force to make it fluid during filling. Conventional gelling agents such as sodium carboxymethyl cellulose, hydroxyethyl cellulose or mixtures thereof may be desirably used for dentifrices containing α-alumina trihydrate as a polishing agent to be loaded onto a dispenser. However, when such a dentifrice contains many sources of active ingredients such as at least two sources of fluorine, a desensitizing agent such as allantoin (C CH HgO₂) and a vasodilator such as pyridylcarbinol

N) -CH -OH

\ = / 2 30 Difficulties occur when the dentifrice is loaded on a mechanically operated or pressure differential dispenser. In particular, dentifrice may seep through the space between a rod and a piston, which is particularly used in a mechanically operated dispenser, and leakage occurs at dispenser openings. Furthermore, the toothpaste strip extruded from a mechanically operated or pressure differential dispenser may be irregular and non-continuous. Since it is particularly 4

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desirable to prepare a dentifrice containing α-alumina trihydrate polishing agent containing several active substances such as those mentioned above, due to problems with the compatibility of such materials with the polishing agent, an alternative gelling system was necessary.

English Publication No. 2,070,695 discloses a dispenser suitable for dispensing paste-like material, such as toothpaste, but the disclosure does not mention anything about the composition of dentifrices suitable for use in the dispenser.

Among alternative types of gelling agents, a mixture of a cellulose gelling agent and i-carrageenan unexpectedly provides an excellent gelling agent mixture when used in a dentifrice containing α-alumina trihydrate and several active ingredients when the dentifrice is intended for filling and pressing from a mechanically driven or differential pressure dispenser. It is noteworthy that xanthan has not previously been compatible with cellulose gelling agents since it may contain cellulase

It is an advantage of the present invention to provide a dentifrice which can be readily filled and extruded from a mechanically operated or pressure differential actuator dispenser.

Other advantages will be apparent from the following description.

The invention relates to a dentifrice suitable for dosing 25 with a mechanical or pressure-controlled dispenser, comprising approx. 20 - approx. 8% by weight of an aqueous wetting agent mixture, approx. 0.1 - approx. 0.5% by weight of the solvent mixture, approx. 20 - approx. 75% by weight of α-alumina trihydrate as a polishing agent, sodium fluoride and sodium monofluorophosphate in an amount to obtain approx. 300 to approx. 10,000 ppm fluorine, approx. 0.05 - approx. 0.5% by weight of allantoin as a desensitizer. 0.05 - approx. 0.5 wt% pyridylcarbinol as a vasodilator.

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The dentifrice according to the invention is characterized in that said gelling agent mixture is a mixture of either a cellulose gelling agent or xanthan with i-carrageenan in a weight ratio of cellulose gelling agent or xanthan to i-carrageenan from ca. 5: 1 to approx. 1: 5.

In the toothpaste composition, the dental carrier comprises a liquid phase added to the gelling agent to form an extrudable creamy mass of desirable consistency. The liquid phase of the dentifrice will comprise mainly water 10 and wetting agent such as polyols, including glycerol, sorbitol, maltitol, xylitol, low molecular weight polyethylene (e.g. 400 or 600), propylene glycol or the like, including suitable mixtures thereof. It is usually advantageous as the liquid phase to use water and a wetting agent, such as glycerol, sorbitol or polyethylene glycol, typically in amounts of about 5%. 10 - approx. 55 wall €% water and approx.

20 - approx. 50 wt% wetting agent.

The dentifrice contains α-alumina trihydrate polishing agent in amounts of approx. 20 - approx. 75% by weight. . α-alumina trihydrate 20 is typically produced by the Bayer process and used as particles having a size below about 40 microns, preferably about 3-ca. 20 microns. Other polishing agents may be incorporated, such as insoluble sodium metaphosphate, dicalcium phosphate, calcined alumina, silica or calcium carbonate in lesser mass relative to α-alumina trihydrate.

The gelling composition according to the invention is present in the dentifrice in an amount of approx. 0.1 - approx. 5% by weight. It contains either a cellulose gelling agent or xanthan mixed with i-carrageenan, wherein the weight ratio of the cellulose gelling agent or xanthan to said i-carrageenan is from ca. 5: 1 to approx. 1: 5, preferably from ca. 1: 1 to approx. The total amount of gelling agent mixture is preferably about 1: 3. 0.2 - approx. 3% by weight.

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As mentioned above, iota-carrageenan is commercially available as "Genuvisco" type 0819 and "Viscarin" TP-5 and has been recommended for use in a toothpaste. Such use in a toothpaste was described in Japanese Publication No. 56,115,117 by Lion Dentifrice Limited, wherein i-carrageenan is referred to as a possible component of a gelling system together with k-carrageenan and alkali metal alginate. In U.S. Patent No. 4,353,890, i-carrageenan is referred to as an alternative to k-carrageenan as a toothpaste gelling agent, wherein the toothpaste is subjected to microwave radiation to reduce the tendency of carrageenan to become thin during manufacture. The carrageenan may be the only gelling agent or may be mixed with other gelling agents. According to the present invention, the dentifrice containing i-carrageenan for loading on a mechanically operated or pressure differential dispenser does not need microwave radiation.

The above-mentioned prior art does not indicate that cellulose gelling and i-carrageenan gelation systems can provide dentifrices containing α-alumina trihydrate polishing agent and many active ingredients with the necessary properties for effective loading on a mechanically operated or pressure differential acting dispenser and for extortion therefrom.

It is worth noting that U.S. Patent No. 4,029,760 discloses an oral agent wherein i-carrageenin is listed as an anti-gum inflammatory agent in comparison to other carrageenans. Carragenins are highly depolymerized derivatives of carrageenans. Carrageenans are found not to provide an antitumor effect.

Dental care products are usually produced by a cold process, e.g. at about. 25 ° C, or in a hot process, e.g. at about. 60 ° C. I-carrageenan can be used in either cold process 7

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engineering or hot process engineering. Since xanthan is made with cold work up, when used, it can easily be mixed with i-carrageenan and thus incorporated together into the dentifrice during cold work up. Xanthan can only be used for hot work-up.

Physical properties of "Genuvisco" type 0819 i-carrageenan are listed below: 1. Viscosity of 0/30% solution of "Genuvisco" type 0819 in lean solvent prepared using a hot process (60 ° C):

Viscosity = 110 + 17 cp at 32 rpm. minute Viscosity = 70 yr 11 cp at 64 rpm minute

Viscosity = 45 + 1 cp at 128 rpm. minutes measured on HAAKE Rotovisco RV3 at 25 ° C.

2. Viscosity of 0.30% solution of "Genuvisco" type 0819 in lean solvent prepared using a cold process (25 ° C):

Viscosity = 85 + 60 cp measured on Brookfield Viscometer LVT at 25 ° C.

20 Viscosity = 85 µt-13 cp at 32 rpm. minute.

Viscosity = 55 + 8 cp at 64 rpm. minute.

Viscosity = 37 + 6 cp at 128 rpm. minute.

Measured on HAAKE Rotovisco RV3 at 25 ° C.

The lean solvent used by the manufacturer of "Genuvisco" 0819 for viscosity determinations contains 220 g of glycerol (100%), 4.20 g of tetrasodium pyrophosphate decahydrate, 7.60 g of sodium monofluorophosphate, 2.00 g of sodium phosphate. triaccharinate and 260.30 g of distilled water.

3. Particle size: Less than 1% rubber of 0.075 mm 30,.

test screen (DIN 80, 200 US)

mesh).

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4. Moisture content: Less than 12%.

5. pH: 8.5 + 1.5 in 0.51 solution in distilled water at 25 ° C.

6. Color: White to cream.

5 "Viscarine" TP-5 i-carrageenan has the following physical properties:

Color Light brown to brown

Particle size: more than 95.0% through a US

standard sieve, 250 nm (Series 10 # 60).

Humidity: maximum 12.0% (Cenco Moisture

Balance).

pH: 7.0 to 9.5, 1.5% solution, 30 ° C.

Typical desirable cellulose gelling agents include alkali metal carboxymethyl cellulose, hydroxymethyl cellulose and hydroxypropyl cellulose. Sodium carboxymethyl cellulose is preferred. The mixed gel system is present in an amount of approx. 0.1 - approx. 5% by weight of the dentifrice, and the weight ratio of 20 cellulose gelling agent to i-carrageenan is from approx. 5: 1 to approx. 1: 5, preferably approx. 1: 1 to approx. It3 and most preferably 1: 1. Thus, a typical preferred dentifrice may contain about. 0.9 - approx. 1.2% gelling agent in "all-inclusive" approx. 0.3 - approx. 0.9% of each of the components cellulose gelling agent 25 and i-carrageenan, the weight ratio of the two components being from about 1: 1 to approx. 1: 3.

It is worth noting that grades of sodium carboxymethyl cellulose that can be used include the following:

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o TABLE I.

SUPPLIER CMC QUALITY VISCOSITY

5 Hercules * 7MXF 300-500

Hercules 7MFD 300-500

Hercules 9M31F 900-1200

Hercules 9M31XF 900-1200

Hercules 12M31XF 900-1200 10 Hercules 7MF 300-500

Hercules 12M31PD 900-1200

Hercules 7M8SXF 200-800

Wolff Walsrode "Walocel" CRT

1000 PA 07 700-1200 15 Nyma "Nymcel" ZMF.3f- 50-80

Enka "Akucell" AC 164 ^ 80 -120

Enka "Akucell" AC 1632 * 60 -120

Cros "Cellogen" HP-SA 700-900

Uddeholm "Cekol" MVEP 500-800 20 -

Hoechst "Tylose" CB 200 ** 120-260 x 1% solution (Brookfield; 25 ° C) ** Hoeppler Viscometer (2%; 20 ° C).

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Additional grades of hydroxyethyl cellulose that may be used include the following:

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o TABLE II.

SUPPLIER HEC QUALITY VISCOSITY

5 Hercules "Natrosol" 250M and MR 4500-6500

Hercules "Natrosol" 250 HRX 1500-2500

and 250HX

Hercules "Natrosol" 250 HHR * 3400-5000

and 250 HH

10 BP Chemicals Cellobond 5000 A 4200-5600 BP Chemicals Cellobond 7000 A 6000-7000

Hoechst "Tylose" H 4000 P5® 3000-5000

Hoechst "Tylose" H 10000 P55 * 7000-12000 15 s 1% solution (Brookfield; 25 ° C).

534 Hoeppler Viscometer (2%; 25 ° C).

The i-carrageenan and cellulose gelling agent may be mixed mechanically prior to mixing with the liquid phase of the dental cream base or may be mixed separately with the liquid phase, either by hot work-up technique (typically about 60 ° C) or by cold work-up technique (typically about 25 ° C).

Xanthan gum is a fermentation product formed by the action of bacteria of the genus Xanthomonas on carbohydrates. Four species of Xanthomonas, namely X campetris, x phaseoli, X malvocearum and X carotae /, have been referred to in the literature as being the most effective rubber producers. Although the exact chemical formula has not been determined, it is generally accepted as a heteropolysaccharide having a molecular weight of several million. It contains D-glucose, D-mannose and D-glucuronic acid in the molar ratio 2.8: 3: 2.0. The molecule contains 4.7% acetyl and approx. 3% pyruvate molecule parts. The proposed chemical formula configuration can be found in McNeelly and Kang, Industrial Gums, published by R.L. Whistler, CH XXI, 2nd edition, New York, 1973. The procedure for cultivating, isolating and purifying xanthan gum is also found in this publication. Further description of xanthan gum can be found in the Manufacturing Chemist,

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May 1960, pages 206-208 (including the discussion on page 208 of 0 possible use of gums described therein for the composition of pastes.

The i-carrageenan and xanthan may be mechanically mixed prior to mixing with the liquid phase 5 of the dental cream base or may be separately mixed with the liquid phase using cold process technique (typically about 25 ° C).

The dentifrice is packaged in a container from which it can be easily extruded or extruded, such as a pressure differential or mechanically operated dispenser for dental cream.

The rheological properties are extremely desirable when using a mechanically operated dispensing vessel of the type described in British Patent Specification No. 2,070,695A published September 9, 1981.

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This dispensing container comprises a dispensing nozzle, a clamping means, a central rod, a piston and a manual actuator.

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Pressure differential acting dispensing vessels may be of the aerosol or vacuum type. Suitable pressure differential dispensers include such comprising a collapsible product-containing bag located in a rigid container containing a propellant fluid. In such dispensing containers, operation of the valve only permits release of the product, the drive fluid being separated from the product by the fluid impermeable bag. Dispensers of this type are described in U.S. Patent Nos. 3,828,977 and 3,838,976. These dispensers are the so-called "Sepro" dispensers. The so-called "Exxel" containers also apply pressure.

Another type of dispenser is the barrier plunger described in U.S. Patent No. 4,171,757. Such a container has a valve, a product-containing compartment, and a substantially fluid-tight barrier piston separating the drive fluid from the contained product (the so-called

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0 mouth "container).

The toothpaste agent contains as active agents a mixture of sodium fluoride and sodium monofluorophosphate to give approx. 300 - approx. 10000 ppm fluorine, e.g. ca. 750 - approx. 2000 ppm, and especially c 3 1400-2000 ppm, such as approx. 1400 - approx. A binary fluoride system of sodium monofluorophosphate and sodium fluoride is advantageously used, wherein approx. 30 - approx. About 40% of the fluorine amount (e.g., about 30 - about 35%) is provided by sodium fluoride.

Sodium monofluorophosphate, Na2PC> 3F, as commercially available, can vary widely in purity. It can be used in any suitable purity, provided that any impurities do not significantly affect the desired properties. In general, it is desirable that the purity is at least 80%. For best results, it should be at least 85% and preferably at least 90% by weight sodium monofluorophosphate, the remainder being primarily impurities or by-products of the preparation such as sodium fluoride and water-soluble sodium phosphate salt. In other words, the sodium monofluorophosphate grade used should have a total fluoride content above 12%, preferably above 12.7%, distributed at a content of not more than 1 1/2%, preferably no more than 1.2% derived from free sodium fluoride, and a fluoride content of at least 12%, preferably at least 12.1%, derived from sodium monofluorophosphate.

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As stated above, sodium fluoride in the binary mixture is a separate fluorine-containing component relative to sodium monofluorophosphate. Ca. 225 - approx. 800 ppm fluorine is preferably provided in the dental cream by means of sodium fluoride.

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Additional active agent is provided in the dentifrice in the presence of ca. 0.05 - approx. 0.5% by weight, preferably approx.

0.08 - approx. 0.2% allantoin desensitizer. Such an agent combats the sensitivity of the leather periodontal tissue and promotes its healing. Allantoin is available from ABM Industrial Products Ltd., Woodley, Stockport, Cheshire, England.

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Pyridylcarbinol used as an active agent in an amount of about 0.05 to ca. 0.5% by weight, preferably approx. 0.08 - approx. 0.2%, the dentifrice has a vasodilating effect.

When using a dentifrice of the invention containing α-aluminum trihydrate polishing agent, binary fluoride system, allantoin desensitizing agent, pyridylcarbinol vasodilator agent and gel system as described above, filling and squeezing takes place using mechanically operated or pressure differential dispensing effectively and rheologically desirable.

Filling is done by conventional technique. For example, when a mechanically operated dispenser of the type described in British Patent Specification No. 2,070,695A is used, a predetermined amount of the dentifrice is pressed through a nozzle to fill the dispenser which is open at its bottom and containing a central rod. A piston having a diameter corresponding to the inner diameter of the dispenser and having a central hole to allow insertion of the central 20 rod therein is slid into place. The dispenser is then closed with a base plate.

Any suitable surfactant or cleanser can be incorporated into the dentifrices. Such compatible materials are desirable for obtaining additional cleansing, foaming and antibacterial properties, depending on the specific type of surfactant, and are selected accordingly. These detergents are usually water-soluble compounds and can be anionic, nonionic or cationic in structure. It is usually preferred to use the water-soluble, non-soap detergents or synthetic organic detergents. Suitable cleaning materials are known and include e.g. the water-soluble salts of higher fatty acid monoglyceride monosulfate detergent (e.g., sodium coconut fatty acid monoglyceride monosulfate), higher alkyl sulfate (e.g., sodium lauryl sulfate), alkylarylsulfonate (e.g., sodium dodecylbenzenesulfonate) and 14

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0 higher fatty acid esters of 1,2-dihydroxypropane sulfonate) and the like.

Additional surfactants include those substantially saturated higher aliphatic acyl amides of lower aliphatic aminocarboxylic acid compounds such as those having 12 to 16 carbon atoms in the acyl group. The amino acid moiety is generally derived from the lower aliphatic saturated monoaminocarboxylic acids of 2 to 6 carbon atoms, usually the mono-: carboxylic acid compounds. Suitable compounds are the fatty acid amides of glycerol, sarcosine, alanine, 3-aminopropionic acid and val with 12 to 16 carbon atoms in the acyl group. However, it is preferred to use the N-lauroyl, myristoyl and palmitoyl sarcoside compounds to obtain optimal effects.

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The amide compounds can be used in the form of the free acid or preferably as the water-soluble salts thereof, such as the alkali metal, ammonium, amine and alkylolamine salts. Specific examples thereof are sodium and potassium N-lauroyl, myristoyl and palmitoyl sarcosides, ammonium and ethanolamine N-lauroyl glycide and alanine. For ease, reference to "aminocarboxylic acid compound", "sarcoside" and the like refers to such compounds having a free carboxylic acid group of the water-soluble carboxylate salts.

Such materials are used in pure or mostly pure form. They should be as free as practicable for soap or similar higher fatty acid material which tends to decrease the activity of these compounds. In practice, the amount of such higher fatty acid materials is usually less than 15% by weight of the amide and insufficient to substantially adversely affect it, and preferably less than 10% of said amide material.

Various other materials can be incorporated into the dentifrice of the invention. Examples of these are coloring or whiteness agents, preservatives such as 15

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0 thyl p-hydroxybenzoate, stabilizers, tetrasodium pyrophosphate, silicones, chlorophyll compounds and ammonia-derived materials such as urea, diammonium phosphate and mixtures thereof. These adjuvants are incorporated in the present compositions in an amount which does not substantially adversely affect the desired properties and characteristics, and they are suitably selected and used in conventional amounts.

For some purposes, it may be desirable to incorporate anti-bacterial agents into the agents of the invention. Typical antibacterial agents which can be used in amounts from about

0.01% by weight to approx. 5% by weight, preferably from ca. 0.05 to approx.

1.0% by weight of the dentifrice includes: N 1 -4 (chlorobenzyl) - N 2 - (2,4-dichlorobenzyl) biguanide; P-chlorophenyl biguanide; 4-chlorbenzhydrylguanid; 4-chlorobenzhydryl guanylurea; N-3-lauroxypropyl-N @ ^ -p-chlorobenzylbiguanide; 1,6-di-p-chlorobenzylbiguanide; 1- (lauryldimethylammonium) -8- (p-chlorobenzyl imethylammonium) octane dichloride; 5.6- dichloro-2-guanidinobenzimidazole? N ^ -p-chlorophenyl-N ^ -laurylbiguanid; 5- amino-1,3-bis- (2-ethylhexyl) -5-methylhexahydropyrimidine; and non-toxic acid addition salts thereof.

Any suitable flavoring or sweetening materials may be used to formulate an aroma for the agents of the present invention. Examples of suitable aroma ingredients include the aromatizing oils, e.g. green mint oil, peppermint oil, winter vegetable oil, sassafras oil, clove oil, sage oil, eucalyptus oil, merry oil, cinnamon oil, lemon oil and orange oil as well as methyl salicylate. Suitable sweeteners include sucrose, lactose, maltose, sorbitol, sodium cyclamate, sodium saccharin dipeptides according to U.S. Patent No. 3,939,261 and oxathiazine salt 16

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tea according to US Patent No. 3,932,606. Suitable aromatizing and sweetening agents may together comprise from ca. 0.01 to approx. 5% or more of the agent.

5 The dentifrices should have a pH value that is convenient for use. A pH range from 3 to 10.5 is particularly desirable. By the reference to the pH value is meant the pH determination directly on the dentifrice. If desired, such materials as benzoic acid or citric acid may be added to adjust the pH to e.g. 4 to 8.5.

The following examples further illustrate the nature of the present invention. All amounts of the various constituents are by weight unless otherwise stated.

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Example 1.

The following dentifrice is prepared by conventional room temperature cold process and loaded onto the mechanically operated dispenser described in British Patent Specification No. 2,070,695A.

Parts 25 -

Sorbitol (70%) 23,000

Sodium saccharin 0.170 I-carrageenan ("Genuvisco" 0819) 0.500

Sodium carboxymethyl cellulose (7MFD) 0.500

Methyl p-hydroxybenzoate 0.080

Allantoin 0.150

Sodium fluoride 0.100

Sodium monofluorophosphate 0.760

Pyridylcarbinol 0.100 α-alumina trihydrate ("Alcoa" 0333) 51,000

Benzoic Acid 0.140

Sodium lauryl sulfate 1.667

Titanium dioxide 0.500

Flavor 1,200

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The dentifrice effectively fills the dispenser and does not undergo leakage during storage at 43 ° C for more than 1 month. It is extruded well from the dispenser after 1 month of storage at 43 ° C.

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Similar satisfactory results are obtained when the dentifrice is modified to contain 0.55 parts of each of the components i-carrageenan and sodium carboxymethyl cellulose in one case and 0.45 parts of each of the components i-carrageenan and sodium carboxymethyl cellulose in another case under the corresponding setting the water content. In fact, absence of leakage as well as good extrudability or extrudability is observed after storage at 43 ° C for 3 months for these dental care products.

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Satisfactory results are also observed when each of the three dentifrices described above is modified to contain 50,000 parts of α-alumina trihydrate in one set of these dentifrices and 52,000 parts of α-alumina trihydrate in another set of the three dentifrices under the corresponding setting of the water content.

Example 2.

The following dentifrice is prepared by the cold process and filled with the same dispenser as in Example 1.

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Parts

Sorbitol (70%) 23,000

Sodium Saccharin 0.170 I-Carrageenan ("Genuvisco" 0819) 0.666 Sodium Carboxymethyl Cellulose (7MFD) 0.334

Methyl p-hydroxybenzoate 0.080

Allantoin 0.150

Sodium fluoride 0.100

Sodium monofluorophosphate 0.760 Pyridylcarbinol 0.100 α-alumina trihydrate ("Alcoa" 0333) 51,500

Benzoic Acid 0.140

Sodium lauryl sulfate 1.667

Titanium dioxide 0.500 Aroma 1,200

Deionized water 19,633

The dentifrice effectively fills the dispenser and does not undergo leakage and extrude well from the dispenser after storage for 1 month at 43 ° C.

Similar desirable effects are achieved when the dentifrices of the examples are filled with a pressure differential dispenser.

When sodium carboxymethyl cellulose is used as the only gelling agent, poor extrusion occurs. When hydroxyethyl cellulose is used as the only gelling agent, leakage occurs. However, when hydroxyethyl cellulose is mixed with i-carrageenan, desirable filling and extrusion are obtained. Example 3

The following dentifrice is prepared by conventional room-temperature-cold process and loaded onto the mechanically operated dispenser disclosed in British Patent Specification No. 2,070,695A.

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19 0 Parts

Sorbitol (70%) 23,000

Sodium saccharin 0.170 I-carrageenan ("Genuvisco" 0819) 0.500

Xanthan ("Keltrol") 0.500 5

Methyl p-hydroxybenzoate 0.080

Allantoin 0.150

Sodium fluoride 0.100

Sodium monofluorophosphate 0.760

Pyridylcarbinol 0.100 α-alumina trihydrate ("Alcoa" C-333) 51,000

Benzoic Acid 0.140

Sodium lauryl sulfate 1.667

Titanium dioxide 0.500

Aroma 1,200 15

Deionized water 20,133

The dentifrice effectively fills the dispenser and does not undergo leakage during storage at 43 ° C for more than 1 month. It extrudes well from the dispenser after 1 month of storage at 20 n 43 ° C.

Similar satisfactory results are obtained when the dentifrice is modified to contain 0.55 parts of each of the components i-carrageenan and xanthan in one case and 0.45 parts of each of the components i-carrageenan and xanthan in another case, corresponding setting of water content. In fact, absence of leakage as well as good extrudability after storage at 43 ° C is observed for 3 months by the dentifrice containing 0.45 parts of each of the components xanthan and i-carrageenan.

Satisfactory results are also observed when each of the three dentifrices described above is modified to contain 50,000 parts of α-alumina trihydrate in one set of

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these dentifrices and 52,000 parts of α-alumina trihydrate in a second set of the three dentifrices, adjusting the water content accordingly.

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Phosphoric acid can be used instead of benzoic acid with similar results.

Example 4

5 The following dentifrice is made by the cold process and filled with the same dispenser as in Example 3.

Parts 10

Sorbitol (70%) 23,000

Sodium Saccharin 0.170 I-Carrageenan ("Genuvisco" 0819) 0.750

Xanthan ("Keltrol") 0.250 15

Methyl p-hydroxyenzoate 0.080

Allantoin 0.150

Sodium fluoride 0.100

Sodium monofluorophosphate 0.760

Pyridylcarbinol 0.100 α-aluminum trihydrate ("Alcoa" C-333) 51,000

Benzoic Acid 0.140

Sodium lauryl sulfate 1.667

Titanium dioxide 0.500

Aroma 1,200 25

Deionized water 20,133

The dentifrice effectively fills the dispenser and does not undergo leakage and extrudes well from the dispenser after storage for 3 months at 43 ° C.

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Similar desirable results are obtained with 50,000 parts of α-alumina trihydrate. Each variant also provides similar results with a gel system containing (a) 0.825 parts of i-carrageenan and 0.275 parts of xanthan and (b) 0.675 parts of i-carrageenan and 0.225 parts of xanthan.

Similar desirable effects are achieved when the dentifrices of the examples are filled with a pressure differential acting

Claims (7)

A dentifrice suitable for dosing with a mechanical or pressure-controlled dispenser, comprising approx. 20 - approx. 80% by weight of an aqueous wetting agent matrix, approx. 0.1 - approx. 5% by weight of gelling agent mixture, approx. 20 - approx. 75% by weight of ot alumina trihydrate as a polishing agent, sodium fluoride and sodium monofluorophosphate in an amount to give approx. 300 to approx. 10,000 ppm fluorine, approx. 0.05 - approx. 0.5% by weight of allantoin as a desensitizer and approx. 0.05 - approx. 0.5% by weight of pyridylcarbinol as a vasodilator, characterized in that said gelling agent mixture is a mixture of either a cellulose gelling agent or xanthan with i-carrageenan in a weight ratio of cellulose gelling agent or xanthan and i-carrageenan from ca. 5: 1 to approx. 1: 5. Dental care agent according to claim 1, characterized in that the weight ratio of the cellulose gelling agent or xanthanethane to the i-carrageenan is from approx. 3: 1 to approx. 1: 3 and that the gelling agent mixture is present in an amount of approx. 0.2 -ca. 3% by weight. Dentifrice according to claim 2, characterized in that the cellulose gelling agent is contained therein and is sodium carboxymethyl cellulose. Dentifrice according to claim 2, characterized in that xanthan is contained therein. 35 Dental care agent according to claim 2, characterized in that the weight ratio of the cellulose gelling agent or xanthanane to the i-carrageenan is approx. 1: 1. 22 DK 163276B Dentifrice according to claim 1, characterized in that sodium fluoride and sodium monofluorophosphate are contained therein in an amount to obtain approx. 750 - approx. 2000 ppm fluorine, and that approx. 30 - approx. 40% of the fluorine amount is provided by sodium fluoride. Dentifrice according to claim 1, characterized in that it is contained in a mechanically operated dispenser. 10 15 20 25 30 35