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ES2720287T3 - Fructosil aminoácido oxidasa - Google Patents

Fructosil aminoácido oxidasa Download PDF

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Publication number
ES2720287T3
ES2720287T3 ES10742433T ES10742433T ES2720287T3 ES 2720287 T3 ES2720287 T3 ES 2720287T3 ES 10742433 T ES10742433 T ES 10742433T ES 10742433 T ES10742433 T ES 10742433T ES 2720287 T3 ES2720287 T3 ES 2720287T3
Authority
ES
Spain
Prior art keywords
amino acid
fructosyl
oxidase
acid oxidase
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10742433T
Other languages
English (en)
Spanish (es)
Inventor
Koji Sode
Kazunori Ikebukuro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Ultizyme International Ltd
Original Assignee
F Hoffmann La Roche AG
Ultizyme International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Ultizyme International Ltd filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2720287T3 publication Critical patent/ES2720287T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
ES10742433T 2009-08-03 2010-08-02 Fructosil aminoácido oxidasa Active ES2720287T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09009969A EP2287295A1 (de) 2009-08-03 2009-08-03 Mutierte Fructosyl Amino Acid Oxidase
PCT/EP2010/004708 WO2011015326A2 (en) 2009-08-03 2010-08-02 Fructosyl amino acid oxidase

Publications (1)

Publication Number Publication Date
ES2720287T3 true ES2720287T3 (es) 2019-07-19

Family

ID=41060017

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10742433T Active ES2720287T3 (es) 2009-08-03 2010-08-02 Fructosil aminoácido oxidasa

Country Status (7)

Country Link
US (1) US8497083B2 (de)
EP (2) EP2287295A1 (de)
JP (1) JP5897463B2 (de)
CN (1) CN102471763B (de)
ES (1) ES2720287T3 (de)
PL (1) PL2462223T3 (de)
WO (1) WO2011015326A2 (de)

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CA2739881A1 (en) 2008-10-09 2010-04-15 Kyowa Medex Co., Ltd. Novel fructosyl peptide oxidase
EP2354224B1 (de) * 2008-10-10 2018-02-14 Toyobo Co., Ltd. Neues protein mit fructosyl-valyl-histidinoxidaseaktivität, modifiziertes produkt daraus und verwendung des proteins oder modifizierten produkts
US9708586B2 (en) 2010-08-06 2017-07-18 Kikkoman Corporation Amadoriase having altered substrate specificity
EP2602318B1 (de) * 2010-08-06 2015-09-30 Kikkoman Corporation Amadoriase mit veränderter substratspezifität
WO2012043601A1 (ja) * 2010-09-29 2012-04-05 キッコーマン株式会社 アマドリアーゼ改変体
US9701949B2 (en) 2011-12-28 2017-07-11 Kikkoman Corporation Amadoriase with improved thermostability, gene and recombinant DNA for the amadoriase, and method for production of amadoriase with improved thermostability
EP2843050B1 (de) 2012-04-27 2019-03-13 Kikkoman Corporation Zur wirkung auf fructosylhexapeptid fähige, modifizierte amadoriase
JP6363327B2 (ja) * 2013-03-25 2018-07-25 キッコーマン株式会社 改変アマドリアーゼ
CN105473715B (zh) * 2013-08-09 2020-02-18 龟甲万株式会社 修饰型阿马多里酶及其制造法、以及阿马多里酶的耐表面活性剂性提高剂和使用它的HbA1c测定用组合物
JP6542671B2 (ja) 2013-10-25 2019-07-10 キッコーマン株式会社 ヘモグロビンＡ１ｃの測定方法および測定キット
EP3061829B1 (de) 2013-10-25 2021-09-22 Kikkoman Corporation Hba1c-messverfahren mit auf glykierte peptide wirkender amadoriase
CN103695380B (zh) * 2013-12-27 2016-05-25 宁波美康生物科技股份有限公司 果糖氨基酸氧化酶、制备方法及含该酶的糖化白蛋白检测试剂盒
JP6980383B2 (ja) * 2014-10-24 2021-12-15 キッコーマン株式会社 デヒドロゲナーゼ活性の向上したアマドリアーゼ
WO2016072520A1 (ja) * 2014-11-07 2016-05-12 キッコーマン株式会社 アニオン性界面活性剤耐性が向上したアマドリアーゼ
JP6576170B2 (ja) * 2015-09-02 2019-09-18 旭化成ファーマ株式会社 くし型電極を用いた糖化タンパク質の測定方法
JP7471772B2 (ja) * 2016-04-22 2024-04-22 キッコーマン株式会社 ＨｂＡ１ｃデヒドロゲナーゼ
US10533160B2 (en) 2016-12-13 2020-01-14 Industrial Technology Research Institute Recombinant protein, and preparation method and application thereof
CN110520728B (zh) * 2017-03-03 2022-12-06 聚合物技术系统公司 用于酶促a1c检测和定量的系统和方法
US11703513B2 (en) 2017-08-07 2023-07-18 Polymer Technology Systems, Inc. Systems and methods for enzymatic A1C detection and quantification
CN109232745B (zh) * 2018-09-18 2020-02-28 深圳瑞健生物科技有限公司 一种可通过血脑屏障的多肽
US11852604B2 (en) 2019-06-26 2023-12-26 Polymer Technology System, Inc. Systems and methods for reduction of oxygen tension in electrochemical biosensors
CN111676236A (zh) * 2020-03-12 2020-09-18 北京达成生物科技有限公司 一种重组flod蛋白的大肠杆菌表达方法
CN118369420A (zh) * 2022-01-27 2024-07-19 株式会社普欧威盖特 果糖基氨基酸氧化酶、果糖基氨基酸氧化酶的制造方法、糖化蛋白传感器和糖化蛋白的测定方法

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EP2096173B1 (de) * 2003-05-21 2019-01-30 Asahi Kasei Pharma Corporation Verfahren zur Messung von glykolisiertem Hämoglobin A1C, dafür zu verwendende Enzyme und Herstellungsverfahren dafür
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Also Published As

Publication number Publication date
JP2013500729A (ja) 2013-01-10
JP5897463B2 (ja) 2016-03-30
US8497083B2 (en) 2013-07-30
CN102471763B (zh) 2014-07-09
WO2011015326A8 (en) 2012-02-23
US20120208226A1 (en) 2012-08-16
CN102471763A (zh) 2012-05-23
EP2462223A2 (de) 2012-06-13
EP2462223B1 (de) 2019-02-13
WO2011015326A2 (en) 2011-02-10
EP2287295A1 (de) 2011-02-23
WO2011015326A3 (en) 2011-07-07
PL2462223T3 (pl) 2019-07-31

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