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NO146599C - Analogifremgangsmaate ved fremstilling av terapeutisk aktivt 6-klor-2-(1`-piperazinyl)-pyrazin og salter derav - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktivt 6-klor-2-(1`-piperazinyl)-pyrazin og salter derav

Info

Publication number
NO146599C
NO146599C NO761207A NO761207A NO146599C NO 146599 C NO146599 C NO 146599C NO 761207 A NO761207 A NO 761207A NO 761207 A NO761207 A NO 761207A NO 146599 C NO146599 C NO 146599C
Authority
NO
Norway
Prior art keywords
pyrazine
piperazinyl
chloro
salts
preparation
Prior art date
Application number
NO761207A
Other languages
English (en)
Other versions
NO146599B (no
NO761207L (no
Inventor
Walfred Spencer Saari
William Carl Lumma Jr
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO761207L publication Critical patent/NO761207L/no
Publication of NO146599B publication Critical patent/NO146599B/no
Publication of NO146599C publication Critical patent/NO146599C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO761207A 1975-04-21 1976-04-08 Analogifremgangsmaate ved fremstilling av terapeutisk aktivt 6-klor-2-(1`-piperazinyl)-pyrazin og salter derav NO146599C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57005275A 1975-04-21 1975-04-21

Publications (3)

Publication Number Publication Date
NO761207L NO761207L (no) 1976-10-22
NO146599B NO146599B (no) 1982-07-26
NO146599C true NO146599C (no) 1982-11-03

Family

ID=24277994

Family Applications (1)

Application Number Title Priority Date Filing Date
NO761207A NO146599C (no) 1975-04-21 1976-04-08 Analogifremgangsmaate ved fremstilling av terapeutisk aktivt 6-klor-2-(1`-piperazinyl)-pyrazin og salter derav

Country Status (36)

Country Link
JP (1) JPS51136688A (no)
AR (1) AR210349A1 (no)
AT (1) AT353795B (no)
AU (1) AU496854B2 (no)
BE (1) BE840904A (no)
BG (1) BG34185A3 (no)
CA (1) CA1059128A (no)
CH (1) CH619462A5 (no)
CS (1) CS195726B2 (no)
CY (1) CY1090A (no)
DD (1) DD124599A5 (no)
DE (1) DE2617205C3 (no)
DK (1) DK143899C (no)
EG (1) EG12387A (no)
ES (4) ES447150A1 (no)
FI (1) FI62666C (no)
FR (1) FR2308367A1 (no)
GB (1) GB1492528A (no)
GR (1) GR59900B (no)
HK (1) HK60380A (no)
HU (1) HU172684B (no)
IE (1) IE42979B1 (no)
IL (1) IL49391A (no)
KE (1) KE3088A (no)
LU (1) LU74795A1 (no)
MY (1) MY8100225A (no)
NL (1) NL167692C (no)
NO (1) NO146599C (no)
PH (1) PH12274A (no)
PL (1) PL99664B1 (no)
PT (1) PT65027B (no)
RO (1) RO73278A (no)
SE (1) SE421695B (no)
SU (1) SU638260A3 (no)
YU (1) YU100676A (no)
ZA (1) ZA762320B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en) 1978-03-17 1979-08-07 Merck & Co., Inc. Piperazinylpyrazines
US4252816A (en) * 1979-12-03 1981-02-24 Merck & Co., Inc. Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en) 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) * 1982-05-06 1985-04-03 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) * 1983-03-25 1985-10-15 Degussa Aktiengesellschaft N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
EP0580465A1 (fr) * 1992-06-25 1994-01-26 Sanofi Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
EP1491532B1 (en) 1997-10-27 2010-12-15 NeuroSearch A/S Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetyloholine receptors
EP1175416B1 (en) 1999-04-26 2003-07-16 Neurosearch A/S Heteroaryl diazacycloalkanes, their preparation and use
CA2398937A1 (en) * 2000-02-16 2001-08-23 Neurogen Corporation Substituted arylpyrazines
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
MXPA05000784A (es) 2002-07-19 2005-06-17 Biovitrum Ab Derivados de piperazinil-pirazinona novedosos para el tratamiento de los trastornos relacionados con el receptor 5-ht2a.
SE0202287D0 (sv) * 2002-07-19 2002-07-19 Biovitrum Ab New compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2606906A (en) * 1948-10-14 1952-08-12 American Cyanamid Co 1-(2-pyridyl) piperazine and process of preparing same

Also Published As

Publication number Publication date
AU1296676A (en) 1977-10-20
ATA288376A (de) 1979-05-15
CS195726B2 (en) 1980-02-29
NO146599B (no) 1982-07-26
DE2617205B2 (de) 1980-05-08
IL49391A0 (en) 1976-06-30
DK143899B (da) 1981-10-26
IE42979L (en) 1976-10-21
PL99664B1 (pl) 1978-07-31
GB1492528A (en) 1977-11-23
NL167692B (nl) 1981-08-17
SE421695B (sv) 1982-01-25
NO761207L (no) 1976-10-22
IE42979B1 (en) 1980-11-19
MY8100225A (en) 1981-12-31
ES459406A1 (es) 1978-08-16
AT353795B (de) 1979-12-10
KE3088A (en) 1980-11-07
HK60380A (en) 1980-11-07
ES459407A1 (es) 1978-08-16
ES447150A1 (es) 1977-09-16
NL167692C (nl) 1982-01-18
IL49391A (en) 1979-09-30
FR2308367B1 (no) 1979-09-21
SE7604093L (sv) 1976-10-22
CA1059128A (en) 1979-07-24
RO73278A (ro) 1982-09-09
CY1090A (en) 1980-12-27
FI62666C (fi) 1983-02-10
ES459405A1 (es) 1978-08-16
DD124599A5 (no) 1977-03-02
JPS5522475B2 (no) 1980-06-17
EG12387A (en) 1978-12-31
SU638260A3 (ru) 1978-12-15
DE2617205C3 (de) 1981-01-29
DK164476A (da) 1976-10-22
FI760978A (no) 1976-10-22
JPS51136688A (en) 1976-11-26
CH619462A5 (en) 1980-09-30
HU172684B (hu) 1978-11-28
PH12274A (en) 1978-12-12
PT65027B (en) 1978-04-03
DE2617205A1 (de) 1976-10-28
ZA762320B (en) 1977-11-30
LU74795A1 (no) 1977-02-07
BG34185A3 (en) 1983-07-15
FI62666B (fi) 1982-10-29
YU100676A (en) 1982-08-31
FR2308367A1 (fr) 1976-11-19
NL7603800A (nl) 1976-10-25
BE840904A (fr) 1976-08-16
AR210349A1 (es) 1977-07-29
PT65027A (en) 1976-05-01
GR59900B (en) 1978-03-16
AU496854B2 (en) 1978-11-02
DK143899C (da) 1982-04-13

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