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ES2015777A6 - Emulsion multiple de hemoglobina. - Google Patents

Emulsion multiple de hemoglobina.

Info

Publication number
ES2015777A6
ES2015777A6 ES8902899A ES8902899A ES2015777A6 ES 2015777 A6 ES2015777 A6 ES 2015777A6 ES 8902899 A ES8902899 A ES 8902899A ES 8902899 A ES8902899 A ES 8902899A ES 2015777 A6 ES2015777 A6 ES 2015777A6
Authority
ES
Spain
Prior art keywords
oxygen
oil
hemoglobin
multiple emulsion
oxygen carrying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8902899A
Other languages
English (en)
Inventor
Richard L Beissinger
Darsh T Wasan
Lahksman R Sehgal
Arthur L Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Illinois Institute of Technology
Original Assignee
Illinois Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illinois Institute of Technology filed Critical Illinois Institute of Technology
Publication of ES2015777A6 publication Critical patent/ES2015777A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4144—Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/922—Colloid systems having specified particle size, range, or distribution, e.g. bimodal particle distribution
    • Y10S516/923—Emulsion

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

EMULSION MULTIPLE DE HEMOGLOBINA. LA PRESENTE INVENCION PROPORCIONA UNA EMULSION MULTIPLE DE UN MATERIAL ACUOSO PORTADOR DE OXIGENO EN ACEITE EN UNA FASE ACUOSA EXTERNA, QUE ES ADECUADA PARA LA PROVISION DE OXIGENO EN PROCESOS DE TRANSFERENCIA DE OXIGENO. MAS CONCRETAMENTE, LA INVENCION PROPORCIONA UNA EMULSION MULTIPLE DE HEMOGLOBINA EN UN ACEITE FISIOLOGICAMENTE COMPATIBLE EN UNA SOLUCION SALINA ACUOSA EXTERNA, CUYAS GOTITAS TIENEN UN TAMAÑO SUFICIENTEMENTE PEQUEÑO PARA SUMINISTRAR UN FLUJO DE OXIGENO A TRAVES DE LOS VASOS SANGUINEOS A LOS TEJIDOS U ORGANOS CORPORALES DESEADOS, POR LO QUE CONSTITUYE UN SUSTITUTO DE SANGRE. LA INVENCION TAMBIEN PROPORCIONA UN PROCEDIMIENTO PARA FORMULAR LA HEMOGLOBINA, UN MATERIAL FRAGIL, EN EMULSIONES MULTIPLES DE AGUA EN ACEITE EN AGUA DE ALTO CONTENIDO EN HEMOGLOBINA, QUE MANTIENEN ALTOS RENDIMIENTOS Y TIENEN UNA BUENA ACTIVIDAD DE INTERCAMBIO DE OXIGENO.
ES8902899A 1988-08-19 1989-08-18 Emulsion multiple de hemoglobina. Expired - Lifetime ES2015777A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/234,386 US5061688A (en) 1988-08-19 1988-08-19 Hemoglobin multiple emulsion

Publications (1)

Publication Number Publication Date
ES2015777A6 true ES2015777A6 (es) 1990-09-01

Family

ID=22881174

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8902899A Expired - Lifetime ES2015777A6 (es) 1988-08-19 1989-08-18 Emulsion multiple de hemoglobina.

Country Status (12)

Country Link
US (3) US5061688A (es)
JP (1) JPH02160724A (es)
AU (1) AU614173B2 (es)
CA (1) CA1330937C (es)
CH (1) CH679206A5 (es)
DE (1) DE3927298C2 (es)
ES (1) ES2015777A6 (es)
FR (1) FR2635458B1 (es)
GB (1) GB2221912B (es)
IT (1) IT1232170B (es)
NL (1) NL194665C (es)
SE (1) SE504671C2 (es)

Families Citing this family (62)

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US5061688A (en) * 1988-08-19 1991-10-29 Illinois Institute Of Technology Hemoglobin multiple emulsion
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US5622649A (en) * 1991-06-27 1997-04-22 Emory University Multiple emulsions and methods of preparation
EP0591452B1 (en) * 1991-06-27 1998-05-06 Emory University Multiple emulsions and methods of preparation
DE4136699A1 (de) * 1991-11-07 1992-10-22 Lancaster Group Ag Verfahren zur herstellung von stabilen, komplexen emulsionssystemen des typs wasser-oel-wasser und deren verwendung als kosmetische praeparate
US5670173A (en) * 1992-09-14 1997-09-23 Mcgill University Biodegradable polymer membrane containing hemoglobin for blood substitute
US6506340B1 (en) 1993-06-01 2003-01-14 Cobe Cardiovascular, Inc. Antifoaming device and method for extracorporeal blood processing
US5578564A (en) * 1993-07-23 1996-11-26 Somatogen, Inc. Nickel-free hemoglobin and methods for producing such hemoglobin
TW381022B (en) 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
DE4341113B4 (de) * 1993-12-02 2006-04-13 IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG Stabile multiple X/O/Y-Emulsion
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US5589177A (en) * 1994-12-06 1996-12-31 Helene Curtis, Inc. Rinse-off water-in-oil-in-water compositions
US6436969B1 (en) * 1995-09-12 2002-08-20 Kansas University Medical Center Research Institute Inc. Dialysis solutions and methods
WO1997025978A1 (fr) * 1996-01-15 1997-07-24 BELOYARTSEV, Arkady Felixovich Procede de production d'emulsions perfluorocarbonees a des fins medicales
US5834519A (en) * 1996-10-11 1998-11-10 Wayne State University Stabilized gas-supersaturated emulsions and suspensions
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
ATE302019T1 (de) 1997-02-28 2005-09-15 Univ California Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
WO1999043301A1 (en) * 1998-02-24 1999-09-02 The Board Of Trustees Of The University Of Illinois Lipid emulsions in the treatment of systemic poisoning
DE60024700T2 (de) * 1999-03-19 2006-09-28 Kao Corp. Verfahren zur Herstellung einer Emulsion
US6500809B1 (en) 1999-11-12 2002-12-31 Neuron Therapeutics, Inc. Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith
US6777450B1 (en) * 2000-05-26 2004-08-17 Color Access, Inc. Water-thin emulsions with low emulsifier levels
DE10034970B4 (de) * 2000-07-19 2004-11-18 Sanguibiotech Gmbh Einen Sauerstoffträger, ausgewählt aus Hämoglobin oder Hämoglobin- und Myoglobin-enthaltende Zubereitung in Form einer Emulsion sowie deren Verwendung als kosmetisches Externum und zur natürlichen Regeneration der Haut bei Sauerstoff-Mangel
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WO2002085111A1 (en) * 2001-04-18 2002-10-31 Northfield Laboratories Flexible container system for storage of stabilized hemoglobin solutions
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
DE10209860A1 (de) * 2002-03-06 2003-09-25 Hemofarm Konzern A D Hydrophobe Nanotropfen mit gebundenen Hämoglobinmolekülen in hydrophiler Phase enthaltene Emulsion als Blutersatzstoff
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
US20040072729A1 (en) * 2002-10-10 2004-04-15 Sunbio Inc. High oxygen affinity PEG-hemoglobin as treatment for brain stroke
US9388427B2 (en) * 2002-12-02 2016-07-12 Biovec, Llc In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors
US7803365B2 (en) * 2002-12-02 2010-09-28 Biovec, Llc Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
KR20050095636A (ko) * 2003-01-29 2005-09-29 노쓰필드 라보라토리스, 인코포레이티드 감소된 양의 테트라머를 지닌 중합된 헤모글로빈 용액 및이의 제조 방법
WO2004076635A2 (en) * 2003-02-25 2004-09-10 Biovec B.V. Therapeutic applications of thrombomodulin gene via viral and non-viral vectors
US20050186183A1 (en) * 2003-12-08 2005-08-25 Deangelo Joseph Stabilized products, processes and devices for preparing same
US7087369B2 (en) * 2003-12-17 2006-08-08 The Regents Of The University Of California Cornea preservation medium
EP1864659B1 (en) * 2005-03-31 2011-11-23 Suntory Holdings Limited Lignane compound-containing oil-in-water emulsion and composition comprising the same
CN1733298B (zh) * 2005-08-16 2011-08-24 华东理工大学 血红蛋白为基础的微囊型血液代用品及其制备方法
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US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
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US8063020B2 (en) * 2007-12-22 2011-11-22 Simpkins Cuthbert O Resuscitation fluid
US8618056B2 (en) 2007-12-22 2013-12-31 Cuthbert O. Simpkins Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries
US20100196461A1 (en) * 2009-01-30 2010-08-05 Simpkins Cuthbert O Resuscitation fluid
US8906855B2 (en) 2007-12-22 2014-12-09 Vivacelle Bio, Inc. Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries
EP2361057A1 (en) 2008-08-07 2011-08-31 Bioactive Surgical, Inc. Stem cell capture and immobilization coatings for medical devices and implants
EP2430109A4 (en) * 2009-04-28 2016-01-06 Israel State EMULSIONS, EMULTER, METHOD OF USE, AND PROCESS FOR PRODUCING THE SAME
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US10252231B2 (en) 2014-10-31 2019-04-09 Massachusetts Institute Of Technology Compositions and methods for forming emulsions
US11119098B2 (en) 2014-10-31 2021-09-14 Massachusetts Institute Of Technology Systems including Janus droplets
ES2861806T3 (es) 2014-12-02 2021-10-06 Novartis Ag Fabricación de composiciones que contienen tensioactivo
US20190170737A1 (en) 2016-09-19 2019-06-06 Massachusetts Institute Of Technology Systems including janus droplets
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Also Published As

Publication number Publication date
FR2635458A1 (fr) 1990-02-23
NL8902100A (nl) 1990-03-16
GB2221912A (en) 1990-02-21
CA1330937C (en) 1994-07-26
US5061688A (en) 1991-10-29
DE3927298C2 (de) 2003-02-06
GB2221912B (en) 1992-09-23
US5438041A (en) 1995-08-01
SE8902773D0 (sv) 1989-08-18
SE8902773L (sv) 1990-02-20
AU614173B2 (en) 1991-08-22
GB8918880D0 (en) 1989-09-27
FR2635458B1 (fr) 1994-11-18
SE504671C2 (sv) 1997-03-24
CH679206A5 (es) 1992-01-15
JPH02160724A (ja) 1990-06-20
AU4008689A (en) 1990-02-22
US5217648A (en) 1993-06-08
NL194665C (nl) 2002-11-04
DE3927298A1 (de) 1990-03-01
IT1232170B (it) 1992-01-25
IT8948297A0 (it) 1989-08-21
NL194665B (nl) 2002-07-01

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SA6 Expiration date (snapshot 920101)

Free format text: 2009-08-18