FI62666C - Foerfarande foer framstaellning av terapeutiskt aktivt 6-klor-2-(1'-piperazinyl)pyrazin och salter daerav - Google Patents

Foerfarande foer framstaellning av terapeutiskt aktivt 6-klor-2-(1'-piperazinyl)pyrazin och salter daerav Download PDF

Info

Publication number: FI62666C
Authority: FI; Finland
Prior art keywords: formula; chloro; compound; piperazinyl; pyrazine
Prior art date: 1975-04-21

Application number

FI760978A

Other languages

English (en)

Finnish (fi)

Other versions

FI760978A (no

FI62666B (fi

Inventor

Walfred Spencer Saari

Jr William Carl Lumma

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-04-21

Filing date

1976-04-09

Publication date

1983-02-10

1976-04-09 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1976-10-22 Publication of FI760978A publication Critical patent/FI760978A/fi

1982-10-29 Application granted granted Critical

1982-10-29 Publication of FI62666B publication Critical patent/FI62666B/fi

1983-02-10 Publication of FI62666C publication Critical patent/FI62666C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FI760978A 1975-04-21 1976-04-09 Foerfarande foer framstaellning av terapeutiskt aktivt 6-klor-2-(1'-piperazinyl)pyrazin och salter daerav FI62666C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57005275A	1975-04-21	1975-04-21
US57005275		1975-04-21

Publications (3)

Publication Number	Publication Date
FI760978A FI760978A (no)	1976-10-22
FI62666B FI62666B (fi)	1982-10-29
FI62666C true FI62666C (fi)	1983-02-10

Family

ID=24277994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI760978A FI62666C (fi)	1975-04-21	1976-04-09	Foerfarande foer framstaellning av terapeutiskt aktivt 6-klor-2-(1'-piperazinyl)pyrazin och salter daerav

Country Status (36)

Country	Link
JP (1)	JPS51136688A (no)
AR (1)	AR210349A1 (no)
AT (1)	AT353795B (no)
AU (1)	AU496854B2 (no)
BE (1)	BE840904A (no)
BG (1)	BG34185A3 (no)
CA (1)	CA1059128A (no)
CH (1)	CH619462A5 (no)
CS (1)	CS195726B2 (no)
CY (1)	CY1090A (no)
DD (1)	DD124599A5 (no)
DE (1)	DE2617205C3 (no)
DK (1)	DK143899C (no)
EG (1)	EG12387A (no)
ES (4)	ES447150A1 (no)
FI (1)	FI62666C (no)
FR (1)	FR2308367A1 (no)
GB (1)	GB1492528A (no)
GR (1)	GR59900B (no)
HK (1)	HK60380A (no)
HU (1)	HU172684B (no)
IE (1)	IE42979B1 (no)
IL (1)	IL49391A (no)
KE (1)	KE3088A (no)
LU (1)	LU74795A1 (no)
MY (1)	MY8100225A (no)
NL (1)	NL167692C (no)
NO (1)	NO146599C (no)
PH (1)	PH12274A (no)
PL (1)	PL99664B1 (no)
PT (1)	PT65027B (no)
RO (1)	RO73278A (no)
SE (1)	SE421695B (no)
SU (1)	SU638260A3 (no)
YU (1)	YU100676A (no)
ZA (1)	ZA762320B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4091098A (en) *	1977-04-25	1978-05-23	Merck & Co., Inc.	3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en)	1978-03-17	1979-08-07	Merck & Co., Inc.	Piperazinylpyrazines
US4252816A (en) *	1979-12-03	1981-02-24	Merck & Co., Inc.	Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en)	1980-12-29	1982-07-13	American Home Products Corporation	2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) *	1982-05-06	1985-04-03	American Cyanamid Company	Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) *	1983-03-25	1985-10-15	Degussa Aktiengesellschaft	N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) *	1987-12-11	1988-11-29	American Home Products Corporation	Serotonergic pyrazine derivatives
EP0580465A1 (fr) *	1992-06-25	1994-01-26	Sanofi	Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
EE04588B1 (et) *	1997-10-27	2006-02-15	Neurosearch A/S	Heteroarüüldiasatsükloalkaanid kui atsetüülkoliini nikotiinretseptorite kolinergilised ligandid, nende kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
NZ514021A (en)	1999-04-26	2001-09-28	Neurosearch As	Heteroaryl diazacycloalkanes, their preparation and use
CZ20022739A3 (cs) *	2000-02-16	2003-02-12	Neurogen Corporation	Substituované arylpyraziny
US6825198B2 (en) *	2001-06-21	2004-11-30	Pfizer Inc	5-HT receptor ligands and uses thereof
SE0202287D0 (sv) *	2002-07-19	2002-07-19	Biovitrum Ab	New compounds
AU2003243101B2 (en) *	2002-07-19	2010-05-13	Biovitrum Ab (Publ)	Novel piperazinyl-pyrazinone derivatives for the treatment of 5-HT2A receptor-related disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2606906A (en) *	1948-10-14	1952-08-12	American Cyanamid Co	1-(2-pyridyl) piperazine and process of preparing same

1976
- 1976-04-07 SE SE7604093A patent/SE421695B/xx not_active IP Right Cessation
- 1976-04-07 EG EG76205A patent/EG12387A/xx active
- 1976-04-07 DK DK164476A patent/DK143899C/da not_active IP Right Cessation
- 1976-04-08 NO NO761207A patent/NO146599C/no unknown
- 1976-04-09 NL NL7603800A patent/NL167692C/xx not_active IP Right Cessation
- 1976-04-09 FI FI760978A patent/FI62666C/fi not_active IP Right Cessation
- 1976-04-12 IL IL49391A patent/IL49391A/xx unknown
- 1976-04-13 AU AU12966/76A patent/AU496854B2/en not_active Expired
- 1976-04-13 GR GR50538A patent/GR59900B/el unknown
- 1976-04-13 PH PH18329A patent/PH12274A/en unknown
- 1976-04-14 CA CA250,732A patent/CA1059128A/en not_active Expired
- 1976-04-14 FR FR7610958A patent/FR2308367A1/fr active Granted
- 1976-04-15 CY CY1090A patent/CY1090A/xx unknown
- 1976-04-15 DD DD192399A patent/DD124599A5/xx unknown
- 1976-04-15 GB GB15644/76A patent/GB1492528A/en not_active Expired
- 1976-04-16 CS CS762549A patent/CS195726B2/cs unknown
- 1976-04-19 JP JP51043763A patent/JPS51136688A/ja active Granted
- 1976-04-19 ES ES447150A patent/ES447150A1/es not_active Expired
- 1976-04-20 SU SU762346054A patent/SU638260A3/ru active
- 1976-04-20 BG BG032968A patent/BG34185A3/xx unknown
- 1976-04-20 LU LU74795A patent/LU74795A1/xx unknown
- 1976-04-20 BE BE166282A patent/BE840904A/xx not_active IP Right Cessation
- 1976-04-20 CH CH492676A patent/CH619462A5/de not_active IP Right Cessation
- 1976-04-20 AR AR262930A patent/AR210349A1/es active
- 1976-04-20 YU YU01006/76A patent/YU100676A/xx unknown
- 1976-04-20 ZA ZA762320A patent/ZA762320B/xx unknown
- 1976-04-20 AT AT288376A patent/AT353795B/de not_active IP Right Cessation
- 1976-04-20 DE DE2617205A patent/DE2617205C3/de not_active Expired
- 1976-04-20 RO RO7685688A patent/RO73278A/ro unknown
- 1976-04-20 PL PL1976188912A patent/PL99664B1/pl unknown
- 1976-04-21 HU HU76ME00001967A patent/HU172684B/hu unknown
- 1976-04-21 IE IE828/76A patent/IE42979B1/en unknown
- 1976-04-21 PT PT65027A patent/PT65027B/pt unknown
1977
- 1977-06-01 ES ES459405A patent/ES459405A1/es not_active Expired
- 1977-06-01 ES ES459406A patent/ES459406A1/es not_active Expired
- 1977-06-01 ES ES459407A patent/ES459407A1/es not_active Expired
1980
- 1980-10-02 KE KE3088A patent/KE3088A/xx unknown
- 1980-10-30 HK HK603/80A patent/HK60380A/xx unknown
1981
- 1981-12-30 MY MY225/81A patent/MY8100225A/xx unknown

Also Published As

Publication number	Publication date
FR2308367B1 (no)	1979-09-21
IE42979L (en)	1976-10-21
DK143899B (da)	1981-10-26
FI760978A (no)	1976-10-22
FR2308367A1 (fr)	1976-11-19
DK164476A (da)	1976-10-22
AR210349A1 (es)	1977-07-29
PL99664B1 (pl)	1978-07-31
LU74795A1 (no)	1977-02-07
DD124599A5 (no)	1977-03-02
HU172684B (hu)	1978-11-28
JPS5522475B2 (no)	1980-06-17
CS195726B2 (en)	1980-02-29
ES447150A1 (es)	1977-09-16
AU496854B2 (en)	1978-11-02
GR59900B (en)	1978-03-16
NO761207L (no)	1976-10-22
NL7603800A (nl)	1976-10-25
JPS51136688A (en)	1976-11-26
KE3088A (en)	1980-11-07
DK143899C (da)	1982-04-13
CH619462A5 (en)	1980-09-30
PT65027A (en)	1976-05-01
NL167692C (nl)	1982-01-18
NO146599C (no)	1982-11-03
ATA288376A (de)	1979-05-15
MY8100225A (en)	1981-12-31
IE42979B1 (en)	1980-11-19
ES459406A1 (es)	1978-08-16
DE2617205B2 (de)	1980-05-08
NO146599B (no)	1982-07-26
IL49391A (en)	1979-09-30
ES459405A1 (es)	1978-08-16
PT65027B (en)	1978-04-03
CY1090A (en)	1980-12-27
CA1059128A (en)	1979-07-24
ES459407A1 (es)	1978-08-16
AT353795B (de)	1979-12-10
ZA762320B (en)	1977-11-30
BG34185A3 (en)	1983-07-15
EG12387A (en)	1978-12-31
AU1296676A (en)	1977-10-20
BE840904A (fr)	1976-08-16
DE2617205C3 (de)	1981-01-29
SU638260A3 (ru)	1978-12-15
YU100676A (en)	1982-08-31
HK60380A (en)	1980-11-07
NL167692B (nl)	1981-08-17
SE421695B (sv)	1982-01-25
IL49391A0 (en)	1976-06-30
RO73278A (ro)	1982-09-09
SE7604093L (sv)	1976-10-22
FI62666B (fi)	1982-10-29
DE2617205A1 (de)	1976-10-28
GB1492528A (en)	1977-11-23
PH12274A (en)	1978-12-12

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Legal Events

Date	Code	Title	Description
2004-08-31	MM	Patent lapsed	Owner name: MERCK & CO INC.