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ES2171056T3 - Procedimiento para la fabricacion de cefuroxima axetil cristalina soluble. - Google Patents

Procedimiento para la fabricacion de cefuroxima axetil cristalina soluble.

Info

Publication number
ES2171056T3
ES2171056T3 ES99103410T ES99103410T ES2171056T3 ES 2171056 T3 ES2171056 T3 ES 2171056T3 ES 99103410 T ES99103410 T ES 99103410T ES 99103410 T ES99103410 T ES 99103410T ES 2171056 T3 ES2171056 T3 ES 2171056T3
Authority
ES
Spain
Prior art keywords
axetil
cefuroxima
procedure
manufacture
soluble crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99103410T
Other languages
English (en)
Inventor
Ahmet Halit Gunduz
Mehmet Bahar
Mehmet Goktepe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fako Ilaclari AS
Original Assignee
Fako Ilaclari AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fako Ilaclari AS filed Critical Fako Ilaclari AS
Application granted granted Critical
Publication of ES2171056T3 publication Critical patent/ES2171056T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

LA INVENCION TRATA DEL PRINCIPIO ACTIVO CEFUROXIMA AXETIL Y EN PARTICULAR UNA FORMA CRISTALINA DEL PRINCIPIO ACTIVO SEGUN LA DEFINICION USP 23, QUE ES SOLUBLE MEJOR QUE OTRAS FORMAS CONOCIDAS CRISTALINAS DE CEFUROXIMA AXETIL. LA INVENCION TRATA TAMBIEN DE UN PROCEDIMIENTO PARA LA PREPARACION DE ESTA FORMA CRISTALINA DEL PRINCIPIO ACTIVO.
ES99103410T 1998-02-20 1999-02-22 Procedimiento para la fabricacion de cefuroxima axetil cristalina soluble. Expired - Lifetime ES2171056T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19807248 1998-02-20

Publications (1)

Publication Number Publication Date
ES2171056T3 true ES2171056T3 (es) 2002-08-16

Family

ID=7858459

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99103410T Expired - Lifetime ES2171056T3 (es) 1998-02-20 1999-02-22 Procedimiento para la fabricacion de cefuroxima axetil cristalina soluble.

Country Status (6)

Country Link
EP (1) EP0937727B1 (es)
AT (1) ATE212638T1 (es)
DE (2) DE59900787D1 (es)
DK (1) DK0937727T3 (es)
ES (1) ES2171056T3 (es)
PT (1) PT937727E (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN190849B (es) * 2000-07-17 2003-08-23 Ranbaxy Lab Ltd
DE102005019458A1 (de) * 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
DE102006019619A1 (de) * 2006-04-25 2007-10-31 Grünenthal GmbH Kristalline Modifikation von Cefuroximaxetil
CN114354800B (zh) * 2021-12-31 2023-04-28 山东大学 头孢呋辛酯中乙酰溴含量的分析方法
CN116284050B (zh) * 2022-12-19 2024-04-12 华北制药河北华民药业有限责任公司 一种高效率结晶型头孢呋辛酯转无定型粉体的方法及产品

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1571683A (en) * 1976-02-16 1980-07-16 Glaxo Operations Ltd Ester derivatives of cefuroxime
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
GB8320521D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
US5063224A (en) * 1990-07-09 1991-11-05 Eli Lilly And Company R-cefuroxime axetil
IT1277426B1 (it) * 1995-08-03 1997-11-10 Acs Dobfar Spa Forma cristallina biodisponibile del cefuroxima axetil
NZ299077A (en) * 1996-07-26 1998-06-26 Apotex Inc Preparation of amorphous cefuroxime axetil (a cephalosporin derivative) by dissolving crystalline cefuroxim axetil in a highly polar solvent, typically dmso and/or dmf
KR100187959B1 (ko) * 1997-03-31 1999-06-01 윤재승 저융점 무정형 세푸록심 악세틸의 제조방법
CA2209868C (en) * 1997-08-15 2001-08-14 Bernard Charles Sherman Pharmaceutical compositions comprising cefuroxime axetil

Also Published As

Publication number Publication date
DE19907521A1 (de) 1999-11-04
PT937727E (pt) 2002-07-31
ATE212638T1 (de) 2002-02-15
EP0937727A1 (de) 1999-08-25
EP0937727B1 (de) 2002-01-30
DE59900787D1 (de) 2002-03-14
DK0937727T3 (da) 2002-05-13

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