FR2586560A1 - CONDITIONED DENTAL CREAM BASED ON POLYETHYLENE GLYCOL - Google Patents

Abstract

THE INVENTION CONCERNS A DENTAL CREAM PACKAGED IN DIRECT CONTACT WITH THE POLYOLEFINIC RESIN SURFACE OF A PACKAGING. THE DENTAL CREAM CONTAINS A POLISHING MATERIAL CONSTITUTED AT LEAST MAJORLY PART OF A WATER-INSOLUBLE SALT OF ALKALINO-EARTH METAL OR ALPHA-ALUMINA TRI-HYDRATED, A LIQUID VEHICLE AND A GELING AGENT AND, IF ALPHA -ALUMINA IS PRESENT IN NOTABLE QUANTITIES, AN AGENT CONTAINING PHOSPHATE IONS TO LOWER THE PH. THE LIQUID VEHICLE CONTAINS WATER, GLYCERIN AND SORBITOL AND, AS AN ADDITIVE TO PREVENT SYNERESIS BY CONTACT OF THE DENTAL CREAM WITH THE POLYOLEFINIC RESIN, POLYETHYLENE-GLYCOL WITH AN AVERAGE MOLECULAR WEIGHT TO ABOUT 1000. APPLICATION: ORAL HYGIENE PRODUCTS.

Description

The present invention relates to a cream

  packaged in a laminated tube made of

  plastic reel, mechanical dispenser, flexible bag, etc. It concerns in particular a cream

  in contact with the surface of the

  lyolefin of a package such as a laminated plastic toothbrush tube, a dispenser

mechanical or a flexible bag.

  Dental creams have been packaged

  for many years in metal tubes

  such as paraffin lined lead pipes, uncoated aluminum tubes or aluminum tubes with epoxy resin coating. In recent years there has been a growing use of laminated

  plastic, flexible, retaining their shape.

  Laminated dental cream tubes

  plastics generally comprise a

  inner layer of polyolefin resin which is in

  direct contact with the dental cream and at least one

  intermediate layer, comprising a thin layer of aluminum

  nium which prevents the loss of aroma of the dental cream.

  Advantageously, a layer is also provided.

  the medium of paper which gives rigidity to the

  be. The outer layers are generally resident

  polyolefinic substances, and one of them may be colored

  in white and bear printed marks,

  layer of transparent polyolefin being

  on top to protect the marks. other

  intermediate laminated layers of plastic

  that flexible may also be present.

  Mechanical dispensers for dental creams may also have a polyolefin surface in contact with the dental cream they contain. In fact, the polyolefin itself may be the casing of the dispenser. The flexible bags may also have a surface of

  polyolefin in contact with dental creams.

  Dental creams generally contain

  a liquid carrier consisting of water and a humectant, a solid vehicle of the gelling agent type and a water-soluble dental polishing agent. Dental creams consisting of such materials in which the humectant comprises glycerine and sorbitol and the polishing material is at least

  most importantly an alkaline-earth metal salt

  luble in water or an alphaalumine trihydrate have

  have been packaged successfully in medium containers

  soft metals for toothpastes comprising

  aluminum tubes with an inner coating

  made of a layer of epoxy resin varnish. However, it is noted that when such dental creams are packaged in containers whose inner surface is of polyolefin, for example dental cream tubes laminated with

  plastic material, dental cream dispensers

  mechanically operated or flexible bags, syneresis appears and the liquids separate

  solids, which makes the dental cream unacceptable

  table, when the pH of the dental cream is reduced by a water soluble material providing ions

phosphate.

  An advantage of the present invention lies in the fact that a phase separation of a cream

  conditioned in contact with a poly-

  olefinic acid is substantially avoided. Other advantages

  will be obvious when reading the description

  next. According to some of its aspects, the present invention relates to a dental cream packaged in

  direct contact with a polyol resin surface

  fine, said dental cream comprising at least

  20% by weight of a liquid vehicle comprising

  water, glycerine, sorbitol, and polyethylene.

  ne-glycol having an average molecular weight of about

  -1000, the weight ratio of glycerine to

  bitol being 0.25: 1 & about 3: 1, and the ratio

  by weight of the total amount of glycerin and

  polyethylene glycol tolerance being from about 60: 1 to about 6: 1, a solid carrier comprising about 0.05 to 10% by weight of a gelling agent, about 75% by weight of an insoluble polishing material in water acceptable to the teeth of which at least one dominant portion is a metal salt

  alkaline-earth-insoluble in water or an alpha-

  alumina trihydrate, and, in the case of the presence of alpha-alumina as the dominant part of the polishing material, a water-soluble material providing phosphate ions, so as to lower the pH of the

dental cream at about 6-8.

  In dental cream compositions,

  liquids and solids are necessarily

  Portioned to form a creamy mass of

  desired strength that can be extruded from its packaging.

  lage. The liquids present in this cream

  mainly include water, glycerol

  and sorbitol, as well as a minor amount of

  polyethylene glycol of about molecular weight.

  200-1000, preferably about 600-1000. The vehicle

  total liquid is at least about 20%

  the weight of the composition. It is better to use

  also read a gelling agent in the creams

  such as natural and synthetic gums

  materials and substances similar to gums, car-

  raggenins such as Irish moss, or io-

  tetrachengin, gum tragacanth, carboxymethyl-

  sodium cellulose, hydroxy-ethyl cellulose, poly-

  vinylpyrrolidone, sodium alginate, guar gum, starch, xanthane, etc., as well as their

  mixtures. Irish moss, carboxymethyl-cel-

  sodium lulose and hydroxyethyl cellulose, as well as their mixtures, are particularly compatible

  and are the preferred gelling agents. Lors-

  that the main polluting agent is a salt of

  water-insoluble alkaline earth, the agent

  gelling agent that is also preferred is the iota-car-

  raghénine. The gum content is generally

  0.05 to 10%, and preferably about 0.5 to 1% by weight of the composition. Water is usually incorporated into the dental cream in a proportion of about 10 to 50%

  by weight, preferably from about 15 to 35%. The gly-

  cerine and sorbitol generally constitute together

  about 15 to 50%, preferably about 20% to 35%, of the weight of the dental cream, the weight ratio of glycerin to sorbitol being from about 0.25: 1 to about 3: 1, generally about 0.25: 1 to about

  0.8: 1, and more preferably from about 0.6: 1 to about 0.8: 1.

  The amounts of sorbitol as used herein consist of sorbitol syrup as commercially available, i.e., 70% by weight.

  weight of sorbitol in 30% by weight of water.

  - - Low molecular weight polyethylene glycol

  with an average molecular weight of about 200-

  1000, preferably about 600-1000, disperses

  easily in the liquid vehicle and effectively prevents

  dental cream to undergo syneresis during

  it is in direct contact with the surface

  of polyolefinic resin from a package of

  silent. In order to easily perform a dispersion,

  Polyethylene glycol grades that are normally

  stably at room temperature are heated

  to be liquefied. The ratio by weight of the

  total amount of glycerin and polyethylene sorbitol

  glycol is from about 60: 1 to about 6: 1, preferably

  from about 15: 1 to about 12: 1 in a cream of

  containing an alkaline earth metal salt

  polishing agent, or about 10: 1 in a

  dental cream containing alpha-alumina trihydrate

  ted. In general, there is at least 0.5% by weight of

  polyethylene glycol, preferably about 0.5-5%.

  The dental cream contains a policeman

  S05 water-insoluble, tooth-acceptable smoothing in a proportion of about 20 to 75% by weight, preferably about 35 to 60%. Most, at least, about 50-100% of the material

  of polishing, consists of alkali metal salt

  soil insoluble in water or tri-alpha-alumina

moisturized.

  Representative examples of metal salts

  water-insoluble alkaline earth levels

  dicalcium phosphate dihydrate, phosphate

  anhydrous dicalcium, calcium carbonate, phos-

  tricalcium phate, calcium pyrophosphate, dimagnesium phosphate trihydrate and magnesium carbonate, and mixtures thereof. It is

  more preferably, a calcium salt, in particular

  bind dicalcium phosphate dihydrate or a mixture of

  age of dicalcium phosphate dihydrate and phosphate

anhydrous dicalcium.

  Alpha-alumina insoluble in water

  ceptable for teeth is usually used in small particle size, for example such

  at least 85% of the particles are inferior

  to 20 micrometers, and is preferably hydra-

  such as the so-called gibbsite (alpha-alumina

  trihydrate) which is normally represented

  by A12033H20 or Ai (OH) 3. The particular dimension

  The average area of gibbsite is usually about

  from 6 to 9 micrometers. However, it is also possible to use an alphaaluminum trihydrate of greater particle size, in which, for example,

  20 to 70% of the particles exceed 20 microns.

  A particularly advantageous quality of alpha-aluminum

  trihydrate mine, available from Alcoa under the

  C-333 is a fine grade of gibbsite with the following particle size distribution Micrometers Percentage

<30 - - - - - - - - - - - 94-99

<20 - - - - - - - 85-93

<10 - - - - - - - - - - - - 56-67

<5 - - - - - - 28-40

  Unless you adjust the pH of the tooth crest

  re, dental cream containing an important quantity

  alpha-alumina trihydrate is usually very

  alkaline, for example at about pH 9-10.5. As a result

  acidic materials are often added to

  such dental creams in order to lower the pH, genera-

  approximately 6-8. Water-soluble phosphates, especially inorganic phosphates, are effective in effecting such a decrease in alkalinity. Of

  Such materials include orthophosphates,

  include orthophosphoric acid and monoacid orthophosphates or orthophosphates diacids of alkali metals or ammonium. Sodium diacid orthophosphate and its hydrates are preferred. The quantity of these

  materials is that which is sufficient to adjust the pH to approximately

  6-8: for example, the diacid orthophosphate of

  sodium (monohydrate or anhydrous) is usually

  are in a proportion of about 0.15-0.50% by weight. Such phosphatic pH adjusting materials render

  dental creams subject to syneresis

  come into contact with a poly-resin surface

  olefinic unless there is an additive

tif to avoid syneresis.

  When the water-insoluble alkaline earth metal salt is the main component of

  the polishing material, alpha-alumina trihydrate

  calcined alumina or other polishing agent

  The additional amount may be present in minor amounts, for example in a weight ratio of alkaline earth metal salt to alumina of from about 2.5: 1 to about 4: 1, the total amount of polishing material in the dental cream being about 25 to

% in weight.

  When it is alpha-alumina trihydrate

  which is the dominant component of polishing matter

  wise, the minor component of the polishing material,

  possibly present, generally constitutes

  5% to 20% of the weight of the polishing material, and it may be a polishing agent such as

  dicalcium phosphate dihydrate, dicalcium phosphate

  than anhydrous, calcium carbonate, phosphate

  tricalcium, calcium pyrophosphate, phospha-

  Dimagnesic trihydrate, magnesium carbonate,

  calcined alumina, zirconium silicate and

insoluble sodium taphosphate.

  Organic surfactants can be used in the dental cream of the present invention.

  invention to obtain an effective prophylactic action

  As a result, the intimate and complete dispersion of the present compositions throughout the oral cavity and make the dental creams more cosmetically acceptable. Organic surfactant

  may be anionic, nonionic, ampholytic

  cationic, but it is preferable to use, as a surfactant, a detersive material which gives the composition detersive and foaming properties. Suitable types of such detergents

  are water-soluble salts of mono-sulphate monosulphates

  glycerides of higher fatty acids such as the sodium salt of monosulfated hydrogenated coconut oil fatty acid monoglyceride, (higher alkyl) sulfates such as sodium lauryl sulfate,

  alkylaryl sulfonates such as dodecylbenzene sulphate

  sodium fonate, olefin sulphonates such as sodium olefin sulphonate in which the olefin group contains 12 to 22 carbon atoms, higher alkyl sulphoacetates, higher fatty acid esters of 1,2-dihydroxypropane -sulfonate, and

  the higher aliphatic acyl amines

  saturated aliphatic amino-carboxylic acids such as those having 12 to 16

  carbon atoms in the fatty acid radicals, alkyl

  the acyl, etc. Examples of the last mentioned amides are N-laureyl sarcosine and

  sodium, potassium and ethanolamine salts of N-

  lauroyl-, N-myristol- or N-palmitoyl-sarcosine, which should be substantially free of soap or other similar higher fatty acid material which tends to substantially reduce the effect of these compounds in the composition of the present invention. The amides are

  particularly advantageous because they exercise

  prolonged and marked inhibition of the

  of acids in the oral cavity by the decomposition

  of carbohydrates in addition to exerting some decrease in the solubility of dental enamel in acidic solutions. Another advantageous material is a sodium monoglyceride sulphonate

  long chain fatty acid used alone or in combination with

  cation with sodium lauryl sulphate.

  Other particulate surfactants

  particularly appropriate include non-ionic agents

  such as monosaccharide condensates

  sorbitan arate with about 20 moles of

  thylene, the condensation product of ethylene oxide with propylene glycol ("Pluronic" materials) and

  amphoteric agents such as (alkyl) amino

  alkylene (long chain alkyl amines), which are

  available under the trademark "Miranol", for example Miranol C2M. We can also use

  antibacterial compounds and surfactant germicides

  cationic agents such as diisobutyl chloride

  phenoxy-ethoxyethyl-dimethyl-benzyl-ammonium, chlo-

  benzyl-dimethylstearyl ammonium chloride, chloride

  benzyl-diethyl-stearyl-ammonium compounds, tertiary amines

  res containing a fatty alkyl group (of 12 to 18 carbon atoms) and two groups (poly>) - oxyethylene connected to nitrogen (for example containing a total of about 2

  has 50 ethanoxy groups per molecule) and their formal salts

  with acids, and compounds of structure: -CH 2 CH 2 O) (CH 2 CH 2 O) xH R-N-CH 2 CH 2 CH 2 (CH 2 CH 2 O) y H wherein R is a fatty alkyl group containing

  about 12 to 18 carbon atoms, and x, y and z total

  read 3 or more, as well as their salts formed with

  organic or mineral acids. It is better to

  use about 0.05 to 5% by weight of

  sio-active above in the dental cream. OS pre-

  at best that the surfactant is a material

  anionic acid, especially lauryl sulphate

dium.

  The dental cream can also contain

  advantageously a fluorinated compound having a beneficial effect

  hygiene and care of the oral cavity, for example by decreasing the solubility of enamel

  acidic environment and protecting the teeth against

  ries. Examples are sodium fluoride,

  stannous fluoride, potassium fluoride, fluorine

  stannous potassium (SnF2.KF), hexafluorostan

  sodium nate, stannous chlorofluoride, fluorine

  sodium zirconate and the sodium monofluorophosphate

  dium. These materials which dissociate or release fluorinated ions in water may advantageously be present in an effective but non-toxic amount, generally in the range of about 0.01 to 1% by weight.

  the weight of the water-soluble fluorine they contain.

  The preferred fluorinated compound is sodium monofluorophosphate, which is generally present in a proportion of about 0.076 to 7.6% by weight.

  weight, preferably 0.76%. A mixture of monofluoro-

  sodium phosphate and sodium fluoride is also

  advantageously, for example in a report in

  weight of about 2: 1 based on fluoride.

  Any flavoring or sweetening material suitable for conferring

  an aroma to the composition of the present invention.

  Examples of suitable flavoring components

  include flavoring essences for example.

  the essences of spearmint, peppermint,

  wintergreen, sassafras, clove, sage, eu-

  calyptus, marjoram, cinnamon, lemon and orange, as well as methyl salicylate. of the

  Suitable sweetening agents include saccharine

  pink, lactose, maltose, xylitol, 6-methyl

  Sodium 3,4-dihydro-1,2,3-oxathiazine-4-one,

  sodium mate, perillartine and sodium saccharinate. Advantageously, the flavoring and sweetening agents together constitute approximately 0.01 to 5%

  or more of the compositions of the present invention.

  Various other materials may be

* corporeal in the dental cream. Examples thereof are coloring or bleaching agents, anti-corrosive agents, silicones, compounds of the

  chlorophyll, ammoniated materials such as

  diammonic phosphate and mixtures thereof, and other constituents. Bleaching agents such as titanium dioxide, usually in proportions

  from about 0.5 to 2%, may be advantageous for

  pect of the dental composition, because it can be

  produce some alteration of color in the old

smoothening.

  Adjuvants are incorporated into the coM-

  positions of the present invention in proportions which do not adversely affect the properties

  and desired characteristics, and they are chosen

  sis and used in correct quantities

type of composition in question.

  Antibacterial agents can also

  be used in the oral compositions of the pre-

  invention in a proportion of about 0.01 to 5

  % in weight. Representative examples of anti-

  bacteria include the following:

  Nl- (4-chlorobenzyl) -N5- (2,4-dichlorobenzyl) -bi-

  guanide; p-chlorophenyl-biguanlde; 4-chlorobenzyhydryl biguanide; 4chlorobenzyhydrylguanylurée; N-3-lauroxypropyl-N5-chlorobenzylbiguanide; 1,6-di-chlorophénylbiguanidohexane; 1,6-bis- (2-éthylhexylbiguanide) hexane;

  1- (lauryl dimethylammonium) dichloride

  chlorobenzyldiméthyl ammonium) -octane; , 6-dichloro-2guanidinobenzimidazole; Nl-p-chlorophenyl-N5-laurylbiguanide; 1,3-Amino-bis (2-ethylhexyl) -5-methylhexahydropyrimidine and their addition salts

non-toxic acids.

  In the dental cream containing an alkaline earth metal salt as a polishing agent, various suppressing agents may also be used.

  calcium and magnesium ions to regulate the

  physical forms of the compositions. Suitable agents are water-soluble mineral polyphosphates such as tetrasodium pyrophosphate or pyrophosphate

  disodium diacid, polyphosphate acid or partially

  neutralized being preferred. Others have appro-

  are the alkali metal salts, preferably

  sodium, citric acid. In general, these compounds

  are a minor amount or proportion of the composition. The exact amount varies depending

  particular composition, for example the characteristics

  physical characteristics of the dental cream, but in general it is in the range of approximately

0.1% to about 3% by weight.

  The dental cream must have a practical PR for its use. A pH range of 5 to 10 is particularly advantageous for dental cream containing a water-insoluble alkaline earth metal salt. The reference to pH refers to the pH determined directly on the dental cream. If desired, materials such as citric acid may be added to adjust the pH, for example to 6-7. For

  a dental cream containing alpha-alumina trihy-

  drate, a pH of about 6-8, obtained by adjusting with

  a water-soluble material providing phosphate ions

  it is particularly advantageous.

  The package in which the dental cream is incorporated may be any polyolefin laminate dental cream tube. For example, the tube may be as basic as that described in US Pat. No. 3,260,410. As described in the example of this patent, a base aluminum sheet having a thickness of about 0.0013 cm is heated to a temperature of about 177 C and one side of the sheet

  heated is brought into contact with an extruded film

  of a random copolymer of ethylene and acrylic acid (acid content of 3 0.5% and melt index 8 1), while its opposite surface is placed against a low polyethylene film

density.

  With trained rollers, we get

  a stratified base in which the layer of copo-

  The polymer has a thickness of about 152.4 microns and the polyethylene layer is about 127

  micrometers. The base is then shaped into tubular

round and round.

  After having cut the tubular form

2586S60

  in tube bodies, the tubes can be filled with

  the dental cream of the present invention.

  Tubes of dentiftice laminated with

  polyolefin containing more intermediate layers

  These diaries can also be used successfully with the dental cream of the present invention without the occurrence of syneresis. For example, the multi-layered flexible sheet structure for the dental cream tubes described in the prior art in US Pat. No. 4,418,841 can be used as well as the structures

  more resistant to the cracks described therein.

  In fact, the dental creams of the present invention

  The composition, packaged in sheets of sheet material identified as prior art "A" and "A-1" in U.S. Patent No. 4,418,841, is very satisfactory and substantially free of syneresis. Such tubes A and A-1 consist of

  layers, as described below, by going from

  most external to the innermost layer.

A A-1

  LDPE = 37.5 Pum LDPE = 37.5 pm Pigmented LDPE = 50 pm Pigmented LDPE = 50 pm Paper = 40 tm Paper = 40 pm LDPE = 17.5 pim LDPE = 50 pun EAA = 82.5 pm OPP = 25 Pm Sheet = 17.5 pm EAA = 25 pm EAA = 50 pn Metal foil = 17.5 pm LDPE 30 w - EAA = 50 p Total 325 "m LDPE = 30 nm Total = 325 pm

  In columns A and A-1, the abbreviations

  tions have the following meanings; LDPE: low density polyethylene, EAA: ethylene-acrylic acid,

OPP: Oriented polypropylene.

  In the implementation of this

  vention, distributors can also be used

  mechanically actuated devices such as the distributor

  In particular, it has been described in US Pat. No. 4,437,591. The package of such dispensers is commonly

  polyolefin resin such as polypropylene.

  Thus, the casing resin is in principle a

  che whose inner surface is in contact with the dental cream. When the dental cream of the

  The present invention is packaged in such a device.

  mechanical tribulator made of polypropylene, it does not

not significantly syneresis.

  We also enjoy the benefits of

  the invention when the dental cream is condition-

  born in a flexible pouch with polyolefin surface, usually low density polyethylene and medium

density.

  The following non-limiting examples

  illustrate the present invention. All quantities and percentages are by weight,

unless otherwise specified.

EXAMPLE I

  The following creams are prepared with a creamy consistency and are filled with tubes each having laminated structures A and A-1, indicated above:

1 2 3 4

  Glycerin 8,000 8,000 8,000 8,000 Sorbitol (70%) 16,000 15,000 15,500 14,000 Sodium carboxymethylcellulose 1 <1,000 1,000 1,000 1,000 Sodium saccharinate 0,200 0,200 0,200 0,200 Sodium monofluorophosphate r0,760 0, 760 0f760 0,760 Sodium dihydrogen phosphate monohydrate 0.250 0.250 0.250 0.250 Deionized water, irradiated 19.700 19.700 19.700 19.700

Alpha-alumina trihydrate

  (C-333) 52,000 52,000 52,000 52,000 Sodium lauryl sulphate 1,200 1,200 1,200 1,200 Flavor 0.890 0r890 0.890 0.890 Polyethylene glycol, average molecular weight

600 - 0.500 2.0

pH 7.0 7.0 7.0 7.1

  After aging for at least 13 months

  at 250C, dental creams (2), (3) and (4)

  remain unctuous in laminate tubes

  one of the laminated structures A and A-1, while the dental cream (1) separates into liquid and solid phases in 1 week at 25 C in each of the two tubes

of structures A and A-1EXAMPLE 2

  The dental creams (1) to (4) are incor-

  pores in a mechanical dispenser according to U.S. Patent No. 4,437,591, consisting of a polypropylene casing. The dental creams (2), (3) and (4) retain their creamy consistency while the

  toothpaste (1) separates into liquid and solid phases.

EXAMPLE 3

  Similar results to those described above for Examples 1 and 2 are observed when: (i) the relative amounts of glycerine,

  sorbitol (70%) and polyethylene glycol (weight

  average lecular of 600) are: 6: 24: 2 instead of 6: 24: 0 and 18: 6: 2 instead of 18: 6: 0;

  (ii) polyethylene glycol of molecular weight

  means 200 and 1000 are used in place of the

  lyene glycol of average molecular weight 600; (iii) the dental creams are packaged in laminated tubes according to the U.S.

A. 3,260,410;

  (iv) dental creams are packaged in crack-resistant laminated tubes according to U.S. Patent No. 4,418,841; (yv) dental creams are packaged in flexible bags with the following structure

  going from the outer layer to the inner layer

  Polyethylene terephthalate, 12.2 μm, white ethylene-acrylic acid, 21.3 μm, metal foil, 9.0 μm, ethylene-acrylic acid, 3.3 μm, medium-density polyethylene, 25.4 μm;

  (vi) a mixture of 0.3 parts of carboxymethyl--

  sodium cellulose and 0.6 parts of substituted xanthan

  carboxymethyl cellulose as the only gel material

fiasco; -

  (vii) 3,000 parts of calcined alumina replaced

  one hundred and three thousand parts of alpha-alumina trihydrate; and

  (viii) 10 parts of sodium metaphosphate

  soluble solution replace 10,000 parts of tri-alpha alumina

hydrated;

  (ix) sodium cyclamate replaces saccha-

sodium rinate.

EXAMPLE 4

  The following dental creams are prepared in unctuous consistency and the conditions in tubes each having laminate structures A and A-1, shown above:

(1) (2)

  Glycerine 10,000 10,000 Sodium monofluorophosphate 0.760 0.760 Sodium carboxymethylcellulose 0.950 0.950 Tetradodic pyrophosphate 0.250 0.250 Sodium saccharinate 0.200 0f200 Sorbitol - 70% solution 15,000 17,000

Polyethylene glycol (molecular weight

mean eye 600) 2,000 -

  Deionized water - irradiated 20,090 20,090 Dicalcium phosphate dihydrate 48, 760 48f760 Flavor 0.890 0.890 Sodium lauryl sulphate 1.10 11100 After aging for at least 20 years

  weeks at 250C, the dental cream (1) remains

  in each of the laminated tubes of structures A and A-1, while the dental cream (2) separates into liquid and solid phases in 4 to 10 days

  at 25 ° C. in the tubes of the two structures A and A-1.

EXAMPLE 5

  Dental creams (1) and (2) are incor-

  porées in a mechanical dispenser according to U.S. Patent No. 4,437,591 consisting of a casing made of

  polypropylene. The dental cream (1) retains its

  creamy while the toothpaste (2)

liquid phase and solid phase.

  Results similar to those described above are observed when:

  (i) calcium carbonate replaces phospha-

dicalcium dihydrate;

  (ii) the substituted diamagnesium phosphate trihydrate

  this dicalcium phosphate dihydrate; (iii) the relative amounts of glycerine,

  sorbitol (70%) and polyethylene glycol - mole

  mean eyelid 600 - are: 6: 24: 2 instead of 6: 24: 0 and 18: 6: 2 instead of 18: 6: 0;

  (iv) polyethylene glycols of molecular weight

  means 200 and 1000 are used in place of the

  ethylene glycol of average molecular weight 600; (v) Dental creams are packaged in laminated tubes according to the U.A.

3,260,410;

  (vi) dental creams are packaged in crack-resistant laminated tubes according to U.S. Patent No. 4,418,841; (vii) dental creams are packaged in flexible pouches having the following structure

  going from the outer layer to the inner layer

  polyethylene terephthalate: 12.2 μmol ethylene-white acrylic acid, 21.3 pmar metal foil, 9.0 μm, ethylene-acrylic acid, 3.3 μm, medium-density polyethylene, 25.4 μm; and

  (viii) a mixture of 0.3 parts of carboxymethyl

  sodium cellulose and 0.6 part of iota-carrageenan replace sodium carboxynmethylcellulose as the only

gelling material.

Claims (20)

  1. Conditioned dental cream, in contact   with a polyolefin resin packaging surface   finique, characterized in that it comprises at least about 20% by weight of a liquid vehicle comprising   water, glycerin, sorbitol and polyethyl-   lene glycol having an average molecular weight of about   -1000, the ratio by weight of glycerin to sorbite   tol is from about 0.25: 1 to about 3: 1, and the ratio   weight of the total amount of polyethylene glycol glycerin and sorbitol being from about 60: 1 to about 6: 1, a solid carrier comprising about 0.05 to 10 weight percent gelling agent, about 20 to about 75 % by weight of a water-insoluble polishing material acceptable for the teeth, at least a dominant portion of which is a water-insoluble alkaline earth metal salt or an alpha-alumina trihydrate and, when the dominant portion of the polishing material is alpha-alumina trihydrate, a water-soluble material providing phosphate ions, to lower the pH of the the tooth cream to about 6-8.   2. Dental cream packaged according to the   claim 1, characterized in that the weight ratio of glycerine to sorbitol is from about 0.25: 1 to about 0.8: 1 and the weight ratio of the total amount of glycerin and sorbitol to polyethylene glycol is about 15: 1 to about 10: 1.   3. Dental cream packaged according to the   claim 2, characterized in that the weight ratio of glycerin to sorbitol is about 0.6: 1 at about 0.8: 1.   4. Dental cream packaged according to the   claim 1, characterized in that the molecular weight   The average weight of polyethylene glycol is about 600- 1,000.   5. Dental cream packaged according to the   claim 4, characterized in that the molecular weight   The average amount of polyethylene glycol is about 600.   6. Dental cream packaged according to the   claim 1, characterized in that the polyethylene   glycol is present in proportion to at least about 0.5% by weight.   7. Dental cream packaged according to the   claim 6, characterized in that the polyethylene   glycol is present in proportion of about 0.5 to 5% in weight.   8. Dental cream packaged according to the   claim 1, characterized in that the alpha-alumina   Trihydrate is the only polishing agent present.   9. Dental cream packaged according to the   8, characterized in that said material which lowers the pH is mineral.   10. Dental cream packaged according to the   9, characterized in that said material   pH-lowering mineral provides orthophosphorus ions. phate.   11. Dental cream packaged according to the   claim 10, characterized in that said orthophosphate ion-providing material is selected from orthophosphoric acid, an alkali metal diacid orthophosphate, ammonium diacid orthophosphate,   monoacid orthophosphate of alkali metal and ortho- monoacid ammonium phosphate.   12. Dental cream packaged according to the   claim 11, characterized in that said material   providing orthophosphate ions is a orthophosphate phate diacid sodium.   13. Dental cream packaged according to the   12, characterized in that the sodium diacid orthophosphate is sodium dihydrogen orthophosphate monohydrate.   14. Dental cream packaged according to the   1, characterized in that the water insoluble alkaline earth metal salt is present and   what it is a calcium salt.   15. Dental cream according to claim 14, characterized in that the. calcium salt is the dicalcium phosphate dihydrate.   16. Dental cream according to claim 1, characterized in that it is packaged in a   laminated plastic tube.   17. Dental cream according to claim 16, characterized in that the inner polyolefin resin surface of the laminate tube made of plastic is polyethylene.   L8. Dental cream according to claim   17, characterized in that the polyethylene is a poly- low density ethylene.   19. Dental cream according to claim 1, characterized in that it is packaged in a mechanical dispenser comprising a housing polyolefin resin. 20. Dental cream according to the claim   19, characterized in that said polyolefin resin   that shoemaker is polypropylene.   21. Dental cream according to claim 1, characterized in that it is packaged in a flexible bag.   22. Dental cream according to claim 21, characterized in that the inner polyolefin resin surface of the bag is a polyethylene   low density or medium density polyethylene.